Homo sapiens

26 known processes

MDH2

malate dehydrogenase 2, NAD (mitochondrial)

(Aliases: M-MDH,MOR1,MDH,MGC:3559)

MDH2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 396 0.970
post embryonic development GO:0009791 2 0.849
Worm Fly
vesicle mediated transport GO:0016192 371 0.725
Worm
nucleotide biosynthetic process GO:0009165 109 0.706
tricarboxylic acid metabolic process GO:0072350 4 0.617
generation of precursor metabolites and energy GO:0006091 68 0.478
Fly
nucleoside phosphate biosynthetic process GO:1901293 109 0.416
multicellular organismal aging GO:0010259 3 0.341
Worm
mitochondrial transport GO:0006839 60 0.283
monovalent inorganic cation transport GO:0015672 128 0.242
purine ribonucleotide biosynthetic process GO:0009152 79 0.231
atp metabolic process GO:0046034 176 0.227
hydrogen ion transmembrane transport GO:1902600 15 0.208
atp biosynthetic process GO:0006754 11 0.198
determination of adult lifespan GO:0008340 2 0.187
Worm
proton transport GO:0015992 22 0.180
cation transmembrane transport GO:0098655 238 0.171
citrate metabolic process GO:0006101 2 0.168
ribonucleotide biosynthetic process GO:0009260 81 0.164
endocytosis GO:0006897 159 0.153
Worm
nucleoside monophosphate biosynthetic process GO:0009124 19 0.127
embryo development ending in birth or egg hatching GO:0009792 34 0.120
Worm
cation transport GO:0006812 331 0.118
mitochondrial membrane organization GO:0007006 40 0.118
energy derivation by oxidation of organic compounds GO:0015980 43 0.117
Fly
inorganic ion transmembrane transport GO:0098660 231 0.116
glycosyl compound biosynthetic process GO:1901659 27 0.114
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.114
Fly
embryo development GO:0009790 123 0.113
Worm
tricarboxylic acid cycle GO:0006099 4 0.109
Fly
ribose phosphate biosynthetic process GO:0046390 82 0.107
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.106
hydrogen transport GO:0006818 23 0.093
purine nucleotide biosynthetic process GO:0006164 84 0.089
organophosphate biosynthetic process GO:0090407 163 0.087
monocarboxylic acid metabolic process GO:0032787 185 0.086
purine ribonucleoside triphosphate biosynthetic process GO:0009206 11 0.085
nucleoside triphosphate biosynthetic process GO:0009142 20 0.083
organic acid catabolic process GO:0016054 71 0.082
nucleoside triphosphate metabolic process GO:0009141 422 0.081
inorganic cation transmembrane transport GO:0098662 194 0.080
carbohydrate derivative biosynthetic process GO:1901137 207 0.074
transmembrane transport GO:0055085 399 0.073
oogenesis GO:0048477 2 0.072
purine nucleoside monophosphate biosynthetic process GO:0009127 16 0.071
carboxylic acid catabolic process GO:0046395 71 0.068
energy coupled proton transport down electrochemical gradient GO:0015985 2 0.068
purine nucleoside monophosphate metabolic process GO:0009126 186 0.060
purine nucleoside triphosphate metabolic process GO:0009144 412 0.059
ribonucleoside monophosphate metabolic process GO:0009161 187 0.059
receptor mediated endocytosis GO:0006898 84 0.056
Worm
female gamete generation GO:0007292 2 0.052
ribonucleoside triphosphate metabolic process GO:0009199 412 0.051
negative regulation of cell proliferation GO:0008285 228 0.048
pyridine nucleotide metabolic process GO:0019362 14 0.047
growth GO:0040007 202 0.046
protein processing GO:0016485 226 0.045
Fly
cell differentiation in spinal cord GO:0021515 1 0.045
positive regulation of apoptotic process GO:0043065 246 0.044
Fly
spermatid development GO:0007286 4 0.042
system process GO:0003008 349 0.042
positive regulation of programmed cell death GO:0043068 249 0.042
Fly
ion transmembrane transport GO:0034220 338 0.041
homeostasis of number of cells GO:0048872 40 0.041
response to hormone GO:0009725 175 0.041
maintenance of location GO:0051235 112 0.040
regulation of nucleotide metabolic process GO:0006140 269 0.040
anatomical structure homeostasis GO:0060249 100 0.038
protein maturation GO:0051604 233 0.037
Fly
cellular respiration GO:0045333 21 0.037
Fly
cellular amino acid metabolic process GO:0006520 116 0.035
neuromuscular junction development GO:0007528 3 0.035
purine ribonucleoside biosynthetic process GO:0046129 23 0.035
lipid localization GO:0010876 106 0.033
immune response GO:0006955 307 0.032
negative regulation of multicellular organismal process GO:0051241 317 0.032
membrane organization GO:0061024 292 0.031
tissue homeostasis GO:0001894 63 0.031
organonitrogen compound biosynthetic process GO:1901566 200 0.031
nucleoside biosynthetic process GO:0009163 26 0.031
aspartate metabolic process GO:0006531 4 0.029
aerobic respiration GO:0009060 7 0.029
Fly
ion homeostasis GO:0050801 230 0.028
dicarboxylic acid catabolic process GO:0043649 9 0.028
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.027
purine ribonucleoside monophosphate biosynthetic process GO:0009168 16 0.027
rna interference GO:0016246 4 0.026
nucleoside monophosphate metabolic process GO:0009123 191 0.026
fatty acid metabolic process GO:0006631 115 0.026
reproduction GO:0000003 63 0.026
pyruvate metabolic process GO:0006090 26 0.026
positive regulation of developmental process GO:0051094 314 0.026
regulation of endopeptidase activity GO:0052548 170 0.025
Fly
ribonucleoside monophosphate biosynthetic process GO:0009156 17 0.025
angiogenesis GO:0001525 147 0.025
glutamate metabolic process GO:0006536 10 0.025
ribonucleoside biosynthetic process GO:0042455 25 0.025
response to abiotic stimulus GO:0009628 336 0.025
spermatid differentiation GO:0048515 4 0.025
carbohydrate metabolic process GO:0005975 207 0.024
oxidoreduction coenzyme metabolic process GO:0006733 19 0.024
lipid metabolic process GO:0006629 381 0.024
cellular macromolecule catabolic process GO:0044265 380 0.024
reproductive structure development GO:0048608 55 0.023
ribonucleoside triphosphate biosynthetic process GO:0009201 12 0.023
purine containing compound biosynthetic process GO:0072522 88 0.022
negative regulation of intracellular signal transduction GO:1902532 183 0.022
defense response GO:0006952 315 0.022
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.022
execution phase of apoptosis GO:0097194 32 0.022
purine nucleoside biosynthetic process GO:0042451 23 0.022
excretion GO:0007588 9 0.022
regulation of immune response GO:0050776 201 0.021
cell development GO:0048468 328 0.021
Worm Fly
isocitrate metabolic process GO:0006102 1 0.021
cell cell signaling GO:0007267 155 0.020
positive regulation of peptidase activity GO:0010952 88 0.020
Fly
adult locomotory behavior GO:0008344 1 0.019
purine nucleoside triphosphate biosynthetic process GO:0009145 11 0.019
positive regulation of hydrolase activity GO:0051345 331 0.019
Fly
purine ribonucleoside metabolic process GO:0046128 437 0.019
positive regulation of cell death GO:0010942 263 0.019
Fly
positive regulation of cellular component organization GO:0051130 376 0.019
single organism membrane organization GO:0044802 268 0.019
mitochondrion organization GO:0007005 156 0.019
posttranscriptional regulation of gene expression GO:0010608 213 0.019
aspartate family amino acid catabolic process GO:0009068 5 0.018
apoptotic nuclear changes GO:0030262 13 0.018
positive regulation of proteolysis GO:0045862 142 0.018
Fly
dicarboxylic acid biosynthetic process GO:0043650 4 0.018
response to biotic stimulus GO:0009607 276 0.017
regulation of cellular amine metabolic process GO:0033238 11 0.017
atp synthesis coupled proton transport GO:0015986 2 0.017
actin filament based process GO:0030029 224 0.017
Worm
multicellular organismal reproductive process GO:0048609 40 0.017
response to virus GO:0009615 126 0.016
biological adhesion GO:0022610 331 0.016
reproductive process GO:0022414 106 0.016
secretion by cell GO:0032940 226 0.016
response to lipid GO:0033993 206 0.016
epithelial cell differentiation GO:0030855 141 0.016
regulation of proteolysis GO:0030162 293 0.016
Fly
dicarboxylic acid metabolic process GO:0043648 29 0.015
anion transport GO:0006820 161 0.015
purine ribonucleoside catabolic process GO:0046130 398 0.015
secretion GO:0046903 254 0.014
negative regulation of developmental process GO:0051093 247 0.014
cellular component disassembly involved in execution phase of apoptosis GO:0006921 13 0.014
intracellular receptor signaling pathway GO:0030522 104 0.014
cellular amide metabolic process GO:0043603 69 0.014
mitochondrial respiratory chain complex i biogenesis GO:0097031 16 0.014
cellular divalent inorganic cation homeostasis GO:0072503 128 0.014
dna catabolic process GO:0006308 49 0.014
glutamate biosynthetic process GO:0006537 3 0.014
epithelial cell proliferation GO:0050673 128 0.014
myoblast fusion GO:0007520 1 0.013
multicellular organism reproduction GO:0032504 42 0.013
cellular protein complex assembly GO:0043623 188 0.013
Worm
regulation of kinase activity GO:0043549 314 0.013
intrinsic apoptotic signaling pathway GO:0097193 127 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
cellular ion homeostasis GO:0006873 168 0.013
small molecule catabolic process GO:0044282 92 0.013
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.013
Fly
lipid catabolic process GO:0016042 84 0.013
protein localization to organelle GO:0033365 280 0.013
intracellular protein transport GO:0006886 270 0.013
regulation of protein stability GO:0031647 87 0.013
regulation of nucleoside metabolic process GO:0009118 209 0.013
cellular response to dna damage stimulus GO:0006974 379 0.013
regulation of peptidase activity GO:0052547 180 0.012
Fly
regulation of transferase activity GO:0051338 355 0.012
positive regulation of organelle organization GO:0010638 195 0.012
nucleoside catabolic process GO:0009164 408 0.012
multicellular organismal homeostasis GO:0048871 67 0.012
aging GO:0007568 66 0.012
Worm
negative regulation of transport GO:0051051 176 0.012
response to other organism GO:0051707 261 0.012
cofactor metabolic process GO:0051186 87 0.012
cellular amino acid catabolic process GO:0009063 31 0.012
regulation of atp metabolic process GO:1903578 29 0.012
chemical homeostasis GO:0048878 306 0.012
regulation of anatomical structure morphogenesis GO:0022603 286 0.012
negative regulation of programmed cell death GO:0043069 321 0.011
ribonucleotide catabolic process GO:0009261 405 0.011
response to external biotic stimulus GO:0043207 261 0.011
single organism reproductive process GO:0044702 98 0.011
2 oxoglutarate metabolic process GO:0006103 4 0.011
anatomical structure formation involved in morphogenesis GO:0048646 284 0.011
Worm
alpha amino acid biosynthetic process GO:1901607 23 0.011
gene silencing by rna GO:0031047 26 0.011
innate immune response GO:0045087 178 0.011
negative regulation of catalytic activity GO:0043086 335 0.011
osteoblast differentiation GO:0001649 92 0.011
response to wounding GO:0009611 168 0.011
purine ribonucleotide catabolic process GO:0009154 404 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.010
negative regulation of cellular catabolic process GO:0031330 83 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.010
Fly
purine nucleoside triphosphate catabolic process GO:0009146 392 0.010
protein targeting GO:0006605 187 0.010
regulation of behavior GO:0050795 82 0.010
alpha amino acid metabolic process GO:1901605 72 0.010

MDH2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.392
inherited metabolic disorder DOID:655 242 0.275
carbohydrate metabolic disorder DOID:2978 55 0.092
amino acid metabolic disorder DOID:9252 50 0.064
central nervous system disease DOID:331 186 0.048
neurodegenerative disease DOID:1289 102 0.048
nervous system disease DOID:863 431 0.048
sensory system disease DOID:0050155 203 0.032
eye and adnexa disease DOID:1492 150 0.032
immune system disease DOID:2914 155 0.017
hematopoietic system disease DOID:74 100 0.017