Homo sapiens

20 known processes

PPP6R3

protein phosphatase 6, regulatory subunit 3

(Aliases: SAP190,SAPL,DKFZp781O2362,FLJ11058,PP6R3,KIAA1558,SAPLa,C11orf23,SAPS3,FLJ43065,MGC125711,MGC125712,DKFZp781E17107,DKFZp781E2374)

PPP6R3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic cell cycle process GO:1903047 286 0.214
Worm
negative regulation of protein metabolic process GO:0051248 391 0.150
positive regulation of phosphorylation GO:0042327 394 0.148
actin filament based process GO:0030029 224 0.143
Worm
chromatin organization GO:0006325 351 0.139
cellular ketone metabolic process GO:0042180 80 0.125
post embryonic development GO:0009791 2 0.119
Worm
cell cycle phase transition GO:0044770 173 0.112
protein deubiquitination GO:0016579 79 0.106
regulation of canonical wnt signaling pathway GO:0060828 88 0.094
chromatin modification GO:0016568 298 0.092
gtp catabolic process GO:0006184 237 0.091
neural tube formation GO:0001841 3 0.089
protein processing GO:0016485 226 0.088
regulation of cellular amino acid metabolic process GO:0006521 6 0.087
cellular response to dna damage stimulus GO:0006974 379 0.083
covalent chromatin modification GO:0016569 254 0.082
cellular amine metabolic process GO:0044106 41 0.079
glycosyl compound catabolic process GO:1901658 413 0.077
protein catabolic process GO:0030163 325 0.076
negative regulation of wnt signaling pathway GO:0030178 69 0.073
purine nucleotide catabolic process GO:0006195 405 0.072
determination of adult lifespan GO:0008340 2 0.071
multicellular organismal aging GO:0010259 3 0.071
mitotic cell cycle GO:0000278 326 0.071
Worm
cellular macromolecule catabolic process GO:0044265 380 0.068
positive regulation of catabolic process GO:0009896 310 0.068
protein maturation GO:0051604 233 0.067
histone modification GO:0016570 251 0.067
positive regulation of protein phosphorylation GO:0001934 313 0.064
guanosine containing compound metabolic process GO:1901068 244 0.064
purine ribonucleotide catabolic process GO:0009154 404 0.064
nucleoside triphosphate catabolic process GO:0009143 394 0.061
nucleoside catabolic process GO:0009164 408 0.061
response to biotic stimulus GO:0009607 276 0.058
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.058
dephosphorylation GO:0016311 209 0.057
regulation of cellular amine metabolic process GO:0033238 11 0.057
rna processing GO:0006396 255 0.056
regulation of cellular ketone metabolic process GO:0010565 50 0.054
cellular amino acid metabolic process GO:0006520 116 0.052
intracellular protein transport GO:0006886 270 0.052
female gamete generation GO:0007292 2 0.052
regulation of purine nucleotide catabolic process GO:0033121 205 0.051
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.051
cytoplasmic transport GO:0016482 379 0.051
mitotic nuclear division GO:0007067 119 0.050
purine containing compound catabolic process GO:0072523 411 0.050
single organism cellular localization GO:1902580 332 0.049
Worm
apoptotic signaling pathway GO:0097190 268 0.048
protein ubiquitination GO:0016567 314 0.047
rho protein signal transduction GO:0007266 26 0.047
response to external biotic stimulus GO:0043207 261 0.047
response to other organism GO:0051707 261 0.047
negative regulation of protein modification process GO:0031400 200 0.047
oogenesis GO:0048477 2 0.046
protein autophosphorylation GO:0046777 123 0.046
hippo signaling GO:0035329 20 0.045
wnt signaling pathway GO:0016055 156 0.045
purine nucleoside triphosphate catabolic process GO:0009146 392 0.045
amine metabolic process GO:0009308 44 0.044
purine nucleoside catabolic process GO:0006152 398 0.044
modification dependent macromolecule catabolic process GO:0043632 212 0.044
embryonic epithelial tube formation GO:0001838 4 0.043
positive regulation of hydrolase activity GO:0051345 331 0.042
negative regulation of apoptotic process GO:0043066 316 0.042
anterior posterior axis specification GO:0009948 2 0.041
mapk cascade GO:0000165 288 0.041
trna processing GO:0008033 23 0.041
locomotory behavior GO:0007626 1 0.040
modification dependent protein catabolic process GO:0019941 209 0.040
purine nucleoside triphosphate metabolic process GO:0009144 412 0.040
cellular protein catabolic process GO:0044257 261 0.040
ubiquitin dependent protein catabolic process GO:0006511 206 0.039
positive regulation of nucleotide catabolic process GO:0030813 185 0.039
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.039
response to fungus GO:0009620 4 0.039
regulation of protein catabolic process GO:0042176 155 0.038
hemopoiesis GO:0030097 180 0.038
segmentation GO:0035282 4 0.038
regulation of cellular component biogenesis GO:0044087 281 0.038
response to oxidative stress GO:0006979 121 0.038
regulation of protein localization GO:0032880 296 0.038
regulation of proteolysis GO:0030162 293 0.037
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.036
nucleoside triphosphate metabolic process GO:0009141 422 0.036
organ morphogenesis GO:0009887 147 0.035
regulation of small gtpase mediated signal transduction GO:0051056 156 0.035
ncrna metabolic process GO:0034660 108 0.035
regulation of dna metabolic process GO:0051052 153 0.034
adult locomotory behavior GO:0008344 1 0.034
vesicle mediated transport GO:0016192 371 0.034
positive regulation of cellular component organization GO:0051130 376 0.034
trna wobble uridine modification GO:0002098 3 0.034
negative regulation of proteolysis GO:0045861 132 0.033
regulation of nucleotide metabolic process GO:0006140 269 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.033
ribonucleoside triphosphate catabolic process GO:0009203 391 0.032
regulation of cellular response to stress GO:0080135 244 0.032
regulation of cell differentiation GO:0045595 393 0.032
g1 s transition of mitotic cell cycle GO:0000082 78 0.032
dna repair GO:0006281 198 0.032
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.032
negative regulation of protein processing GO:0010955 142 0.032
immune response GO:0006955 307 0.032
negative regulation of catalytic activity GO:0043086 335 0.032
positive regulation of kinase activity GO:0033674 204 0.031
negative regulation of cellular protein metabolic process GO:0032269 353 0.031
cell projection organization GO:0030030 252 0.031
neuromuscular junction development GO:0007528 3 0.031
regulation of gtp catabolic process GO:0033124 180 0.030
negative regulation of protein maturation GO:1903318 142 0.030
nucleoside phosphate catabolic process GO:1901292 412 0.030
regulation of mapk cascade GO:0043408 262 0.030
positive regulation of protein kinase activity GO:0045860 190 0.030
regulation of protein maturation GO:1903317 150 0.030
protein oligomerization GO:0051259 173 0.030
negative regulation of organelle organization GO:0010639 126 0.030
regulation of purine nucleotide metabolic process GO:1900542 264 0.029
canonical wnt signaling pathway GO:0060070 116 0.029
trna metabolic process GO:0006399 35 0.029
negative regulation of phosphorylation GO:0042326 174 0.029
organelle fission GO:0048285 149 0.029
endomembrane system organization GO:0010256 196 0.028
anatomical structure formation involved in morphogenesis GO:0048646 284 0.028
regulation of cellular protein catabolic process GO:1903362 96 0.027
ras protein signal transduction GO:0007265 73 0.027
ribonucleoside triphosphate metabolic process GO:0009199 412 0.027
cell cycle g1 s phase transition GO:0044843 80 0.027
mitotic cell cycle phase transition GO:0044772 162 0.027
regulation of protein processing GO:0070613 150 0.027
embryo development GO:0009790 123 0.027
Worm
protein modification by small protein removal GO:0070646 92 0.026
positive regulation of nucleoside metabolic process GO:0045979 186 0.026
tube development GO:0035295 125 0.026
positive regulation of cellular amine metabolic process GO:0033240 7 0.026
regulation of response to external stimulus GO:0032101 222 0.026
negative regulation of phosphorus metabolic process GO:0010563 267 0.025
negative regulation of transport GO:0051051 176 0.025
negative regulation of cell proliferation GO:0008285 228 0.025
morphogenesis of embryonic epithelium GO:0016331 4 0.025
trna wobble base modification GO:0002097 3 0.025
negative regulation of cell death GO:0060548 345 0.025
gtp metabolic process GO:0046039 239 0.025
nucleotide catabolic process GO:0009166 408 0.025
system process GO:0003008 349 0.025
positive regulation of proteolysis GO:0045862 142 0.025
regulation of kinase activity GO:0043549 314 0.025
regulation of anatomical structure morphogenesis GO:0022603 286 0.025
negative regulation of intracellular signal transduction GO:1902532 183 0.024
positive regulation of cell cycle GO:0045787 140 0.024
heart development GO:0007507 95 0.024
trna modification GO:0006400 10 0.024
i kappab kinase nf kappab signaling GO:0007249 166 0.024
protein dephosphorylation GO:0006470 81 0.024
regulation of proteasomal protein catabolic process GO:0061136 87 0.023
replicative cell aging GO:0001302 3 0.023
actin cytoskeleton organization GO:0030036 207 0.023
Worm
positive regulation of cell death GO:0010942 263 0.023
negative regulation of cell differentiation GO:0045596 171 0.022
regulation of neurogenesis GO:0050767 82 0.022
ribonucleoside catabolic process GO:0042454 406 0.022
cell morphogenesis GO:0000902 296 0.022
protein localization to organelle GO:0033365 280 0.022
protein modification by small protein conjugation GO:0032446 342 0.022
proteasomal protein catabolic process GO:0010498 176 0.022
posttranscriptional regulation of gene expression GO:0010608 213 0.022
nervous system development GO:0007399 293 0.021
regulation of dephosphorylation GO:0035303 96 0.021
cell fate determination GO:0001709 3 0.021
positive regulation of cellular component biogenesis GO:0044089 158 0.021
histone acetylation GO:0016573 93 0.021
positive regulation of developmental process GO:0051094 314 0.021
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.021
negative regulation of programmed cell death GO:0043069 321 0.021
single organism membrane organization GO:0044802 268 0.021
positive regulation of gtp catabolic process GO:0033126 166 0.021
positive regulation of programmed cell death GO:0043068 249 0.021
signal transduction by phosphorylation GO:0023014 297 0.021
cellular response to oxidative stress GO:0034599 85 0.021
peptidyl serine modification GO:0018209 106 0.021
positive regulation of transferase activity GO:0051347 227 0.020
neural tube closure GO:0001843 3 0.020
tor signaling GO:0031929 39 0.020
hematopoietic or lymphoid organ development GO:0048534 186 0.020
blastoderm segmentation GO:0007350 2 0.020
internal protein amino acid acetylation GO:0006475 101 0.020
cell division GO:0051301 168 0.020
cellular macromolecular complex assembly GO:0034622 324 0.020
protein targeting GO:0006605 187 0.020
cellular protein complex assembly GO:0043623 188 0.020
positive regulation of transport GO:0051050 336 0.020
cellular component morphogenesis GO:0032989 314 0.020
negative regulation of cellular protein catabolic process GO:1903363 38 0.019
regulation of cytoskeleton organization GO:0051493 177 0.019
histone deubiquitination GO:0016578 16 0.019
regulation of protein ubiquitination GO:0031396 95 0.019
peptidyl serine phosphorylation GO:0018105 101 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
motor neuron axon guidance GO:0008045 2 0.019
regulation of cell cycle process GO:0010564 266 0.019
regeneration GO:0031099 4 0.019
negative regulation of phosphate metabolic process GO:0045936 267 0.019
spermatid development GO:0007286 4 0.019
regulation of mitotic cell cycle GO:0007346 189 0.019
organophosphate catabolic process GO:0046434 430 0.019
nucleocytoplasmic transport GO:0006913 176 0.018
regulation of intracellular transport GO:0032386 195 0.018
compound eye development GO:0048749 1 0.018
regulation of cell cycle GO:0051726 393 0.018
innate immune response GO:0045087 178 0.018
regulation of protein transport GO:0051223 213 0.018
neuroblast proliferation GO:0007405 4 0.018
regulation of apoptotic signaling pathway GO:2001233 175 0.018
defense response GO:0006952 315 0.018
endocytosis GO:0006897 159 0.018
positive regulation of immune system process GO:0002684 283 0.017
immune system development GO:0002520 195 0.017
rhythmic behavior GO:0007622 2 0.017
cell cycle checkpoint GO:0000075 117 0.017
positive regulation of apoptotic process GO:0043065 246 0.017
primary neural tube formation GO:0014020 3 0.017
engulfment of apoptotic cell GO:0043652 2 0.017
small gtpase mediated signal transduction GO:0007264 78 0.017
rna splicing GO:0008380 131 0.017
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.017
regulation of transferase activity GO:0051338 355 0.017
protein polyubiquitination GO:0000209 110 0.017
epithelium development GO:0060429 227 0.017
plasma membrane organization GO:0007009 115 0.017
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.016
regulation of establishment of protein localization GO:0070201 242 0.016
response to oxygen containing compound GO:1901700 369 0.016
membrane organization GO:0061024 292 0.016
golgi vesicle transport GO:0048193 80 0.016
cellular lipid metabolic process GO:0044255 303 0.016
cardiovascular system development GO:0072358 262 0.016
nerve development GO:0021675 4 0.016
nuclear division GO:0000280 128 0.016
peripheral nervous system development GO:0007422 2 0.016
negative regulation of cell cycle GO:0045786 193 0.016
protein acylation GO:0043543 138 0.016
negative regulation of catabolic process GO:0009895 104 0.016
rna modification GO:0009451 27 0.016
regulation of ras protein signal transduction GO:0046578 155 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.016
nuclear transport GO:0051169 179 0.016
mrna metabolic process GO:0016071 175 0.015
cell development GO:0048468 328 0.015
oocyte development GO:0048599 1 0.015
cellular homeostasis GO:0019725 196 0.015
negative regulation of cell cycle phase transition GO:1901988 89 0.015
activation of jnkk activity GO:0007256 1 0.015
generation of neurons GO:0048699 152 0.015
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.015
stress activated protein kinase signaling cascade GO:0031098 94 0.015
peptidyl lysine acetylation GO:0018394 101 0.015
purine ribonucleoside metabolic process GO:0046128 437 0.015
regulation of ras gtpase activity GO:0032318 128 0.015
negative regulation of glial cell proliferation GO:0060253 2 0.015
peptidyl lysine modification GO:0018205 144 0.015
regulation of response to dna damage stimulus GO:2001020 94 0.015
regulation of protein complex assembly GO:0043254 147 0.015
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.014
cell growth GO:0016049 160 0.014
peptidyl tyrosine modification GO:0018212 170 0.014
protein localization to membrane GO:0072657 160 0.014
protein import into nucleus GO:0006606 104 0.014
endosome organization GO:0007032 20 0.014
growth GO:0040007 202 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.014
circulatory system development GO:0072359 262 0.014
response to lipid GO:0033993 206 0.014
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.014
positive regulation of protein complex assembly GO:0031334 86 0.014
rna interference GO:0016246 4 0.014
neurological system process GO:0050877 163 0.014
negative regulation of chromatin silencing GO:0031936 4 0.014
tissue regeneration GO:0042246 3 0.014
regulation of microtubule based process GO:0032886 74 0.014
regulation of protein serine threonine kinase activity GO:0071900 179 0.014
positive regulation of mapk cascade GO:0043410 190 0.014
ncrna processing GO:0034470 83 0.014
regulation of mitotic cell cycle phase transition GO:1901990 118 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
peptidyl tyrosine phosphorylation GO:0018108 170 0.013
actin filament organization GO:0007015 128 0.013
regulation of odontogenesis GO:0042481 4 0.013
spermatid differentiation GO:0048515 4 0.013
ribonucleotide catabolic process GO:0009261 405 0.013
cell adhesion GO:0007155 325 0.013
neurogenesis GO:0022008 169 0.013
organelle localization GO:0051640 84 0.013
Worm
actin filament based movement GO:0030048 17 0.013
negative regulation of cellular catabolic process GO:0031330 83 0.013
circadian behavior GO:0048512 2 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
regulation of protein kinase activity GO:0045859 289 0.013
regulation of immune response GO:0050776 201 0.013
oocyte differentiation GO:0009994 2 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
regulation of defense response GO:0031347 154 0.013
myeloid cell differentiation GO:0030099 117 0.013
carbohydrate derivative biosynthetic process GO:1901137 207 0.013
embryonic placenta development GO:0001892 1 0.013
microtubule based process GO:0007017 210 0.013
Worm
intrinsic apoptotic signaling pathway GO:0097193 127 0.013
microtubule cytoskeleton organization GO:0000226 176 0.013
Worm
interspecies interaction between organisms GO:0044419 156 0.013
negative regulation of protein catabolic process GO:0042177 59 0.013
establishment of protein localization to organelle GO:0072594 172 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.013
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.012
memory GO:0007613 3 0.012
tube closure GO:0060606 3 0.012
mrna splicing via spliceosome GO:0000398 89 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
organophosphate biosynthetic process GO:0090407 163 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
regulation of cell cycle phase transition GO:1901987 126 0.012
negative regulation of multicellular organismal process GO:0051241 317 0.012
cellular component disassembly GO:0022411 92 0.012
positive regulation of mitotic cell cycle GO:0045931 60 0.012
positive regulation of cell proliferation GO:0008284 301 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.012
positive regulation of protein catabolic process GO:0045732 75 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
reproductive process GO:0022414 106 0.012
regulation of chromosome organization GO:0033044 103 0.012
purine ribonucleoside catabolic process GO:0046130 398 0.012
protein stabilization GO:0050821 64 0.012
epithelial cell differentiation GO:0030855 141 0.012
regulation of actin cytoskeleton organization GO:0032956 116 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
positive regulation of cell cycle process GO:0090068 106 0.012
negative regulation of protein kinase activity GO:0006469 98 0.012
regulation of vesicle mediated transport GO:0060627 130 0.012
salivary gland morphogenesis GO:0007435 4 0.012
somitogenesis GO:0001756 2 0.012
internal peptidyl lysine acetylation GO:0018393 97 0.012
protein localization to nucleus GO:0034504 136 0.012
response to abiotic stimulus GO:0009628 336 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.012
epidermis morphogenesis GO:0048730 3 0.012
positive regulation of cytokine production GO:0001819 167 0.012
histone lysine methylation GO:0034968 50 0.012
regulation of cell morphogenesis GO:0022604 153 0.011
methylation GO:0032259 106 0.011
embryonic morphogenesis GO:0048598 85 0.011
oxidation reduction process GO:0055114 396 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
protein acetylation GO:0006473 116 0.011
negative regulation of developmental process GO:0051093 247 0.011
cation transport GO:0006812 331 0.011
behavior GO:0007610 112 0.011
negative regulation of dna metabolic process GO:0051053 57 0.011
positive regulation of cell differentiation GO:0045597 211 0.011
regulation of multi organism process GO:0043900 157 0.011
regulation of synaptic plasticity GO:0048167 3 0.011
cardiac muscle cell contraction GO:0086003 4 0.011
intracellular receptor signaling pathway GO:0030522 104 0.011
nucleosome organization GO:0034728 66 0.011
hindbrain development GO:0030902 3 0.011
metal ion transport GO:0030001 272 0.011
tripartite regional subdivision GO:0007351 2 0.011
cell part morphogenesis GO:0032990 137 0.011
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.011
somatic stem cell maintenance GO:0035019 4 0.011
regulation of protein stability GO:0031647 87 0.011
epidermal cell differentiation GO:0009913 45 0.011
cell projection morphogenesis GO:0048858 129 0.011
regulation of growth GO:0040008 165 0.011
blood vessel development GO:0001568 172 0.011
striated muscle contraction GO:0006941 52 0.011
endosomal transport GO:0016197 129 0.011
regulation of actin filament based process GO:0032970 141 0.010
negative regulation of apoptotic signaling pathway GO:2001234 97 0.010
response to organic cyclic compound GO:0014070 204 0.010
nuclear import GO:0051170 106 0.010
actin mediated cell contraction GO:0070252 12 0.010
negative regulation of protein ubiquitination GO:0031397 35 0.010
cell aging GO:0007569 52 0.010
protein methylation GO:0006479 74 0.010
muscle contraction GO:0006936 73 0.010
organelle assembly GO:0070925 176 0.010
maintenance of location GO:0051235 112 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.010
positive regulation of dna repair GO:0045739 25 0.010
regulation of anatomical structure size GO:0090066 101 0.010
inorganic ion transmembrane transport GO:0098660 231 0.010
negative regulation of kinase activity GO:0033673 106 0.010
stem cell differentiation GO:0048863 93 0.010
regulation of cellular component movement GO:0051270 334 0.010
membrane protein proteolysis GO:0033619 38 0.010
positive regulation of organelle organization GO:0010638 195 0.010
negative regulation of cell cycle process GO:0010948 121 0.010
syncytium formation by plasma membrane fusion GO:0000768 2 0.010
regulation of cell motility GO:2000145 299 0.010
negative regulation of endopeptidase activity GO:0010951 84 0.010
regulation of protein polyubiquitination GO:1902914 8 0.010
cation transmembrane transport GO:0098655 238 0.010
negative regulation of transferase activity GO:0051348 124 0.010

PPP6R3 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.034
eye and adnexa disease DOID:1492 150 0.034
nervous system disease DOID:863 431 0.034
eye disease DOID:5614 149 0.034
cancer DOID:162 167 0.031
disease of cellular proliferation DOID:14566 174 0.031
organ system cancer DOID:0050686 164 0.031
musculoskeletal system disease DOID:17 223 0.023