|
|
positive regulation of interleukin 1 beta secretion
|
GO:0050718 |
11 |
0.980
|
Mouse |
|
|
regulation of interleukin 1 beta secretion
|
GO:0050706 |
12 |
0.903
|
Mouse |
|
|
regulation of circadian sleep wake cycle
|
GO:0042749 |
2 |
0.777
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.741
|
Human Zebrafish Fly |
|
|
response to other organism
|
GO:0051707 |
261 |
0.715
|
Fly |
|
|
protein maturation
|
GO:0051604 |
233 |
0.710
|
Human Fly |
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.673
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.660
|
Human Fly |
|
|
immune response
|
GO:0006955 |
307 |
0.636
|
Fly |
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.618
|
Fly |
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway
|
GO:2001269 |
1 |
0.595
|
Fly |
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.565
|
Fly |
|
|
positive regulation of humoral immune response
|
GO:0002922 |
3 |
0.545
|
Fly |
|
|
defense response
|
GO:0006952 |
315 |
0.531
|
Fly |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.497
|
Human Zebrafish Fly |
|
|
membrane hyperpolarization
|
GO:0060081 |
1 |
0.453
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.429
|
Human Fly |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.428
|
Human Zebrafish Fly |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.415
|
Human |
|
|
midgut development
|
GO:0007494 |
1 |
0.393
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.352
|
Human Fly |
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.350
|
Mouse Fly |
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.345
|
Human |
|
|
cell activation
|
GO:0001775 |
213 |
0.334
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.333
|
Human Fly |
|
|
regulation of cell cycle arrest
|
GO:0071156 |
36 |
0.332
|
Human |
|
|
signal transduction involved in mitotic dna damage checkpoint
|
GO:1902402 |
13 |
0.325
|
Human |
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.322
|
Mouse |
|
|
positive regulation of cell cycle arrest
|
GO:0071158 |
23 |
0.318
|
Human |
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.316
|
Human Fly |
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.315
|
Human |
|
|
cytokine production
|
GO:0001816 |
247 |
0.308
|
Mouse |
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.304
|
Fly |
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.301
|
Human |
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.289
|
Fly |
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.289
|
Human |
|
|
positive regulation of interleukin 1 beta production
|
GO:0032731 |
13 |
0.280
|
Mouse |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.278
|
Human Fly |
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.272
|
Human |
|
|
response to bacterium
|
GO:0009617 |
144 |
0.270
|
Fly |
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
44 |
0.270
|
Human |
|
|
regulation of antimicrobial humoral response
|
GO:0002759 |
1 |
0.267
|
Fly |
|
|
innate immune response
|
GO:0045087 |
178 |
0.259
|
Fly |
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.247
|
Human |
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.245
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.240
|
Mouse |
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.238
|
Fly |
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.237
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.237
|
Human Fly |
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.226
|
Fly |
|
|
alpha beta t cell proliferation
|
GO:0046633 |
5 |
0.214
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.213
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.211
|
Human |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.207
|
Mouse |
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.205
|
Human |
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.204
|
Human |
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.204
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.204
|
Human |
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.203
|
Human Fly |
|
|
positive regulation of macrophage differentiation
|
GO:0045651 |
7 |
0.200
|
Human |
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.199
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.184
|
Human |
|
|
inflammatory response
|
GO:0006954 |
79 |
0.183
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.182
|
Fly |
|
|
epithelium development
|
GO:0060429 |
227 |
0.181
|
Human |
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.181
|
Fly |
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.181
|
Human |
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.177
|
|
|
|
amide biosynthetic process
|
GO:0043604 |
15 |
0.174
|
Fly |
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.174
|
Fly |
|
|
melanin metabolic process
|
GO:0006582 |
1 |
0.173
|
Fly |
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.170
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.170
|
Human |
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.167
|
Human |
|
|
signal transduction involved in mitotic g1 dna damage checkpoint
|
GO:0072431 |
10 |
0.167
|
Human |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.166
|
Human Fly |
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.164
|
Fly |
|
|
negative regulation of g1 s transition of mitotic cell cycle
|
GO:2000134 |
29 |
0.163
|
Human |
|
|
activation of innate immune response
|
GO:0002218 |
55 |
0.162
|
|
|
|
intracellular signal transduction involved in g1 dna damage checkpoint
|
GO:1902400 |
10 |
0.160
|
Human |
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.160
|
Fly |
|
|
positive regulation of interleukin 1 production
|
GO:0032732 |
14 |
0.157
|
Mouse |
|
|
regulation of circadian sleep wake cycle sleep
|
GO:0045187 |
2 |
0.155
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.155
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.153
|
|
|
|
circadian sleep wake cycle process
|
GO:0022410 |
2 |
0.151
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.150
|
Fly |
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.150
|
|
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.148
|
Mouse |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.146
|
Fly |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.143
|
Human |
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.143
|
Human |
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
2 |
0.141
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.140
|
|
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
72 |
0.138
|
Human |
|
|
spermatid development
|
GO:0007286 |
4 |
0.136
|
Fly |
|
|
memory
|
GO:0007613 |
3 |
0.136
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.136
|
Human |
|
|
autophagic cell death
|
GO:0048102 |
3 |
0.135
|
Fly |
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.135
|
Human |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.134
|
Fly |
|
|
protein secretion
|
GO:0009306 |
98 |
0.134
|
Mouse |
|
|
negative regulation of cell cycle g1 s phase transition
|
GO:1902807 |
29 |
0.133
|
Human |
|
|
compound eye development
|
GO:0048749 |
1 |
0.132
|
Fly |
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
24 |
0.131
|
Human |
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.131
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.130
|
Fly |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.130
|
Human |
|
|
circadian sleep wake cycle sleep
|
GO:0050802 |
2 |
0.129
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.127
|
Fly |
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.126
|
Human |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.125
|
Mouse |
|
|
interleukin 1 secretion
|
GO:0050701 |
18 |
0.124
|
Mouse |
|
|
blood vessel development
|
GO:0001568 |
172 |
0.121
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.120
|
Human Fly |
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.119
|
Fly |
|
|
myoblast fusion
|
GO:0007520 |
1 |
0.119
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.118
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.118
|
Human |
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.117
|
Fly |
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.117
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.116
|
Human Fly |
|
|
execution phase of apoptosis
|
GO:0097194 |
32 |
0.115
|
Human |
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.115
|
Human |
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.115
|
Human |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.114
|
Human |
|
|
signal transduction involved in mitotic cell cycle checkpoint
|
GO:0072413 |
13 |
0.114
|
Human |
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.113
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
37 |
0.113
|
Human |
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.113
|
Human |
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.113
|
|
|
|
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest
|
GO:0006977 |
9 |
0.113
|
Human |
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.111
|
Human |
|
|
circadian behavior
|
GO:0048512 |
2 |
0.110
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.110
|
Human |
|
|
cellular response to uv
|
GO:0034644 |
32 |
0.109
|
Human |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.108
|
Human |
|
|
programmed necrotic cell death
|
GO:0097300 |
18 |
0.108
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.108
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.105
|
|
|
|
sleep
|
GO:0030431 |
2 |
0.104
|
|
|
|
natural killer cell proliferation
|
GO:0001787 |
4 |
0.103
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.102
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.102
|
Human |
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.101
|
|
|
|
regulation of behavior
|
GO:0050795 |
82 |
0.099
|
|
|
|
trail activated apoptotic signaling pathway
|
GO:0036462 |
4 |
0.097
|
Human |
|
|
peptide metabolic process
|
GO:0006518 |
51 |
0.096
|
Fly |
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.095
|
Human |
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.095
|
Human |
|
|
t cell activation
|
GO:0042110 |
99 |
0.095
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.095
|
Fly |
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.094
|
Fly |
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.094
|
Human |
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.093
|
Human |
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.092
|
Fly |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.092
|
Human |
|
|
protein heterooligomerization
|
GO:0051291 |
16 |
0.092
|
Fly |
|
|
autophagy
|
GO:0006914 |
88 |
0.091
|
Fly |
|
|
neuron remodeling
|
GO:0016322 |
2 |
0.091
|
Fly |
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.088
|
Human |
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.088
|
Mouse |
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.087
|
Human |
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
42 |
0.087
|
Human |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.086
|
Human |
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.086
|
Human |
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.083
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
39 |
0.083
|
Human |
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.081
|
Mouse |
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.081
|
|
|
|
signal transduction involved in dna integrity checkpoint
|
GO:0072401 |
15 |
0.080
|
Human |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.080
|
|
|
|
toxin transport
|
GO:1901998 |
4 |
0.077
|
|
|
|
nk t cell proliferation
|
GO:0001866 |
3 |
0.077
|
|
|
|
alpha beta t cell activation
|
GO:0046631 |
15 |
0.076
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.076
|
Mouse |
|
|
zymogen activation
|
GO:0031638 |
70 |
0.075
|
Human Fly |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.075
|
|
|
|
signal transduction involved in mitotic dna integrity checkpoint
|
GO:1902403 |
13 |
0.075
|
Human |
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.074
|
Human |
|
|
interleukin 1 beta secretion
|
GO:0050702 |
15 |
0.074
|
Mouse |
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.073
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.073
|
Human Fly |
|
|
dna integrity checkpoint
|
GO:0031570 |
71 |
0.073
|
Human |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.072
|
Fly |
|
|
cell development
|
GO:0048468 |
328 |
0.072
|
Mouse Fly |
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.072
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.071
|
Fly |
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.068
|
|
|
|
response to organophosphorus
|
GO:0046683 |
41 |
0.067
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.067
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.067
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.066
|
Fly |
|
|
secretion
|
GO:0046903 |
254 |
0.066
|
Mouse |
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.066
|
Human |
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.065
|
Human |
|
|
nervous system development
|
GO:0007399 |
293 |
0.065
|
Fly |
|
|
positive regulation of cell cycle process
|
GO:0090068 |
106 |
0.065
|
Human |
|
|
cation transport
|
GO:0006812 |
331 |
0.065
|
|
|
|
regulation of defense response to bacterium
|
GO:1900424 |
2 |
0.065
|
Fly |
|
|
defense response to virus
|
GO:0051607 |
71 |
0.064
|
Fly |
|
|
g1 dna damage checkpoint
|
GO:0044783 |
18 |
0.063
|
Human |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.063
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.062
|
Human |
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.062
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.061
|
Human Fly |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.061
|
|
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.060
|
Human |
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.060
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.059
|
|
|
|
natural killer cell activation
|
GO:0030101 |
12 |
0.059
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.058
|
|
|
|
positive regulation of multi organism process
|
GO:0043902 |
56 |
0.057
|
Fly |
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.056
|
Human |
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.056
|
Human |
|
|
response to drug
|
GO:0042493 |
81 |
0.056
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.056
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.056
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.055
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.054
|
Fly |
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.054
|
Mouse |
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.054
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.053
|
Mouse |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.052
|
Human Fly |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.052
|
Human Fly |
|
|
cellular response to light stimulus
|
GO:0071482 |
34 |
0.051
|
Human |
|
|
mitotic dna damage checkpoint
|
GO:0044773 |
28 |
0.051
|
Human |
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.051
|
|
|
|
mitotic dna integrity checkpoint
|
GO:0044774 |
30 |
0.049
|
Human |
|
|
regulation of inflammatory response
|
GO:0050727 |
46 |
0.049
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.049
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.049
|
Human Fly |
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.048
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.048
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.048
|
Mouse |
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.048
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.048
|
|
|
|
detection of stimulus
|
GO:0051606 |
85 |
0.047
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
46 |
0.047
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.047
|
|
|
|
signal transduction involved in cell cycle checkpoint
|
GO:0072395 |
16 |
0.047
|
Human |
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.046
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.046
|
Human Fly |
|
|
signal transduction involved in dna damage checkpoint
|
GO:0072422 |
15 |
0.046
|
Human |
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.045
|
|
|
|
cellular amide metabolic process
|
GO:0043603 |
69 |
0.044
|
Fly |
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.044
|
Human |
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.044
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.043
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.043
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.043
|
|
|
|
response to toxic substance
|
GO:0009636 |
37 |
0.043
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.043
|
Fly |
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.042
|
Fly |
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.042
|
Human |
|
|
positive regulation of protein secretion
|
GO:0050714 |
60 |
0.042
|
Mouse |
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
26 |
0.042
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.042
|
Mouse |
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.042
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.042
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.042
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.041
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway
|
GO:2001267 |
2 |
0.041
|
Fly |
|
|
secretion by cell
|
GO:0032940 |
226 |
0.041
|
Mouse |
|
|
positive regulation of viral entry into host cell
|
GO:0046598 |
3 |
0.041
|
|
|
|
alpha amino acid metabolic process
|
GO:1901605 |
72 |
0.040
|
|
|
|
cellular modified amino acid metabolic process
|
GO:0006575 |
64 |
0.040
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.040
|
Fly |
|
|
regulation of cytokine secretion
|
GO:0050707 |
57 |
0.039
|
Mouse |
|
|
positive regulation of antimicrobial humoral response
|
GO:0002760 |
1 |
0.038
|
Fly |
|
|
metal ion transport
|
GO:0030001 |
272 |
0.038
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.038
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.038
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.037
|
Human Fly |
|
|
immune effector process
|
GO:0002252 |
159 |
0.037
|
Fly |
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.037
|
Human |
|
|
response to virus
|
GO:0009615 |
126 |
0.036
|
Fly |
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.036
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.034
|
Fly |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.034
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.033
|
Mouse |
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.033
|
Human |
|
|
maintenance of location
|
GO:0051235 |
112 |
0.033
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.033
|
|
|
|
regulation of fas signaling pathway
|
GO:1902044 |
2 |
0.033
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.033
|
Human |
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.032
|
|
|
|
positive regulation of cytokine secretion
|
GO:0050715 |
42 |
0.032
|
Mouse |
|
|
humoral immune response
|
GO:0006959 |
49 |
0.032
|
Fly |
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
11 |
0.032
|
Fly |
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.031
|
|
|
|
regulation of circadian sleep wake cycle non rem sleep
|
GO:0045188 |
1 |
0.030
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.030
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.030
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.030
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.030
|
|
|
|
response to oxygen levels
|
GO:0070482 |
100 |
0.030
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.030
|
|
|
|
regulation of interleukin 1 secretion
|
GO:0050704 |
14 |
0.030
|
Mouse |
|
|
interleukin 1 alpha secretion
|
GO:0050703 |
1 |
0.030
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.030
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.029
|
|
|
|
cofactor metabolic process
|
GO:0051186 |
87 |
0.029
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.029
|
Human |
|
|
regulation of endothelial cell migration
|
GO:0010594 |
67 |
0.028
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.027
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.027
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
40 |
0.027
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.027
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.027
|
|
|
|
secondary metabolic process
|
GO:0019748 |
17 |
0.027
|
Fly |
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.027
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.027
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.027
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.027
|
Human |
|
|
myeloid leukocyte activation
|
GO:0002274 |
34 |
0.027
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.027
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.026
|
Fly |
|
|
negative regulation of secretion
|
GO:0051048 |
58 |
0.026
|
|
|
|
positive regulation of homeostatic process
|
GO:0032846 |
47 |
0.026
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.026
|
|
|
|
necrotic cell death
|
GO:0070265 |
21 |
0.026
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.026
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.026
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.025
|
|
|
|
cellular response to radiation
|
GO:0071478 |
65 |
0.025
|
Human |
|
|
interleukin 1 alpha production
|
GO:0032610 |
2 |
0.025
|
|
|
|
coenzyme metabolic process
|
GO:0006732 |
65 |
0.025
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.025
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.025
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.025
|
Human |
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.025
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.025
|
|
|
|
positive regulation of natural killer cell proliferation
|
GO:0032819 |
3 |
0.025
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.024
|
Fly |
|
|
regulation of mitochondrial membrane potential
|
GO:0051881 |
23 |
0.024
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
65 |
0.024
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.024
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.024
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.024
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.024
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.023
|
|
|
|
microglial cell activation
|
GO:0001774 |
2 |
0.023
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.023
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.023
|
|
|
|
purine nucleobase metabolic process
|
GO:0006144 |
5 |
0.023
|
|
|
|
regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902041 |
24 |
0.023
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.023
|
|
|
|
t cell differentiation
|
GO:0030217 |
29 |
0.023
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.022
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.022
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.022
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.022
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.022
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.022
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.022
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.022
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.022
|
Human |
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.022
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.021
|
|
|
|
system process
|
GO:0003008 |
349 |
0.021
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.021
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.021
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.021
|
Fly |
|
|
positive regulation of interleukin 1 secretion
|
GO:0050716 |
11 |
0.021
|
Mouse |
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.021
|
Fly |
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.021
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.021
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.021
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.021
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.020
|
Human |
|
|
positive regulation of protein oligomerization
|
GO:0032461 |
17 |
0.020
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.020
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.020
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.020
|
Mouse Fly |
|
|
macrophage differentiation
|
GO:0030225 |
11 |
0.020
|
Human |
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.020
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.020
|
Fly |
|
|
negative regulation of cell activation
|
GO:0050866 |
33 |
0.020
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.019
|
Fly |
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.019
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.019
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.019
|
|
|
|
alditol phosphate metabolic process
|
GO:0052646 |
3 |
0.019
|
|
|
|
purine nucleobase biosynthetic process
|
GO:0009113 |
3 |
0.019
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.019
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.019
|
|
|
|
positive regulation of circadian sleep wake cycle sleep
|
GO:0045938 |
1 |
0.019
|
|
|
|
positive regulation of behavior
|
GO:0048520 |
60 |
0.019
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.019
|
|
|
|
interleukin 1 production
|
GO:0032612 |
26 |
0.019
|
Mouse |
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
55 |
0.019
|
Fly |
|
|
regulation of adaptive immune response
|
GO:0002819 |
33 |
0.019
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.019
|
Fly |
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.019
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.019
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
40 |
0.019
|
Fly |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.019
|
Human |
|
|
negative regulation of intracellular transport of viral material
|
GO:1901253 |
2 |
0.019
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.019
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.019
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.018
|
Fly |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.018
|
|
|
|
regulation of intracellular transport of viral material
|
GO:1901252 |
2 |
0.018
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.018
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.018
|
|
|
|
pigment metabolic process
|
GO:0042440 |
16 |
0.018
|
Fly |
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.018
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
42 |
0.018
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.018
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.018
|
Fly |
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.017
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.017
|
|
|
|
negative regulation of viral transcription
|
GO:0032897 |
23 |
0.017
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.017
|
|
|
|
regulation of humoral immune response
|
GO:0002920 |
11 |
0.017
|
Fly |
|
|
angiogenesis
|
GO:0001525 |
147 |
0.017
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.017
|
|
|
|
multicellular organism reproduction
|
GO:0032504 |
42 |
0.017
|
Mouse Fly |
|
|
cell adhesion
|
GO:0007155 |
325 |
0.017
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.017
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.017
|
Fly |
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.017
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.016
|
|
|
|
nucleobase biosynthetic process
|
GO:0046112 |
4 |
0.016
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.016
|
|
|
|
regulation of viral entry into host cell
|
GO:0046596 |
17 |
0.016
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.016
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.016
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.016
|
|
|
|
response to interferon gamma
|
GO:0034341 |
39 |
0.016
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.016
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.016
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.016
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.016
|
Mouse Fly |
|
|
endosomal transport
|
GO:0016197 |
129 |
0.015
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.015
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.015
|
Fly |
|
|
regulation of defense response to virus
|
GO:0050688 |
33 |
0.015
|
Fly |
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.015
|
|
|
|
regulation of vasculature development
|
GO:1901342 |
97 |
0.015
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.015
|
Fly |
|
|
cognition
|
GO:0050890 |
43 |
0.015
|
|
|
|
positive regulation of neutrophil apoptotic process
|
GO:0033031 |
1 |
0.015
|
|
|
|
cellular response to triacyl bacterial lipopeptide
|
GO:0071727 |
2 |
0.015
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.015
|
|
|
|
cellular response to interferon gamma
|
GO:0071346 |
24 |
0.015
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.015
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.015
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
|
GO:0042771 |
23 |
0.015
|
|
|
|
negative regulation of epithelial cell migration
|
GO:0010633 |
38 |
0.015
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.015
|
Fly |
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.015
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.014
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.014
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.014
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.014
|
|
|
|
positive regulation of ossification
|
GO:0045778 |
32 |
0.014
|
|
|
|
cellular response to glucocorticoid stimulus
|
GO:0071385 |
4 |
0.014
|
|
|
|
response to hyperoxia
|
GO:0055093 |
4 |
0.014
|
|
|
|
dendrite development
|
GO:0016358 |
24 |
0.014
|
Fly |
|
|
lymphocyte homeostasis
|
GO:0002260 |
4 |
0.014
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.014
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.014
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.014
|
|
|
|
inflammatory cell apoptotic process
|
GO:0006925 |
3 |
0.014
|
|
|
|
regulation of protein oligomerization
|
GO:0032459 |
26 |
0.014
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.014
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.014
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.013
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.013
|
|
|
|
dna recombination
|
GO:0006310 |
77 |
0.013
|
|
|
|
chemotaxis
|
GO:0006935 |
157 |
0.013
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.013
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.013
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.013
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.013
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.013
|
Fly |
|
|
positive regulation of protein complex assembly
|
GO:0031334 |
86 |
0.013
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.013
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.013
|
|
|
|
viral life cycle
|
GO:0019058 |
132 |
0.013
|
|
|
|
aging
|
GO:0007568 |
66 |
0.013
|
Fly |
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.013
|
|
|
|
striated muscle cell differentiation
|
GO:0051146 |
43 |
0.013
|
|
|
|
response to increased oxygen levels
|
GO:0036296 |
4 |
0.013
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.013
|
|
|
|
positive regulation of response to biotic stimulus
|
GO:0002833 |
18 |
0.013
|
Fly |
|
|
purine nucleoside monophosphate catabolic process
|
GO:0009128 |
158 |
0.013
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.013
|
|
