|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
1.000
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.999
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.999
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.999
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.999
|
Human |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.998
|
Human |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.997
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.996
|
|
|
|
regulation of tor signaling
|
GO:0032006 |
30 |
0.996
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.996
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.996
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.996
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.996
|
Human |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.995
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.995
|
Fly |
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.994
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.994
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.993
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.993
|
Rat |
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.993
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.991
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.991
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.990
|
Fly |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.989
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.989
|
Mouse |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.989
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.987
|
Rat |
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.987
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.986
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.983
|
Human Mouse Fly |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.983
|
|
|
|
tor signaling
|
GO:0031929 |
39 |
0.980
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.978
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.977
|
Worm |
|
|
positive regulation of cell size
|
GO:0045793 |
3 |
0.977
|
Fly |
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.976
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.976
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.975
|
Human Rat |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.974
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.974
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.972
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.971
|
Rat Fly |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.969
|
Human |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.961
|
Yeast |
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.960
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.959
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.953
|
|
|
|
negative regulation of phosphatase activity
|
GO:0010923 |
61 |
0.951
|
|
|
|
cellular polysaccharide metabolic process
|
GO:0044264 |
27 |
0.950
|
|
|
|
regulation of synaptic vesicle exocytosis
|
GO:2000300 |
2 |
0.947
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.944
|
Fly |
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.944
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.938
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.937
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.937
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.933
|
Mouse |
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.932
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.931
|
Human Fly |
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.930
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.930
|
|
|
|
cellular glucan metabolic process
|
GO:0006073 |
22 |
0.927
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.926
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.924
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.924
|
Worm |
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.923
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.919
|
Mouse |
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.917
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.915
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.913
|
Human |
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.912
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.912
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.912
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.909
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.907
|
Rat |
|
|
muscle structure development
|
GO:0061061 |
98 |
0.904
|
Mouse Fly |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.901
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.896
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.890
|
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.890
|
Human |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.888
|
Human Rat |
|
|
regulation of cell cycle arrest
|
GO:0071156 |
36 |
0.888
|
|
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.887
|
Human |
|
|
behavior
|
GO:0007610 |
112 |
0.886
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.882
|
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.880
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.880
|
Human Mouse Fly |
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.879
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.871
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.863
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.863
|
Human Mouse Fly |
|
|
cell projection organization
|
GO:0030030 |
252 |
0.863
|
Human Mouse Rat Fly |
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.863
|
Fly |
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.859
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.858
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.847
|
Rat |
|
|
membrane organization
|
GO:0061024 |
292 |
0.846
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.838
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.835
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.833
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.830
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.827
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.826
|
Fly |
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.820
|
|
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.817
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.816
|
Fly |
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.815
|
Rat Fly |
|
|
regulation of growth
|
GO:0040008 |
165 |
0.803
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.800
|
Fly |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.799
|
Human Rat |
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.795
|
Rat |
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.784
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.782
|
Mouse |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.772
|
Human Rat |
|
|
glucan metabolic process
|
GO:0044042 |
22 |
0.771
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.764
|
Human Fly |
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.760
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.760
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.755
|
|
|
|
cell cell junction organization
|
GO:0045216 |
69 |
0.754
|
Human |
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.752
|
Fly |
|
|
cell death in response to oxidative stress
|
GO:0036473 |
29 |
0.751
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.748
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.746
|
Human |
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.744
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.744
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.732
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.729
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.720
|
Human Mouse |
|
|
regulation of protein dephosphorylation
|
GO:0035304 |
18 |
0.716
|
Human |
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.715
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.714
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.708
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.705
|
Mouse |
|
|
phospholipid catabolic process
|
GO:0009395 |
12 |
0.704
|
Human |
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.702
|
Human Mouse |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.701
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.687
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.681
|
Fly |
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.679
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.673
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.671
|
Human Mouse Fly |
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.667
|
Yeast |
|
|
protein processing
|
GO:0016485 |
226 |
0.665
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.664
|
Mouse |
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.662
|
Human Rat Fly |
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.651
|
Mouse Rat |
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.645
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.644
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.633
|
|
|
|
regulation of protein localization to plasma membrane
|
GO:1903076 |
40 |
0.616
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.614
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.613
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.605
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.603
|
Mouse Rat |
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.599
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.595
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.595
|
|
|
|
somatic muscle development
|
GO:0007525 |
1 |
0.594
|
Fly |
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.592
|
Human Mouse Fly |
|
|
macroautophagy
|
GO:0016236 |
39 |
0.592
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.588
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.585
|
Human Mouse Fly |
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.583
|
|
|
|
negative regulation of ion transmembrane transport
|
GO:0034766 |
26 |
0.580
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.569
|
|
|
|
aging
|
GO:0007568 |
66 |
0.565
|
Human Rat Worm |
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.564
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.562
|
Human Mouse Fly |
|
|
fat cell differentiation
|
GO:0045444 |
32 |
0.537
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.535
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.534
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.529
|
Human Mouse Fly |
|
|
innate immune response activating signal transduction
|
GO:0002758 |
48 |
0.527
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.511
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.502
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.502
|
Mouse |
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.501
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.493
|
Human Mouse Fly |
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.491
|
|
|
|
regulation of phosphatase activity
|
GO:0010921 |
81 |
0.487
|
|
|
|
renal system development
|
GO:0072001 |
63 |
0.482
|
|
|
|
intrinsic apoptotic signaling pathway in response to oxidative stress
|
GO:0008631 |
21 |
0.481
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.480
|
Human |
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.477
|
Mouse |
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.474
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.463
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.460
|
|
|
|
somitogenesis
|
GO:0001756 |
2 |
0.459
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.458
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.457
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.456
|
Human |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.456
|
Mouse |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.455
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.454
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.452
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.451
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.448
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.445
|
|
|
|
translation
|
GO:0006412 |
132 |
0.442
|
Rat |
|
|
regulation of peroxidase activity
|
GO:2000468 |
2 |
0.439
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.437
|
Fly |
|
|
positive regulation of tor signaling
|
GO:0032008 |
11 |
0.437
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.435
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.432
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.432
|
Fly |
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.431
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.428
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.423
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.418
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.415
|
Human Rat |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.411
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.409
|
Yeast Mouse |
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.402
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.402
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.401
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.400
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.397
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.396
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.396
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.395
|
Fly |
|
|
secretion
|
GO:0046903 |
254 |
0.394
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.392
|
Mouse |
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.391
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.391
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.390
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.384
|
Mouse |
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.384
|
|
|
|
growth
|
GO:0040007 |
202 |
0.383
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.381
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.380
|
Human |
|
|
system process
|
GO:0003008 |
349 |
0.377
|
Rat |
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.376
|
Human Mouse |
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.376
|
|
|
|
negative regulation of protein dephosphorylation
|
GO:0035308 |
3 |
0.374
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.373
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.373
|
|
|
|
telencephalon development
|
GO:0021537 |
17 |
0.370
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.369
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.367
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.362
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.361
|
Mouse |
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
84 |
0.359
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.358
|
Yeast |
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.357
|
|
|
|
cell aging
|
GO:0007569 |
52 |
0.356
|
Human |
|
|
activation of innate immune response
|
GO:0002218 |
55 |
0.352
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.351
|
Yeast |
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.347
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.346
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.344
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.342
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.340
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.339
|
Mouse |
|
|
striated muscle cell apoptotic process
|
GO:0010658 |
3 |
0.338
|
|
|
|
response to nutrient
|
GO:0007584 |
20 |
0.335
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.335
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.334
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.326
|
Human Rat |
|
|
regulation of cell size
|
GO:0008361 |
19 |
0.325
|
Rat Fly |
|
|
regulation of glucosylceramide catabolic process
|
GO:2000752 |
1 |
0.322
|
Human |
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.321
|
Mouse |
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.321
|
Human Mouse Fly |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.321
|
Mouse |
|
|
lipid localization
|
GO:0010876 |
106 |
0.316
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.312
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.311
|
|
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.309
|
|
|
|
regulation of translation
|
GO:0006417 |
89 |
0.309
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.306
|
|
|
|
reproduction
|
GO:0000003 |
63 |
0.306
|
Mouse Fly |
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.305
|
|
|
|
negative regulation of striated muscle cell apoptotic process
|
GO:0010664 |
2 |
0.304
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
11 |
0.300
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.299
|
Mouse |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.296
|
|
|
|
midbrain development
|
GO:0030901 |
45 |
0.288
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.288
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.286
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.284
|
Mouse Rat |
|
|
positive regulation of protein complex assembly
|
GO:0031334 |
86 |
0.283
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.278
|
|
|
|
t cell differentiation
|
GO:0030217 |
29 |
0.278
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.278
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.275
|
|
|
|
negative regulation of transmembrane transport
|
GO:0034763 |
29 |
0.274
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.274
|
Mouse |
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.274
|
Human |
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.271
|
Fly |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.270
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.270
|
Human Mouse Fly |
|
|
positive regulation of cell cycle arrest
|
GO:0071158 |
23 |
0.270
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.267
|
|
|
|
regulation of phosphoprotein phosphatase activity
|
GO:0043666 |
23 |
0.265
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.264
|
Human Mouse |
|
|
dna integrity checkpoint
|
GO:0031570 |
71 |
0.263
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.262
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.258
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.257
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.257
|
|
|
|
cellular response to hypoxia
|
GO:0071456 |
51 |
0.255
|
Rat |
|
|
cellular response to starvation
|
GO:0009267 |
58 |
0.254
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.252
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.248
|
Fly |
|
|
immune effector process
|
GO:0002252 |
159 |
0.248
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.247
|
Human |
|
|
regulation of neural precursor cell proliferation
|
GO:2000177 |
4 |
0.245
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.242
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.241
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.240
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.239
|
Human Mouse Rat |
|
|
negative regulation of lipid metabolic process
|
GO:0045833 |
38 |
0.239
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.239
|
Human |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.236
|
|
|
|
negative regulation of autophagy
|
GO:0010507 |
14 |
0.235
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.232
|
Rat |
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.231
|
|
|
|
response to starvation
|
GO:0042594 |
59 |
0.230
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.230
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.230
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.229
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.229
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.227
|
|
|
|
regulation of cell shape
|
GO:0008360 |
48 |
0.226
|
Fly |
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.226
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.224
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.222
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.222
|
|
|
|
exocytosis
|
GO:0006887 |
71 |
0.219
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.219
|
|
|
|
neurotransmitter secretion
|
GO:0007269 |
4 |
0.214
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.213
|
|
|
|
negative regulation of t cell apoptotic process
|
GO:0070233 |
4 |
0.212
|
Human |
|
|
positive regulation of interleukin 5 production
|
GO:0032754 |
3 |
0.211
|
|
|
|
embryonic placenta development
|
GO:0001892 |
1 |
0.209
|
Mouse |
|
|
g1 dna damage checkpoint
|
GO:0044783 |
18 |
0.209
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.209
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.208
|
Mouse |
|
|
somatic stem cell division
|
GO:0048103 |
1 |
0.207
|
|
|
|
regulation of glucan biosynthetic process
|
GO:0010962 |
14 |
0.207
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.205
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.205
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.205
|
|
|
|
head development
|
GO:0060322 |
108 |
0.204
|
|
|
|
myoblast fusion
|
GO:0007520 |
1 |
0.203
|
Fly |
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.203
|
|
|
|
purine nucleoside monophosphate catabolic process
|
GO:0009128 |
158 |
0.201
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.200
|
|
|
|
positive regulation of myotube differentiation
|
GO:0010831 |
3 |
0.200
|
|
|
|
action potential
|
GO:0001508 |
34 |
0.199
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.197
|
Mouse |
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.196
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.196
|
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
72 |
0.193
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
35 |
0.192
|
Human |
|
|
regulation of response to drug
|
GO:2001023 |
3 |
0.187
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.186
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.184
|
Rat |
|
|
peptidyl serine dephosphorylation
|
GO:0070262 |
2 |
0.184
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.181
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.180
|
|
|
|
polysaccharide biosynthetic process
|
GO:0000271 |
27 |
0.180
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.180
|
Mouse |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.179
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
54 |
0.179
|
Human Fly |
|
|
maintenance of location in cell
|
GO:0051651 |
62 |
0.179
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
63 |
0.177
|
Mouse Fly |
|
|
jnk cascade
|
GO:0007254 |
80 |
0.175
|
Rat |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.175
|
Fly |
|
|
regulation of synaptic transmission
|
GO:0050804 |
11 |
0.173
|
Fly |
|
|
regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay
|
GO:1900151 |
8 |
0.173
|
Yeast |
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.173
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.172
|
|
|
|
establishment of protein localization to plasma membrane
|
GO:0090002 |
68 |
0.172
|
|
|
|
regulation of polysaccharide biosynthetic process
|
GO:0032885 |
20 |
0.171
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.170
|
Mouse |
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.170
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.170
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.168
|
|
|
|
extrinsic apoptotic signaling pathway in absence of ligand
|
GO:0097192 |
22 |
0.168
|
|
|
|
outflow tract septum morphogenesis
|
GO:0003148 |
4 |
0.167
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.163
|
|
|
|
mrna 3 end processing
|
GO:0031124 |
24 |
0.162
|
Yeast |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.161
|
Mouse |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.159
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.158
|
Mouse |
|
|
response to other organism
|
GO:0051707 |
261 |
0.156
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.156
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.155
|
|
|
|
negative regulation of intracellular transport
|
GO:0032387 |
60 |
0.154
|
|
|
|
developmental growth involved in morphogenesis
|
GO:0060560 |
23 |
0.153
|
|
|
|
protein stabilization
|
GO:0050821 |
64 |
0.152
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.152
|
|
|
|
positive regulation of lipase activity
|
GO:0060193 |
28 |
0.152
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.151
|
Mouse |
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.149
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.149
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.149
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.148
|
Mouse |
|
|
morphogenesis of a branching structure
|
GO:0001763 |
21 |
0.146
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.144
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.142
|
|
|
|
mitotic g1 dna damage checkpoint
|
GO:0031571 |
17 |
0.141
|
|
|
|
regulation of kidney size
|
GO:0035564 |
2 |
0.141
|
|
|
|
positive regulation of adenylate cyclase activity
|
GO:0045762 |
12 |
0.138
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.138
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.138
|
|
|
|
signal transduction in absence of ligand
|
GO:0038034 |
22 |
0.136
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.136
|
|
|
|
carbon catabolite activation of transcription
|
GO:0045991 |
3 |
0.135
|
|
|
|
regulation of macroautophagy
|
GO:0016241 |
19 |
0.132
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.132
|
Human |
|
|
regulation of cardiac muscle cell apoptotic process
|
GO:0010665 |
3 |
0.132
|
|
|
|
negative regulation of transcription initiation from rna polymerase ii promoter
|
GO:0060633 |
3 |
0.130
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.130
|
Mouse |
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.129
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.128
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.127
|
|
|
|
rhythmic process
|
GO:0048511 |
31 |
0.127
|
Fly |
|
|
glucosylceramide metabolic process
|
GO:0006678 |
3 |
0.127
|
Human |
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.127
|
Human Mouse |
|
|
cell division
|
GO:0051301 |
168 |
0.126
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.126
|
Fly |
|
|
regulation of binding
|
GO:0051098 |
111 |
0.125
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.124
|
|
|
|
synaptic vesicle exocytosis
|
GO:0016079 |
3 |
0.123
|
|
|
|
negative regulation of cell size
|
GO:0045792 |
3 |
0.122
|
Rat |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.121
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.121
|
|
|
|
neural nucleus development
|
GO:0048857 |
47 |
0.120
|
|
|
|
positive regulation of transcription by galactose
|
GO:0000411 |
1 |
0.116
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.116
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.116
|
|
|
|
energy reserve metabolic process
|
GO:0006112 |
22 |
0.114
|
|
|
|
substantia nigra development
|
GO:0021762 |
45 |
0.114
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.112
|
|
|
|
establishment of vesicle localization
|
GO:0051650 |
23 |
0.110
|
|
|
|
chordate embryonic development
|
GO:0043009 |
34 |
0.109
|
Mouse |
|
|
positive regulation of fat cell differentiation
|
GO:0045600 |
12 |
0.109
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.108
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.107
|
Rat |
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.107
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.106
|
|
|
|
regulation of lipid kinase activity
|
GO:0043550 |
19 |
0.104
|
|
|
|
visual learning
|
GO:0008542 |
1 |
0.104
|
|
|
|
cellular senescence
|
GO:0090398 |
34 |
0.104
|
Human |
|
|
lipid transport
|
GO:0006869 |
90 |
0.103
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.102
|
|
|
|
positive regulation of cell morphogenesis involved in differentiation
|
GO:0010770 |
50 |
0.102
|
|
|
|
regulation of mitosis
|
GO:0007088 |
63 |
0.102
|
|
|
|
polysaccharide metabolic process
|
GO:0005976 |
33 |
0.101
|
|
|
|
peroxisome degradation
|
GO:0030242 |
1 |
0.101
|
Yeast |
|
|
negative regulation of rho gtpase activity
|
GO:0034259 |
4 |
0.101
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.100
|
|
|
|
hexose metabolic process
|
GO:0019318 |
55 |
0.100
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.099
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.099
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.099
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.098
|
Human Rat |
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.098
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.098
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.097
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.097
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.097
|
|
|
|
asymmetric neuroblast division
|
GO:0055059 |
1 |
0.097
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.096
|
|
|
|
regulation of calcium ion transmembrane transporter activity
|
GO:1901019 |
28 |
0.095
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
44 |
0.095
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.095
|
|
|
|
regulation of multicellular organism growth
|
GO:0040014 |
8 |
0.093
|
Fly |
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.093
|
|
|
|
neuroblast division
|
GO:0055057 |
1 |
0.092
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.092
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.092
|
|
|
|
defense response to fungus
|
GO:0050832 |
4 |
0.090
|
|
|
|
response to salt stress
|
GO:0009651 |
3 |
0.090
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.089
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.089
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.087
|
Mouse |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.087
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.086
|
|
|
|
multicellular organism reproduction
|
GO:0032504 |
42 |
0.086
|
Mouse Fly |
|
|
protein import
|
GO:0017038 |
130 |
0.086
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.085
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.085
|
Fly |
|
|
positive regulation of cell cycle process
|
GO:0090068 |
106 |
0.084
|
|
|
|
mitochondrial transport
|
GO:0006839 |
60 |
0.084
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.084
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.083
|
|
|
|
negative regulation of response to extracellular stimulus
|
GO:0032105 |
5 |
0.083
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.083
|
|
|
|
establishment or maintenance of cytoskeleton polarity
|
GO:0030952 |
3 |
0.082
|
|
|
|
cell matrix adhesion
|
GO:0007160 |
85 |
0.082
|
|
