Homo sapiens

93 known processes

HSP90B1

heat shock protein 90kDa beta (Grp94), member 1

(Aliases: GP96,GRP94,TRA1,ECGP)

HSP90B1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to topologically incorrect protein GO:0035967 19 0.994
endoplasmic reticulum unfolded protein response GO:0030968 16 0.991
response to unfolded protein GO:0006986 24 0.988
response to endoplasmic reticulum stress GO:0034976 49 0.986
er nucleus signaling pathway GO:0006984 23 0.969
response to topologically incorrect protein GO:0035966 29 0.958
post embryonic development GO:0009791 2 0.913
Worm
cellular response to unfolded protein GO:0034620 16 0.899
intrinsic apoptotic signaling pathway GO:0097193 127 0.705
activation of signaling protein activity involved in unfolded protein response GO:0006987 3 0.594
regeneration GO:0031099 4 0.535
endoplasmic reticulum organization GO:0007029 20 0.431
protein folding GO:0006457 38 0.420
apoptotic signaling pathway GO:0097190 268 0.418
negative regulation of neurological system process GO:0031645 2 0.340
determination of adult lifespan GO:0008340 2 0.279
positive regulation of developmental process GO:0051094 314 0.260
chaperone mediated protein folding GO:0061077 13 0.253
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.253
protein catabolic process GO:0030163 325 0.216
ribonucleoside catabolic process GO:0042454 406 0.201
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.193
nucleoside phosphate catabolic process GO:1901292 412 0.186
purine nucleoside catabolic process GO:0006152 398 0.150
modification dependent macromolecule catabolic process GO:0043632 212 0.139
negative regulation of developmental process GO:0051093 247 0.135
modification dependent protein catabolic process GO:0019941 209 0.128
axon regeneration GO:0031103 1 0.127
posttranscriptional regulation of gene expression GO:0010608 213 0.119
regulation of cell cycle phase transition GO:1901987 126 0.119
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.119
ubiquitin dependent protein catabolic process GO:0006511 206 0.114
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.112
vesicle mediated transport GO:0016192 371 0.108
Worm
multicellular organismal aging GO:0010259 3 0.101
protein localization to endoplasmic reticulum GO:0070972 19 0.096
regulation of growth GO:0040008 165 0.095
ribonucleotide catabolic process GO:0009261 405 0.089
cellular response to cytokine stimulus GO:0071345 181 0.088
negative regulation of programmed cell death GO:0043069 321 0.088
neuron projection regeneration GO:0031102 1 0.087
regulation of cell cycle process GO:0010564 266 0.087
enzyme linked receptor protein signaling pathway GO:0007167 303 0.082
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 28 0.081
regulation of cell motility GO:2000145 299 0.079
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.079
purine ribonucleoside catabolic process GO:0046130 398 0.079
purine ribonucleotide catabolic process GO:0009154 404 0.078
cellular response to biotic stimulus GO:0071216 71 0.077
positive regulation of catabolic process GO:0009896 310 0.073
membrane organization GO:0061024 292 0.073
response to inorganic substance GO:0010035 127 0.071
regulation of proteolysis GO:0030162 293 0.070
protein transmembrane transport GO:0071806 25 0.069
oxidation reduction process GO:0055114 396 0.069
endomembrane system organization GO:0010256 196 0.066
positive regulation of hydrolase activity GO:0051345 331 0.066
eye pigmentation GO:0048069 1 0.063
regulation of homeostatic process GO:0032844 121 0.063
lipid localization GO:0010876 106 0.063
Worm
hindbrain development GO:0030902 3 0.062
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.061
regulation of nuclease activity GO:0032069 11 0.058
cell cycle phase transition GO:0044770 173 0.058
positive regulation of apoptotic signaling pathway GO:2001235 70 0.058
response to axon injury GO:0048678 1 0.057
maintenance of protein localization in organelle GO:0072595 15 0.057
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.057
regulation of purine nucleotide catabolic process GO:0033121 205 0.056
cellular macromolecule catabolic process GO:0044265 380 0.055
negative regulation of phosphorus metabolic process GO:0010563 267 0.054
receptor mediated endocytosis GO:0006898 84 0.053
Worm
glycosyl compound catabolic process GO:1901658 413 0.051
maintenance of protein location GO:0045185 57 0.051
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.050
establishment of protein localization to membrane GO:0090150 121 0.049
regulation of binding GO:0051098 111 0.048
positive regulation of endopeptidase activity GO:0010950 84 0.048
male genitalia development GO:0030539 1 0.048
response to transforming growth factor beta GO:0071559 94 0.047
regulation of peptidase activity GO:0052547 180 0.047
regulation of endopeptidase activity GO:0052548 170 0.046
organophosphate catabolic process GO:0046434 430 0.046
actin filament based process GO:0030029 224 0.046
response to organic cyclic compound GO:0014070 204 0.044
regulation of cell migration GO:0030334 289 0.043
ribonucleoside monophosphate catabolic process GO:0009158 158 0.043
regulation of behavior GO:0050795 82 0.043
response to cytokine GO:0034097 232 0.043
neuronal action potential GO:0019228 9 0.043
locomotory behavior GO:0007626 1 0.042
regulation of cell cycle GO:0051726 393 0.042
nucleotide catabolic process GO:0009166 408 0.041
cellular response to lipid GO:0071396 127 0.041
purine nucleotide catabolic process GO:0006195 405 0.040
single organism cellular localization GO:1902580 332 0.040
growth GO:0040007 202 0.040
reproductive process GO:0022414 106 0.040
protein n linked glycosylation GO:0006487 23 0.040
protein localization to organelle GO:0033365 280 0.039
aging GO:0007568 66 0.039
cellular response to endogenous stimulus GO:0071495 336 0.039
zymogen activation GO:0031638 70 0.038
fatty acid metabolic process GO:0006631 115 0.038
protein targeting to membrane GO:0006612 42 0.038
intracellular protein transport GO:0006886 270 0.037
negative regulation of apoptotic process GO:0043066 316 0.037
intracellular protein transmembrane transport GO:0065002 24 0.037
regulation of cysteine type endopeptidase activity GO:2000116 127 0.037
regulation of apoptotic signaling pathway GO:2001233 175 0.036
proteasomal protein catabolic process GO:0010498 176 0.036
regulation of cell differentiation GO:0045595 393 0.036
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.035
maintenance of location GO:0051235 112 0.035
Worm
response to abiotic stimulus GO:0009628 336 0.034
protein stabilization GO:0050821 64 0.034
transmembrane transport GO:0055085 399 0.034
regulation of locomotion GO:0040012 329 0.034
system process GO:0003008 349 0.034
ribonucleoside triphosphate catabolic process GO:0009203 391 0.034
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.033
monocarboxylic acid metabolic process GO:0032787 185 0.033
somitogenesis GO:0001756 2 0.033
cytoplasmic transport GO:0016482 379 0.032
response to oxygen containing compound GO:1901700 369 0.032
protein ubiquitination GO:0016567 314 0.032
rhythmic behavior GO:0007622 2 0.032
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.032
mitotic cell cycle phase transition GO:0044772 162 0.031
mitotic cell cycle GO:0000278 326 0.031
sex differentiation GO:0007548 45 0.031
regulation of t cell activation GO:0050863 77 0.030
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 12 0.030
nervous system development GO:0007399 293 0.030
purine ribonucleoside metabolic process GO:0046128 437 0.029
negative regulation of catalytic activity GO:0043086 335 0.029
cerebellar cortex development GO:0021695 1 0.029
positive regulation of growth GO:0045927 58 0.028
response to biotic stimulus GO:0009607 276 0.028
negative regulation of cellular protein metabolic process GO:0032269 353 0.028
endocytosis GO:0006897 159 0.028
Worm
negative regulation of cell death GO:0060548 345 0.028
activation of cysteine type endopeptidase activity GO:0097202 57 0.028
positive regulation of multicellular organism growth GO:0040018 6 0.028
atp catabolic process GO:0006200 157 0.027
negative regulation of multicellular organismal process GO:0051241 317 0.027
response to disaccharide GO:0034285 1 0.027
regulation of mitotic cell cycle GO:0007346 189 0.027
positive regulation of cellular catabolic process GO:0031331 284 0.027
calcium mediated signaling GO:0019722 44 0.027
response to growth factor GO:0070848 205 0.026
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.025
nucleoside monophosphate catabolic process GO:0009125 159 0.025
cellular protein catabolic process GO:0044257 261 0.025
purine nucleoside monophosphate catabolic process GO:0009128 158 0.025
reproduction GO:0000003 63 0.024
Worm
neurological system process GO:0050877 163 0.024
negative regulation of protein phosphorylation GO:0001933 140 0.024
regulation of atpase activity GO:0043462 25 0.024
regulation of membrane potential GO:0042391 95 0.024
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.023
positive regulation of developmental growth GO:0048639 16 0.023
positive regulation of proteolysis GO:0045862 142 0.023
nucleoside triphosphate catabolic process GO:0009143 394 0.023
protein maturation GO:0051604 233 0.022
embryo development GO:0009790 123 0.022
Worm
regulation of atp metabolic process GO:1903578 29 0.022
brain development GO:0007420 97 0.022
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.022
midbrain development GO:0030901 45 0.021
protein localization to membrane GO:0072657 160 0.021
regulation of cellular amino acid metabolic process GO:0006521 6 0.021
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.021
positive regulation of programmed cell death GO:0043068 249 0.021
negative regulation of protein metabolic process GO:0051248 391 0.021
positive regulation of nucleotide catabolic process GO:0030813 185 0.021
autophagy GO:0006914 88 0.021
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.021
cellular amino acid metabolic process GO:0006520 116 0.021
regulation of cellular protein catabolic process GO:1903362 96 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.020
positive regulation of cell differentiation GO:0045597 211 0.020
synaptic vesicle endocytosis GO:0048488 2 0.020
nucleoside triphosphate metabolic process GO:0009141 422 0.020
toxin transport GO:1901998 4 0.020
metencephalon development GO:0022037 2 0.020
regulation of translation GO:0006417 89 0.020
positive regulation of immune system process GO:0002684 283 0.019
purine containing compound catabolic process GO:0072523 411 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.019
heart development GO:0007507 95 0.019
regulation of nucleoside metabolic process GO:0009118 209 0.019
positive regulation of protein ubiquitination GO:0031398 53 0.019
mitotic cell cycle process GO:1903047 286 0.019
intracellular receptor signaling pathway GO:0030522 104 0.019
male sex differentiation GO:0046661 25 0.019
regulation of mitotic cell cycle phase transition GO:1901990 118 0.018
protein modification by small protein conjugation GO:0032446 342 0.018
guanosine containing compound catabolic process GO:1901069 239 0.018
regulation of meiotic cell cycle GO:0051445 4 0.018
oocyte differentiation GO:0009994 2 0.018
cellular response to growth factor stimulus GO:0071363 197 0.017
calcium ion transport into cytosol GO:0060402 48 0.017
regulation of cellular ketone metabolic process GO:0010565 50 0.017
single organism reproductive process GO:0044702 98 0.017
regulation of ion transport GO:0043269 189 0.017
regulation of cellular response to stress GO:0080135 244 0.017
cellular metal ion homeostasis GO:0006875 146 0.017
cellular component morphogenesis GO:0032989 314 0.017
regulation of wnt protein secretion GO:0061356 1 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
regulation of cellular component movement GO:0051270 334 0.017
response to nitrogen compound GO:1901698 184 0.017
regulation of response to external stimulus GO:0032101 222 0.017
single organism membrane organization GO:0044802 268 0.017
response to lipid GO:0033993 206 0.017
cellular protein complex assembly GO:0043623 188 0.016
negative regulation of cell cycle GO:0045786 193 0.016
regulation of nucleotide metabolic process GO:0006140 269 0.016
circulatory system development GO:0072359 262 0.016
response to extracellular stimulus GO:0009991 85 0.016
reproductive system development GO:0061458 56 0.016
multicellular organismal reproductive process GO:0048609 40 0.016
head development GO:0060322 108 0.016
regulation of protein stability GO:0031647 87 0.016
purine nucleoside triphosphate metabolic process GO:0009144 412 0.016
negative regulation of cell cycle process GO:0010948 121 0.016
protein oligomerization GO:0051259 173 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.015
ribonucleoside triphosphate metabolic process GO:0009199 412 0.015
regulation of metal ion transport GO:0010959 120 0.015
cardiovascular system development GO:0072358 262 0.015
response to fungus GO:0009620 4 0.015
oogenesis GO:0048477 2 0.015
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.015
reactive oxygen species metabolic process GO:0072593 75 0.015
translation GO:0006412 132 0.015
response to metal ion GO:0010038 84 0.015
anterior posterior axis specification GO:0009948 2 0.015
positive regulation of cell death GO:0010942 263 0.015
cellular divalent inorganic cation homeostasis GO:0072503 128 0.015
regulation of protein ubiquitination GO:0031396 95 0.014
fat cell differentiation GO:0045444 32 0.014
positive regulation of nucleotide metabolic process GO:0045981 230 0.014
regulation of autophagy GO:0010506 52 0.014
activation of phospholipase d activity GO:0031584 3 0.014
positive regulation of peptidase activity GO:0010952 88 0.014
purine nucleoside triphosphate catabolic process GO:0009146 392 0.014
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.014
cellular response to dna damage stimulus GO:0006974 379 0.014
cellular response to lithium ion GO:0071285 2 0.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.014
divalent inorganic cation transport GO:0072511 158 0.014
central nervous system development GO:0007417 123 0.013
response to sucrose GO:0009744 1 0.013
positive regulation of cellular component movement GO:0051272 181 0.013
protein processing GO:0016485 226 0.013
developmental growth GO:0048589 48 0.013
circadian behavior GO:0048512 2 0.013
nuclear export GO:0051168 69 0.013
microtubule based process GO:0007017 210 0.013
positive regulation of systemic arterial blood pressure GO:0003084 2 0.013
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.013
cellular amine metabolic process GO:0044106 41 0.013
reproductive structure development GO:0048608 55 0.012
response to electrical stimulus GO:0051602 1 0.012
embryo development ending in birth or egg hatching GO:0009792 34 0.012
Worm
cellular homeostasis GO:0019725 196 0.012
oocyte development GO:0048599 1 0.012
positive regulation of cell development GO:0010720 92 0.012
positive regulation of phosphorylation GO:0042327 394 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.012
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.012
lipid catabolic process GO:0016042 84 0.012
mitotic cell cycle checkpoint GO:0007093 68 0.012
protein targeting GO:0006605 187 0.012
mitochondrion organization GO:0007005 156 0.012
response to peptide GO:1901652 65 0.012
response to toxic substance GO:0009636 37 0.012
sleep GO:0030431 2 0.012
cellular chemical homeostasis GO:0055082 180 0.012
sensory organ development GO:0007423 52 0.012
Zebrafish
response to starvation GO:0042594 59 0.012
divalent metal ion transport GO:0070838 152 0.011
cation homeostasis GO:0055080 189 0.011
cellular response to external stimulus GO:0071496 111 0.011
renal system development GO:0072001 63 0.011
lymphocyte activation GO:0046649 133 0.011
primary neural tube formation GO:0014020 3 0.011
positive regulation of protein catabolic process GO:0045732 75 0.011
regulation of neurogenesis GO:0050767 82 0.011
cation transport GO:0006812 331 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
establishment of protein localization to endoplasmic reticulum GO:0072599 11 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
regulation of cell growth GO:0001558 135 0.011
mating GO:0007618 1 0.011
regulation of dna replication GO:0006275 68 0.011
cellular response to insulin stimulus GO:0032869 41 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
posttranscriptional gene silencing GO:0016441 25 0.011
myosin filament organization GO:0031033 2 0.011
glycogen metabolic process GO:0005977 22 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.011
cell growth GO:0016049 160 0.011
cell division GO:0051301 168 0.011
reactive nitrogen species metabolic process GO:2001057 3 0.011
t cell activation GO:0042110 99 0.011
response to external biotic stimulus GO:0043207 261 0.011
circadian sleep wake cycle sleep GO:0050802 2 0.011
response to estrogen GO:0043627 47 0.011
gamete generation GO:0007276 25 0.010
positive regulation of transferase activity GO:0051347 227 0.010
cell cycle checkpoint GO:0000075 117 0.010
developmental process involved in reproduction GO:0003006 66 0.010
rna interference GO:0016246 4 0.010
response to hormone GO:0009725 175 0.010
defense response GO:0006952 315 0.010
calcium ion transport GO:0006816 147 0.010
neural nucleus development GO:0048857 47 0.010
compound eye development GO:0048749 1 0.010
regulation of calcium ion transport GO:0051924 79 0.010
regulation of cell morphogenesis GO:0022604 153 0.010
cytosolic calcium ion transport GO:0060401 48 0.010
leukocyte activation GO:0045321 164 0.010

HSP90B1 disease predictions

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 55 0.052
bone disease DOID:0080001 88 0.052
musculoskeletal system disease DOID:17 223 0.052
connective tissue disease DOID:65 109 0.052
cancer DOID:162 167 0.046
disease of cellular proliferation DOID:14566 174 0.046
organ system cancer DOID:0050686 164 0.046
immune system disease DOID:2914 155 0.026
anemia DOID:2355 55 0.026
hematopoietic system disease DOID:74 100 0.026
osteochondrodysplasia DOID:2256 35 0.022
central nervous system disease DOID:331 186 0.011
brain disease DOID:936 73 0.011
nervous system disease DOID:863 431 0.011