Homo sapiens

4 known processes

ASPM

asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

(Aliases: DKFZp686N06184,FLJ10517,ASP,MCPH5,FLJ10549,FLJ43117,Calmbp1)

ASPM biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromosome segregation GO:0007059 114 0.650
ribonucleotide catabolic process GO:0009261 405 0.639
sister chromatid segregation GO:0000819 54 0.618
nuclear division GO:0000280 128 0.600
Mouse Worm
regulation of cell cycle GO:0051726 393 0.598
ribonucleoside monophosphate catabolic process GO:0009158 158 0.518
purine ribonucleotide catabolic process GO:0009154 404 0.492
sister chromatid biorientation GO:0031134 2 0.468
mitotic cell cycle GO:0000278 326 0.438
Fly
attachment of mitotic spindle microtubules to kinetochore GO:0051315 3 0.413
meiotic chromosome segregation GO:0045132 4 0.405
mitotic sister chromatid segregation GO:0000070 53 0.396
mitotic cell cycle process GO:1903047 286 0.387
Fly
ribonucleoside triphosphate catabolic process GO:0009203 391 0.373
nucleoside monophosphate catabolic process GO:0009125 159 0.355
cell division GO:0051301 168 0.348
Mouse Fly
nucleoside triphosphate metabolic process GO:0009141 422 0.335
cellular macromolecular complex assembly GO:0034622 324 0.307
Fly
maintenance of location in cell GO:0051651 62 0.299
Mouse
spindle assembly involved in mitosis GO:0090307 12 0.290
nucleoside phosphate catabolic process GO:1901292 412 0.262
mitotic nuclear division GO:0007067 119 0.260
microtubule anchoring GO:0034453 24 0.255
microtubule based process GO:0007017 210 0.233
Mouse Worm Fly
regulation of cell cycle process GO:0010564 266 0.221
organelle fission GO:0048285 149 0.208
Mouse Worm
regulation of attachment of spindle microtubules to kinetochore GO:0051988 9 0.204
glycosyl compound catabolic process GO:1901658 413 0.199
maintenance of protein location GO:0045185 57 0.191
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.190
spindle elongation GO:0051231 4 0.185
atp catabolic process GO:0006200 157 0.184
nucleoside triphosphate catabolic process GO:0009143 394 0.183
maintenance of location GO:0051235 112 0.183
Mouse
maintenance of protein location in cell GO:0032507 56 0.167
microtubule cytoskeleton organization GO:0000226 176 0.165
Mouse Worm Fly
regulation of cell division GO:0051302 116 0.164
Mouse
ribonucleoside catabolic process GO:0042454 406 0.163
ribonucleoside triphosphate metabolic process GO:0009199 412 0.155
ribonucleoside monophosphate metabolic process GO:0009161 187 0.155
purine ribonucleoside catabolic process GO:0046130 398 0.148
nucleoside monophosphate metabolic process GO:0009123 191 0.139
regulation of chromosome segregation GO:0051983 44 0.138
purine nucleoside monophosphate metabolic process GO:0009126 186 0.137
regulation of mitotic sister chromatid segregation GO:0033047 27 0.133
nucleotide catabolic process GO:0009166 408 0.133
regulation of sister chromatid segregation GO:0033045 27 0.130
purine nucleoside triphosphate metabolic process GO:0009144 412 0.129
purine nucleotide catabolic process GO:0006195 405 0.124
regulation of microtubule based process GO:0032886 74 0.124
organophosphate catabolic process GO:0046434 430 0.122
negative regulation of cellular component organization GO:0051129 235 0.120
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.119
mitotic spindle elongation GO:0000022 4 0.118
attachment of spindle microtubules to kinetochore GO:0008608 17 0.117
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.115
purine nucleoside catabolic process GO:0006152 398 0.112
organelle assembly GO:0070925 176 0.110
Mouse
dna conformation change GO:0071103 113 0.105
regulation of mitotic cell cycle GO:0007346 189 0.104
cytokinesis GO:0000910 96 0.104
single organism cellular localization GO:1902580 332 0.103
Worm Fly
stem cell division GO:0017145 2 0.103
Mouse Fly
microtubule based movement GO:0007018 32 0.099
nucleoside catabolic process GO:0009164 408 0.097
purine ribonucleoside metabolic process GO:0046128 437 0.096
post embryonic development GO:0009791 2 0.094
Worm
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.088
cellular protein complex assembly GO:0043623 188 0.087
Fly
spindle assembly GO:0051225 29 0.082
Mouse
atp metabolic process GO:0046034 176 0.080
negative regulation of cell cycle GO:0045786 193 0.077
ubiquitin dependent protein catabolic process GO:0006511 206 0.076
purine nucleoside triphosphate catabolic process GO:0009146 392 0.074
metaphase plate congression GO:0051310 18 0.074
positive regulation of cell cycle GO:0045787 140 0.074
regulation of cytoskeleton organization GO:0051493 177 0.071
nucleus localization GO:0051647 1 0.069
Fly
positive regulation of protein kinase activity GO:0045860 190 0.069
dna packaging GO:0006323 77 0.068
positive regulation of protein phosphorylation GO:0001934 313 0.068
positive regulation of catabolic process GO:0009896 310 0.067
mitotic spindle midzone assembly GO:0051256 4 0.066
cellular component disassembly GO:0022411 92 0.066
regulation of protein localization GO:0032880 296 0.065
Worm
mitotic spindle organization GO:0007052 27 0.059
Fly
regulation of transferase activity GO:0051338 355 0.058
meiotic nuclear division GO:0007126 10 0.058
Mouse Worm
negative regulation of organelle organization GO:0010639 126 0.055
blastocyst development GO:0001824 3 0.054
protein depolymerization GO:0051261 30 0.053
positive regulation of proteolysis GO:0045862 142 0.053
regulation of kinase activity GO:0043549 314 0.053
neuroblast division GO:0055057 1 0.053
Mouse
cytoskeleton dependent cytokinesis GO:0061640 22 0.052
purine containing compound catabolic process GO:0072523 411 0.051
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.051
embryo development GO:0009790 123 0.050
Worm
posttranscriptional regulation of gene expression GO:0010608 213 0.049
cellular macromolecule catabolic process GO:0044265 380 0.049
kinetochore organization GO:0051383 8 0.048
Fly
protein maturation GO:0051604 233 0.048
positive regulation of organelle organization GO:0010638 195 0.048
spindle organization GO:0007051 53 0.046
Mouse Worm Fly
spindle checkpoint GO:0031577 26 0.046
embryonic epithelial tube formation GO:0001838 4 0.045
positive regulation of phosphorylation GO:0042327 394 0.043
purine nucleoside monophosphate catabolic process GO:0009128 158 0.043
negative regulation of proteolysis GO:0045861 132 0.042
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.042
positive regulation of cell cycle process GO:0090068 106 0.041
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.040
positive regulation of cellular catabolic process GO:0031331 284 0.040
positive regulation of protein transport GO:0051222 135 0.037
regulation of cellular component biogenesis GO:0044087 281 0.036
somatic stem cell division GO:0048103 1 0.036
Mouse
positive regulation of kinase activity GO:0033674 204 0.036
spindle midzone assembly GO:0051255 4 0.036
establishment of organelle localization GO:0051656 59 0.036
Worm Fly
cell cycle phase transition GO:0044770 173 0.035
protein catabolic process GO:0030163 325 0.034
intracellular protein transport GO:0006886 270 0.034
cytoplasmic transport GO:0016482 379 0.033
male meiosis GO:0007140 1 0.033
cellular pigmentation GO:0033059 17 0.033
nuclear migration GO:0007097 1 0.033
Fly
epithelium development GO:0060429 227 0.032
positive regulation of apoptotic process GO:0043065 246 0.031
chromosome separation GO:0051304 23 0.031
protein processing GO:0016485 226 0.030
regulation of mitotic recombination GO:0000019 1 0.030
regulation of protein processing GO:0070613 150 0.030
regulation of nucleocytoplasmic transport GO:0046822 98 0.030
regulation of protein catabolic process GO:0042176 155 0.030
positive regulation of cellular component organization GO:0051130 376 0.030
regulation of cell cycle phase transition GO:1901987 126 0.030
protein targeting GO:0006605 187 0.029
protein targeting to nucleus GO:0044744 104 0.029
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.029
vesicle mediated transport GO:0016192 371 0.029
positive regulation of programmed cell death GO:0043068 249 0.029
regulation of proteolysis GO:0030162 293 0.028
regulation of protein complex assembly GO:0043254 147 0.028
ras protein signal transduction GO:0007265 73 0.028
regulation of establishment of protein localization GO:0070201 242 0.028
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.028
positive regulation of cell division GO:0051781 59 0.028
regulation of mitotic cell cycle phase transition GO:1901990 118 0.027
regulation of microtubule cytoskeleton organization GO:0070507 61 0.027
establishment of nucleus localization GO:0040023 1 0.027
Fly
positive regulation of mitosis GO:0045840 25 0.027
modification dependent protein catabolic process GO:0019941 209 0.027
neurogenesis GO:0022008 169 0.027
Mouse
modification dependent macromolecule catabolic process GO:0043632 212 0.026
embryo development ending in birth or egg hatching GO:0009792 34 0.026
Worm
protein import GO:0017038 130 0.025
small gtpase mediated signal transduction GO:0007264 78 0.025
regulation of endopeptidase activity GO:0052548 170 0.025
regeneration GO:0031099 4 0.025
negative regulation of protein metabolic process GO:0051248 391 0.025
protein polyubiquitination GO:0000209 110 0.025
regulation of cytokinesis GO:0032465 45 0.024
regulation of cell differentiation GO:0045595 393 0.024
Mouse
regulation of cellular response to stress GO:0080135 244 0.024
protein localization to organelle GO:0033365 280 0.024
anatomical structure homeostasis GO:0060249 100 0.023
positive regulation of cytokinesis GO:0032467 29 0.023
cell fate determination GO:0001709 3 0.023
positive regulation of mitotic cell cycle GO:0045931 60 0.023
somatic muscle development GO:0007525 1 0.023
regulation of dna metabolic process GO:0051052 153 0.023
regulation of mitosis GO:0007088 63 0.022
positive regulation of transport GO:0051050 336 0.022
negative regulation of protein complex disassembly GO:0043242 20 0.022
neuroblast proliferation GO:0007405 4 0.022
Mouse
dephosphorylation GO:0016311 209 0.022
meiosis i GO:0007127 4 0.022
organelle localization GO:0051640 84 0.022
Mouse Worm Fly
proteasomal protein catabolic process GO:0010498 176 0.021
regulation of cytoplasmic transport GO:1903649 149 0.021
protein import into nucleus GO:0006606 104 0.021
positive regulation of hydrolase activity GO:0051345 331 0.021
regulation of cellular amine metabolic process GO:0033238 11 0.021
regulation of cellular amino acid metabolic process GO:0006521 6 0.020
chromatin modification GO:0016568 298 0.020
protein modification by small protein conjugation GO:0032446 342 0.020
negative regulation of integrin activation GO:0033624 2 0.020
mitotic cell cycle checkpoint GO:0007093 68 0.020
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.020
negative regulation of mitotic cell cycle GO:0045930 102 0.020
cellular amino acid metabolic process GO:0006520 116 0.020
regulation of cell migration GO:0030334 289 0.020
cellular protein catabolic process GO:0044257 261 0.020
regulation of protein kinase activity GO:0045859 289 0.020
microtubule bundle formation GO:0001578 15 0.019
sex determination GO:0007530 3 0.019
mitotic cell cycle phase transition GO:0044772 162 0.019
tissue regeneration GO:0042246 3 0.019
protein ubiquitination GO:0016567 314 0.019
wnt signaling pathway GO:0016055 156 0.019
Mouse
negative regulation of protein maturation GO:1903318 142 0.019
regulation of protein maturation GO:1903317 150 0.019
negative regulation of cellular catabolic process GO:0031330 83 0.019
negative regulation of protein catabolic process GO:0042177 59 0.018
mitotic cytokinesis GO:0000281 19 0.018
reproduction GO:0000003 63 0.018
Mouse Worm Fly
regulation of locomotion GO:0040012 329 0.018
anatomical structure formation involved in morphogenesis GO:0048646 284 0.018
Fly
regulation of proteasomal protein catabolic process GO:0061136 87 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.018
nucleocytoplasmic transport GO:0006913 176 0.018
protein dephosphorylation GO:0006470 81 0.018
centrosome organization GO:0051297 58 0.018
Fly
regulation of cellular ketone metabolic process GO:0010565 50 0.017
regulation of cell morphogenesis GO:0022604 153 0.017
chromosome condensation GO:0030261 15 0.017
regulation of binding GO:0051098 111 0.017
regulation of protein import into nucleus GO:0042306 78 0.017
cytidine deamination GO:0009972 7 0.017
regulation of nuclear division GO:0051783 65 0.017
regulation of protein transport GO:0051223 213 0.017
cellular response to dna damage stimulus GO:0006974 379 0.017
mitotic metaphase plate congression GO:0007080 14 0.017
negative regulation of protein processing GO:0010955 142 0.017
cellular component morphogenesis GO:0032989 314 0.017
establishment of protein localization to organelle GO:0072594 172 0.017
nervous system development GO:0007399 293 0.017
Mouse Fly
chromatin organization GO:0006325 351 0.017
response to abiotic stimulus GO:0009628 336 0.017
immune system development GO:0002520 195 0.017
response to radiation GO:0009314 151 0.016
positive regulation of nucleotide metabolic process GO:0045981 230 0.016
primary neural tube formation GO:0014020 3 0.016
actin filament based process GO:0030029 224 0.016
Fly
establishment of chromosome localization GO:0051303 20 0.016
positive regulation of cytoskeleton organization GO:0051495 83 0.016
negative regulation of cellular protein metabolic process GO:0032269 353 0.016
protein complex disassembly GO:0043241 52 0.016
regulation of viral process GO:0050792 103 0.016
regulation of cellular component movement GO:0051270 334 0.016
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.016
positive regulation of nuclear division GO:0051785 27 0.016
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.016
cellular amine metabolic process GO:0044106 41 0.016
oogenesis GO:0048477 2 0.015
Mouse Fly
cellular protein complex disassembly GO:0043624 36 0.015
positive regulation of intracellular transport GO:0032388 104 0.015
negative regulation of cell cycle phase transition GO:1901988 89 0.015
multi organism metabolic process GO:0044033 41 0.015
regulation of intracellular protein transport GO:0033157 123 0.015
positive regulation of cell death GO:0010942 263 0.015
negative regulation of cell division GO:0051782 31 0.015
Mouse
enzyme linked receptor protein signaling pathway GO:0007167 303 0.015
asymmetric neuroblast division GO:0055059 1 0.015
reproductive process GO:0022414 106 0.015
Mouse Worm Fly
regulation of response to dna damage stimulus GO:2001020 94 0.015
receptor mediated endocytosis GO:0006898 84 0.015
mitotic sister chromatid separation GO:0051306 18 0.015
regulation of mitotic sister chromatid separation GO:0010965 27 0.015
peptidyl tyrosine modification GO:0018212 170 0.015
positive regulation of attachment of spindle microtubules to kinetochore GO:0051987 2 0.015
hemopoiesis GO:0030097 180 0.015
receptor metabolic process GO:0043112 81 0.014
endomembrane system organization GO:0010256 196 0.014
mitotic spindle checkpoint GO:0071174 18 0.014
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.014
endosomal transport GO:0016197 129 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014
Mouse
regulation of meiosis GO:0040020 3 0.014
positive regulation of chromosome organization GO:2001252 41 0.014
biological adhesion GO:0022610 331 0.014
growth GO:0040007 202 0.014
Mouse
macromolecular complex disassembly GO:0032984 60 0.014
endocytosis GO:0006897 159 0.014
positive regulation of nucleotide catabolic process GO:0030813 185 0.014
cytokinesis completion of separation GO:0007109 3 0.014
regulation of cellular protein catabolic process GO:1903362 96 0.014
regulation of dephosphorylation GO:0035303 96 0.013
regulation of protein stability GO:0031647 87 0.013
regulation of protein serine threonine kinase activity GO:0071900 179 0.013
regulation of protein dephosphorylation GO:0035304 18 0.013
regulation of cysteine type endopeptidase activity GO:2000116 127 0.013
cellular ketone metabolic process GO:0042180 80 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.013
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.013
cell morphogenesis GO:0000902 296 0.013
nuclear import GO:0051170 106 0.013
regulation of peptidase activity GO:0052547 180 0.013
cytokinetic process GO:0032506 12 0.013
neural tube closure GO:0001843 3 0.013
cardiovascular system development GO:0072358 262 0.013
regulation of cell motility GO:2000145 299 0.012
reciprocal meiotic recombination GO:0007131 4 0.012
peptidyl serine modification GO:0018209 106 0.012
neuronal stem cell division GO:0036445 1 0.012
Mouse
negative regulation of programmed cell death GO:0043069 321 0.012
regulation of intracellular transport GO:0032386 195 0.012
regulation of mapk cascade GO:0043408 262 0.012
negative regulation of wnt signaling pathway GO:0030178 69 0.012
negative regulation of catabolic process GO:0009895 104 0.012
gtp catabolic process GO:0006184 237 0.012
regulation of chromosome organization GO:0033044 103 0.012
positive regulation of protein catabolic process GO:0045732 75 0.012
centrosome separation GO:0051299 3 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.011
positive regulation of peptidase activity GO:0010952 88 0.011
protein localization to nucleus GO:0034504 136 0.011
negative regulation of catalytic activity GO:0043086 335 0.011
negative regulation of cell cycle process GO:0010948 121 0.011
cdc42 protein signal transduction GO:0032488 4 0.011
protein autophosphorylation GO:0046777 123 0.011
multi organism cellular process GO:0044764 156 0.011
actin cytoskeleton organization GO:0030036 207 0.011
Fly
single organism membrane organization GO:0044802 268 0.011
single organism reproductive process GO:0044702 98 0.011
Mouse Worm Fly
response to oxygen containing compound GO:1901700 369 0.011
regulation of gtpase activity GO:0043087 180 0.011
negative regulation of chromosome organization GO:2001251 48 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.011
viral genome replication GO:0019079 50 0.011
positive regulation of intracellular protein transport GO:0090316 76 0.011
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 0.011
ribosome assembly GO:0042255 9 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.011
positive regulation of cytoplasmic transport GO:1903651 82 0.011
negative regulation of cellular protein catabolic process GO:1903363 38 0.011
positive regulation of transferase activity GO:0051347 227 0.011
vesicle organization GO:0016050 62 0.011
dna recombination GO:0006310 77 0.010
negative regulation of dna templated transcription initiation GO:2000143 3 0.010
positive regulation of wnt signaling pathway GO:0030177 54 0.010
Mouse
negative regulation of sister chromatid segregation GO:0033046 17 0.010
mitotic chromosome condensation GO:0007076 11 0.010
response to oxidative stress GO:0006979 121 0.010
regulation of purine nucleotide metabolic process GO:1900542 264 0.010
regulation of nucleotide metabolic process GO:0006140 269 0.010
morphogenesis of embryonic epithelium GO:0016331 4 0.010
regulation of meiotic cell cycle GO:0051445 4 0.010
immune response GO:0006955 307 0.010

ASPM disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.021
physical disorder DOID:0080015 41 0.007
congenital nervous system abnormality DOID:2490 21 0.007
microcephaly DOID:10907 6 0.002