Homo sapiens

86 known processes

LEPRE1

leucine proline-enriched proteoglycan (leprecan) 1

(Aliases: MGC117314,GROS1,P3H1,OI8)

LEPRE1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell adhesion GO:0007155 325 0.124
carbohydrate metabolic process GO:0005975 207 0.084
carbohydrate derivative biosynthetic process GO:1901137 207 0.076
post embryonic development GO:0009791 2 0.067
cellular amino acid metabolic process GO:0006520 116 0.056
single organism carbohydrate metabolic process GO:0044723 193 0.056
epithelium development GO:0060429 227 0.054
multicellular organismal macromolecule metabolic process GO:0044259 29 0.054
Human
cellular response to endogenous stimulus GO:0071495 336 0.052
glycosyl compound catabolic process GO:1901658 413 0.050
organonitrogen compound biosynthetic process GO:1901566 200 0.050
biological adhesion GO:0022610 331 0.045
response to abiotic stimulus GO:0009628 336 0.044
cell development GO:0048468 328 0.044
organophosphate catabolic process GO:0046434 430 0.043
membrane organization GO:0061024 292 0.043
nucleoside triphosphate metabolic process GO:0009141 422 0.041
extracellular structure organization GO:0043062 41 0.041
Mouse
nucleoside phosphate catabolic process GO:1901292 412 0.040
purine ribonucleoside metabolic process GO:0046128 437 0.038
purine nucleoside catabolic process GO:0006152 398 0.036
protein maturation GO:0051604 233 0.035
cellular component morphogenesis GO:0032989 314 0.034
oxidation reduction process GO:0055114 396 0.033
Human
ribonucleoside catabolic process GO:0042454 406 0.033
purine nucleotide catabolic process GO:0006195 405 0.032
basement membrane organization GO:0071711 3 0.032
ribonucleotide catabolic process GO:0009261 405 0.032
nucleotide catabolic process GO:0009166 408 0.031
semaphorin plexin signaling pathway GO:0071526 4 0.031
multicellular organismal aging GO:0010259 3 0.030
purine nucleoside triphosphate catabolic process GO:0009146 392 0.030
regulation of purine nucleotide metabolic process GO:1900542 264 0.030
cellular ketone metabolic process GO:0042180 80 0.029
ribonucleoside triphosphate metabolic process GO:0009199 412 0.029
regulation of cellular amine metabolic process GO:0033238 11 0.029
regulation of cellular amino acid metabolic process GO:0006521 6 0.029
glycoprotein biosynthetic process GO:0009101 91 0.029
nucleoside catabolic process GO:0009164 408 0.028
immune response GO:0006955 307 0.028
determination of adult lifespan GO:0008340 2 0.028
endochondral bone morphogenesis GO:0060350 3 0.028
negative regulation of catalytic activity GO:0043086 335 0.028
gtp metabolic process GO:0046039 239 0.028
transmembrane transport GO:0055085 399 0.028
positive regulation of hydrolase activity GO:0051345 331 0.028
epidermis morphogenesis GO:0048730 3 0.027
purine containing compound catabolic process GO:0072523 411 0.027
cell morphogenesis GO:0000902 296 0.027
amine metabolic process GO:0009308 44 0.027
guanosine containing compound metabolic process GO:1901068 244 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.027
cell projection organization GO:0030030 252 0.027
ribonucleoside triphosphate catabolic process GO:0009203 391 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.026
nervous system development GO:0007399 293 0.026
vesicle mediated transport GO:0016192 371 0.025
skin development GO:0043588 76 0.025
patterning of blood vessels GO:0001569 2 0.025
negative regulation of protein metabolic process GO:0051248 391 0.025
positive regulation of cellular catabolic process GO:0031331 284 0.024
peptidyl tyrosine modification GO:0018212 170 0.024
purine ribonucleoside catabolic process GO:0046130 398 0.024
purine ribonucleotide catabolic process GO:0009154 404 0.023
secretion GO:0046903 254 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
protein processing GO:0016485 226 0.022
positive regulation of cell proliferation GO:0008284 301 0.022
response to oxygen containing compound GO:1901700 369 0.022
negative regulation of phosphorus metabolic process GO:0010563 267 0.022
regulation of gtp catabolic process GO:0033124 180 0.022
purine nucleoside triphosphate metabolic process GO:0009144 412 0.022
regulation of nucleotide metabolic process GO:0006140 269 0.022
regulation of anatomical structure morphogenesis GO:0022603 286 0.022
negative regulation of cellular protein metabolic process GO:0032269 353 0.021
segmentation GO:0035282 4 0.021
neural crest cell development GO:0014032 3 0.021
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.020
memory GO:0007613 3 0.020
response to decreased oxygen levels GO:0036293 96 0.020
regeneration GO:0031099 4 0.020
salivary gland morphogenesis GO:0007435 4 0.020
female gamete generation GO:0007292 2 0.020
response to axon injury GO:0048678 1 0.020
regulation of cellular ketone metabolic process GO:0010565 50 0.020
macromolecule glycosylation GO:0043413 63 0.020
regulation of protein localization GO:0032880 296 0.020
neural crest cell migration GO:0001755 2 0.020
positive regulation of cellular component organization GO:0051130 376 0.020
neuron projection regeneration GO:0031102 1 0.020
sulfur compound metabolic process GO:0006790 101 0.020
response to radiation GO:0009314 151 0.020
extracellular matrix organization GO:0030198 41 0.020
Mouse
regulation of nucleoside metabolic process GO:0009118 209 0.020
cerebellum development GO:0021549 2 0.019
regulation of nucleotide catabolic process GO:0030811 205 0.019
small gtpase mediated signal transduction GO:0007264 78 0.019
system process GO:0003008 349 0.019
negative regulation of phosphate metabolic process GO:0045936 267 0.019
cytoplasmic transport GO:0016482 379 0.019
guanosine containing compound catabolic process GO:1901069 239 0.018
single organism membrane organization GO:0044802 268 0.018
cellular amine metabolic process GO:0044106 41 0.018
regulation of cellular response to stress GO:0080135 244 0.018
epidermis development GO:0008544 59 0.018
innate immune response GO:0045087 178 0.018
blastoderm segmentation GO:0007350 2 0.018
locomotory behavior GO:0007626 1 0.018
small molecule biosynthetic process GO:0044283 157 0.018
nucleoside triphosphate catabolic process GO:0009143 394 0.018
single organism cellular localization GO:1902580 332 0.018
tube development GO:0035295 125 0.018
negative regulation of multicellular organismal process GO:0051241 317 0.018
positive regulation of cellular amine metabolic process GO:0033240 7 0.018
protein catabolic process GO:0030163 325 0.018
regulation of cell differentiation GO:0045595 393 0.017
regulation of response to external stimulus GO:0032101 222 0.017
positive regulation of catabolic process GO:0009896 310 0.017
response to oxygen levels GO:0070482 100 0.017
regulation of cellular component movement GO:0051270 334 0.017
regulation of proteolysis GO:0030162 293 0.017
response to hormone GO:0009725 175 0.017
vasodilation GO:0042311 4 0.017
regulation of secretion by cell GO:1903530 177 0.017
response to hypoxia GO:0001666 96 0.017
positive regulation of nucleotide metabolic process GO:0045981 230 0.017
cell substrate adhesion GO:0031589 132 0.017
rho protein signal transduction GO:0007266 26 0.017
dephosphorylation GO:0016311 209 0.017
actin filament based process GO:0030029 224 0.017
response to growth factor GO:0070848 205 0.017
cell morphogenesis involved in differentiation GO:0000904 144 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.016
apoptotic signaling pathway GO:0097190 268 0.016
cellular macromolecule catabolic process GO:0044265 380 0.016
monocarboxylic acid metabolic process GO:0032787 185 0.016
negative regulation of hydrolase activity GO:0051346 182 0.016
neuromuscular junction development GO:0007528 3 0.016
protein localization to organelle GO:0033365 280 0.016
regulation of gtpase activity GO:0043087 180 0.016
hindbrain development GO:0030902 3 0.016
regulation of apoptotic signaling pathway GO:2001233 175 0.016
sulfur compound biosynthetic process GO:0044272 38 0.016
protein o linked glycosylation via serine GO:0018242 3 0.016
intracellular protein transport GO:0006886 270 0.015
mesenchyme development GO:0060485 59 0.015
regulation of multi organism process GO:0043900 157 0.015
regulation of growth GO:0040008 165 0.015
anterior posterior axis specification GO:0009948 2 0.015
response to biotic stimulus GO:0009607 276 0.015
positive regulation of cell death GO:0010942 263 0.015
circulatory system development GO:0072359 262 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
metencephalon development GO:0022037 2 0.015
secretion by cell GO:0032940 226 0.015
cartilage development involved in endochondral bone morphogenesis GO:0060351 2 0.015
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.015
positive regulation of gtp catabolic process GO:0033126 166 0.015
neurological system process GO:0050877 163 0.015
interspecies interaction between organisms GO:0044419 156 0.014
nitrogen compound transport GO:0071705 191 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
cell part morphogenesis GO:0032990 137 0.014
positive regulation of transport GO:0051050 336 0.014
protein oligomerization GO:0051259 173 0.014
chromatin modification GO:0016568 298 0.014
retina vasculature morphogenesis in camera type eye GO:0061299 3 0.014
regulation of cell morphogenesis GO:0022604 153 0.014
regulation of cell cycle GO:0051726 393 0.014
cellular lipid metabolic process GO:0044255 303 0.014
negative regulation of developmental process GO:0051093 247 0.014
peptidyl lysine modification GO:0018205 144 0.014
cation transport GO:0006812 331 0.014
multi organism cellular process GO:0044764 156 0.014
regulation of peptidase activity GO:0052547 180 0.014
cellular protein catabolic process GO:0044257 261 0.014
blood vessel development GO:0001568 172 0.014
lipid biosynthetic process GO:0008610 177 0.014
negative regulation of cell death GO:0060548 345 0.013
positive regulation of immune response GO:0050778 159 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
modification dependent macromolecule catabolic process GO:0043632 212 0.013
chromatin organization GO:0006325 351 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.013
regulation of protein transport GO:0051223 213 0.013
gtp catabolic process GO:0006184 237 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
oocyte differentiation GO:0009994 2 0.013
positive regulation of immune system process GO:0002684 283 0.013
dermatan sulfate proteoglycan biosynthetic process GO:0050651 4 0.013
morphogenesis of embryonic epithelium GO:0016331 4 0.013
ribonucleoside monophosphate metabolic process GO:0009161 187 0.013
neuron development GO:0048666 113 0.013
protein hydroxylation GO:0018126 9 0.013
oocyte development GO:0048599 1 0.013
regulation of epithelial cell proliferation GO:0050678 113 0.013
ubiquitin dependent protein catabolic process GO:0006511 206 0.013
defense response GO:0006952 315 0.013
regulation of angiogenesis GO:0045765 92 0.013
regulation of cell motility GO:2000145 299 0.013
anion transport GO:0006820 161 0.013
modification dependent protein catabolic process GO:0019941 209 0.013
glycoprotein metabolic process GO:0009100 110 0.013
negative regulation of catabolic process GO:0009895 104 0.013
skeletal system development GO:0001501 79 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.013
ion transmembrane transport GO:0034220 338 0.013
regulation of intracellular protein transport GO:0033157 123 0.013
circadian behavior GO:0048512 2 0.013
cellular homeostasis GO:0019725 196 0.012
neurogenesis GO:0022008 169 0.012
alpha amino acid metabolic process GO:1901605 72 0.012
positive regulation of programmed cell death GO:0043068 249 0.012
oxidative stress induced premature senescence GO:0090403 3 0.012
maintenance of location GO:0051235 112 0.012
spermatid development GO:0007286 4 0.012
multicellular organismal metabolic process GO:0044236 34 0.012
Human
nucleoside monophosphate metabolic process GO:0009123 191 0.012
protein o linked glycosylation via threonine GO:0018243 4 0.012
organ morphogenesis GO:0009887 147 0.012
aminoglycan biosynthetic process GO:0006023 29 0.012
protein glycosylation GO:0006486 62 0.012
chondrocyte development GO:0002063 1 0.012
retina vasculature development in camera type eye GO:0061298 3 0.012
sex determination GO:0007530 3 0.012
cellular protein complex assembly GO:0043623 188 0.012
regulation of cell migration GO:0030334 289 0.012
regulation of protein kinase activity GO:0045859 289 0.012
regulation of intracellular transport GO:0032386 195 0.012
cellular chemical homeostasis GO:0055082 180 0.012
rhythmic behavior GO:0007622 2 0.012
central nervous system development GO:0007417 123 0.012
immune effector process GO:0002252 159 0.012
regulation of cysteine type endopeptidase activity GO:2000116 127 0.012
regulation of protein secretion GO:0050708 86 0.012
carboxylic acid biosynthetic process GO:0046394 97 0.012
nuclear transport GO:0051169 179 0.012
blood vessel morphogenesis GO:0048514 162 0.012
angiogenesis GO:0001525 147 0.012
cellular response to dna damage stimulus GO:0006974 379 0.011
compound eye development GO:0048749 1 0.011
glycosylation GO:0070085 71 0.011
regulation of secretion GO:0051046 194 0.011
organelle assembly GO:0070925 176 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.011
vasculature development GO:0001944 181 0.011
protein targeting GO:0006605 187 0.011
anatomical structure formation involved in morphogenesis GO:0048646 284 0.011
dna repair GO:0006281 198 0.011
viral life cycle GO:0019058 132 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
protein localization to nucleus GO:0034504 136 0.011
taxis GO:0042330 157 0.011
metal ion transport GO:0030001 272 0.011
response to virus GO:0009615 126 0.011
lipid metabolic process GO:0006629 381 0.011
regulation of immune response GO:0050776 201 0.011
epithelial cell proliferation GO:0050673 128 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
Human
purine nucleoside monophosphate metabolic process GO:0009126 186 0.011
organic acid biosynthetic process GO:0016053 97 0.011
regulation of meiotic cell cycle GO:0051445 4 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
regulation of protein processing GO:0070613 150 0.011
enzyme linked receptor protein signaling pathway GO:0007167 303 0.011
ameboidal type cell migration GO:0001667 135 0.011
peripheral nervous system development GO:0007422 2 0.011
viral process GO:0016032 146 0.011
positive regulation of cytokine production GO:0001819 167 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
bone development GO:0060348 26 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
embryonic epithelial tube formation GO:0001838 4 0.011
cellular macromolecular complex assembly GO:0034622 324 0.011
collagen fibril organization GO:0030199 10 0.011
Mouse
axon regeneration GO:0031103 1 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.011
epithelial cell differentiation GO:0030855 141 0.011
aminoglycan metabolic process GO:0006022 39 0.011
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.011
negative regulation of programmed cell death GO:0043069 321 0.011
regulation of defense response GO:0031347 154 0.011
response to cytokine GO:0034097 232 0.011
response to external biotic stimulus GO:0043207 261 0.011
chemical homeostasis GO:0048878 306 0.011
regulation of cell cycle process GO:0010564 266 0.011
negative regulation of cell cycle GO:0045786 193 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.011
cellular carbohydrate metabolic process GO:0044262 84 0.011
oogenesis GO:0048477 2 0.011
tripartite regional subdivision GO:0007351 2 0.010
establishment of protein localization to organelle GO:0072594 172 0.010
spermatid differentiation GO:0048515 4 0.010
head development GO:0060322 108 0.010
glycosaminoglycan metabolic process GO:0030203 35 0.010
positive regulation of cell migration GO:0030335 172 0.010
positive regulation of nucleoside metabolic process GO:0045979 186 0.010
positive regulation of synaptic transmission GO:0050806 4 0.010
reactive oxygen species metabolic process GO:0072593 75 0.010
positive regulation of phosphorylation GO:0042327 394 0.010
organophosphate biosynthetic process GO:0090407 163 0.010
regulation of endopeptidase activity GO:0052548 170 0.010
negative regulation of protein modification process GO:0031400 200 0.010
ion homeostasis GO:0050801 230 0.010
cardiovascular system development GO:0072358 262 0.010
covalent chromatin modification GO:0016569 254 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.010
epithelial cell migration GO:0010631 119 0.010
negative regulation of protein maturation GO:1903318 142 0.010
protein modification by small protein conjugation GO:0032446 342 0.010
regulation of innate immune response GO:0045088 97 0.010
limbic system development GO:0021761 3 0.010
positive regulation of secretion GO:0051047 116 0.010

LEPRE1 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.645
connective tissue disease DOID:65 109 0.595
bone disease DOID:0080001 88 0.164
bone development disease DOID:0080006 55 0.149
osteochondrodysplasia DOID:2256 35 0.130
osteogenesis imperfecta DOID:12347 13 0.120
disease of metabolism DOID:0014667 295 0.033
inherited metabolic disorder DOID:655 242 0.033
disease of cellular proliferation DOID:14566 174 0.018
sensory system disease DOID:0050155 203 0.018
nervous system disease DOID:863 431 0.018
collagen disease DOID:854 9 0.018
ehlers danlos syndrome DOID:13359 9 0.018
myopathy DOID:423 104 0.016
muscular disease DOID:0080000 114 0.016
muscle tissue disease DOID:66 113 0.016
eye and adnexa disease DOID:1492 150 0.015
eye disease DOID:5614 149 0.015
carbohydrate metabolic disorder DOID:2978 55 0.013
cancer DOID:162 167 0.013
organ system cancer DOID:0050686 164 0.013
retinal disease DOID:5679 118 0.013
central nervous system disease DOID:331 186 0.012
brain disease DOID:936 73 0.012