Homo sapiens

0 known processes

SH2D1B

SH2 domain containing 1B

(Aliases: EAT2)

SH2D1B biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 11 0.628
Mouse
single organism membrane fusion GO:0044801 37 0.246
positive regulation of natural killer cell mediated immunity GO:0002717 12 0.200
Mouse
organelle fusion GO:0048284 36 0.144
vesicle mediated transport GO:0016192 371 0.107
vesicle organization GO:0016050 62 0.102
vesicle fusion GO:0006906 17 0.098
actin filament based process GO:0030029 224 0.086
leukocyte mediated immunity GO:0002443 59 0.076
Mouse
negative regulation of protein metabolic process GO:0051248 391 0.073
Mouse
innate immune response GO:0045087 178 0.068
Mouse
determination of adult lifespan GO:0008340 2 0.068
single organism membrane organization GO:0044802 268 0.066
myeloid cell differentiation GO:0030099 117 0.061
regulation of immune effector process GO:0002697 91 0.056
Mouse
multicellular organismal aging GO:0010259 3 0.053
hemopoiesis GO:0030097 180 0.053
regulation of innate immune response GO:0045088 97 0.050
Mouse
positive regulation of cell death GO:0010942 263 0.049
immune system development GO:0002520 195 0.047
cell killing GO:0001906 34 0.047
Mouse
organophosphate catabolic process GO:0046434 430 0.047
post embryonic development GO:0009791 2 0.047
membrane fusion GO:0061025 43 0.046
actin filament organization GO:0007015 128 0.045
negative regulation of multicellular organismal process GO:0051241 317 0.045
Mouse
regulation of vesicle mediated transport GO:0060627 130 0.045
actin cytoskeleton organization GO:0030036 207 0.043
cytokine production GO:0001816 247 0.043
Mouse
segmentation GO:0035282 4 0.042
purine ribonucleotide catabolic process GO:0009154 404 0.041
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.040
positive regulation of immune effector process GO:0002699 40 0.040
Mouse
nucleotide catabolic process GO:0009166 408 0.039
ribonucleoside triphosphate metabolic process GO:0009199 412 0.039
defense response GO:0006952 315 0.039
Mouse
ribonucleotide catabolic process GO:0009261 405 0.039
regulation of kinase activity GO:0043549 314 0.038
regulation of protein localization GO:0032880 296 0.038
natural killer cell mediated immunity GO:0002228 23 0.038
Mouse
lymphocyte mediated immunity GO:0002449 48 0.037
Mouse
regulation of cellular amine metabolic process GO:0033238 11 0.037
negative regulation of catalytic activity GO:0043086 335 0.036
nucleoside phosphate catabolic process GO:1901292 412 0.036
natural killer cell mediated cytotoxicity GO:0042267 23 0.035
Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.035
regulation of purine nucleotide metabolic process GO:1900542 264 0.033
lipid metabolic process GO:0006629 381 0.033
negative regulation of cellular protein metabolic process GO:0032269 353 0.032
Mouse
guanosine containing compound catabolic process GO:1901069 239 0.032
female gamete generation GO:0007292 2 0.032
negative regulation of monocyte differentiation GO:0045656 3 0.031
ras protein signal transduction GO:0007265 73 0.031
positive regulation of cellular catabolic process GO:0031331 284 0.031
ribonucleoside catabolic process GO:0042454 406 0.031
associative learning GO:0008306 1 0.031
regulation of lymphocyte mediated immunity GO:0002706 33 0.030
Mouse
regulation of proteolysis GO:0030162 293 0.030
regulation of transferase activity GO:0051338 355 0.030
purine ribonucleoside catabolic process GO:0046130 398 0.029
positive regulation of lymphocyte activation GO:0051251 73 0.029
purine nucleoside catabolic process GO:0006152 398 0.029
motor neuron axon guidance GO:0008045 2 0.029
replacement ossification GO:0036075 1 0.029
response to oxygen containing compound GO:1901700 369 0.028
regulation of establishment of protein localization GO:0070201 242 0.028
enzyme linked receptor protein signaling pathway GO:0007167 303 0.028
cell adhesion GO:0007155 325 0.028
gtp metabolic process GO:0046039 239 0.027
activation of immune response GO:0002253 114 0.027
regulation of vesicle fusion GO:0031338 5 0.027
regulation of cellular response to stress GO:0080135 244 0.027
regulation of protein transport GO:0051223 213 0.026
purine containing compound catabolic process GO:0072523 411 0.026
positive regulation of cytokine production GO:0001819 167 0.026
regulation of intracellular transport GO:0032386 195 0.026
cellular macromolecular complex assembly GO:0034622 324 0.026
negative regulation of hydrolase activity GO:0051346 182 0.026
lymphocyte activation GO:0046649 133 0.026
Mouse
regulation of osteoclast differentiation GO:0045670 18 0.026
neuromuscular junction development GO:0007528 3 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.025
regulation of protein maturation GO:1903317 150 0.025
protein processing GO:0016485 226 0.025
hematopoietic or lymphoid organ development GO:0048534 186 0.025
regulation of reactive oxygen species metabolic process GO:2000377 41 0.025
negative regulation of phosphate metabolic process GO:0045936 267 0.025
Mouse
regulation of protein processing GO:0070613 150 0.024
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.024
nucleoside triphosphate catabolic process GO:0009143 394 0.024
cytoplasmic transport GO:0016482 379 0.024
mitotic cell cycle process GO:1903047 286 0.023
microtubule based process GO:0007017 210 0.023
positive regulation of immune response GO:0050778 159 0.023
Mouse
nucleoside triphosphate metabolic process GO:0009141 422 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
purine nucleoside triphosphate catabolic process GO:0009146 392 0.022
cellular response to dna damage stimulus GO:0006974 379 0.022
regulation of peptidase activity GO:0052547 180 0.022
phospholipid metabolic process GO:0006644 99 0.022
cellular component morphogenesis GO:0032989 314 0.022
transmembrane transport GO:0055085 399 0.022
dephosphorylation GO:0016311 209 0.022
oogenesis GO:0048477 2 0.022
positive regulation of transport GO:0051050 336 0.022
cellular amino acid metabolic process GO:0006520 116 0.021
memory GO:0007613 3 0.021
negative regulation of immune response GO:0050777 40 0.021
Mouse
positive regulation of cell differentiation GO:0045597 211 0.021
blastoderm segmentation GO:0007350 2 0.021
regulation of gtpase activity GO:0043087 180 0.021
chemical homeostasis GO:0048878 306 0.021
regulation of cellular ketone metabolic process GO:0010565 50 0.021
cellular lipid metabolic process GO:0044255 303 0.021
locomotory behavior GO:0007626 1 0.021
regulation of gtp catabolic process GO:0033124 180 0.021
immune response GO:0006955 307 0.021
Mouse
regulation of response to external stimulus GO:0032101 222 0.020
reactive oxygen species biosynthetic process GO:1903409 4 0.020
regulation of nucleotide metabolic process GO:0006140 269 0.020
response to growth factor GO:0070848 205 0.020
regulation of mapk cascade GO:0043408 262 0.020
cation transport GO:0006812 331 0.020
negative regulation of proteolysis GO:0045861 132 0.020
anatomical structure formation involved in morphogenesis GO:0048646 284 0.020
ion transmembrane transport GO:0034220 338 0.020
organophosphate biosynthetic process GO:0090407 163 0.020
regulation of cellular amino acid metabolic process GO:0006521 6 0.020
regulation of cytoplasmic transport GO:1903649 149 0.020
maintenance of location GO:0051235 112 0.020
regulation of response to wounding GO:1903034 101 0.020
embryonic viscerocranium morphogenesis GO:0048703 1 0.020
regulation of cell cycle process GO:0010564 266 0.020
regulation of protein kinase activity GO:0045859 289 0.020
chromatin organization GO:0006325 351 0.019
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.019
Mouse
endochondral bone morphogenesis GO:0060350 3 0.019
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.019
regulation of apoptotic signaling pathway GO:2001233 175 0.019
peptidyl tyrosine phosphorylation GO:0018108 170 0.019
Mouse
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.019
multicellular organismal homeostasis GO:0048871 67 0.019
response to virus GO:0009615 126 0.019
regulation of cytokine production GO:0001817 232 0.019
Mouse
system process GO:0003008 349 0.019
regulation of myeloid leukocyte mediated immunity GO:0002886 4 0.019
positive regulation of catabolic process GO:0009896 310 0.019
oxidation reduction process GO:0055114 396 0.019
protein catabolic process GO:0030163 325 0.019
endocytosis GO:0006897 159 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
Mouse
protein maturation GO:0051604 233 0.018
covalent chromatin modification GO:0016569 254 0.018
positive regulation of phosphorylation GO:0042327 394 0.018
Mouse
regulation of cell activation GO:0050865 125 0.018
Mouse
regulation of myeloid cell differentiation GO:0045637 81 0.018
purine nucleoside triphosphate metabolic process GO:0009144 412 0.018
response to organic cyclic compound GO:0014070 204 0.018
t cell activation GO:0042110 99 0.018
protein oligomerization GO:0051259 173 0.017
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.017
Mouse
oocyte development GO:0048599 1 0.017
modification dependent macromolecule catabolic process GO:0043632 212 0.017
posttranscriptional regulation of gene expression GO:0010608 213 0.017
proteasomal protein catabolic process GO:0010498 176 0.017
negative regulation of peptidase activity GO:0010466 91 0.017
photoreceptor cell differentiation GO:0046530 2 0.017
positive regulation of developmental process GO:0051094 314 0.017
regulation of cell motility GO:2000145 299 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
cellular protein complex assembly GO:0043623 188 0.017
positive regulation of nucleotide catabolic process GO:0030813 185 0.017
positive regulation of protein transport GO:0051222 135 0.017
peptidyl tyrosine modification GO:0018212 170 0.017
Mouse
negative regulation of cell death GO:0060548 345 0.017
small molecule biosynthetic process GO:0044283 157 0.017
divalent metal ion transport GO:0070838 152 0.017
sequestering of calcium ion GO:0051208 17 0.016
positive regulation of organelle organization GO:0010638 195 0.016
mitotic cell cycle phase transition GO:0044772 162 0.016
regulation of astrocyte chemotaxis GO:2000458 1 0.016
biological adhesion GO:0022610 331 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
anterior posterior axis specification GO:0009948 2 0.016
regulation of cellular component movement GO:0051270 334 0.016
organonitrogen compound biosynthetic process GO:1901566 200 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
positive regulation of gtpase activity GO:0043547 166 0.016
lipid biosynthetic process GO:0008610 177 0.016
chemokine c c motif ligand 11 production GO:0071954 1 0.016
carbohydrate derivative biosynthetic process GO:1901137 207 0.015
modification dependent protein catabolic process GO:0019941 209 0.015
response to lipid GO:0033993 206 0.015
protein autophosphorylation GO:0046777 123 0.015
organ formation GO:0048645 3 0.015
cardiac muscle cell contraction GO:0086003 4 0.015
response to nitrogen compound GO:1901698 184 0.015
cell morphogenesis GO:0000902 296 0.015
nervous system development GO:0007399 293 0.015
cellular protein catabolic process GO:0044257 261 0.015
spermatid differentiation GO:0048515 4 0.015
response to fungus GO:0009620 4 0.015
cell cycle phase transition GO:0044770 173 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.015
immune effector process GO:0002252 159 0.015
Mouse
negative regulation of protein processing GO:0010955 142 0.015
negative regulation of apoptotic process GO:0043066 316 0.015
anterior posterior axis specification embryo GO:0008595 2 0.015
ubiquitin dependent protein catabolic process GO:0006511 206 0.014
adult locomotory behavior GO:0008344 1 0.014
rna processing GO:0006396 255 0.014
negative regulation of homeostatic process GO:0032845 59 0.014
regulation of nucleoside metabolic process GO:0009118 209 0.014
regulation of cell growth GO:0001558 135 0.014
positive regulation of nucleotide metabolic process GO:0045981 230 0.014
neurological system process GO:0050877 163 0.014
reactive oxygen species metabolic process GO:0072593 75 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.014
Mouse
purine ribonucleoside metabolic process GO:0046128 437 0.014
somitogenesis GO:0001756 2 0.014
mitotic cell cycle GO:0000278 326 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
purine nucleoside monophosphate metabolic process GO:0009126 186 0.014
long term memory GO:0007616 2 0.014
regulation of ras protein signal transduction GO:0046578 155 0.014
chromatin modification GO:0016568 298 0.014
regulation of microtubule based process GO:0032886 74 0.014
positive regulation of transferase activity GO:0051347 227 0.014
establishment of tissue polarity GO:0007164 3 0.014
positive regulation of cell killing GO:0031343 19 0.014
Mouse
regulation of cell cycle GO:0051726 393 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.014
amine metabolic process GO:0009308 44 0.014
atp metabolic process GO:0046034 176 0.014
regeneration GO:0031099 4 0.014
ribonucleoside triphosphate catabolic process GO:0009203 391 0.014
establishment of planar polarity GO:0001736 3 0.014
cellular response to endogenous stimulus GO:0071495 336 0.014
nucleoside monophosphate metabolic process GO:0009123 191 0.014
nucleocytoplasmic transport GO:0006913 176 0.014
divalent inorganic cation transport GO:0072511 158 0.014
metencephalon development GO:0022037 2 0.014
response to bacterium GO:0009617 144 0.014
syncytium formation by plasma membrane fusion GO:0000768 2 0.014
regulation of cell migration GO:0030334 289 0.013
regulation of endopeptidase activity GO:0052548 170 0.013
negative regulation of protein modification process GO:0031400 200 0.013
Mouse
gtp catabolic process GO:0006184 237 0.013
tissue migration GO:0090130 119 0.013
melanin metabolic process GO:0006582 1 0.013
response to organonitrogen compound GO:0010243 156 0.013
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.013
oocyte differentiation GO:0009994 2 0.013
membrane organization GO:0061024 292 0.013
cellular response to hormone stimulus GO:0032870 125 0.013
cation transmembrane transport GO:0098655 238 0.013
inorganic ion transmembrane transport GO:0098660 231 0.013
morphogenesis of a polarized epithelium GO:0001738 3 0.013
positive regulation of protein kinase activity GO:0045860 190 0.013
regulation of nucleotide catabolic process GO:0030811 205 0.013
single organism carbohydrate metabolic process GO:0044723 193 0.013
cell fate determination GO:0001709 3 0.013
tissue regeneration GO:0042246 3 0.013
regulation of intracellular protein transport GO:0033157 123 0.013
thymus development GO:0048538 3 0.013
growth GO:0040007 202 0.013
histone modification GO:0016570 251 0.013
negative regulation of endopeptidase activity GO:0010951 84 0.013
positive regulation of lymphocyte proliferation GO:0050671 46 0.013
morphogenesis of embryonic epithelium GO:0016331 4 0.013
regulation of calcium ion transport into cytosol GO:0010522 33 0.013
visual behavior GO:0007632 2 0.013
regulation of ras gtpase activity GO:0032318 128 0.013
glycoprotein metabolic process GO:0009100 110 0.013
response to transforming growth factor beta GO:0071559 94 0.012
tongue development GO:0043586 1 0.012
cellular ketone metabolic process GO:0042180 80 0.012
peripheral nervous system development GO:0007422 2 0.012
negative regulation of cell cycle GO:0045786 193 0.012
regulation of protein catabolic process GO:0042176 155 0.012
embryonic forelimb morphogenesis GO:0035115 4 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
negative regulation of protein maturation GO:1903318 142 0.012
cell growth GO:0016049 160 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
cell cycle checkpoint GO:0000075 117 0.012
compound eye development GO:0048749 1 0.012
methylation GO:0032259 106 0.012
cell part morphogenesis GO:0032990 137 0.012
positive regulation of immune system process GO:0002684 283 0.012
Mouse
immune response activating signal transduction GO:0002757 90 0.012
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
glycerophospholipid metabolic process GO:0006650 84 0.012
organic hydroxy compound metabolic process GO:1901615 147 0.012
regulation of multi organism process GO:0043900 157 0.012
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.012
microtubule cytoskeleton organization GO:0000226 176 0.012
apoptotic signaling pathway GO:0097190 268 0.012
negative regulation of reactive oxygen species biosynthetic process GO:1903427 1 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
trabecula morphogenesis GO:0061383 2 0.012
positive regulation of kinase activity GO:0033674 204 0.012
protein acylation GO:0043543 138 0.012
positive regulation of leukocyte differentiation GO:1902107 37 0.012
negative regulation of cellular component organization GO:0051129 235 0.012
autophagy GO:0006914 88 0.012
actin mediated cell contraction GO:0070252 12 0.012
endosomal transport GO:0016197 129 0.012
cranial nerve development GO:0021545 4 0.012
regulation of cytokine secretion GO:0050707 57 0.012
circadian behavior GO:0048512 2 0.012
nerve development GO:0021675 4 0.012
axis elongation GO:0003401 4 0.012
startle response GO:0001964 3 0.012
regulation of growth GO:0040008 165 0.011
negative regulation of programmed cell death GO:0043069 321 0.011
translation GO:0006412 132 0.011
intracellular protein transport GO:0006886 270 0.011
heart formation GO:0060914 2 0.011
tissue homeostasis GO:0001894 63 0.011
negative regulation of organelle organization GO:0010639 126 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
embryonic epithelial tube formation GO:0001838 4 0.011
second messenger mediated signaling GO:0019932 78 0.011
regulation of myeloid leukocyte differentiation GO:0002761 39 0.011
protein targeting GO:0006605 187 0.011
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.011
chemotaxis GO:0006935 157 0.011
response to peptide GO:1901652 65 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
regulation of chromosome organization GO:0033044 103 0.011
regulation of rho protein signal transduction GO:0035023 79 0.011
protein localization to organelle GO:0033365 280 0.011
nucleoside monophosphate catabolic process GO:0009125 159 0.011
convergent extension GO:0060026 1 0.011
positive regulation of secretion GO:0051047 116 0.011
protein localization to nucleus GO:0034504 136 0.011
regulation of endothelial cell proliferation GO:0001936 56 0.011
tripartite regional subdivision GO:0007351 2 0.011
receptor metabolic process GO:0043112 81 0.011
rhythmic behavior GO:0007622 2 0.011
response to external biotic stimulus GO:0043207 261 0.011
hindbrain development GO:0030902 3 0.011
humoral immune response GO:0006959 49 0.011
guanosine containing compound metabolic process GO:1901068 244 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.011
nuclear transport GO:0051169 179 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
wnt signaling pathway GO:0016055 156 0.011
response to cytokine GO:0034097 232 0.011
response to abiotic stimulus GO:0009628 336 0.011
negative regulation of hydrogen peroxide metabolic process GO:0010727 3 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
stress activated mapk cascade GO:0051403 93 0.011
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.011
atp catabolic process GO:0006200 157 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.011
positive regulation of locomotion GO:0040017 186 0.011
glycerolipid metabolic process GO:0046486 107 0.011
single organism cellular localization GO:1902580 332 0.010
limbic system development GO:0021761 3 0.010
glycosyl compound catabolic process GO:1901658 413 0.010
carbohydrate metabolic process GO:0005975 207 0.010
regulation of transmembrane transport GO:0034762 139 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.010
cellular response to oxygen containing compound GO:1901701 276 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.010
b cell proliferation GO:0042100 22 0.010
regulation of cellular component biogenesis GO:0044087 281 0.010
dna repair GO:0006281 198 0.010
eosinophil activation involved in immune response GO:0002278 2 0.010
primary neural tube formation GO:0014020 3 0.010
nitrogen compound transport GO:0071705 191 0.010
inorganic cation transmembrane transport GO:0098662 194 0.010
positive regulation of intracellular transport GO:0032388 104 0.010
regulation of meiosis GO:0040020 3 0.010
protein homooligomerization GO:0051260 100 0.010
spermatid development GO:0007286 4 0.010
monocarboxylic acid metabolic process GO:0032787 185 0.010
regulation of protein secretion GO:0050708 86 0.010
organelle assembly GO:0070925 176 0.010
meiosis i GO:0007127 4 0.010
regulation of cell cycle phase transition GO:1901987 126 0.010
establishment of protein localization to organelle GO:0072594 172 0.010
regulation of defense response GO:0031347 154 0.010
Mouse
cerebellum development GO:0021549 2 0.010
rna interference GO:0016246 4 0.010
protein polymerization GO:0051258 71 0.010
sleep GO:0030431 2 0.010
reactive nitrogen species metabolic process GO:2001057 3 0.010
nuclear export GO:0051168 69 0.010
cellular response to lipid GO:0071396 127 0.010
positive regulation of vasoconstriction GO:0045907 3 0.010
regulation of sensory perception GO:0051931 3 0.010
macromolecule methylation GO:0043414 97 0.010

SH2D1B disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.028
disease of metabolism DOID:0014667 295 0.024
cancer DOID:162 167 0.021
disease of cellular proliferation DOID:14566 174 0.021
inherited metabolic disorder DOID:655 242 0.019
sensory system disease DOID:0050155 203 0.018
nervous system disease DOID:863 431 0.018
organ system cancer DOID:0050686 164 0.018
eye and adnexa disease DOID:1492 150 0.016
eye disease DOID:5614 149 0.016
immune system disease DOID:2914 155 0.016
cardiovascular system disease DOID:1287 106 0.015
central nervous system disease DOID:331 186 0.014
muscular disease DOID:0080000 114 0.014
muscle tissue disease DOID:66 113 0.013
retinal disease DOID:5679 118 0.012
myopathy DOID:423 104 0.012
retinal degeneration DOID:8466 89 0.010