Homo sapiens

44 known processes

IRAK4

interleukin-1 receptor-associated kinase 4

(Aliases: REN64,IPD1,NY-REN-64)

IRAK4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to bacterial lipoprotein GO:0071220 3 0.985
growth of symbiont in host GO:0044117 1 0.834
positive regulation of toll like receptor 3 signaling pathway GO:0034141 1 0.802
positive regulation of toll like receptor signaling pathway GO:0034123 10 0.799
positive regulation of toll like receptor 2 signaling pathway GO:0034137 2 0.658
growth of symbiont involved in interaction with host GO:0044116 2 0.574
response to bacterial lipopeptide GO:0070339 3 0.342
response to bacterial lipoprotein GO:0032493 3 0.330
toll like receptor 2 signaling pathway GO:0034134 4 0.326
toll like receptor 4 signaling pathway GO:0034142 12 0.317
modulation of growth of symbiont involved in interaction with host GO:0044144 2 0.316
regulation of mapk cascade GO:0043408 262 0.272
activation of innate immune response GO:0002218 55 0.261
positive regulation of phosphorylation GO:0042327 394 0.255
mapk cascade GO:0000165 288 0.230
positive regulation of mapk cascade GO:0043410 190 0.223
pattern recognition receptor signaling pathway GO:0002221 48 0.218
defense response GO:0006952 315 0.209
Fly
i kappab kinase nf kappab signaling GO:0007249 166 0.206
negative regulation of growth of symbiont involved in interaction with host GO:0044146 2 0.197
regulation of cytokine production GO:0001817 232 0.195
growth involved in symbiotic interaction GO:0044110 2 0.194
signal transduction by phosphorylation GO:0023014 297 0.188
cellular response to bacterial lipopeptide GO:0071221 3 0.184
response to cytokine GO:0034097 232 0.177
Mouse
interleukin 17 production GO:0032620 12 0.174
positive regulation of cytokine production GO:0001819 167 0.171
positive regulation of immune system process GO:0002684 283 0.170
detection of bacterial lipoprotein GO:0042494 3 0.169
immune response activating signal transduction GO:0002757 90 0.167
response to other organism GO:0051707 261 0.157
Fly
activation of immune response GO:0002253 114 0.151
innate immune response activating signal transduction GO:0002758 48 0.148
positive regulation of innate immune response GO:0045089 79 0.143
cytokine production GO:0001816 247 0.141
Mouse
response to lipoteichoic acid GO:0070391 3 0.137
myeloid cell differentiation GO:0030099 117 0.133
response to bacterium GO:0009617 144 0.124
regulation of immune response GO:0050776 201 0.119
positive regulation of toll like receptor 4 signaling pathway GO:0034145 6 0.119
immune response GO:0006955 307 0.115
Fly
regulation of innate immune response GO:0045088 97 0.113
response to biotic stimulus GO:0009607 276 0.110
Fly
regulation of growth of symbiont in host GO:0044126 1 0.108
negative regulation of growth of symbiont in host GO:0044130 1 0.108
immune response regulating signaling pathway GO:0002764 97 0.107
protein modification by small protein conjugation GO:0032446 342 0.105
positive regulation of defense response GO:0031349 87 0.100
chemokine biosynthetic process GO:0042033 4 0.100
rna stabilization GO:0043489 18 0.098
positive regulation of locomotion GO:0040017 186 0.096
positive regulation of immune response GO:0050778 159 0.096
cell activation GO:0001775 213 0.095
interspecies interaction between organisms GO:0044419 156 0.093
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.090
innate immune response GO:0045087 178 0.088
regulation of defense response GO:0031347 154 0.084
regulation of leukocyte proliferation GO:0070663 67 0.082
positive regulation of interleukin 23 production GO:0032747 4 0.081
positive regulation of cell proliferation GO:0008284 301 0.080
regulation of mononuclear cell proliferation GO:0032944 65 0.080
regulation of chemokine biosynthetic process GO:0045073 4 0.078
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.078
interleukin 6 production GO:0032635 37 0.077
regulation of interleukin 17 production GO:0032660 12 0.076
response to oxygen containing compound GO:1901700 369 0.073
negative regulation of phosphate metabolic process GO:0045936 267 0.070
regulation of lymphocyte proliferation GO:0050670 64 0.070
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.069
toll like receptor 3 signaling pathway GO:0034138 4 0.067
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.067
cellular response to triacyl bacterial lipopeptide GO:0071727 2 0.067
positive regulation of leukocyte proliferation GO:0070665 48 0.066
regulation of cellular amino acid metabolic process GO:0006521 6 0.066
regulation of cellular component movement GO:0051270 334 0.066
regulation of transferase activity GO:0051338 355 0.065
response to peptidoglycan GO:0032494 3 0.063
regulation of cell activation GO:0050865 125 0.062
cellular amino acid metabolic process GO:0006520 116 0.061
regulation of leukocyte activation GO:0002694 115 0.061
negative regulation of protein metabolic process GO:0051248 391 0.061
cell chemotaxis GO:0060326 112 0.060
nucleoside triphosphate metabolic process GO:0009141 422 0.060
positive regulation of interleukin 8 production GO:0032757 36 0.060
regulation of toll like receptor 3 signaling pathway GO:0034139 2 0.059
cellular amine metabolic process GO:0044106 41 0.059
positive regulation of lymphocyte proliferation GO:0050671 46 0.059
response to external biotic stimulus GO:0043207 261 0.059
Fly
lymphocyte activation GO:0046649 133 0.058
response to triacyl bacterial lipopeptide GO:0071725 2 0.057
response to molecule of bacterial origin GO:0002237 82 0.057
multicellular organismal aging GO:0010259 3 0.057
negative regulation of cell proliferation GO:0008285 228 0.056
chemokine metabolic process GO:0050755 4 0.056
regulation of cellular response to stress GO:0080135 244 0.054
protein catabolic process GO:0030163 325 0.054
mononuclear cell proliferation GO:0032943 71 0.053
regulation of kinase activity GO:0043549 314 0.053
toll like receptor signaling pathway GO:0002224 25 0.053
positive regulation of chemokine production GO:0032722 22 0.053
regulation of cell motility GO:2000145 299 0.052
regulation of protein serine threonine kinase activity GO:0071900 179 0.052
negative regulation of phosphorus metabolic process GO:0010563 267 0.052
regulation of chemokine production GO:0032642 31 0.052
positive regulation of cell activation GO:0050867 81 0.051
leukocyte chemotaxis GO:0030595 76 0.051
immune effector process GO:0002252 159 0.050
regulation of cytokine mediated signaling pathway GO:0001959 41 0.050
positive regulation of mononuclear cell proliferation GO:0032946 47 0.050
regulation of lymphocyte activation GO:0051249 103 0.050
regulation of response to cytokine stimulus GO:0060759 46 0.049
protein ubiquitination GO:0016567 314 0.049
regulation of response to external stimulus GO:0032101 222 0.048
cellular response to oxygen containing compound GO:1901701 276 0.048
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.048
regulation of locomotion GO:0040012 329 0.048
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.048
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.047
hemopoiesis GO:0030097 180 0.047
regulation of protein kinase activity GO:0045859 289 0.046
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.046
regulation of chemokine c x c motif ligand 2 production GO:2000341 2 0.045
nucleotide catabolic process GO:0009166 408 0.044
positive regulation of protein phosphorylation GO:0001934 313 0.044
positive regulation of humoral immune response GO:0002922 3 0.044
extrinsic apoptotic signaling pathway GO:0097191 119 0.044
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.044
regulation of cell migration GO:0030334 289 0.044
regulation of neutrophil chemotaxis GO:0090022 10 0.044
nucleoside phosphate catabolic process GO:1901292 412 0.043
negative regulation of multi organism process GO:0043901 92 0.043
chemokine c x c motif ligand 2 production GO:0072567 3 0.043
response to lipid GO:0033993 206 0.042
response to organonitrogen compound GO:0010243 156 0.042
leukocyte activation GO:0045321 164 0.042
positive regulation of chemokine biosynthetic process GO:0045080 3 0.042
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.042
intracellular protein transport GO:0006886 270 0.042
mrna stabilization GO:0048255 18 0.041
positive regulation of chemotaxis GO:0050921 57 0.041
purine nucleotide catabolic process GO:0006195 405 0.040
posttranscriptional regulation of gene expression GO:0010608 213 0.040
response to abiotic stimulus GO:0009628 336 0.040
positive regulation of jnk cascade GO:0046330 52 0.039
cellular ketone metabolic process GO:0042180 80 0.039
lymphocyte proliferation GO:0046651 70 0.039
regulation of response to wounding GO:1903034 101 0.039
interleukin 12 production GO:0032615 15 0.039
negative regulation of cytokine mediated signaling pathway GO:0001960 22 0.039
organophosphate catabolic process GO:0046434 430 0.039
ribonucleoside catabolic process GO:0042454 406 0.039
regulation of interleukin 6 production GO:0032675 37 0.038
regulation of chemotaxis GO:0050920 74 0.038
positive regulation of cell migration GO:0030335 172 0.038
cellular response to hypoxia GO:0071456 51 0.038
interferon alpha biosynthetic process GO:0045349 4 0.038
chemokine production GO:0032602 32 0.038
negative regulation of cellular protein metabolic process GO:0032269 353 0.038
detection of diacyl bacterial lipopeptide GO:0042496 2 0.037
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.037
protein k48 linked ubiquitination GO:0070936 38 0.037
type i interferon production GO:0032606 27 0.036
activation of protein kinase activity GO:0032147 90 0.036
regulation of multi organism process GO:0043900 157 0.036
apoptotic signaling pathway GO:0097190 268 0.036
epithelium development GO:0060429 227 0.036
stress activated protein kinase signaling cascade GO:0031098 94 0.036
amine metabolic process GO:0009308 44 0.035
regulation of leukocyte migration GO:0002685 63 0.035
positive regulation of protein kinase activity GO:0045860 190 0.035
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.035
jnk cascade GO:0007254 80 0.035
positive regulation of map kinase activity GO:0043406 80 0.035
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.035
antifungal humoral response GO:0019732 2 0.034
Fly
regulation of toll like receptor signaling pathway GO:0034121 17 0.034
response to fungus GO:0009620 4 0.034
Fly
negative regulation of tumor necrosis factor production GO:0032720 20 0.034
oogenesis GO:0048477 2 0.033
defense response to gram positive bacterium GO:0050830 29 0.033
positive regulation of leukocyte activation GO:0002696 80 0.033
regulation of interferon beta production GO:0032648 22 0.033
regulation of stress activated mapk cascade GO:0032872 84 0.033
negative regulation of programmed cell death GO:0043069 321 0.033
defense response to virus GO:0051607 71 0.033
regulation of b cell activation GO:0050864 24 0.033
positive regulation of cell motility GO:2000147 177 0.033
negative regulation of apoptotic process GO:0043066 316 0.033
regulation of tumor necrosis factor production GO:0032680 43 0.033
chromatin organization GO:0006325 351 0.033
post embryonic development GO:0009791 2 0.033
response to lipopolysaccharide GO:0032496 70 0.033
purine nucleoside catabolic process GO:0006152 398 0.032
regulation of jnk cascade GO:0046328 73 0.032
positive regulation of response to external stimulus GO:0032103 88 0.032
negative regulation of growth GO:0045926 97 0.031
rhythmic behavior GO:0007622 2 0.031
female gamete generation GO:0007292 2 0.031
purine nucleoside triphosphate metabolic process GO:0009144 412 0.031
response to oxygen levels GO:0070482 100 0.031
regulation of establishment of protein localization GO:0070201 242 0.031
regulation of protein transport GO:0051223 213 0.031
leukocyte migration GO:0050900 107 0.031
positive regulation of tumor necrosis factor production GO:0032760 21 0.031
circadian behavior GO:0048512 2 0.031
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.031
positive regulation of apoptotic process GO:0043065 246 0.030
negative regulation of cholesterol efflux GO:0090370 2 0.030
positive regulation of b cell activation GO:0050871 17 0.030
positive regulation of lymphocyte activation GO:0051251 73 0.030
regulation of leukocyte chemotaxis GO:0002688 46 0.030
regulation of apoptotic signaling pathway GO:2001233 175 0.030
immune system development GO:0002520 195 0.029
cellular response to diacyl bacterial lipopeptide GO:0071726 2 0.029
epithelial cell differentiation GO:0030855 141 0.029
negative regulation of cellular component organization GO:0051129 235 0.029
segmentation GO:0035282 4 0.029
positive regulation of leukocyte migration GO:0002687 46 0.029
cytokine mediated signaling pathway GO:0019221 109 0.029
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.028
positive regulation of stress activated mapk cascade GO:0032874 60 0.028
interferon beta production GO:0032608 23 0.028
regulation of protein binding GO:0043393 66 0.028
purine ribonucleoside metabolic process GO:0046128 437 0.028
positive regulation of cytokine biosynthetic process GO:0042108 25 0.028
lipid metabolic process GO:0006629 381 0.028
cellular lipid metabolic process GO:0044255 303 0.028
nucleoside triphosphate catabolic process GO:0009143 394 0.028
ribonucleoside triphosphate metabolic process GO:0009199 412 0.028
response to virus GO:0009615 126 0.027
locomotory behavior GO:0007626 1 0.027
regulation of cellular amine metabolic process GO:0033238 11 0.027
negative regulation of immune system process GO:0002683 136 0.027
ribonucleoside triphosphate catabolic process GO:0009203 391 0.027
3 utr mediated mrna stabilization GO:0070935 8 0.027
b cell activation GO:0042113 33 0.027
negative regulation of cell death GO:0060548 345 0.027
purine ribonucleoside catabolic process GO:0046130 398 0.027
response to organic cyclic compound GO:0014070 204 0.027
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.027
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.027
negative regulation of transport GO:0051051 176 0.026
negative regulation of multicellular organismal process GO:0051241 317 0.026
determination of adult lifespan GO:0008340 2 0.026
guanosine containing compound metabolic process GO:1901068 244 0.026
protein targeting GO:0006605 187 0.026
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.026
organophosphate biosynthetic process GO:0090407 163 0.025
cellular protein catabolic process GO:0044257 261 0.025
purine ribonucleotide catabolic process GO:0009154 404 0.025
interleukin 8 production GO:0032637 51 0.025
neuromuscular junction development GO:0007528 3 0.025
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.025
defense response to fungus GO:0050832 4 0.025
Fly
regulation of intracellular transport GO:0032386 195 0.024
protein autophosphorylation GO:0046777 123 0.024
Fly
myeloid leukocyte migration GO:0097529 62 0.024
ribonucleotide catabolic process GO:0009261 405 0.024
positive regulation of interferon beta biosynthetic process GO:0045359 4 0.024
regulation of mrna stability GO:0043488 23 0.024
system process GO:0003008 349 0.024
cellular component morphogenesis GO:0032989 314 0.024
regulation of proteolysis GO:0030162 293 0.024
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.023
negative regulation of catabolic process GO:0009895 104 0.023
positive regulation of antimicrobial humoral response GO:0002760 1 0.023
response to diacyl bacterial lipopeptide GO:0071724 2 0.023
positive regulation of granulocyte chemotaxis GO:0071624 9 0.023
regulation of b cell proliferation GO:0030888 18 0.023
growth GO:0040007 202 0.023
regulation of binding GO:0051098 111 0.023
cellular response to dna damage stimulus GO:0006974 379 0.023
regulation of interleukin 12 production GO:0032655 15 0.023
stress activated mapk cascade GO:0051403 93 0.023
positive regulation of leukocyte chemotaxis GO:0002690 38 0.023
cellular macromolecule catabolic process GO:0044265 380 0.022
regulation of nucleotide metabolic process GO:0006140 269 0.022
cholesterol transport GO:0030301 39 0.022
anatomical structure homeostasis GO:0060249 100 0.022
cellular response to tumor necrosis factor GO:0071356 63 0.022
regulation of sensory perception GO:0051931 3 0.022
erk1 and erk2 cascade GO:0070371 104 0.022
cytoplasmic transport GO:0016482 379 0.022
nucleoside catabolic process GO:0009164 408 0.022
regulation of erk1 and erk2 cascade GO:0070372 99 0.022
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.022
regulation of growth GO:0040008 165 0.022
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.022
taxis GO:0042330 157 0.021
toll signaling pathway GO:0008063 2 0.021
memory GO:0007613 3 0.021
positive regulation of transferase activity GO:0051347 227 0.021
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.021
regulation of granulocyte chemotaxis GO:0071622 16 0.021
morphogenesis of embryonic epithelium GO:0016331 4 0.021
lipid transport GO:0006869 90 0.021
positive regulation of nucleotide metabolic process GO:0045981 230 0.021
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
positive regulation of interferon alpha biosynthetic process GO:0045356 4 0.021
gtp metabolic process GO:0046039 239 0.020
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 4 0.020
i kappab phosphorylation GO:0007252 7 0.020
nitrogen compound transport GO:0071705 191 0.020
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.020
granulocyte chemotaxis GO:0071621 37 0.020
cell morphogenesis GO:0000902 296 0.020
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.020
positive regulation of interleukin 17 production GO:0032740 8 0.020
vesicle mediated transport GO:0016192 371 0.020
gtp catabolic process GO:0006184 237 0.019
t cell activation GO:0042110 99 0.019
positive regulation of protein binding GO:0032092 24 0.019
blastoderm segmentation GO:0007350 2 0.019
negative regulation of phosphorylation GO:0042326 174 0.019
chemotaxis GO:0006935 157 0.019
negative regulation of catalytic activity GO:0043086 335 0.019
regulation of synaptic plasticity GO:0048167 3 0.019
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.019
organonitrogen compound biosynthetic process GO:1901566 200 0.019
tumor necrosis factor production GO:0032640 43 0.019
regulation of neutrophil migration GO:1902622 10 0.019
positive regulation of interleukin 6 production GO:0032755 21 0.019
protein maturation GO:0051604 233 0.019
purine containing compound catabolic process GO:0072523 411 0.019
cellular macromolecular complex assembly GO:0034622 324 0.019
regulation of protein catabolic process GO:0042176 155 0.018
compound eye development GO:0048749 1 0.018
spermatid differentiation GO:0048515 4 0.018
positive regulation of hormone biosynthetic process GO:0046886 4 0.018
membrane organization GO:0061024 292 0.018
response to nitrogen compound GO:1901698 184 0.018
single organism membrane organization GO:0044802 268 0.018
peripheral nervous system development GO:0007422 2 0.018
regulation of immune effector process GO:0002697 91 0.018
cell adhesion GO:0007155 325 0.018
cellular response to endogenous stimulus GO:0071495 336 0.018
regulation of behavior GO:0050795 82 0.018
cellular response to cytokine stimulus GO:0071345 181 0.018
Mouse
anatomical structure formation involved in morphogenesis GO:0048646 284 0.018
anterior posterior axis specification GO:0009948 2 0.018
response to interleukin 1 GO:0070555 47 0.018
response to tumor necrosis factor GO:0034612 76 0.018
purine nucleoside triphosphate catabolic process GO:0009146 392 0.017
negative regulation of mapk cascade GO:0043409 56 0.017
metal ion transport GO:0030001 272 0.017
cellular response to molecule of bacterial origin GO:0071219 62 0.017
ion homeostasis GO:0050801 230 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.017
actin filament based process GO:0030029 224 0.017
regeneration GO:0031099 4 0.017
negative regulation of protein modification process GO:0031400 200 0.017
cation transport GO:0006812 331 0.017
defense response to other organism GO:0098542 129 0.017
Fly
regulation of interferon beta biosynthetic process GO:0045357 4 0.017
cell growth GO:0016049 160 0.017
neurotransmitter secretion GO:0007269 4 0.017
regulation of gtp catabolic process GO:0033124 180 0.017
positive regulation of transport GO:0051050 336 0.017
cell substrate adhesion GO:0031589 132 0.017
histone modification GO:0016570 251 0.016
icosanoid metabolic process GO:0006690 35 0.016
spermatid development GO:0007286 4 0.016
neuroblast proliferation GO:0007405 4 0.016
cellular response to organonitrogen compound GO:0071417 124 0.016
single organism cellular localization GO:1902580 332 0.016
mitotic cell cycle process GO:1903047 286 0.016
regulation of nucleoside metabolic process GO:0009118 209 0.016
regulation of purine nucleotide catabolic process GO:0033121 205 0.016
neutrophil chemotaxis GO:0030593 24 0.016
regulation of protein localization GO:0032880 296 0.016
negative regulation of lipid transport GO:0032369 18 0.016
protein homooligomerization GO:0051260 100 0.016
nuclear transport GO:0051169 179 0.016
defense response to bacterium GO:0042742 63 0.016
regulation of cell differentiation GO:0045595 393 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.016
long term memory GO:0007616 2 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.015
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 4 0.015
regulation of cytoplasmic transport GO:1903649 149 0.015
regulation of interferon alpha biosynthetic process GO:0045354 4 0.015
microtubule based process GO:0007017 210 0.015
regulation of cell cycle process GO:0010564 266 0.015
negative regulation of protein kinase activity GO:0006469 98 0.015
biological adhesion GO:0022610 331 0.015
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 4 0.015
guanosine containing compound catabolic process GO:1901069 239 0.015
detection of bacterial lipopeptide GO:0070340 3 0.015
visual behavior GO:0007632 2 0.015
leukocyte proliferation GO:0070661 74 0.015
cellular response to decreased oxygen levels GO:0036294 51 0.015
dephosphorylation GO:0016311 209 0.015
ribonucleoside monophosphate metabolic process GO:0009161 187 0.015
secretion by cell GO:0032940 226 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.015
b cell proliferation GO:0042100 22 0.015
neurological system process GO:0050877 163 0.015
regulation of lipid transport GO:0032368 44 0.015
regulation of reactive oxygen species metabolic process GO:2000377 41 0.015
carbohydrate derivative biosynthetic process GO:1901137 207 0.015
cellular response to oxygen levels GO:0071453 55 0.015
adult locomotory behavior GO:0008344 1 0.015
neutrophil migration GO:1990266 25 0.015
regulation of nucleotide catabolic process GO:0030811 205 0.015
rna processing GO:0006396 255 0.015
oocyte development GO:0048599 1 0.015
negative regulation of protein phosphorylation GO:0001933 140 0.015
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.014
spinal cord development GO:0021510 4 0.014
lipid biosynthetic process GO:0008610 177 0.014
photoreceptor cell differentiation GO:0046530 2 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
protein localization to membrane GO:0072657 160 0.014
protein oligomerization GO:0051259 173 0.014
chromatin modification GO:0016568 298 0.014
muscle system process GO:0003012 81 0.014
regulation of small gtpase mediated signal transduction GO:0051056 156 0.014
fatty acid metabolic process GO:0006631 115 0.014
regulation of purine nucleotide metabolic process GO:1900542 264 0.014
meiosis i GO:0007127 4 0.014
glial cell migration GO:0008347 4 0.014
positive regulation of catabolic process GO:0009896 310 0.014
peptidyl tyrosine phosphorylation GO:0018108 170 0.014
positive regulation of gtp catabolic process GO:0033126 166 0.014
ras protein signal transduction GO:0007265 73 0.014
oocyte differentiation GO:0009994 2 0.014
organic hydroxy compound transport GO:0015850 63 0.014
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.014
mitochondrion organization GO:0007005 156 0.014
endomembrane system organization GO:0010256 196 0.014
cellular protein complex assembly GO:0043623 188 0.014
behavior GO:0007610 112 0.014
ubiquitin dependent protein catabolic process GO:0006511 206 0.014
small gtpase mediated signal transduction GO:0007264 78 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
cellular response to lipid GO:0071396 127 0.014
response to hypoxia GO:0001666 96 0.014
regulation of cellular component biogenesis GO:0044087 281 0.014
hindbrain development GO:0030902 3 0.013
lymphocyte mediated immunity GO:0002449 48 0.013
atp metabolic process GO:0046034 176 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.013
actin filament based movement GO:0030048 17 0.013
regulation of gtpase activity GO:0043087 180 0.013
regulation of type i interferon production GO:0032479 26 0.013
cardiac muscle cell contraction GO:0086003 4 0.013
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
t cell differentiation in thymus GO:0033077 4 0.013
negative regulation of cholesterol transport GO:0032375 8 0.013
positive regulation of multi organism process GO:0043902 56 0.013
rho protein signal transduction GO:0007266 26 0.013
negative regulation of cell cycle GO:0045786 193 0.013
positive regulation of binding GO:0051099 45 0.013
regulation of inflammatory response GO:0050727 46 0.013
oxidation reduction process GO:0055114 396 0.013
regulation of cytokine biosynthetic process GO:0042035 35 0.013
establishment of endothelial barrier GO:0061028 16 0.013
hematopoietic or lymphoid organ development GO:0048534 186 0.013
protein processing GO:0016485 226 0.013
cellular response to biotic stimulus GO:0071216 71 0.013
chemical homeostasis GO:0048878 306 0.013
response to toxic substance GO:0009636 37 0.013
cell fate determination GO:0001709 3 0.013
transmembrane transport GO:0055085 399 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
glycosyl compound catabolic process GO:1901658 413 0.013
actin cytoskeleton organization GO:0030036 207 0.013
primary neural tube formation GO:0014020 3 0.013
embryonic epithelial tube formation GO:0001838 4 0.013
cytokine biosynthetic process GO:0042089 37 0.013
positive regulation of jun kinase activity GO:0043507 23 0.013

IRAK4 disease predictions

Disease DO term ID Size Probability Func Analog Org
parasitic infectious disease DOID:1398 16 0.188
disease by infectious agent DOID:0050117 34 0.188
parasitic protozoa infectious disease DOID:2789 16 0.188
cancer DOID:162 167 0.060
disease of cellular proliferation DOID:14566 174 0.060
organ system cancer DOID:0050686 164 0.057
retinal disease DOID:5679 118 0.036
retinal degeneration DOID:8466 89 0.036
sensory system disease DOID:0050155 203 0.036
eye and adnexa disease DOID:1492 150 0.036
nervous system disease DOID:863 431 0.036
eye disease DOID:5614 149 0.036
disease of metabolism DOID:0014667 295 0.030
musculoskeletal system disease DOID:17 223 0.026
inherited metabolic disorder DOID:655 242 0.022
malaria DOID:12365 16 0.019
immune system disease DOID:2914 155 0.018
central nervous system disease DOID:331 186 0.016
macular degeneration DOID:4448 20 0.014
immune system cancer DOID:0060083 36 0.013
hematologic cancer DOID:2531 36 0.013
muscular disease DOID:0080000 114 0.013