Homo sapiens

277 known processes

SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

(Aliases: PAI,PAI1,PAI-1,PLANH1)

SERPINE1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
kinin cascade GO:0002254 1 1.000
positive regulation of fibrinolysis GO:0051919 4 1.000
plasminogen activation GO:0031639 11 1.000
positive regulation of plasminogen activation GO:0010756 3 1.000
regulation of fibrinolysis GO:0051917 8 1.000
positive regulation of blood coagulation GO:0030194 11 1.000
positive regulation of hemostasis GO:1900048 11 1.000
factor xii activation GO:0002542 1 1.000
positive regulation of acute inflammatory response GO:0002675 2 1.000
regulation of branching involved in salivary gland morphogenesis by mesenchymal epithelial signaling GO:0060665 1 1.000
branching involved in salivary gland morphogenesis GO:0060445 1 0.999
negative regulation of hydrogen peroxide mediated programmed cell death GO:1901299 3 0.999
regulation of smooth muscle cell matrix adhesion GO:2000097 3 0.999
cellular response to hepatocyte growth factor stimulus GO:0035729 6 0.999
positive regulation of protein processing GO:0010954 6 0.998
programmed cell death in response to reactive oxygen species GO:0097468 4 0.998
negative regulation of fibrinolysis GO:0051918 5 0.997
regulation of hydrogen peroxide mediated programmed cell death GO:1901298 4 0.997
fibrinolysis GO:0042730 11 0.995
negative regulation of blood coagulation GO:0030195 22 0.994
negative regulation of hemostasis GO:1900047 22 0.994
negative regulation of wound healing GO:0061045 25 0.992
cell adhesion mediated by integrin GO:0033627 27 0.991
mesenchymal epithelial cell signaling GO:0060638 1 0.991
positive regulation of locomotion GO:0040017 186 0.989
protein autoprocessing GO:0016540 4 0.988
hydrogen peroxide mediated programmed cell death GO:0010421 4 0.986
regulation of cell migration GO:0030334 289 0.985
positive regulation of cellular amine metabolic process GO:0033240 7 0.985
regulation of plasminogen activation GO:0010755 7 0.983
positive regulation of cell motility GO:2000147 177 0.982
amine metabolic process GO:0009308 44 0.982
cellular response to ammonium ion GO:0071242 4 0.975
cell substrate adhesion GO:0031589 132 0.975
regulation of smooth muscle cell migration GO:0014910 15 0.973
cellular response to oxidative stress GO:0034599 85 0.971
Rat
biological adhesion GO:0022610 331 0.970
muscle cell migration GO:0014812 19 0.970
hemostasis GO:0007599 76 0.968
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.967
positive regulation of cell migration GO:0030335 172 0.967
coagulation GO:0050817 78 0.966
regulation of oxidative stress induced cell death GO:1903201 24 0.965
regulation of blood coagulation GO:0030193 42 0.964
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.962
response to growth factor GO:0070848 205 0.961
Mouse Rat
hepatocyte growth factor receptor signaling pathway GO:0048012 8 0.960
regulation of hemostasis GO:1900046 42 0.959
blood vessel morphogenesis GO:0048514 162 0.959
cellular ketone metabolic process GO:0042180 80 0.958
regulation of cellular ketone metabolic process GO:0010565 50 0.957
regulation of cell matrix adhesion GO:0001952 42 0.956
cell chemotaxis GO:0060326 112 0.951
negative regulation of coagulation GO:0050819 24 0.950
positive regulation of protein maturation GO:1903319 6 0.949
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.946
smooth muscle cell matrix adhesion GO:0061302 5 0.943
regulation of cellular amino acid metabolic process GO:0006521 6 0.940
enzyme linked receptor protein signaling pathway GO:0007167 303 0.937
regulation of cellular component movement GO:0051270 334 0.934
anatomical structure formation involved in morphogenesis GO:0048646 284 0.934
negative regulation of oxidative stress induced cell death GO:1903202 17 0.930
wound healing GO:0042060 115 0.929
positive regulation of coagulation GO:0050820 11 0.927
regulation of cell adhesion GO:0030155 166 0.927
regulation of peptidase activity GO:0052547 180 0.922
vasculature development GO:0001944 181 0.920
positive regulation of phosphorylation GO:0042327 394 0.918
zymogen activation GO:0031638 70 0.917
cellular amine metabolic process GO:0044106 41 0.917
regulation of endopeptidase activity GO:0052548 170 0.916
positive regulation of cellular component movement GO:0051272 181 0.915
regulation of body fluid levels GO:0050878 99 0.912
regulation of coagulation GO:0050818 44 0.912
regulation of cell adhesion mediated by integrin GO:0033628 22 0.911
response to hydrogen peroxide GO:0042542 40 0.909
Rat
release of cytochrome c from mitochondria GO:0001836 35 0.908
regulation of cellular amine metabolic process GO:0033238 11 0.907
circulatory system development GO:0072359 262 0.907
cell death in response to hydrogen peroxide GO:0036474 10 0.904
regulation of wound healing GO:0061041 56 0.903
positive regulation of protein phosphorylation GO:0001934 313 0.903
response to reactive oxygen species GO:0000302 61 0.902
Rat
cell death in response to oxidative stress GO:0036473 29 0.900
peptidyl tyrosine modification GO:0018212 170 0.900
regulation of response to reactive oxygen species GO:1901031 12 0.893
response to oxidative stress GO:0006979 121 0.891
Rat
negative regulation of response to oxidative stress GO:1902883 18 0.890
blood coagulation GO:0007596 76 0.884
cell matrix adhesion GO:0007160 85 0.884
regulation of cell motility GO:2000145 299 0.884
extracellular matrix disassembly GO:0022617 16 0.884
negative regulation of programmed cell death GO:0043069 321 0.883
peptidyl tyrosine phosphorylation GO:0018108 170 0.883
protein activation cascade GO:0072376 22 0.879
negative regulation of response to wounding GO:1903035 47 0.875
morphogenesis of a branching structure GO:0001763 21 0.873
cellular response to endogenous stimulus GO:0071495 336 0.870
Mouse Rat
positive regulation of wound healing GO:0090303 20 0.866
regulation of mitochondrion organization GO:0010821 54 0.862
response to decreased oxygen levels GO:0036293 96 0.859
Rat
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.852
response to increased oxygen levels GO:0036296 4 0.850
Rat
cellular amino acid metabolic process GO:0006520 116 0.847
apoptotic signaling pathway GO:0097190 268 0.847
salivary gland morphogenesis GO:0007435 4 0.847
positive regulation of dna biosynthetic process GO:2000573 8 0.846
negative regulation of peptidase activity GO:0010466 91 0.844
positive regulation of cell proliferation GO:0008284 301 0.831
Rat
cell adhesion GO:0007155 325 0.827
organ morphogenesis GO:0009887 147 0.825
female gamete generation GO:0007292 2 0.822
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.817
apoptotic mitochondrial changes GO:0008637 57 0.812
response to lipid GO:0033993 206 0.809
regulation of branching involved in salivary gland morphogenesis GO:0060693 1 0.802
cellular response to growth factor stimulus GO:0071363 197 0.802
Mouse Rat
regulation of cellular response to oxidative stress GO:1900407 26 0.801
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.800
smooth muscle cell migration GO:0014909 18 0.798
regulation of locomotion GO:0040012 329 0.797
regulation of angiogenesis GO:0045765 92 0.797
response to hypoxia GO:0001666 96 0.796
Rat
angiogenesis GO:0001525 147 0.790
regulation of cell substrate adhesion GO:0010810 68 0.789
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.783
cellular response to reactive oxygen species GO:0034614 50 0.781
Rat
regulation of release of cytochrome c from mitochondria GO:0090199 29 0.773
negative regulation of hydrogen peroxide induced cell death GO:1903206 9 0.770
cellular response to hydrogen peroxide GO:0070301 37 0.755
Rat
response to inorganic substance GO:0010035 127 0.729
Rat
negative regulation of cell death GO:0060548 345 0.727
protein processing GO:0016485 226 0.727
regulation of inflammatory response GO:0050727 46 0.720
negative regulation of cellular response to oxidative stress GO:1900408 18 0.718
positive regulation of smooth muscle cell migration GO:0014911 6 0.715
regulation of response to wounding GO:1903034 101 0.710
regulation of proteolysis GO:0030162 293 0.699
extrinsic apoptotic signaling pathway GO:0097191 119 0.696
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.694
defense response GO:0006952 315 0.689
protein maturation GO:0051604 233 0.681
response to organic cyclic compound GO:0014070 204 0.677
Rat
mitochondrion organization GO:0007005 156 0.677
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.674
response to hormone GO:0009725 175 0.672
Rat
regulation of anatomical structure morphogenesis GO:0022603 286 0.668
negative regulation of apoptotic process GO:0043066 316 0.661
inflammatory response GO:0006954 79 0.661
dna biosynthetic process GO:0071897 40 0.656
response to oxygen levels GO:0070482 100 0.650
Rat
regulation of cysteine type endopeptidase activity GO:2000116 127 0.649
negative regulation of response to external stimulus GO:0032102 83 0.647
regulation of apoptotic signaling pathway GO:2001233 175 0.645
response to abiotic stimulus GO:0009628 336 0.643
Rat
negative regulation of cell adhesion GO:0007162 64 0.641
response to wounding GO:0009611 168 0.637
regulation of multi organism process GO:0043900 157 0.632
single organismal cell cell adhesion GO:0016337 148 0.630
extracellular matrix organization GO:0030198 41 0.624
response to topologically incorrect protein GO:0035966 29 0.623
negative regulation of hydrolase activity GO:0051346 182 0.623
positive regulation of response to wounding GO:1903036 28 0.618
negative regulation of organelle organization GO:0010639 126 0.617
response to oxygen containing compound GO:1901700 369 0.610
erk1 and erk2 cascade GO:0070371 104 0.609
blood vessel development GO:0001568 172 0.605
regulation of protein processing GO:0070613 150 0.598
acute inflammatory response GO:0002526 21 0.586
phosphatidylinositol mediated signaling GO:0048015 55 0.584
regulation of cell differentiation GO:0045595 393 0.581
Human
epithelium development GO:0060429 227 0.580
positive chemotaxis GO:0050918 33 0.567
negative regulation of cellular protein metabolic process GO:0032269 353 0.565
cellular response to glucocorticoid stimulus GO:0071385 4 0.561
Rat
taxis GO:0042330 157 0.560
regulation of vasculature development GO:1901342 97 0.559
endoderm formation GO:0001706 33 0.556
regulation of defense response GO:0031347 154 0.550
morphogenesis of a branching epithelium GO:0061138 20 0.548
cellular response to oxygen containing compound GO:1901701 276 0.545
negative regulation of multicellular organismal process GO:0051241 317 0.536
negative regulation of protein maturation GO:1903318 142 0.535
response to misfolded protein GO:0051788 5 0.531
negative regulation of apoptotic signaling pathway GO:2001234 97 0.525
cellular response to decreased oxygen levels GO:0036294 51 0.525
Rat
plasma kallikrein kinin cascade GO:0002353 1 0.517
response to nitrogen compound GO:1901698 184 0.505
Rat
cellular response to fluid shear stress GO:0071498 7 0.500
positive regulation of inflammatory response GO:0050729 10 0.482
cellular response to biotic stimulus GO:0071216 71 0.481
positive regulation of reproductive process GO:2000243 9 0.477
tissue morphogenesis GO:0048729 96 0.471
activation of plasma proteins involved in acute inflammatory response GO:0002541 2 0.466
regulation of leukocyte migration GO:0002685 63 0.462
negative regulation of catalytic activity GO:0043086 335 0.456
inositol lipid mediated signaling GO:0048017 55 0.443
cellular component disassembly GO:0022411 92 0.443
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.433
chemotaxis GO:0006935 157 0.430
regulation of morphogenesis of a branching structure GO:0060688 6 0.428
gland morphogenesis GO:0022612 8 0.425
reactive oxygen species metabolic process GO:0072593 75 0.420
regulation of hydrogen peroxide induced cell death GO:1903205 10 0.416
positive regulation of response to external stimulus GO:0032103 88 0.403
positive regulation of cell adhesion GO:0045785 84 0.383
regulation of organ morphogenesis GO:2000027 24 0.378
chemical homeostasis GO:0048878 306 0.367
Rat
positive regulation of defense response GO:0031349 87 0.359
response to hyperoxia GO:0055093 4 0.352
Rat
morphogenesis of an epithelium GO:0002009 60 0.345
negative regulation of cell substrate adhesion GO:0010812 24 0.335
regulation of receptor activity GO:0010469 47 0.334
response to activity GO:0014823 0 0.333
negative regulation of cellular component organization GO:0051129 235 0.328
regulation of reactive oxygen species metabolic process GO:2000377 41 0.328
cellular response to nitrogen compound GO:1901699 144 0.327
Rat
regulation of dna biosynthetic process GO:2000278 18 0.324
positive regulation of dna metabolic process GO:0051054 73 0.322
positive regulation of cellular component organization GO:0051130 376 0.313
negative regulation of mitochondrion organization GO:0010823 22 0.312
regulation of dna metabolic process GO:0051052 153 0.309
cellular response to lipid GO:0071396 127 0.302
regulation of cellular response to stress GO:0080135 244 0.299
response to alcohol GO:0097305 64 0.298
Rat
tissue regeneration GO:0042246 3 0.298
Rat
response to purine containing compound GO:0014074 40 0.297
Rat
negative regulation of plasminogen activation GO:0010757 4 0.287
nervous system development GO:0007399 293 0.287
Human
response to glucocorticoid GO:0051384 13 0.278
Rat
response to corticosteroid GO:0031960 15 0.277
Rat
extracellular structure organization GO:0043062 41 0.275
regulation of synaptic plasticity GO:0048167 3 0.264
tube development GO:0035295 125 0.253
regulation of protein localization GO:0032880 296 0.252
response to steroid hormone GO:0048545 80 0.249
Rat
response to carbohydrate GO:0009743 21 0.248
Rat
response to organophosphorus GO:0046683 41 0.248
Rat
regulation of cell development GO:0060284 161 0.245
Human
positive regulation of multi organism process GO:0043902 56 0.245
gland development GO:0048732 48 0.243
regulation of protein maturation GO:1903317 150 0.237
response to organonitrogen compound GO:0010243 156 0.232
Rat
cellular glucose homeostasis GO:0001678 11 0.232
Rat
response to camp GO:0051591 25 0.215
Rat
regulation of cell cell adhesion GO:0022407 57 0.214
leukocyte migration GO:0050900 107 0.212
cellular response to molecule of bacterial origin GO:0071219 62 0.206
cellular response to organic cyclic compound GO:0071407 127 0.201
Rat
cellular response to alkaloid GO:0071312 11 0.201
Rat
regulation of response to external stimulus GO:0032101 222 0.200
endothelial cell migration GO:0043542 86 0.197
response to biotic stimulus GO:0009607 276 0.192
positive regulation of keratinocyte migration GO:0051549 4 0.191
Rat
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.184
negative regulation of proteolysis GO:0045861 132 0.176
negative regulation of cellular component movement GO:0051271 106 0.173
regulation of chemotaxis GO:0050920 74 0.173
cellular response to organonitrogen compound GO:0071417 124 0.170
Rat
negative regulation of protein processing GO:0010955 142 0.169
generation of neurons GO:0048699 152 0.165
Human
post embryonic development GO:0009791 2 0.158
negative regulation of protein metabolic process GO:0051248 391 0.156
response to hexose GO:0009746 20 0.154
Rat
regulation of response to oxidative stress GO:1902882 26 0.152
cardiovascular system development GO:0072358 262 0.148
response to other organism GO:0051707 261 0.148
positive regulation of macrophage chemotaxis GO:0010759 3 0.145
regeneration GO:0031099 4 0.145
Rat
multicellular organismal metabolic process GO:0044236 34 0.142
epithelial cell proliferation GO:0050673 128 0.142
cellular response to oxygen levels GO:0071453 55 0.140
Rat
negative regulation of response to reactive oxygen species GO:1901032 10 0.138
cell morphogenesis involved in differentiation GO:0000904 144 0.138
cellular response to lipopolysaccharide GO:0071222 57 0.135
cytokine production GO:0001816 247 0.135
cyclic nucleotide metabolic process GO:0009187 82 0.134
embryonic morphogenesis GO:0048598 85 0.133
positive regulation of developmental process GO:0051094 314 0.131
response to fluid shear stress GO:0034405 14 0.128
Rat
cellular response to monosaccharide stimulus GO:0071326 10 0.128
Rat
hepatocyte proliferation GO:0072574 1 0.125
cell development GO:0048468 328 0.123
Human
connective tissue development GO:0061448 39 0.120
single organism reproductive process GO:0044702 98 0.118
Rat
cellular response to dexamethasone stimulus GO:0071549 1 0.117
Rat
cellular response to glucose stimulus GO:0071333 10 0.117
Rat
regulation of transferase activity GO:0051338 355 0.115
positive regulation of fibroblast migration GO:0010763 3 0.113
response to lipopolysaccharide GO:0032496 70 0.112
immune response GO:0006955 307 0.111
glial cell migration GO:0008347 4 0.110
regulation of cell projection organization GO:0031344 107 0.110
protein catabolic process GO:0030163 325 0.105
monocarboxylic acid metabolic process GO:0032787 185 0.105
cell growth GO:0016049 160 0.105
positive regulation of epithelial cell migration GO:0010634 55 0.104
Rat
regulation of epithelial cell proliferation GO:0050678 113 0.104
positive regulation of nervous system development GO:0051962 54 0.104
Human
digestive tract development GO:0048565 75 0.102
viral life cycle GO:0019058 132 0.102
female pregnancy GO:0007565 17 0.099
Rat
response to molecule of bacterial origin GO:0002237 82 0.098
response to metal ion GO:0010038 84 0.098
Rat
growth GO:0040007 202 0.098
Rat
urogenital system development GO:0001655 65 0.098
embryo development GO:0009790 123 0.093
positive regulation of programmed cell death GO:0043068 249 0.090
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.088
cell part morphogenesis GO:0032990 137 0.087
positive regulation of immune system process GO:0002684 283 0.087
positive regulation of axon extension GO:0045773 4 0.087
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.087
negative regulation of release of cytochrome c from mitochondria GO:0090201 11 0.084
regulation of vesicle mediated transport GO:0060627 130 0.083
cellular response to carbohydrate stimulus GO:0071322 11 0.081
Rat
positive regulation of cell projection organization GO:0031346 64 0.078
cellular response to alcohol GO:0097306 29 0.078
Rat
regulation of growth GO:0040008 165 0.078
g protein coupled receptor signaling pathway GO:0007186 207 0.076
response to bacterium GO:0009617 144 0.075
reproductive process GO:0022414 106 0.075
Rat
actin cytoskeleton organization GO:0030036 207 0.075
cellular response to hexose stimulus GO:0071331 10 0.074
Rat
renal system development GO:0072001 63 0.074
positive regulation of protein kinase activity GO:0045860 190 0.073
regulation of leukocyte cell cell adhesion GO:1903037 7 0.073
nerve development GO:0021675 4 0.072
positive regulation of transport GO:0051050 336 0.072
muscle structure development GO:0061061 98 0.072
myeloid leukocyte migration GO:0097529 62 0.072
cell morphogenesis GO:0000902 296 0.071
neurogenesis GO:0022008 169 0.071
Human
actin filament based process GO:0030029 224 0.071
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.069
regulation of synaptic transmission GO:0050804 11 0.068
cellular response to steroid hormone stimulus GO:0071383 37 0.067
Rat
developmental growth GO:0048589 48 0.066
Rat
positive regulation of neurogenesis GO:0050769 49 0.063
Human
regulation of protein import into nucleus GO:0042306 78 0.062
cellular response to corticosteroid stimulus GO:0071384 5 0.062
Rat
positive regulation of apoptotic process GO:0043065 246 0.062
osteoblast differentiation GO:0001649 92 0.060
positive regulation of secretion GO:0051047 116 0.060
regulation of actin filament based process GO:0032970 141 0.060
cation transport GO:0006812 331 0.060
Rat
epithelial cell differentiation GO:0030855 141 0.060
muscle system process GO:0003012 81 0.059
positive regulation of cell differentiation GO:0045597 211 0.059
Human
regulation of establishment of protein localization GO:0070201 242 0.058
regulation of cellular component biogenesis GO:0044087 281 0.058
skeletal muscle tissue regeneration GO:0043403 2 0.055
carbohydrate metabolic process GO:0005975 207 0.054
positive regulation of intracellular protein transport GO:0090316 76 0.054
purine nucleoside triphosphate metabolic process GO:0009144 412 0.053
ribonucleoside triphosphate catabolic process GO:0009203 391 0.053
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.053
viral process GO:0016032 146 0.053
liver development GO:0001889 9 0.053
response to monosaccharide GO:0034284 20 0.053
Rat
smooth muscle cell proliferation GO:0048659 28 0.051
granulocyte chemotaxis GO:0071621 37 0.051
hematopoietic or lymphoid organ development GO:0048534 186 0.050
regulation of cell growth GO:0001558 135 0.050
exocrine system development GO:0035272 7 0.050
positive regulation of cell death GO:0010942 263 0.050
regulation of binding GO:0051098 111 0.050
positive regulation of neuron differentiation GO:0045666 40 0.048
multi multicellular organism process GO:0044706 18 0.048
Rat
positive regulation of protein tyrosine kinase activity GO:0061098 24 0.047
cell cell signaling GO:0007267 155 0.047
rhythmic behavior GO:0007622 2 0.046
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.046
positive regulation of nucleotide metabolic process GO:0045981 230 0.046
membrane organization GO:0061024 292 0.046
single organism carbohydrate metabolic process GO:0044723 193 0.046
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.044
positive regulation of fibroblast proliferation GO:0048146 21 0.044
Rat
locomotory behavior GO:0007626 1 0.044
response to hepatocyte growth factor GO:0035728 6 0.044
positive regulation of organelle organization GO:0010638 195 0.044
calcium ion transport GO:0006816 147 0.043
Rat
regulation of protein transport GO:0051223 213 0.043
embryonic placenta development GO:0001892 1 0.043
regulation of secretion by cell GO:1903530 177 0.042
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.042
formation of primary germ layer GO:0001704 42 0.042
response to mechanical stimulus GO:0009612 51 0.042
Rat
regulation of astrocyte differentiation GO:0048710 3 0.041
Human
positive regulation of cell substrate adhesion GO:0010811 37 0.041
regulation of lipase activity GO:0060191 37 0.040
regulation of ossification GO:0030278 58 0.040
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.040
Mouse Rat
endothelial cell proliferation GO:0001935 65 0.040
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.040
regulation of kinase activity GO:0043549 314 0.039
regulation of keratinocyte migration GO:0051547 4 0.039
Rat
regulation of cytoskeleton organization GO:0051493 177 0.039
hepaticobiliary system development GO:0061008 10 0.039
regulation of actin cytoskeleton organization GO:0032956 116 0.038
negative regulation of smooth muscle cell migration GO:0014912 7 0.038
stress activated protein kinase signaling cascade GO:0031098 94 0.038
positive regulation of transferase activity GO:0051347 227 0.038
neuromuscular junction development GO:0007528 3 0.038
positive regulation of angiogenesis GO:0045766 51 0.038
alcohol metabolic process GO:0006066 114 0.038
neutrophil chemotaxis GO:0030593 24 0.037
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.037
secretion GO:0046903 254 0.037
motor neuron axon guidance GO:0008045 2 0.037
regulation of cell cycle GO:0051726 393 0.036
i kappab kinase nf kappab signaling GO:0007249 166 0.036
skin development GO:0043588 76 0.036
regulation of hepatocyte proliferation GO:2000345 1 0.036
neuron death GO:0070997 65 0.036
cellular component morphogenesis GO:0032989 314 0.036
cellular chemical homeostasis GO:0055082 180 0.035
Rat
regulation of reproductive process GO:2000241 15 0.035
axon regeneration GO:0031103 1 0.035
cell substrate adherens junction assembly GO:0007045 30 0.034
regulation of protein binding GO:0043393 66 0.034
cellular macromolecular complex assembly GO:0034622 324 0.034
regulation of neuron differentiation GO:0045664 70 0.034
establishment of protein localization to organelle GO:0072594 172 0.034
cellular protein catabolic process GO:0044257 261 0.034
positive regulation of protein kinase b signaling GO:0051897 42 0.033
lipid metabolic process GO:0006629 381 0.033
neuron projection regeneration GO:0031102 1 0.033
response to axon injury GO:0048678 1 0.032
regulation of cytokine production GO:0001817 232 0.032
regulation of secretion GO:0051046 194 0.032
negative regulation of phosphorus metabolic process GO:0010563 267 0.032
purine nucleotide catabolic process GO:0006195 405 0.031
ion homeostasis GO:0050801 230 0.031
cellular homeostasis GO:0019725 196 0.030
Rat
positive regulation of proteolysis GO:0045862 142 0.030
muscle cell differentiation GO:0042692 63 0.030
response to cytokine GO:0034097 232 0.030
Rat
positive regulation of apoptotic signaling pathway GO:2001235 70 0.030
salivary gland development GO:0007431 5 0.030
regulation of system process GO:0044057 101 0.030
multi organism reproductive process GO:0044703 54 0.030
Rat
positive regulation of neuron projection development GO:0010976 34 0.030
negative regulation of transport GO:0051051 176 0.030
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.030
segmentation GO:0035282 4 0.029
positive regulation of hydrolase activity GO:0051345 331 0.029
actin filament organization GO:0007015 128 0.029
cellular response to nutrient levels GO:0031669 69 0.029
striated muscle cell differentiation GO:0051146 43 0.029
response to ketone GO:1901654 19 0.029
Rat
regulation of extent of cell growth GO:0061387 9 0.029
interspecies interaction between organisms GO:0044419 156 0.029
positive regulation of t cell proliferation GO:0042102 33 0.029
ossification GO:0001503 121 0.029
dna replication GO:0006260 116 0.028
multicellular organismal reproductive process GO:0048609 40 0.028
Rat
organic hydroxy compound metabolic process GO:1901615 147 0.028
stress fiber assembly GO:0043149 40 0.028
regulation of neurogenesis GO:0050767 82 0.028
Human
maintenance of location GO:0051235 112 0.028
tyrosine phosphorylation of stat protein GO:0007260 33 0.028
intracellular protein transport GO:0006886 270 0.028
regulation of vascular wound healing GO:0061043 2 0.028
positive regulation of cytokine production GO:0001819 167 0.028
positive regulation of peptidase activity GO:0010952 88 0.027
cell projection organization GO:0030030 252 0.027
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.027
circulatory system process GO:0003013 113 0.027
regulation of actin filament bundle assembly GO:0032231 36 0.027
developmental process involved in reproduction GO:0003006 66 0.027
Rat
regulation of protein kinase b signaling GO:0051896 61 0.027
positive regulation of leukocyte chemotaxis GO:0002690 38 0.027
epithelial cell migration GO:0010631 119 0.026
Rat
regulation of protein kinase activity GO:0045859 289 0.026
transmembrane transport GO:0055085 399 0.026
Rat
purine containing compound biosynthetic process GO:0072522 88 0.026
epithelium migration GO:0090132 119 0.026
Rat
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.026
positive regulation of cell growth GO:0030307 48 0.026
organonitrogen compound biosynthetic process GO:1901566 200 0.025
regulation of lymphocyte migration GO:2000401 22 0.025
regulation of protein catabolic process GO:0042176 155 0.025
positive regulation of homeostatic process GO:0032846 47 0.025
positive regulation of cellular component biogenesis GO:0044089 158 0.025
cellular response to dna damage stimulus GO:0006974 379 0.025
cell division GO:0051301 168 0.025
positive regulation of protein complex assembly GO:0031334 86 0.025
cell junction organization GO:0034330 79 0.024
regulation of nucleotide metabolic process GO:0006140 269 0.024

SERPINE1 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.439
Human
neurodegenerative disease DOID:1289 102 0.439
Human
nervous system disease DOID:863 431 0.439
Human
dementia DOID:1307 19 0.404
alzheimer s disease DOID:10652 16 0.404
disease of mental health DOID:150 70 0.404
tauopathy DOID:680 16 0.404
cognitive disorder DOID:1561 29 0.404