Homo sapiens

80 known processes

INSIG2

insulin induced gene 2

(Aliases: MGC26273)

INSIG2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
purine ribonucleoside catabolic process GO:0046130 398 0.323
purine nucleotide catabolic process GO:0006195 405 0.260
glycosyl compound catabolic process GO:1901658 413 0.250
nucleoside triphosphate catabolic process GO:0009143 394 0.217
nucleoside triphosphate metabolic process GO:0009141 422 0.204
organophosphate catabolic process GO:0046434 430 0.198
cytoplasmic transport GO:0016482 379 0.185
Human
ribonucleoside triphosphate metabolic process GO:0009199 412 0.179
gtp catabolic process GO:0006184 237 0.161
nucleoside catabolic process GO:0009164 408 0.145
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.143
guanosine containing compound metabolic process GO:1901068 244 0.141
purine containing compound catabolic process GO:0072523 411 0.135
nucleoside phosphate catabolic process GO:1901292 412 0.134
guanosine containing compound catabolic process GO:1901069 239 0.119
ribonucleoside triphosphate catabolic process GO:0009203 391 0.119
ribonucleotide catabolic process GO:0009261 405 0.114
purine nucleoside triphosphate catabolic process GO:0009146 392 0.111
purine nucleoside catabolic process GO:0006152 398 0.109
purine ribonucleoside metabolic process GO:0046128 437 0.101
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.099
purine ribonucleotide catabolic process GO:0009154 404 0.095
post embryonic development GO:0009791 2 0.093
nucleotide catabolic process GO:0009166 408 0.093
cellular amino acid metabolic process GO:0006520 116 0.088
protein localization to organelle GO:0033365 280 0.084
purine nucleoside triphosphate metabolic process GO:0009144 412 0.075
single organism membrane organization GO:0044802 268 0.067
Human
gtp metabolic process GO:0046039 239 0.067
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.066
positive regulation of hydrolase activity GO:0051345 331 0.060
membrane organization GO:0061024 292 0.059
Human
positive regulation of catabolic process GO:0009896 310 0.056
regulation of nucleoside metabolic process GO:0009118 209 0.055
regulation of purine nucleotide metabolic process GO:1900542 264 0.053
regulation of nucleotide catabolic process GO:0030811 205 0.051
endomembrane system organization GO:0010256 196 0.046
positive regulation of nucleoside metabolic process GO:0045979 186 0.045
cellular macromolecule catabolic process GO:0044265 380 0.043
vesicle mediated transport GO:0016192 371 0.042
Human
intracellular protein transport GO:0006886 270 0.040
ribonucleoside catabolic process GO:0042454 406 0.039
transmembrane transport GO:0055085 399 0.038
regulation of nucleotide metabolic process GO:0006140 269 0.038
spermatid development GO:0007286 4 0.038
amine metabolic process GO:0009308 44 0.037
positive regulation of cellular catabolic process GO:0031331 284 0.035
small molecule biosynthetic process GO:0044283 157 0.035
Mouse
metal ion transport GO:0030001 272 0.035
divalent inorganic cation transport GO:0072511 158 0.034
positive regulation of nucleotide metabolic process GO:0045981 230 0.033
apoptotic signaling pathway GO:0097190 268 0.033
positive regulation of cellular amine metabolic process GO:0033240 7 0.033
cell cycle phase transition GO:0044770 173 0.033
single organism membrane fusion GO:0044801 37 0.032
cellular amine metabolic process GO:0044106 41 0.032
regulation of transferase activity GO:0051338 355 0.032
spermatid differentiation GO:0048515 4 0.032
negative regulation of programmed cell death GO:0043069 321 0.031
regulation of cell cycle GO:0051726 393 0.031
positive regulation of gtp catabolic process GO:0033126 166 0.031
positive regulation of immune system process GO:0002684 283 0.031
regulation of purine nucleotide catabolic process GO:0033121 205 0.031
negative regulation of cell cycle GO:0045786 193 0.031
anion transport GO:0006820 161 0.030
system process GO:0003008 349 0.030
mitochondrion organization GO:0007005 156 0.030
response to decreased oxygen levels GO:0036293 96 0.029
negative regulation of cellular protein metabolic process GO:0032269 353 0.029
positive regulation of transport GO:0051050 336 0.029
regulation of gtp catabolic process GO:0033124 180 0.029
negative regulation of catalytic activity GO:0043086 335 0.028
positive regulation of cellular component organization GO:0051130 376 0.028
single organism cellular localization GO:1902580 332 0.028
Human
positive regulation of phosphorylation GO:0042327 394 0.028
cation transport GO:0006812 331 0.027
secretion GO:0046903 254 0.027
negative regulation of cell proliferation GO:0008285 228 0.027
epithelium development GO:0060429 227 0.026
response to external biotic stimulus GO:0043207 261 0.026
establishment of protein localization to membrane GO:0090150 121 0.026
negative regulation of cellular component organization GO:0051129 235 0.026
Human
regulation of gtpase activity GO:0043087 180 0.025
response to hypoxia GO:0001666 96 0.025
establishment of protein localization to organelle GO:0072594 172 0.025
negative regulation of organelle organization GO:0010639 126 0.025
Human
negative regulation of protein modification process GO:0031400 200 0.025
regulation of protein kinase activity GO:0045859 289 0.025
regulation of protein localization GO:0032880 296 0.025
regulation of proteolysis GO:0030162 293 0.024
oogenesis GO:0048477 2 0.024
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.024
peptidyl serine modification GO:0018209 106 0.024
negative regulation of apoptotic process GO:0043066 316 0.024
negative regulation of protein metabolic process GO:0051248 391 0.024
negative regulation of phosphorus metabolic process GO:0010563 267 0.023
positive regulation of nucleotide catabolic process GO:0030813 185 0.023
locomotory behavior GO:0007626 1 0.022
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
signal transduction by phosphorylation GO:0023014 297 0.022
sequestering of metal ion GO:0051238 24 0.022
regulation of cellular ketone metabolic process GO:0010565 50 0.022
Mouse
maintenance of location GO:0051235 112 0.022
growth GO:0040007 202 0.022
mitotic cell cycle process GO:1903047 286 0.022
ras protein signal transduction GO:0007265 73 0.021
protein ubiquitination GO:0016567 314 0.021
regulation of cellular amine metabolic process GO:0033238 11 0.021
regulation of establishment of protein localization GO:0070201 242 0.021
adult locomotory behavior GO:0008344 1 0.021
negative regulation of transport GO:0051051 176 0.021
Human
negative regulation of cell death GO:0060548 345 0.021
regulation of ion transport GO:0043269 189 0.021
regulation of cellular component movement GO:0051270 334 0.020
response to oxygen levels GO:0070482 100 0.020
mitotic cell cycle phase transition GO:0044772 162 0.020
membrane fusion GO:0061025 43 0.020
cellular response to hormone stimulus GO:0032870 125 0.020
cell growth GO:0016049 160 0.020
methylation GO:0032259 106 0.020
modification dependent macromolecule catabolic process GO:0043632 212 0.020
golgi vesicle transport GO:0048193 80 0.020
Human
anterior posterior axis specification GO:0009948 2 0.020
protein localization to membrane GO:0072657 160 0.019
regulation of intracellular protein transport GO:0033157 123 0.019
regulation of protein transport GO:0051223 213 0.019
regulation of kinase activity GO:0043549 314 0.019
protein targeting GO:0006605 187 0.019
organic anion transport GO:0015711 103 0.019
mitotic cell cycle GO:0000278 326 0.019
positive regulation of cell migration GO:0030335 172 0.019
positive regulation of transferase activity GO:0051347 227 0.019
calcium ion transport GO:0006816 147 0.019
associative learning GO:0008306 1 0.019
regulation of cell migration GO:0030334 289 0.018
regulation of apoptotic signaling pathway GO:2001233 175 0.018
glycoprotein biosynthetic process GO:0009101 91 0.018
lipid biosynthetic process GO:0008610 177 0.018
Mouse
regulation of vesicle mediated transport GO:0060627 130 0.018
Human
response to other organism GO:0051707 261 0.018
blastoderm segmentation GO:0007350 2 0.018
immune effector process GO:0002252 159 0.018
rhythmic behavior GO:0007622 2 0.018
positive regulation of apoptotic process GO:0043065 246 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.017
reactive oxygen species metabolic process GO:0072593 75 0.017
regulation of cellular response to stress GO:0080135 244 0.017
cellular metal ion homeostasis GO:0006875 146 0.017
organophosphate biosynthetic process GO:0090407 163 0.017
ion transmembrane transport GO:0034220 338 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
sequestering of calcium ion GO:0051208 17 0.017
cellular ketone metabolic process GO:0042180 80 0.017
Mouse
regulation of small gtpase mediated signal transduction GO:0051056 156 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.017
stem cell division GO:0017145 2 0.017
regulation of locomotion GO:0040012 329 0.017
demethylation GO:0070988 37 0.017
protein catabolic process GO:0030163 325 0.017
segmentation GO:0035282 4 0.017
regulation of immune response GO:0050776 201 0.017
regulation of cytoplasmic transport GO:1903649 149 0.016
Human
positive regulation of gtpase activity GO:0043547 166 0.016
response to abiotic stimulus GO:0009628 336 0.016
cellular homeostasis GO:0019725 196 0.016
cellular response to endogenous stimulus GO:0071495 336 0.016
proteasomal protein catabolic process GO:0010498 176 0.016
memory GO:0007613 3 0.016
protein maturation GO:0051604 233 0.016
golgi organization GO:0007030 38 0.016
endosomal transport GO:0016197 129 0.016
inner ear morphogenesis GO:0042472 4 0.016
Mouse
chemical homeostasis GO:0048878 306 0.016
intrinsic apoptotic signaling pathway GO:0097193 127 0.015
cellular modified amino acid metabolic process GO:0006575 64 0.015
positive regulation of cellular component movement GO:0051272 181 0.015
mapk cascade GO:0000165 288 0.015
response to biotic stimulus GO:0009607 276 0.015
regulation of cell growth GO:0001558 135 0.015
atp catabolic process GO:0006200 157 0.015
retrograde transport endosome to golgi GO:0042147 45 0.015
immune response GO:0006955 307 0.015
organelle fusion GO:0048284 36 0.015
positive regulation of protein kinase activity GO:0045860 190 0.015
regulation of ras gtpase activity GO:0032318 128 0.015
defense response GO:0006952 315 0.015
neurological system process GO:0050877 163 0.015
regulation of growth GO:0040008 165 0.015
glycoprotein metabolic process GO:0009100 110 0.015
regulation of mitotic cell cycle GO:0007346 189 0.015
regulation of cell cycle process GO:0010564 266 0.014
female gamete generation GO:0007292 2 0.014
protein alkylation GO:0008213 74 0.014
tripartite regional subdivision GO:0007351 2 0.014
endocytosis GO:0006897 159 0.014
cytokine production GO:0001816 247 0.014
meiosis i GO:0007127 4 0.014
g1 s transition of mitotic cell cycle GO:0000082 78 0.014
regulation of intracellular transport GO:0032386 195 0.014
Human
negative regulation of hydrolase activity GO:0051346 182 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.014
biological adhesion GO:0022610 331 0.014
long term memory GO:0007616 2 0.014
negative regulation of cell cycle phase transition GO:1901988 89 0.013
atp metabolic process GO:0046034 176 0.013
regulation of protein ubiquitination GO:0031396 95 0.013
lipid metabolic process GO:0006629 381 0.013
Mouse
regulation of cell motility GO:2000145 299 0.013
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.013
cell adhesion GO:0007155 325 0.013
multicellular organismal aging GO:0010259 3 0.013
cellular protein catabolic process GO:0044257 261 0.013
vacuolar transport GO:0007034 34 0.013
response to inorganic substance GO:0010035 127 0.013
cation homeostasis GO:0055080 189 0.013
double strand break repair GO:0006302 101 0.013
plasma membrane organization GO:0007009 115 0.013
defense response to other organism GO:0098542 129 0.013
cellular protein complex assembly GO:0043623 188 0.013
Human
rho protein signal transduction GO:0007266 26 0.013
tissue morphogenesis GO:0048729 96 0.013
neuromuscular junction development GO:0007528 3 0.013
carbohydrate metabolic process GO:0005975 207 0.013
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
alpha amino acid metabolic process GO:1901605 72 0.012
positive regulation of protein phosphorylation GO:0001934 313 0.012
regulation of cell adhesion GO:0030155 166 0.012
peptidyl lysine modification GO:0018205 144 0.012
anatomical structure formation involved in morphogenesis GO:0048646 284 0.012
protein oligomerization GO:0051259 173 0.012
embryo development GO:0009790 123 0.012
Mouse
dna repair GO:0006281 198 0.012
regulation of cell cycle phase transition GO:1901987 126 0.012
nucleocytoplasmic transport GO:0006913 176 0.012
positive regulation of kinase activity GO:0033674 204 0.012
apoptotic mitochondrial changes GO:0008637 57 0.012
organelle assembly GO:0070925 176 0.012
negative regulation of cell cycle process GO:0010948 121 0.012
positive regulation of cell motility GO:2000147 177 0.012
positive regulation of ras gtpase activity GO:0032320 117 0.012
positive regulation of protein transport GO:0051222 135 0.012
cellular cation homeostasis GO:0030003 163 0.012
positive regulation of organelle organization GO:0010638 195 0.012
peptidyl serine phosphorylation GO:0018105 101 0.012
limbic system development GO:0021761 3 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
dephosphorylation GO:0016311 209 0.012
regulation of secretion GO:0051046 194 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
microtubule based process GO:0007017 210 0.011
regulation of chromosome organization GO:0033044 103 0.011
positive regulation of proteolysis GO:0045862 142 0.011
regulation of membrane potential GO:0042391 95 0.011
purine nucleoside monophosphate metabolic process GO:0009126 186 0.011
chromatin modification GO:0016568 298 0.011
response to oxidative stress GO:0006979 121 0.011
embryonic morphogenesis GO:0048598 85 0.011
Mouse
cell development GO:0048468 328 0.011
protein localization to plasma membrane GO:0072659 93 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.011
nervous system development GO:0007399 293 0.011
determination of adult lifespan GO:0008340 2 0.011
covalent chromatin modification GO:0016569 254 0.011
maintenance of location in cell GO:0051651 62 0.011
chemotaxis GO:0006935 157 0.011
mitochondrial transport GO:0006839 60 0.011
ion homeostasis GO:0050801 230 0.011
regulation of protein processing GO:0070613 150 0.011
cardiovascular system development GO:0072358 262 0.011
oxidation reduction process GO:0055114 396 0.011
positive regulation of locomotion GO:0040017 186 0.011
blood vessel development GO:0001568 172 0.011
histone modification GO:0016570 251 0.011
calcium ion homeostasis GO:0055074 122 0.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.010
defense response to fungus GO:0050832 4 0.010
histone methylation GO:0016571 60 0.010
regulation of reactive oxygen species metabolic process GO:2000377 41 0.010
positive regulation of mapk cascade GO:0043410 190 0.010
morphogenesis of a polarized epithelium GO:0001738 3 0.010
cell projection organization GO:0030030 252 0.010
regulation of mitotic cell cycle phase transition GO:1901990 118 0.010
single organism carbohydrate metabolic process GO:0044723 193 0.010
regulation of mitochondrion organization GO:0010821 54 0.010
cellular chemical homeostasis GO:0055082 180 0.010
alcohol metabolic process GO:0006066 114 0.010
Mouse
regulation of cysteine type endopeptidase activity GO:2000116 127 0.010
actin filament based process GO:0030029 224 0.010
cell morphogenesis GO:0000902 296 0.010
mitochondrial membrane organization GO:0007006 40 0.010
protein localization to nucleus GO:0034504 136 0.010
negative regulation of multicellular organismal process GO:0051241 317 0.010
positive regulation of protein catabolic process GO:0045732 75 0.010

INSIG2 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.027
nervous system disease DOID:863 431 0.027
disease of metabolism DOID:0014667 295 0.027
carbohydrate metabolic disorder DOID:2978 55 0.027
inherited metabolic disorder DOID:655 242 0.027
cancer DOID:162 167 0.019
disease of cellular proliferation DOID:14566 174 0.019
organ system cancer DOID:0050686 164 0.019
musculoskeletal system disease DOID:17 223 0.016
neurodegenerative disease DOID:1289 102 0.013