Homo sapiens

64 known processes

KLHL20

kelch-like 20 (Drosophila)

(Aliases: KLEIP,KHLHX,RP3-383J4.3,KLHLX)

KLHL20 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
posttranscriptional regulation of gene expression GO:0010608 213 0.330
Human
translation GO:0006412 132 0.312
Human
regulation of translation GO:0006417 89 0.309
Human
copii vesicle coating GO:0048208 2 0.300
Human
vesicle targeting rough er to cis golgi GO:0048207 2 0.271
Human
defense response GO:0006952 315 0.212
innate immune response GO:0045087 178 0.205
cellular macromolecule catabolic process GO:0044265 380 0.180
protein ubiquitination GO:0016567 314 0.142
chromatin organization GO:0006325 351 0.115
nucleoside triphosphate catabolic process GO:0009143 394 0.115
response to interferon gamma GO:0034341 39 0.111
ribonucleoside triphosphate metabolic process GO:0009199 412 0.103
regulation of cell cycle process GO:0010564 266 0.098
Human
modification dependent protein catabolic process GO:0019941 209 0.098
purine ribonucleoside catabolic process GO:0046130 398 0.095
cellular response to cytokine stimulus GO:0071345 181 0.093
oogenesis GO:0048477 2 0.091
cellular component morphogenesis GO:0032989 314 0.083
Fly
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.079
membrane organization GO:0061024 292 0.078
Human
apoptotic signaling pathway GO:0097190 268 0.073
segmentation GO:0035282 4 0.071
purine nucleotide catabolic process GO:0006195 405 0.071
anatomical structure formation involved in morphogenesis GO:0048646 284 0.067
post embryonic development GO:0009791 2 0.064
vesicle mediated transport GO:0016192 371 0.064
immune response GO:0006955 307 0.063
single organism cellular localization GO:1902580 332 0.061
Human
determination of adult lifespan GO:0008340 2 0.055
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.055
protein modification by small protein conjugation GO:0032446 342 0.053
glycosyl compound catabolic process GO:1901658 413 0.053
response to cytokine GO:0034097 232 0.053
neural tube formation GO:0001841 3 0.052
single organism membrane organization GO:0044802 268 0.051
Human
cytoplasmic transport GO:0016482 379 0.050
protein autophosphorylation GO:0046777 123 0.050
chromatin modification GO:0016568 298 0.049
nucleoside triphosphate metabolic process GO:0009141 422 0.048
ribonucleotide catabolic process GO:0009261 405 0.047
regulation of protein ubiquitination GO:0031396 95 0.047
purine containing compound catabolic process GO:0072523 411 0.047
multicellular organismal aging GO:0010259 3 0.046
negative regulation of protein metabolic process GO:0051248 391 0.044
Human
protein catabolic process GO:0030163 325 0.043
response to other organism GO:0051707 261 0.042
positive regulation of programmed cell death GO:0043068 249 0.041
cellular response to interferon gamma GO:0071346 24 0.041
cell morphogenesis involved in differentiation GO:0000904 144 0.040
positive regulation of developmental process GO:0051094 314 0.040
regulation of mitotic cell cycle GO:0007346 189 0.040
modification dependent macromolecule catabolic process GO:0043632 212 0.039
ion homeostasis GO:0050801 230 0.039
Human
regulation of cellular response to stress GO:0080135 244 0.038
negative regulation of cellular protein metabolic process GO:0032269 353 0.038
Human
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.038
ubiquitin dependent protein catabolic process GO:0006511 206 0.037
guanosine containing compound catabolic process GO:1901069 239 0.037
organophosphate catabolic process GO:0046434 430 0.037
purine ribonucleotide catabolic process GO:0009154 404 0.037
vesicle organization GO:0016050 62 0.036
Human
positive regulation of transferase activity GO:0051347 227 0.036
protein localization to organelle GO:0033365 280 0.035
Human
regulation of anatomical structure morphogenesis GO:0022603 286 0.034
cellular ketone metabolic process GO:0042180 80 0.034
proteasomal protein catabolic process GO:0010498 176 0.034
negative regulation of translation GO:0017148 37 0.034
Human
intracellular protein transport GO:0006886 270 0.034
regulation of cell differentiation GO:0045595 393 0.033
ribonucleoside triphosphate catabolic process GO:0009203 391 0.033
purine nucleoside triphosphate metabolic process GO:0009144 412 0.032
endomembrane system organization GO:0010256 196 0.032
nucleoside catabolic process GO:0009164 408 0.031
mitotic cell cycle GO:0000278 326 0.031
establishment of protein localization to membrane GO:0090150 121 0.031
dna conformation change GO:0071103 113 0.030
cellular protein catabolic process GO:0044257 261 0.030
response to abiotic stimulus GO:0009628 336 0.030
rna interference GO:0016246 4 0.029
neuromuscular junction development GO:0007528 3 0.029
stem cell division GO:0017145 2 0.029
histone modification GO:0016570 251 0.029
positive regulation of cell cycle GO:0045787 140 0.028
interspecies interaction between organisms GO:0044419 156 0.028
hindbrain development GO:0030902 3 0.028
regulation of cellular ketone metabolic process GO:0010565 50 0.028
regulation of response to external stimulus GO:0032101 222 0.028
cell cycle phase transition GO:0044770 173 0.028
negative regulation of intracellular signal transduction GO:1902532 183 0.028
purine nucleoside catabolic process GO:0006152 398 0.028
nucleoside phosphate catabolic process GO:1901292 412 0.028
nervous system development GO:0007399 293 0.027
Fly
positive regulation of apoptotic process GO:0043065 246 0.027
metal ion transport GO:0030001 272 0.027
Human
regulation of protein catabolic process GO:0042176 155 0.027
tube development GO:0035295 125 0.026
Human
biological adhesion GO:0022610 331 0.026
regulation of cell cycle phase transition GO:1901987 126 0.026
negative regulation of cell cycle process GO:0010948 121 0.026
regulation of apoptotic signaling pathway GO:2001233 175 0.026
protein polyubiquitination GO:0000209 110 0.026
regulation of kinase activity GO:0043549 314 0.026
negative regulation of cell cycle phase transition GO:1901988 89 0.026
regulation of dna metabolic process GO:0051052 153 0.025
nucleotide catabolic process GO:0009166 408 0.025
small gtpase mediated signal transduction GO:0007264 78 0.025
atp metabolic process GO:0046034 176 0.025
guanosine containing compound metabolic process GO:1901068 244 0.025
regulation of purine nucleotide catabolic process GO:0033121 205 0.025
ras protein signal transduction GO:0007265 73 0.024
multi organism cellular process GO:0044764 156 0.024
purine ribonucleoside metabolic process GO:0046128 437 0.024
chemical homeostasis GO:0048878 306 0.024
Human
positive regulation of catabolic process GO:0009896 310 0.024
digestive system development GO:0055123 75 0.024
cell morphogenesis GO:0000902 296 0.024
Fly
negative regulation of multicellular organismal process GO:0051241 317 0.024
protein import GO:0017038 130 0.024
negative regulation of developmental process GO:0051093 247 0.024
regulation of cell morphogenesis GO:0022604 153 0.023
post golgi vesicle mediated transport GO:0006892 36 0.023
regulation of cell cycle GO:0051726 393 0.023
Human
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.023
mitotic cell cycle phase transition GO:0044772 162 0.023
positive regulation of cell cycle process GO:0090068 106 0.023
positive regulation of organelle organization GO:0010638 195 0.023
rho protein signal transduction GO:0007266 26 0.023
mating GO:0007618 1 0.022
positive regulation of cell death GO:0010942 263 0.022
microtubule based process GO:0007017 210 0.022
golgi vesicle transport GO:0048193 80 0.022
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.022
immune system development GO:0002520 195 0.022
enzyme linked receptor protein signaling pathway GO:0007167 303 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
establishment of protein localization to organelle GO:0072594 172 0.021
morphogenesis of embryonic epithelium GO:0016331 4 0.021
regulation of growth GO:0040008 165 0.021
purine nucleoside triphosphate catabolic process GO:0009146 392 0.021
regulation of cellular amine metabolic process GO:0033238 11 0.021
histone arginine methylation GO:0034969 6 0.021
cell division GO:0051301 168 0.021
Human
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.021
regulation of cell growth GO:0001558 135 0.021
hematopoietic or lymphoid organ development GO:0048534 186 0.021
negative regulation of cell cycle GO:0045786 193 0.020
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.020
embryonic epithelial tube formation GO:0001838 4 0.020
peptidyl serine phosphorylation GO:0018105 101 0.020
regulation of protein kinase activity GO:0045859 289 0.020
mitotic cell cycle process GO:1903047 286 0.019
positive regulation of transport GO:0051050 336 0.019
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.019
viral life cycle GO:0019058 132 0.019
growth GO:0040007 202 0.019
Fly
nuclear import GO:0051170 106 0.019
regulation of gene expression epigenetic GO:0040029 73 0.019
negative regulation of catabolic process GO:0009895 104 0.019
ribonucleoside monophosphate metabolic process GO:0009161 187 0.019
response to external biotic stimulus GO:0043207 261 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
regulation of transferase activity GO:0051338 355 0.019
cellular response to oxidative stress GO:0034599 85 0.019
ribonucleoside monophosphate catabolic process GO:0009158 158 0.018
defense response to other organism GO:0098542 129 0.018
regulation of protein transport GO:0051223 213 0.018
negative regulation of protein modification process GO:0031400 200 0.018
female gamete generation GO:0007292 2 0.018
protein localization to plasma membrane GO:0072659 93 0.018
regulation of cell development GO:0060284 161 0.018
atp catabolic process GO:0006200 157 0.018
negative regulation of immune system process GO:0002683 136 0.018
monovalent inorganic cation transport GO:0015672 128 0.018
Human
regulation of axon extension involved in axon guidance GO:0048841 2 0.018
regulation of cell division GO:0051302 116 0.018
Human
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.018
proteasomal ubiquitin independent protein catabolic process GO:0010499 3 0.018
Human
purine nucleoside monophosphate catabolic process GO:0009128 158 0.018
immune effector process GO:0002252 159 0.017
regulation of mitotic cell cycle phase transition GO:1901990 118 0.017
regulation of homeostatic process GO:0032844 121 0.017
positive regulation of cell differentiation GO:0045597 211 0.017
positive regulation of proteolysis GO:0045862 142 0.017
vesicle targeting to from or within golgi GO:0048199 6 0.017
Human
positive regulation of immune system process GO:0002684 283 0.017
protein localization to nucleus GO:0034504 136 0.017
cellular macromolecular complex assembly GO:0034622 324 0.017
regulation of gtpase activity GO:0043087 180 0.017
response to virus GO:0009615 126 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.017
negative regulation of mitotic cell cycle GO:0045930 102 0.017
negative regulation of cell death GO:0060548 345 0.017
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.017
cell development GO:0048468 328 0.017
Fly
regulation of gtp catabolic process GO:0033124 180 0.017
nucleus localization GO:0051647 1 0.016
renal sodium ion absorption GO:0070294 2 0.016
Human
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.016
Human
regulation of nucleotide catabolic process GO:0030811 205 0.016
protein targeting GO:0006605 187 0.016
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.016
purine nucleoside monophosphate metabolic process GO:0009126 186 0.016
endocytosis GO:0006897 159 0.016
regulation of neurogenesis GO:0050767 82 0.016
cellular response to dna damage stimulus GO:0006974 379 0.016
anatomical structure homeostasis GO:0060249 100 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.016
organelle fission GO:0048285 149 0.016
gene silencing GO:0016458 49 0.016
amine metabolic process GO:0009308 44 0.016
blastocyst development GO:0001824 3 0.016
inner ear morphogenesis GO:0042472 4 0.016
nucleoside monophosphate metabolic process GO:0009123 191 0.016
mitotic sister chromatid segregation GO:0000070 53 0.016
mrna metabolic process GO:0016071 175 0.016
regulation of mapk cascade GO:0043408 262 0.016
neuron projection development GO:0031175 106 0.015
Fly
copii coated vesicle budding GO:0090114 5 0.015
Human
protein k33 linked ubiquitination GO:1990390 1 0.015
protein localization to membrane GO:0072657 160 0.015
regulation of vasculature development GO:1901342 97 0.015
cellular response to growth factor stimulus GO:0071363 197 0.015
negative regulation of phosphate metabolic process GO:0045936 267 0.015
digestive tract development GO:0048565 75 0.015
lymphocyte activation GO:0046649 133 0.015
trophectodermal cell differentiation GO:0001829 3 0.015
regulation of multi organism process GO:0043900 157 0.015
covalent chromatin modification GO:0016569 254 0.015
blastoderm segmentation GO:0007350 2 0.015
regulation of viral process GO:0050792 103 0.015
methylation GO:0032259 106 0.015
cytokinesis GO:0000910 96 0.015
Human
neuroblast proliferation GO:0007405 4 0.015
regulation of neural precursor cell proliferation GO:2000177 4 0.015
locomotory behavior GO:0007626 1 0.014
memory GO:0007613 3 0.014
autophagy GO:0006914 88 0.014
establishment of protein localization to plasma membrane GO:0090002 68 0.014
primary neural tube formation GO:0014020 3 0.014
ribonucleoside catabolic process GO:0042454 406 0.014
regulation of endopeptidase activity GO:0052548 170 0.014
distal tubule development GO:0072017 4 0.014
Human
positive regulation of nucleoside metabolic process GO:0045979 186 0.014
regulation of protein stability GO:0031647 87 0.014
nucleoside monophosphate catabolic process GO:0009125 159 0.014
positive regulation of cellular amine metabolic process GO:0033240 7 0.014
spermatid differentiation GO:0048515 4 0.014
positive regulation of protein ubiquitination GO:0031398 53 0.014
generation of neurons GO:0048699 152 0.014
Fly
protein targeting to nucleus GO:0044744 104 0.014
regulation of proteolysis GO:0030162 293 0.014
negative regulation of viral process GO:0048525 66 0.014
nucleocytoplasmic transport GO:0006913 176 0.014
positive regulation of nucleotide metabolic process GO:0045981 230 0.014
cellular lipid metabolic process GO:0044255 303 0.014
cell projection morphogenesis GO:0048858 129 0.014
Fly
blood vessel development GO:0001568 172 0.014
negative regulation of cellular component organization GO:0051129 235 0.013
negative regulation of multi organism process GO:0043901 92 0.013
ncrna metabolic process GO:0034660 108 0.013
regulation of locomotion GO:0040012 329 0.013
angiogenesis GO:0001525 147 0.013
establishment of nucleus localization GO:0040023 1 0.013
protein maturation GO:0051604 233 0.013
cellular homeostasis GO:0019725 196 0.013
chromosome segregation GO:0007059 114 0.013
maintenance of location GO:0051235 112 0.013
negative regulation of protein processing GO:0010955 142 0.013
sensory perception GO:0007600 103 0.013
i kappab kinase nf kappab signaling GO:0007249 166 0.013
stress activated mapk cascade GO:0051403 93 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
protein k48 linked ubiquitination GO:0070936 38 0.013
Human
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.013
mapk cascade GO:0000165 288 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.013
positive regulation of binding GO:0051099 45 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.013
somitogenesis GO:0001756 2 0.013
positive regulation of leukocyte differentiation GO:1902107 37 0.013
regulation of protein processing GO:0070613 150 0.013
regulation of ras protein signal transduction GO:0046578 155 0.013
nuclear migration GO:0007097 1 0.012
negative regulation of organelle organization GO:0010639 126 0.012
chondrocyte proliferation GO:0035988 4 0.012
negative regulation of phosphorus metabolic process GO:0010563 267 0.012
cation transport GO:0006812 331 0.012
Human
protein stabilization GO:0050821 64 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
circulatory system development GO:0072359 262 0.012
microtubule cytoskeleton organization GO:0000226 176 0.012
viral process GO:0016032 146 0.012
regulation of defense response GO:0031347 154 0.012
positive regulation of kinase activity GO:0033674 204 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
regulation of cell motility GO:2000145 299 0.012
head development GO:0060322 108 0.012
regulation of lymphocyte activation GO:0051249 103 0.012
transmembrane transport GO:0055085 399 0.012
cellular divalent inorganic cation homeostasis GO:0072503 128 0.012
blood vessel morphogenesis GO:0048514 162 0.012
sister chromatid segregation GO:0000819 54 0.012
positive regulation of hydrolase activity GO:0051345 331 0.012
negative regulation of apoptotic process GO:0043066 316 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
neural tube closure GO:0001843 3 0.012
spermatid development GO:0007286 4 0.012
digestive tract morphogenesis GO:0048546 56 0.012
response to biotic stimulus GO:0009607 276 0.012
embryo development GO:0009790 123 0.012
chromatin assembly GO:0031497 61 0.012
morphogenesis of an epithelium GO:0002009 60 0.011
Human
positive regulation of cell proliferation GO:0008284 301 0.011
detection of stimulus GO:0051606 85 0.011
regulation of cellular component biogenesis GO:0044087 281 0.011
peptidyl serine modification GO:0018209 106 0.011
hemopoiesis GO:0030097 180 0.011
plasma membrane organization GO:0007009 115 0.011
regulation of small gtpase mediated signal transduction GO:0051056 156 0.011
regulation of angiogenesis GO:0045765 92 0.011
cell growth GO:0016049 160 0.011
Fly
cellular response to radiation GO:0071478 65 0.011
metencephalon development GO:0022037 2 0.011
circadian behavior GO:0048512 2 0.011
epithelial tube morphogenesis GO:0060562 38 0.011
Human
histone methylation GO:0016571 60 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.011
vesicle localization GO:0051648 26 0.011
Human
response to nitrogen compound GO:1901698 184 0.011
regulation of cell cycle arrest GO:0071156 36 0.011
negative regulation of rho protein signal transduction GO:0035024 7 0.011
negative regulation of cell differentiation GO:0045596 171 0.011
cellular chemical homeostasis GO:0055082 180 0.011
single organism nuclear import GO:1902593 104 0.011
regulation of protein complex assembly GO:0043254 147 0.011
regulation of axon guidance GO:1902667 3 0.011
positive regulation of ras gtpase activity GO:0032320 117 0.011
regulation of leukocyte activation GO:0002694 115 0.011
cytokine production GO:0001816 247 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.011
brain morphogenesis GO:0048854 1 0.011
associative learning GO:0008306 1 0.011
central nervous system development GO:0007417 123 0.011
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.011
response to inorganic substance GO:0010035 127 0.011
gastrulation GO:0007369 51 0.011
renal sodium ion transport GO:0003096 2 0.011
Human
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.011
calcium ion homeostasis GO:0055074 122 0.010
response to radiation GO:0009314 151 0.010
response to bacterium GO:0009617 144 0.010
response to uv GO:0009411 73 0.010
regulation of behavior GO:0050795 82 0.010
regulation of cellular amino acid metabolic process GO:0006521 6 0.010
cellular response to endogenous stimulus GO:0071495 336 0.010
nuclear transport GO:0051169 179 0.010
tissue regeneration GO:0042246 3 0.010
neurotransmitter secretion GO:0007269 4 0.010
neurogenesis GO:0022008 169 0.010
Fly
epithelium development GO:0060429 227 0.010
Human
dna packaging GO:0006323 77 0.010
response to transforming growth factor beta GO:0071559 94 0.010
glial cell migration GO:0008347 4 0.010

KLHL20 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.025
cancer DOID:162 167 0.018
disease of cellular proliferation DOID:14566 174 0.018
organ system cancer DOID:0050686 164 0.018
sensory system disease DOID:0050155 203 0.014
nervous system disease DOID:863 431 0.014
musculoskeletal system disease DOID:17 223 0.013