Homo sapiens

90 known processes

POLQ

polymerase (DNA directed), theta

(Aliases: DKFZp781A0112,PRO0327,POLH)

POLQ biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ribonucleoside catabolic process GO:0042454 406 0.323
ribonucleoside triphosphate catabolic process GO:0009203 391 0.318
ribonucleoside monophosphate metabolic process GO:0009161 187 0.221
cellular response to dna damage stimulus GO:0006974 379 0.206
Human Mouse Fly
chromosome segregation GO:0007059 114 0.206
nucleotide catabolic process GO:0009166 408 0.181
post embryonic development GO:0009791 2 0.173
nucleoside triphosphate metabolic process GO:0009141 422 0.170
purine ribonucleoside metabolic process GO:0046128 437 0.166
nucleoside monophosphate metabolic process GO:0009123 191 0.166
nucleoside phosphate catabolic process GO:1901292 412 0.155
mitotic cell cycle GO:0000278 326 0.148
nucleoside triphosphate catabolic process GO:0009143 394 0.140
purine nucleoside monophosphate catabolic process GO:0009128 158 0.139
regulation of cell cycle GO:0051726 393 0.139
purine ribonucleotide catabolic process GO:0009154 404 0.138
purine nucleoside catabolic process GO:0006152 398 0.137
purine ribonucleoside catabolic process GO:0046130 398 0.132
dna dependent dna replication GO:0006261 44 0.130
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.127
chromatin modification GO:0016568 298 0.126
organophosphate catabolic process GO:0046434 430 0.124
nuclear division GO:0000280 128 0.119
cell division GO:0051301 168 0.118
purine nucleoside monophosphate metabolic process GO:0009126 186 0.118
dna replication GO:0006260 116 0.116
atp catabolic process GO:0006200 157 0.112
purine nucleoside triphosphate metabolic process GO:0009144 412 0.110
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.103
meiotic chromosome segregation GO:0045132 4 0.090
nucleoside catabolic process GO:0009164 408 0.089
purine nucleotide catabolic process GO:0006195 405 0.088
purine containing compound catabolic process GO:0072523 411 0.087
atp metabolic process GO:0046034 176 0.085
mitotic nuclear division GO:0007067 119 0.080
regulation of mitotic cell cycle GO:0007346 189 0.076
nucleoside monophosphate catabolic process GO:0009125 159 0.075
ribonucleoside monophosphate catabolic process GO:0009158 158 0.075
ribonucleoside triphosphate metabolic process GO:0009199 412 0.075
ribonucleotide catabolic process GO:0009261 405 0.074
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.074
dna recombination GO:0006310 77 0.068
Human
cellular ketone metabolic process GO:0042180 80 0.067
regulation of kinase activity GO:0043549 314 0.063
organelle fission GO:0048285 149 0.062
regulation of cell cycle process GO:0010564 266 0.062
cellular macromolecule catabolic process GO:0044265 380 0.060
anatomical structure homeostasis GO:0060249 100 0.060
mitotic cell cycle process GO:1903047 286 0.059
positive regulation of protein kinase activity GO:0045860 190 0.056
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.055
regulation of cell division GO:0051302 116 0.052
positive regulation of cell proliferation GO:0008284 301 0.051
double strand break repair GO:0006302 101 0.049
Human Fly
dna repair GO:0006281 198 0.049
Human Mouse Fly
positive regulation of catabolic process GO:0009896 310 0.047
regulation of cellular ketone metabolic process GO:0010565 50 0.046
mitotic cell cycle phase transition GO:0044772 162 0.046
positive regulation of kinase activity GO:0033674 204 0.046
dna catabolic process GO:0006308 49 0.045
female gamete generation GO:0007292 2 0.044
cell cycle phase transition GO:0044770 173 0.042
microtubule based process GO:0007017 210 0.042
cellular amine metabolic process GO:0044106 41 0.042
glycosyl compound catabolic process GO:1901658 413 0.042
negative regulation of cell cycle GO:0045786 193 0.041
positive regulation of phosphorylation GO:0042327 394 0.040
male meiosis GO:0007140 1 0.039
immune response GO:0006955 307 0.038
regulation of protein kinase activity GO:0045859 289 0.038
positive regulation of organelle organization GO:0010638 195 0.038
cell cycle checkpoint GO:0000075 117 0.038
regulation of cell cycle phase transition GO:1901987 126 0.037
meiotic nuclear division GO:0007126 10 0.036
purine nucleoside triphosphate catabolic process GO:0009146 392 0.035
negative regulation of programmed cell death GO:0043069 321 0.035
meiosis i GO:0007127 4 0.035
positive regulation of mitotic cell cycle GO:0045931 60 0.034
organelle assembly GO:0070925 176 0.034
sister chromatid segregation GO:0000819 54 0.034
regulation of cellular component biogenesis GO:0044087 281 0.033
cellular component morphogenesis GO:0032989 314 0.033
regulation of transferase activity GO:0051338 355 0.032
cell development GO:0048468 328 0.032
ubiquitin dependent protein catabolic process GO:0006511 206 0.032
regulation of dna replication GO:0006275 68 0.031
neuroblast division GO:0055057 1 0.031
protein catabolic process GO:0030163 325 0.030
primary neural tube formation GO:0014020 3 0.030
positive regulation of protein phosphorylation GO:0001934 313 0.030
cerebral cortex cell migration GO:0021795 3 0.028
cellular amino acid metabolic process GO:0006520 116 0.028
regulation of purine nucleotide metabolic process GO:1900542 264 0.028
telomere maintenance GO:0000723 32 0.028
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.028
regulation of cellular amine metabolic process GO:0033238 11 0.027
morphogenesis of embryonic epithelium GO:0016331 4 0.027
positive regulation of cellular catabolic process GO:0031331 284 0.027
recombinational repair GO:0000725 50 0.027
Human
negative regulation of cell cycle phase transition GO:1901988 89 0.026
chromatin organization GO:0006325 351 0.026
negative regulation of developmental process GO:0051093 247 0.026
tube closure GO:0060606 3 0.026
positive regulation of cellular amine metabolic process GO:0033240 7 0.026
dna geometric change GO:0032392 32 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
maintenance of location GO:0051235 112 0.024
regulation of protein serine threonine kinase activity GO:0071900 179 0.024
cellular macromolecular complex assembly GO:0034622 324 0.024
regulation of proteolysis GO:0030162 293 0.023
positive regulation of nucleoside metabolic process GO:0045979 186 0.023
determination of adult lifespan GO:0008340 2 0.023
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.023
positive regulation of hydrolase activity GO:0051345 331 0.023
chromatin assembly or disassembly GO:0006333 78 0.022
positive regulation of nucleotide metabolic process GO:0045981 230 0.022
positive regulation of cell cycle GO:0045787 140 0.022
regulation of chromosome segregation GO:0051983 44 0.022
regulation of mitotic sister chromatid segregation GO:0033047 27 0.022
positive regulation of dna metabolic process GO:0051054 73 0.022
cell activation GO:0001775 213 0.022
protein localization to organelle GO:0033365 280 0.022
cell cycle g2 m phase transition GO:0044839 43 0.021
regulation of cellular amino acid metabolic process GO:0006521 6 0.021
negative regulation of cellular protein metabolic process GO:0032269 353 0.021
amine metabolic process GO:0009308 44 0.021
neural tube closure GO:0001843 3 0.021
negative regulation of cell cycle process GO:0010948 121 0.021
vesicle mediated transport GO:0016192 371 0.020
cell morphogenesis GO:0000902 296 0.020
meiotic cell cycle GO:0051321 13 0.020
regeneration GO:0031099 4 0.020
negative regulation of cellular component organization GO:0051129 235 0.020
leukocyte activation GO:0045321 164 0.019
negative regulation of phosphate metabolic process GO:0045936 267 0.019
regulation of nucleoside metabolic process GO:0009118 209 0.019
negative regulation of mitotic cell cycle GO:0045930 102 0.019
cellular protein catabolic process GO:0044257 261 0.019
positive regulation of nucleotide catabolic process GO:0030813 185 0.019
apoptotic signaling pathway GO:0097190 268 0.019
dephosphorylation GO:0016311 209 0.019
negative regulation of cell size GO:0045792 3 0.018
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.018
lymphocyte activation GO:0046649 133 0.018
sister chromatid biorientation GO:0031134 2 0.018
actin filament based process GO:0030029 224 0.018
spermatid development GO:0007286 4 0.018
mitotic sister chromatid segregation GO:0000070 53 0.018
negative regulation of catalytic activity GO:0043086 335 0.018
regulation of cell morphogenesis GO:0022604 153 0.018
g2 m transition of mitotic cell cycle GO:0000086 41 0.017
mitotic cell cycle checkpoint GO:0007093 68 0.017
response to abiotic stimulus GO:0009628 336 0.017
embryonic epithelial tube formation GO:0001838 4 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
regulation of dna metabolic process GO:0051052 153 0.017
chemical homeostasis GO:0048878 306 0.017
regulation of protein catabolic process GO:0042176 155 0.017
cellular homeostasis GO:0019725 196 0.016
maintenance of location in cell GO:0051651 62 0.016
mitotic sister chromatid separation GO:0051306 18 0.016
regulation of protein complex assembly GO:0043254 147 0.016
regulation of protein processing GO:0070613 150 0.015
biological adhesion GO:0022610 331 0.015
regulation of protein maturation GO:1903317 150 0.015
regulation of nucleotide metabolic process GO:0006140 269 0.015
positive regulation of programmed cell death GO:0043068 249 0.015
neural tube formation GO:0001841 3 0.015
regulation of proteasomal protein catabolic process GO:0061136 87 0.015
reproduction GO:0000003 63 0.015
negative regulation of apoptotic process GO:0043066 316 0.015
regulation of purine nucleotide catabolic process GO:0033121 205 0.015
double strand break repair via homologous recombination GO:0000724 50 0.015
Human
cell fate determination GO:0001709 3 0.014
dna conformation change GO:0071103 113 0.014
negative regulation of protein maturation GO:1903318 142 0.014
regulation of nucleotide catabolic process GO:0030811 205 0.014
protein maturation GO:0051604 233 0.014
negative regulation of phosphorus metabolic process GO:0010563 267 0.014
regulation of binding GO:0051098 111 0.014
positive regulation of cell cycle process GO:0090068 106 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.014
intracellular protein transport GO:0006886 270 0.014
positive regulation of meiotic cell cycle GO:0051446 2 0.014
anatomical structure formation involved in morphogenesis GO:0048646 284 0.014
negative regulation of cell death GO:0060548 345 0.014
spermatid differentiation GO:0048515 4 0.014
dna duplex unwinding GO:0032508 30 0.014
reproductive process GO:0022414 106 0.014
forebrain generation of neurons GO:0021872 3 0.013
protein dna complex subunit organization GO:0071824 80 0.013
blastocyst development GO:0001824 3 0.013
protein ubiquitination GO:0016567 314 0.013
cellular chemical homeostasis GO:0055082 180 0.013
cytoplasmic transport GO:0016482 379 0.013
oocyte development GO:0048599 1 0.013
regulation of establishment of protein localization GO:0070201 242 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.012
protein modification by small protein conjugation GO:0032446 342 0.012
positive regulation of developmental process GO:0051094 314 0.012
head development GO:0060322 108 0.012
positive regulation of apoptotic process GO:0043065 246 0.012
regulation of cytoskeleton organization GO:0051493 177 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.012
immune effector process GO:0002252 159 0.012
cell projection organization GO:0030030 252 0.012
cellular protein complex assembly GO:0043623 188 0.012
protein targeting GO:0006605 187 0.012
establishment of nucleus localization GO:0040023 1 0.012
peptidyl lysine modification GO:0018205 144 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
negative regulation of protein metabolic process GO:0051248 391 0.012
oocyte differentiation GO:0009994 2 0.012
peripheral nervous system development GO:0007422 2 0.012
positive regulation of cellular component organization GO:0051130 376 0.012
regulation of cell differentiation GO:0045595 393 0.012
cell activation involved in immune response GO:0002263 30 0.011
actin filament based movement GO:0030048 17 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.011
regulation of chromosome organization GO:0033044 103 0.011
neuronal stem cell division GO:0036445 1 0.011
centrosome organization GO:0051297 58 0.011
modification dependent protein catabolic process GO:0019941 209 0.011
negative regulation of multicellular organismal process GO:0051241 317 0.011
cellular lipid metabolic process GO:0044255 303 0.011
negative regulation of cellular protein catabolic process GO:1903363 38 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.011
cell adhesion GO:0007155 325 0.011
proteasomal protein catabolic process GO:0010498 176 0.011
negative regulation of intracellular signal transduction GO:1902532 183 0.011
single organism cellular localization GO:1902580 332 0.011
regulation of anatomical structure size GO:0090066 101 0.011
negative regulation of methylation dependent chromatin silencing GO:0090310 2 0.011
actin cytoskeleton organization GO:0030036 207 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
negative regulation of catabolic process GO:0009895 104 0.011
single organism reproductive process GO:0044702 98 0.010
oogenesis GO:0048477 2 0.010
cell part morphogenesis GO:0032990 137 0.010
centrosome cycle GO:0007098 32 0.010
rna splicing GO:0008380 131 0.010
embryo development GO:0009790 123 0.010
telomere organization GO:0032200 33 0.010
nervous system development GO:0007399 293 0.010
positive regulation of proteolysis GO:0045862 142 0.010
dna catabolic process exonucleolytic GO:0000738 17 0.010
peptidyl tyrosine modification GO:0018212 170 0.010
gtp catabolic process GO:0006184 237 0.010
regulation of dephosphorylation GO:0035303 96 0.010
growth GO:0040007 202 0.010

POLQ disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.059
disease of cellular proliferation DOID:14566 174 0.059
immune system disease DOID:2914 155 0.031
hematopoietic system disease DOID:74 100 0.031
organ system cancer DOID:0050686 164 0.029
breast cancer DOID:1612 21 0.025
thoracic cancer DOID:5093 21 0.025
physical disorder DOID:0080015 41 0.021
congenital nervous system abnormality DOID:2490 21 0.021