Homo sapiens

2 known processes

FH

fumarate hydratase

(Aliases: MCUL1,MCL,LRCC,HLRCC)

FH biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 396 0.954
tricarboxylic acid cycle GO:0006099 4 0.706
post embryonic development GO:0009791 2 0.672
Worm
vesicle mediated transport GO:0016192 371 0.529
Worm
determination of adult lifespan GO:0008340 2 0.490
dicarboxylic acid metabolic process GO:0043648 29 0.474
multicellular organismal aging GO:0010259 3 0.445
coenzyme metabolic process GO:0006732 65 0.331
positive regulation of peptidase activity GO:0010952 88 0.319
cellular respiration GO:0045333 21 0.264
cofactor metabolic process GO:0051186 87 0.251
energy derivation by oxidation of organic compounds GO:0015980 43 0.228
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.224
citrate metabolic process GO:0006101 2 0.213
apoptotic mitochondrial changes GO:0008637 57 0.204
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.186
response to oxygen containing compound GO:1901700 369 0.176
protein maturation GO:0051604 233 0.172
zymogen activation GO:0031638 70 0.171
sulfur compound metabolic process GO:0006790 101 0.169
regulation of peptidase activity GO:0052547 180 0.164
protein processing GO:0016485 226 0.161
carbohydrate derivative biosynthetic process GO:1901137 207 0.160
nucleotide biosynthetic process GO:0009165 109 0.158
monocarboxylic acid metabolic process GO:0032787 185 0.152
nucleoside phosphate biosynthetic process GO:1901293 109 0.152
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.151
positive regulation of apoptotic process GO:0043065 246 0.141
regulation of endopeptidase activity GO:0052548 170 0.141
cofactor biosynthetic process GO:0051188 31 0.138
cellular amino acid metabolic process GO:0006520 116 0.137
embryo development GO:0009790 123 0.128
Worm
atp metabolic process GO:0046034 176 0.125
generation of precursor metabolites and energy GO:0006091 68 0.120
ribonucleoside monophosphate metabolic process GO:0009161 187 0.114
ribonucleoside triphosphate metabolic process GO:0009199 412 0.114
small molecule biosynthetic process GO:0044283 157 0.108
cell cell signaling GO:0007267 155 0.105
glycerol metabolic process GO:0006071 4 0.091
positive regulation of hydrolase activity GO:0051345 331 0.084
cellular amino acid biosynthetic process GO:0008652 30 0.081
positive regulation of programmed cell death GO:0043068 249 0.078
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.078
endocytosis GO:0006897 159 0.076
Worm
glutamate biosynthetic process GO:0006537 3 0.076
positive regulation of proteolysis GO:0045862 142 0.075
glutamate metabolic process GO:0006536 10 0.075
lipid metabolic process GO:0006629 381 0.072
regulation of proteolysis GO:0030162 293 0.072
receptor mediated endocytosis GO:0006898 84 0.070
Worm
sulfur compound biosynthetic process GO:0044272 38 0.069
activation of cysteine type endopeptidase activity GO:0097202 57 0.069
positive regulation of endopeptidase activity GO:0010950 84 0.067
alpha amino acid biosynthetic process GO:1901607 23 0.066
organonitrogen compound biosynthetic process GO:1901566 200 0.063
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.061
purine nucleoside monophosphate metabolic process GO:0009126 186 0.059
defense response GO:0006952 315 0.056
purine nucleoside triphosphate metabolic process GO:0009144 412 0.055
mitochondrial transport GO:0006839 60 0.053
reproduction GO:0000003 63 0.052
Worm
spermatid differentiation GO:0048515 4 0.051
transmembrane transport GO:0055085 399 0.050
glutamine family amino acid metabolic process GO:0009064 17 0.047
regulation of membrane potential GO:0042391 95 0.046
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.045
regulation of cysteine type endopeptidase activity GO:2000116 127 0.045
mitochondrion organization GO:0007005 156 0.045
nucleoside triphosphate metabolic process GO:0009141 422 0.044
fatty acid metabolic process GO:0006631 115 0.042
positive regulation of cell death GO:0010942 263 0.041
anion transport GO:0006820 161 0.041
thioester metabolic process GO:0035383 23 0.040
nadh dehydrogenase complex assembly GO:0010257 16 0.038
alpha amino acid metabolic process GO:1901605 72 0.036
system process GO:0003008 349 0.036
cellular ketone metabolic process GO:0042180 80 0.035
aspartate family amino acid catabolic process GO:0009068 5 0.034
purine ribonucleoside monophosphate biosynthetic process GO:0009168 16 0.034
innate immune response GO:0045087 178 0.034
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 18 0.034
small molecule catabolic process GO:0044282 92 0.034
spermatid development GO:0007286 4 0.034
purine ribonucleoside metabolic process GO:0046128 437 0.033
tricarboxylic acid metabolic process GO:0072350 4 0.032
mitochondrial membrane organization GO:0007006 40 0.032
aging GO:0007568 66 0.029
central nervous system development GO:0007417 123 0.028
alditol metabolic process GO:0019400 5 0.028
organic hydroxy compound metabolic process GO:1901615 147 0.027
ribonucleotide biosynthetic process GO:0009260 81 0.027
nervous system development GO:0007399 293 0.026
protein acetylation GO:0006473 116 0.026
secretion by cell GO:0032940 226 0.026
nucleoside monophosphate metabolic process GO:0009123 191 0.025
mitochondrial atp synthesis coupled electron transport GO:0042775 4 0.025
ribonucleotide catabolic process GO:0009261 405 0.025
anatomical structure formation involved in morphogenesis GO:0048646 284 0.024
cellular lipid metabolic process GO:0044255 303 0.024
response to wounding GO:0009611 168 0.024
rna interference GO:0016246 4 0.024
embryo development ending in birth or egg hatching GO:0009792 34 0.023
Worm
maintenance of location GO:0051235 112 0.022
adult locomotory behavior GO:0008344 1 0.021
coenzyme biosynthetic process GO:0009108 24 0.021
carbohydrate metabolic process GO:0005975 207 0.021
cation transport GO:0006812 331 0.020
organic acid biosynthetic process GO:0016053 97 0.020
carboxylic acid catabolic process GO:0046395 71 0.019
actin filament based process GO:0030029 224 0.019
organic acid catabolic process GO:0016054 71 0.019
dicarboxylic acid catabolic process GO:0043649 9 0.018
atp synthesis coupled electron transport GO:0042773 4 0.018
multicellular organismal response to stress GO:0033555 1 0.018
protein acylation GO:0043543 138 0.018
ion transmembrane transport GO:0034220 338 0.018
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.018
ribonucleoside triphosphate catabolic process GO:0009203 391 0.018
organophosphate biosynthetic process GO:0090407 163 0.017
membrane organization GO:0061024 292 0.017
neuromuscular junction development GO:0007528 3 0.017
oogenesis GO:0048477 2 0.017
cellular macromolecular complex assembly GO:0034622 324 0.016
mitochondrial electron transport nadh to ubiquinone GO:0006120 2 0.016
response to biotic stimulus GO:0009607 276 0.016
single organism membrane organization GO:0044802 268 0.016
angiogenesis GO:0001525 147 0.016
aerobic respiration GO:0009060 7 0.016
acyl coa biosynthetic process GO:0071616 6 0.015
muscle system process GO:0003012 81 0.015
dna catabolic process GO:0006308 49 0.015
lipid catabolic process GO:0016042 84 0.015
pyruvate metabolic process GO:0006090 26 0.015
chemical homeostasis GO:0048878 306 0.015
negative regulation of transport GO:0051051 176 0.015
growth GO:0040007 202 0.015
posttranscriptional regulation of gene expression GO:0010608 213 0.015
locomotory behavior GO:0007626 1 0.014
ion homeostasis GO:0050801 230 0.014
response to hormone GO:0009725 175 0.014
brain development GO:0007420 97 0.014
wound healing GO:0042060 115 0.014
cell development GO:0048468 328 0.014
reactive oxygen species metabolic process GO:0072593 75 0.014
muscle structure development GO:0061061 98 0.013
developmental process involved in reproduction GO:0003006 66 0.013
regeneration GO:0031099 4 0.013
nucleoside biosynthetic process GO:0009163 26 0.013
synaptic transmission GO:0007268 61 0.013
inorganic ion transmembrane transport GO:0098660 231 0.013
protein localization to organelle GO:0033365 280 0.013
acetyl coa biosynthetic process from pyruvate GO:0006086 4 0.013
immune response GO:0006955 307 0.013
purine ribonucleoside catabolic process GO:0046130 398 0.013
cellular chemical homeostasis GO:0055082 180 0.013
female gamete generation GO:0007292 2 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
internal protein amino acid acetylation GO:0006475 101 0.012
purine ribonucleotide biosynthetic process GO:0009152 79 0.012
nucleotide catabolic process GO:0009166 408 0.012
acyl coa metabolic process GO:0006637 23 0.012
nucleoside catabolic process GO:0009164 408 0.012
negative regulation of intracellular signal transduction GO:1902532 183 0.011
glycosyl compound biosynthetic process GO:1901659 27 0.011
head development GO:0060322 108 0.011
response to oxidative stress GO:0006979 121 0.011
fear response GO:0042596 0 0.011
organophosphate catabolic process GO:0046434 430 0.011
cellular metal ion homeostasis GO:0006875 146 0.011
behavioral defense response GO:0002209 0 0.010
behavioral fear response GO:0001662 0 0.010
nucleoside triphosphate catabolic process GO:0009143 394 0.010
defense response to other organism GO:0098542 129 0.010
response to drug GO:0042493 81 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.010

FH disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.867
inherited metabolic disorder DOID:655 242 0.867
amino acid metabolic disorder DOID:9252 50 0.641
neuromuscular disease DOID:440 38 0.023
nervous system disease DOID:863 431 0.023
neuropathy DOID:870 52 0.023
immune system disease DOID:2914 155 0.016
carbohydrate metabolic disorder DOID:2978 55 0.016
cancer DOID:162 167 0.010
disease of cellular proliferation DOID:14566 174 0.010
organ system cancer DOID:0050686 164 0.010