Homo sapiens

38 known processes

TONSL

tonsoku-like, DNA repair protein

(Aliases: IKBR,FLJ40087,NFKBIL2)

TONSL biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
replication fork processing GO:0031297 13 0.930
dna replication dependent nucleosome assembly GO:0006335 32 0.433
double strand break repair GO:0006302 101 0.424
double strand break repair via homologous recombination GO:0000724 50 0.398
dna conformation change GO:0071103 113 0.394
dna repair GO:0006281 198 0.378
cellular response to dna damage stimulus GO:0006974 379 0.337
cellular amino acid metabolic process GO:0006520 116 0.330
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.321
chromatin organization GO:0006325 351 0.309
cellular ketone metabolic process GO:0042180 80 0.292
regulation of cellular ketone metabolic process GO:0010565 50 0.281
recombinational repair GO:0000725 50 0.274
post embryonic development GO:0009791 2 0.270
positive regulation of cellular amine metabolic process GO:0033240 7 0.266
amine metabolic process GO:0009308 44 0.263
chromatin assembly or disassembly GO:0006333 78 0.253
female gamete generation GO:0007292 2 0.213
chromatin assembly GO:0031497 61 0.208
dna dependent dna replication GO:0006261 44 0.206
regulation of cellular amine metabolic process GO:0033238 11 0.204
dna replication independent nucleosome assembly GO:0006336 27 0.191
regulation of cellular amino acid metabolic process GO:0006521 6 0.187
oogenesis GO:0048477 2 0.154
dna replication dependent nucleosome organization GO:0034723 32 0.144
dna replication GO:0006260 116 0.141
positive regulation of cellular component organization GO:0051130 376 0.118
histone modification GO:0016570 251 0.117
positive regulation of chromatin modification GO:1903310 30 0.109
chromatin modification GO:0016568 298 0.099
regulation of cell cycle GO:0051726 393 0.088
cellular amine metabolic process GO:0044106 41 0.076
protein ubiquitination GO:0016567 314 0.073
Human
chromatin disassembly GO:0031498 13 0.071
histone ubiquitination GO:0016574 31 0.071
cell morphogenesis GO:0000902 296 0.068
protein dna complex subunit organization GO:0071824 80 0.067
internal protein amino acid acetylation GO:0006475 101 0.066
rna processing GO:0006396 255 0.064
cellular macromolecular complex assembly GO:0034622 324 0.057
covalent chromatin modification GO:0016569 254 0.056
muscle organ development GO:0007517 56 0.053
protein acylation GO:0043543 138 0.049
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.049
histone methylation GO:0016571 60 0.048
regulation of histone modification GO:0031056 47 0.046
mrna metabolic process GO:0016071 175 0.046
rna splicing via transesterification reactions GO:0000375 90 0.045
methylation GO:0032259 106 0.045
cell projection organization GO:0030030 252 0.045
macromolecule methylation GO:0043414 97 0.044
modification dependent protein catabolic process GO:0019941 209 0.042
protein catabolic process GO:0030163 325 0.040
regulation of chromosome organization GO:0033044 103 0.039
multicellular organismal aging GO:0010259 3 0.039
positive regulation of organelle organization GO:0010638 195 0.039
nervous system development GO:0007399 293 0.038
determination of adult lifespan GO:0008340 2 0.038
response to abiotic stimulus GO:0009628 336 0.037
generation of neurons GO:0048699 152 0.037
segmentation GO:0035282 4 0.036
peptidyl lysine acetylation GO:0018394 101 0.034
cellular response to abiotic stimulus GO:0071214 117 0.034
response to uv GO:0009411 73 0.033
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.033
cellular macromolecule catabolic process GO:0044265 380 0.033
response to radiation GO:0009314 151 0.032
positive regulation of histone modification GO:0031058 29 0.031
negative regulation of protein metabolic process GO:0051248 391 0.031
regulation of protein kinase activity GO:0045859 289 0.031
rna splicing GO:0008380 131 0.031
transmembrane transport GO:0055085 399 0.031
anion transport GO:0006820 161 0.031
apoptotic signaling pathway GO:0097190 268 0.031
organonitrogen compound biosynthetic process GO:1901566 200 0.030
muscle structure development GO:0061061 98 0.030
cell growth GO:0016049 160 0.030
protein localization to organelle GO:0033365 280 0.030
response to biotic stimulus GO:0009607 276 0.030
positive regulation of catabolic process GO:0009896 310 0.029
negative regulation of cellular protein metabolic process GO:0032269 353 0.029
dna packaging GO:0006323 77 0.028
regulation of protein acetylation GO:1901983 25 0.028
regulation of protein localization GO:0032880 296 0.028
Human
regulation of transferase activity GO:0051338 355 0.028
protein methylation GO:0006479 74 0.028
immune response GO:0006955 307 0.028
regulation of cell cycle process GO:0010564 266 0.028
regulation of chromatin organization GO:1902275 56 0.027
negative regulation of mitotic cell cycle GO:0045930 102 0.027
response to light stimulus GO:0009416 87 0.027
mitochondrion organization GO:0007005 156 0.027
protein alkylation GO:0008213 74 0.027
protein complex disassembly GO:0043241 52 0.026
neuron differentiation GO:0030182 138 0.026
establishment of protein localization to organelle GO:0072594 172 0.026
cellular lipid metabolic process GO:0044255 303 0.026
cell cycle checkpoint GO:0000075 117 0.026
posttranscriptional regulation of gene expression GO:0010608 213 0.025
peptidyl lysine modification GO:0018205 144 0.025
macromolecular complex disassembly GO:0032984 60 0.024
negative regulation of developmental process GO:0051093 247 0.024
cell cycle phase transition GO:0044770 173 0.024
regulation of mitotic cell cycle GO:0007346 189 0.024
negative regulation of catalytic activity GO:0043086 335 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.024
cellular component morphogenesis GO:0032989 314 0.024
lipid biosynthetic process GO:0008610 177 0.024
notch signaling pathway GO:0007219 31 0.023
positive regulation of cell proliferation GO:0008284 301 0.023
ribonucleoside triphosphate catabolic process GO:0009203 391 0.023
carboxylic acid biosynthetic process GO:0046394 97 0.023
histone lysine methylation GO:0034968 50 0.023
cellular protein catabolic process GO:0044257 261 0.022
regulation of chromatin modification GO:1903308 51 0.022
inorganic ion transmembrane transport GO:0098660 231 0.022
protein processing GO:0016485 226 0.022
membrane organization GO:0061024 292 0.022
regulation of proteasomal protein catabolic process GO:0061136 87 0.022
response to external biotic stimulus GO:0043207 261 0.021
reactive nitrogen species metabolic process GO:2001057 3 0.021
regulation of protein stability GO:0031647 87 0.021
dna geometric change GO:0032392 32 0.021
regulation of kinase activity GO:0043549 314 0.020
growth GO:0040007 202 0.020
regulation of growth GO:0040008 165 0.020
regulation of cell cycle phase transition GO:1901987 126 0.020
organ formation GO:0048645 3 0.020
protein stabilization GO:0050821 64 0.020
negative regulation of hydrolase activity GO:0051346 182 0.019
cardiovascular system development GO:0072358 262 0.019
positive regulation of hydrolase activity GO:0051345 331 0.019
defense response GO:0006952 315 0.019
spinal cord development GO:0021510 4 0.019
purine nucleoside triphosphate metabolic process GO:0009144 412 0.019
positive regulation of transferase activity GO:0051347 227 0.019
immune system development GO:0002520 195 0.019
ion transmembrane transport GO:0034220 338 0.019
negative regulation of dna metabolic process GO:0051053 57 0.019
g1 s transition of mitotic cell cycle GO:0000082 78 0.019
ribonucleotide catabolic process GO:0009261 405 0.019
response to oxidative stress GO:0006979 121 0.019
regulation of dna templated transcription elongation GO:0032784 23 0.018
positive regulation of cell death GO:0010942 263 0.018
Human
neuromuscular junction development GO:0007528 3 0.018
negative regulation of dna replication GO:0008156 29 0.018
mitotic cell cycle GO:0000278 326 0.018
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.018
mitotic cell cycle phase transition GO:0044772 162 0.018
regulation of dna metabolic process GO:0051052 153 0.018
neuron projection development GO:0031175 106 0.018
neuron development GO:0048666 113 0.018
reproductive process GO:0022414 106 0.018
cerebellum development GO:0021549 2 0.018
vesicle mediated transport GO:0016192 371 0.017
actin filament based process GO:0030029 224 0.017
regeneration GO:0031099 4 0.017
spermatid differentiation GO:0048515 4 0.017
syncytium formation by plasma membrane fusion GO:0000768 2 0.017
histone acetylation GO:0016573 93 0.017
cellular response to oxygen containing compound GO:1901701 276 0.017
myoblast fusion GO:0007520 1 0.017
regulation of nucleotide metabolic process GO:0006140 269 0.017
atp metabolic process GO:0046034 176 0.017
regulation of anatomical structure morphogenesis GO:0022603 286 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.016
organic acid biosynthetic process GO:0016053 97 0.016
cation transmembrane transport GO:0098655 238 0.016
cell morphogenesis involved in differentiation GO:0000904 144 0.016
regulation of cellular response to oxidative stress GO:1900407 26 0.016
peripheral nervous system development GO:0007422 2 0.016
locomotory behavior GO:0007626 1 0.016
positive regulation of phosphorylation GO:0042327 394 0.016
cell projection morphogenesis GO:0048858 129 0.016
embryo development GO:0009790 123 0.016
cell differentiation in spinal cord GO:0021515 1 0.016
oxidation reduction process GO:0055114 396 0.016
ubiquitin dependent protein catabolic process GO:0006511 206 0.016
cell development GO:0048468 328 0.016
negative regulation of protein maturation GO:1903318 142 0.016
positive regulation of cell growth GO:0030307 48 0.016
negative regulation of cell death GO:0060548 345 0.016
Human
histone h2b ubiquitination GO:0033523 8 0.016
positive regulation of cellular catabolic process GO:0031331 284 0.016
response to other organism GO:0051707 261 0.016
morphogenesis of embryonic epithelium GO:0016331 4 0.016
protein maturation GO:0051604 233 0.016
regulation of cell growth GO:0001558 135 0.016
ribonucleoside catabolic process GO:0042454 406 0.016
positive regulation of cellular component biogenesis GO:0044089 158 0.015
anterior posterior axis specification GO:0009948 2 0.015
hematopoietic or lymphoid organ development GO:0048534 186 0.015
regulation of cellular response to stress GO:0080135 244 0.015
protein dna complex disassembly GO:0032986 12 0.015
spermatid development GO:0007286 4 0.015
modification dependent macromolecule catabolic process GO:0043632 212 0.015
purine nucleoside triphosphate catabolic process GO:0009146 392 0.015
reactive oxygen species biosynthetic process GO:1903409 4 0.015
anatomical structure formation involved in morphogenesis GO:0048646 284 0.015
positive regulation of nucleotide metabolic process GO:0045981 230 0.015
regulation of purine nucleotide metabolic process GO:1900542 264 0.015
somatic stem cell maintenance GO:0035019 4 0.015
microtubule cytoskeleton organization GO:0000226 176 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.015
reactive oxygen species metabolic process GO:0072593 75 0.015
negative regulation of phosphate metabolic process GO:0045936 267 0.015
embryonic epithelial tube formation GO:0001838 4 0.015
dephosphorylation GO:0016311 209 0.015
cellular response to radiation GO:0071478 65 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
mitotic sister chromatid segregation GO:0000070 53 0.015
hindbrain development GO:0030902 3 0.015
purine nucleotide catabolic process GO:0006195 405 0.015
metencephalon development GO:0022037 2 0.015
blastoderm segmentation GO:0007350 2 0.015
ribonucleoside triphosphate metabolic process GO:0009199 412 0.014
protein acetylation GO:0006473 116 0.014
negative regulation of programmed cell death GO:0043069 321 0.014
Human
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.014
forebrain neuron differentiation GO:0021879 3 0.014
negative regulation of multicellular organismal process GO:0051241 317 0.014
regulation of mitotic cell cycle phase transition GO:1901990 118 0.014
negative regulation of cell cycle GO:0045786 193 0.014
secretion GO:0046903 254 0.014
male meiosis GO:0007140 1 0.014
organic anion transport GO:0015711 103 0.014
nucleoside triphosphate metabolic process GO:0009141 422 0.014
purine ribonucleoside metabolic process GO:0046128 437 0.014
specification of organ identity GO:0010092 3 0.014
nerve development GO:0021675 4 0.014
response to oxygen containing compound GO:1901700 369 0.014
cation transport GO:0006812 331 0.014
protein localization to chromosome GO:0034502 30 0.014
cranial nerve development GO:0021545 4 0.014
dna replication independent nucleosome organization GO:0034724 27 0.014
cellular component disassembly GO:0022411 92 0.014
glycosyl compound catabolic process GO:1901658 413 0.013
purine containing compound catabolic process GO:0072523 411 0.013
engulfment of apoptotic cell GO:0043652 2 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
Human
triglyceride biosynthetic process GO:0019432 10 0.013
purine ribonucleotide catabolic process GO:0009154 404 0.013
blood vessel development GO:0001568 172 0.013
lipid transport GO:0006869 90 0.013
nuclear transport GO:0051169 179 0.013
Human
regulation of nucleoside metabolic process GO:0009118 209 0.013
circulatory system development GO:0072359 262 0.013
regulation of protein maturation GO:1903317 150 0.013
memory GO:0007613 3 0.013
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.013
negative regulation of cell cycle phase transition GO:1901988 89 0.013
behavioral response to ethanol GO:0048149 2 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
negative regulation of cellular amine metabolic process GO:0033239 3 0.013
neuron fate commitment GO:0048663 2 0.013
cell projection assembly GO:0030031 126 0.013
positive regulation of transport GO:0051050 336 0.013
inorganic cation transmembrane transport GO:0098662 194 0.013
regulation of cell division GO:0051302 116 0.013
positive regulation of developmental process GO:0051094 314 0.013
nucleotide catabolic process GO:0009166 408 0.013
nucleosome organization GO:0034728 66 0.013
negative regulation of organelle organization GO:0010639 126 0.013
cell adhesion GO:0007155 325 0.013
cell part morphogenesis GO:0032990 137 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
intrinsic apoptotic signaling pathway GO:0097193 127 0.012
motor neuron axon guidance GO:0008045 2 0.012
nucleoside phosphate catabolic process GO:1901292 412 0.012
regulation of mrna metabolic process GO:1903311 53 0.012
cardiac right ventricle morphogenesis GO:0003215 3 0.012
somatostatin signaling pathway GO:0038170 1 0.012
biological adhesion GO:0022610 331 0.012
negative regulation of cellular component organization GO:0051129 235 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
vasculature development GO:0001944 181 0.012
microtubule based process GO:0007017 210 0.012
negative regulation of protein processing GO:0010955 142 0.012
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.012
monocarboxylic acid metabolic process GO:0032787 185 0.012
nuclear division GO:0000280 128 0.012
nucleoside monophosphate metabolic process GO:0009123 191 0.012
morphogenesis of a polarized epithelium GO:0001738 3 0.012
organic acid catabolic process GO:0016054 71 0.012
nucleoside catabolic process GO:0009164 408 0.012
mitotic cell cycle process GO:1903047 286 0.012
developmental process involved in reproduction GO:0003006 66 0.012
response to axon injury GO:0048678 1 0.012
nucleosome assembly GO:0006334 50 0.012
epithelium development GO:0060429 227 0.012
chromatin remodeling GO:0006338 55 0.012
organelle assembly GO:0070925 176 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
small molecule catabolic process GO:0044282 92 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
histone h3 k9 modification GO:0061647 11 0.011
organophosphate catabolic process GO:0046434 430 0.011
positive regulation of glucocorticoid secretion GO:2000851 4 0.011
regulation of endopeptidase activity GO:0052548 170 0.011
negative regulation of cytosolic calcium ion concentration GO:0051481 1 0.011
chromosome segregation GO:0007059 114 0.011
oocyte differentiation GO:0009994 2 0.011
mitotic nuclear division GO:0007067 119 0.011
positive regulation of chromosome organization GO:2001252 41 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
epithelial cell differentiation GO:0030855 141 0.011
regulation of reactive oxygen species metabolic process GO:2000377 41 0.011
behavior GO:0007610 112 0.011
mapk cascade GO:0000165 288 0.011
regulation of myeloid cell differentiation GO:0045637 81 0.011
positive regulation of apoptotic signaling pathway GO:2001235 70 0.011
carboxylic acid catabolic process GO:0046395 71 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
organic acid transport GO:0015849 65 0.011
humoral immune response GO:0006959 49 0.011
cellular response to organonitrogen compound GO:0071417 124 0.011
regulation of proteolysis GO:0030162 293 0.011
defense response to other organism GO:0098542 129 0.011
angiogenesis GO:0001525 147 0.011
positive regulation of protein phosphorylation GO:0001934 313 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
cellular response to uv GO:0034644 32 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.011
cell cycle g1 s phase transition GO:0044843 80 0.011
rho protein signal transduction GO:0007266 26 0.011
negative regulation of catabolic process GO:0009895 104 0.011
system process GO:0003008 349 0.011
purine nucleoside catabolic process GO:0006152 398 0.011
atp catabolic process GO:0006200 157 0.011
intracellular protein transport GO:0006886 270 0.011
Human
response to wounding GO:0009611 168 0.011
developmental programmed cell death GO:0010623 3 0.010
chemical homeostasis GO:0048878 306 0.010
oocyte development GO:0048599 1 0.010
maintenance of location GO:0051235 112 0.010
regulation of protein catabolic process GO:0042176 155 0.010
negative regulation of protein modification process GO:0031400 200 0.010
regulation of response to external stimulus GO:0032101 222 0.010
regulation of lipid biosynthetic process GO:0046890 47 0.010
mrna splicing via spliceosome GO:0000398 89 0.010
negative regulation of cellular catabolic process GO:0031330 83 0.010
ameboidal type cell migration GO:0001667 135 0.010
protein targeting GO:0006605 187 0.010
positive regulation of immune system process GO:0002684 283 0.010
guanosine containing compound metabolic process GO:1901068 244 0.010
meiosis i GO:0007127 4 0.010
regulation of protein processing GO:0070613 150 0.010
positive regulation of synaptic transmission GO:0050806 4 0.010
negative regulation of transport GO:0051051 176 0.010
Human
mitochondrial transport GO:0006839 60 0.010
regulation of rna splicing GO:0043484 62 0.010
alpha amino acid metabolic process GO:1901605 72 0.010
positive regulation of protein kinase activity GO:0045860 190 0.010
guanosine containing compound catabolic process GO:1901069 239 0.010
fatty acid metabolic process GO:0006631 115 0.010
ion homeostasis GO:0050801 230 0.010
heart formation GO:0060914 2 0.010

TONSL disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.031
hematopoietic system disease DOID:74 100 0.031
musculoskeletal system disease DOID:17 223 0.027
connective tissue disease DOID:65 109 0.027
disease of metabolism DOID:0014667 295 0.020
disease of cellular proliferation DOID:14566 174 0.019
Human
cancer DOID:162 167 0.016
Human
organ system cancer DOID:0050686 164 0.016
Human
bone disease DOID:0080001 88 0.016
bone development disease DOID:0080006 55 0.015
dysostosis DOID:1934 22 0.015
inherited metabolic disorder DOID:655 242 0.014
sensory system disease DOID:0050155 203 0.014
nervous system disease DOID:863 431 0.014
central nervous system disease DOID:331 186 0.013
eye and adnexa disease DOID:1492 150 0.011
retinal disease DOID:5679 118 0.011
eye disease DOID:5614 149 0.011
brain disease DOID:936 73 0.010