Homo sapiens

201 known processes

ERCC2

excision repair cross-complementing rodent repair deficiency, complementation group 2

(Aliases: MGC126218,MGC102762,MGC126219,XPD,COFS2,EM9,TTD)

ERCC2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 116 0.130
glycosyl compound catabolic process GO:1901658 413 0.120
purine nucleotide catabolic process GO:0006195 405 0.117
nucleoside triphosphate metabolic process GO:0009141 422 0.114
cellular amine metabolic process GO:0044106 41 0.106
purine containing compound catabolic process GO:0072523 411 0.101
purine nucleoside triphosphate catabolic process GO:0009146 392 0.097
amine metabolic process GO:0009308 44 0.096
regulation of cellular ketone metabolic process GO:0010565 50 0.095
nucleoside phosphate catabolic process GO:1901292 412 0.094
dna repair GO:0006281 198 0.090
nucleotide excision repair dna incision GO:0033683 7 0.088
purine nucleoside catabolic process GO:0006152 398 0.086
nucleotide catabolic process GO:0009166 408 0.081
regulation of cellular amino acid metabolic process GO:0006521 6 0.080
cellular response to dna damage stimulus GO:0006974 379 0.079
purine ribonucleoside metabolic process GO:0046128 437 0.078
purine nucleoside triphosphate metabolic process GO:0009144 412 0.076
cellular ketone metabolic process GO:0042180 80 0.073
regulation of cellular amine metabolic process GO:0033238 11 0.072
ribonucleoside triphosphate catabolic process GO:0009203 391 0.071
post embryonic development GO:0009791 2 0.070
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.068
purine ribonucleoside catabolic process GO:0046130 398 0.067
nucleoside triphosphate catabolic process GO:0009143 394 0.066
ribonucleoside triphosphate metabolic process GO:0009199 412 0.066
organophosphate catabolic process GO:0046434 430 0.065
nucleotide excision repair GO:0006289 31 0.064
purine ribonucleotide catabolic process GO:0009154 404 0.063
nucleoside catabolic process GO:0009164 408 0.062
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.062
positive regulation of cellular amine metabolic process GO:0033240 7 0.061
ribonucleoside catabolic process GO:0042454 406 0.060
regulation of transferase activity GO:0051338 355 0.059
response to oxidative stress GO:0006979 121 0.058
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.054
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.046
ribonucleotide catabolic process GO:0009261 405 0.045
determination of adult lifespan GO:0008340 2 0.044
multicellular organismal aging GO:0010259 3 0.041
negative regulation of cellular protein metabolic process GO:0032269 353 0.038
female gamete generation GO:0007292 2 0.037
purine nucleoside monophosphate catabolic process GO:0009128 158 0.037
regulation of cell cycle GO:0051726 393 0.037
ribonucleoside monophosphate catabolic process GO:0009158 158 0.034
cellular macromolecule catabolic process GO:0044265 380 0.034
cytoplasmic transport GO:0016482 379 0.033
vesicle mediated transport GO:0016192 371 0.033
negative regulation of protein metabolic process GO:0051248 391 0.033
response to oxygen containing compound GO:1901700 369 0.033
negative regulation of catalytic activity GO:0043086 335 0.032
carbohydrate metabolic process GO:0005975 207 0.032
positive regulation of phosphorylation GO:0042327 394 0.032
ras protein signal transduction GO:0007265 73 0.031
positive regulation of protein phosphorylation GO:0001934 313 0.031
atp catabolic process GO:0006200 157 0.031
regulation of kinase activity GO:0043549 314 0.031
protein modification by small protein conjugation GO:0032446 342 0.030
ribonucleoside monophosphate metabolic process GO:0009161 187 0.030
positive regulation of developmental process GO:0051094 314 0.030
gtp metabolic process GO:0046039 239 0.029
positive regulation of catabolic process GO:0009896 310 0.029
atp metabolic process GO:0046034 176 0.029
positive regulation of hydrolase activity GO:0051345 331 0.028
guanosine containing compound metabolic process GO:1901068 244 0.028
protein catabolic process GO:0030163 325 0.028
apoptotic signaling pathway GO:0097190 268 0.027
nucleoside monophosphate catabolic process GO:0009125 159 0.027
dna recombination GO:0006310 77 0.026
Yeast
regulation of nucleoside metabolic process GO:0009118 209 0.026
regulation of protein kinase activity GO:0045859 289 0.026
regulation of dna metabolic process GO:0051052 153 0.026
Yeast
protein ubiquitination GO:0016567 314 0.026
oogenesis GO:0048477 2 0.025
regulation of purine nucleotide metabolic process GO:1900542 264 0.025
purine nucleoside monophosphate metabolic process GO:0009126 186 0.025
mapk cascade GO:0000165 288 0.025
response to radiation GO:0009314 151 0.025
regulation of cellular response to stress GO:0080135 244 0.025
histone modification GO:0016570 251 0.025
single organism carbohydrate metabolic process GO:0044723 193 0.025
small gtpase mediated signal transduction GO:0007264 78 0.024
regulation of mapk cascade GO:0043408 262 0.024
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.024
positive regulation of cellular component organization GO:0051130 376 0.024
chromatin organization GO:0006325 351 0.024
locomotory behavior GO:0007626 1 0.024
guanosine containing compound catabolic process GO:1901069 239 0.024
cellular lipid metabolic process GO:0044255 303 0.024
protein localization to organelle GO:0033365 280 0.024
regulation of cell cycle process GO:0010564 266 0.024
positive regulation of cellular catabolic process GO:0031331 284 0.024
negative regulation of cellular component organization GO:0051129 235 0.023
system process GO:0003008 349 0.023
regulation of mitotic cell cycle GO:0007346 189 0.023
response to abiotic stimulus GO:0009628 336 0.023
transmembrane transport GO:0055085 399 0.023
regeneration GO:0031099 4 0.023
negative regulation of programmed cell death GO:0043069 321 0.023
posttranscriptional regulation of gene expression GO:0010608 213 0.023
regulation of cell growth GO:0001558 135 0.023
negative regulation of apoptotic process GO:0043066 316 0.022
covalent chromatin modification GO:0016569 254 0.022
gtp catabolic process GO:0006184 237 0.022
regulation of wnt signaling pathway GO:0030111 123 0.022
negative regulation of phosphorus metabolic process GO:0010563 267 0.022
nucleoside monophosphate metabolic process GO:0009123 191 0.022
monocarboxylic acid metabolic process GO:0032787 185 0.022
regulation of protein localization GO:0032880 296 0.022
cellular macromolecular complex assembly GO:0034622 324 0.021
negative regulation of organelle organization GO:0010639 126 0.021
negative regulation of cellular amine metabolic process GO:0033239 3 0.021
epithelium development GO:0060429 227 0.021
segmentation GO:0035282 4 0.021
negative regulation of phosphate metabolic process GO:0045936 267 0.021
chemical homeostasis GO:0048878 306 0.021
actin filament based process GO:0030029 224 0.021
cellular protein catabolic process GO:0044257 261 0.021
peptidyl tyrosine phosphorylation GO:0018108 170 0.021
positive regulation of transferase activity GO:0051347 227 0.021
protein processing GO:0016485 226 0.021
nitrogen compound transport GO:0071705 191 0.021
lipid metabolic process GO:0006629 381 0.021
regulation of secretion by cell GO:1903530 177 0.021
regulation of proteolysis GO:0030162 293 0.020
positive regulation of immune system process GO:0002684 283 0.020
lipid biosynthetic process GO:0008610 177 0.020
regulation of nucleotide metabolic process GO:0006140 269 0.020
peptidyl tyrosine modification GO:0018212 170 0.020
cation transport GO:0006812 331 0.020
immune response GO:0006955 307 0.020
meiotic chromosome segregation GO:0045132 4 0.020
regulation of secretion GO:0051046 194 0.020
anatomical structure homeostasis GO:0060249 100 0.019
protein maturation GO:0051604 233 0.019
mitotic cell cycle GO:0000278 326 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
regulation of nucleotide catabolic process GO:0030811 205 0.019
cell activation GO:0001775 213 0.019
secretion by cell GO:0032940 226 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.019
biological adhesion GO:0022610 331 0.019
single organism cellular localization GO:1902580 332 0.019
regulation of locomotion GO:0040012 329 0.019
negative regulation of phosphorylation GO:0042326 174 0.019
positive regulation of nucleotide metabolic process GO:0045981 230 0.019
positive regulation of transport GO:0051050 336 0.019
negative regulation of protein modification process GO:0031400 200 0.019
protein oligomerization GO:0051259 173 0.019
signal transduction by phosphorylation GO:0023014 297 0.019
endocytosis GO:0006897 159 0.018
intracellular protein transport GO:0006886 270 0.018
cell projection organization GO:0030030 252 0.018
regulation of gtp catabolic process GO:0033124 180 0.018
cellular component morphogenesis GO:0032989 314 0.018
chromosome segregation GO:0007059 114 0.018
regulation of purine nucleotide catabolic process GO:0033121 205 0.018
dephosphorylation GO:0016311 209 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.018
negative regulation of transport GO:0051051 176 0.018
chromatin modification GO:0016568 298 0.018
positive regulation of cell death GO:0010942 263 0.018
negative regulation of cell death GO:0060548 345 0.018
defense response GO:0006952 315 0.018
limbic system development GO:0021761 3 0.018
cell cycle phase transition GO:0044770 173 0.017
innate immune response GO:0045087 178 0.017
neuromuscular junction development GO:0007528 3 0.017
enzyme linked receptor protein signaling pathway GO:0007167 303 0.017
organonitrogen compound biosynthetic process GO:1901566 200 0.017
response to other organism GO:0051707 261 0.017
endomembrane system organization GO:0010256 196 0.017
spermatid differentiation GO:0048515 4 0.017
cardiovascular system development GO:0072358 262 0.017
positive regulation of programmed cell death GO:0043068 249 0.017
negative regulation of homeostatic process GO:0032845 59 0.017
regulation of cell motility GO:2000145 299 0.017
regulation of immune response GO:0050776 201 0.016
cell morphogenesis GO:0000902 296 0.016
endosomal transport GO:0016197 129 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
regulation of homeostatic process GO:0032844 121 0.016
mitotic cell cycle phase transition GO:0044772 162 0.016
rna processing GO:0006396 255 0.016
nuclear transport GO:0051169 179 0.016
cellular response to endogenous stimulus GO:0071495 336 0.016
regulation of protein transport GO:0051223 213 0.016
maintenance of location GO:0051235 112 0.016
anatomical structure formation involved in morphogenesis GO:0048646 284 0.016
positive regulation of apoptotic process GO:0043065 246 0.016
positive regulation of nucleotide catabolic process GO:0030813 185 0.016
positive regulation of cell differentiation GO:0045597 211 0.016
membrane organization GO:0061024 292 0.015
regulation of anatomical structure morphogenesis GO:0022603 286 0.015
response to decreased oxygen levels GO:0036293 96 0.015
cell growth GO:0016049 160 0.015
microtubule based process GO:0007017 210 0.015
regulation of endopeptidase activity GO:0052548 170 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.015
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.015
microtubule cytoskeleton organization GO:0000226 176 0.015
cell division GO:0051301 168 0.015
ion homeostasis GO:0050801 230 0.015
regulation of cell differentiation GO:0045595 393 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
regulation of gtpase activity GO:0043087 180 0.015
neurogenesis GO:0022008 169 0.015
regulation of cellular component movement GO:0051270 334 0.015
regulation of hormone levels GO:0010817 125 0.015
regulation of ras gtpase activity GO:0032318 128 0.015
regulation of chromosome organization GO:0033044 103 0.015
cellular response to cytokine stimulus GO:0071345 181 0.015
organic acid biosynthetic process GO:0016053 97 0.015
proteasomal protein catabolic process GO:0010498 176 0.015
nucleocytoplasmic transport GO:0006913 176 0.014
modification dependent protein catabolic process GO:0019941 209 0.014
regulation of protein serine threonine kinase activity GO:0071900 179 0.014
response to oxygen levels GO:0070482 100 0.014
oocyte differentiation GO:0009994 2 0.014
protein modification by small protein removal GO:0070646 92 0.014
protein localization to nucleus GO:0034504 136 0.014
cell projection morphogenesis GO:0048858 129 0.014
regulation of growth GO:0040008 165 0.014
rho protein signal transduction GO:0007266 26 0.014
nervous system development GO:0007399 293 0.014
regulation of synaptic plasticity GO:0048167 3 0.014
protein targeting GO:0006605 187 0.014
regulation of response to external stimulus GO:0032101 222 0.014
carbohydrate derivative biosynthetic process GO:1901137 207 0.014
mrna metabolic process GO:0016071 175 0.014
single organism membrane organization GO:0044802 268 0.014
negative regulation of protein maturation GO:1903318 142 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
response to wounding GO:0009611 168 0.014
oocyte development GO:0048599 1 0.014
regulation of intracellular transport GO:0032386 195 0.014
negative regulation of cell cycle GO:0045786 193 0.014
establishment of protein localization to organelle GO:0072594 172 0.014
negative regulation of transferase activity GO:0051348 124 0.014
cellular response to oxygen containing compound GO:1901701 276 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.014
regulation of cell migration GO:0030334 289 0.014
organelle fission GO:0048285 149 0.014
growth GO:0040007 202 0.013
immune system development GO:0002520 195 0.013
ion transmembrane transport GO:0034220 338 0.013
positive regulation of gtp catabolic process GO:0033126 166 0.013
response to cytokine GO:0034097 232 0.013
regulation of protein catabolic process GO:0042176 155 0.013
positive regulation of cellular component biogenesis GO:0044089 158 0.013
positive regulation of nucleoside metabolic process GO:0045979 186 0.013
regulation of peptidase activity GO:0052547 180 0.013
response to uv GO:0009411 73 0.013
response to lipid GO:0033993 206 0.013
metal ion transport GO:0030001 272 0.013
carboxylic acid biosynthetic process GO:0046394 97 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
negative regulation of dna metabolic process GO:0051053 57 0.013
ubiquitin dependent protein catabolic process GO:0006511 206 0.013
response to biotic stimulus GO:0009607 276 0.013
regulation of protein maturation GO:1903317 150 0.013
negative regulation of proteolysis GO:0045861 132 0.013
blastoderm segmentation GO:0007350 2 0.013
protein autophosphorylation GO:0046777 123 0.013
regulation of cysteine type endopeptidase activity GO:2000116 127 0.013
spermatid development GO:0007286 4 0.013
negative regulation of protein processing GO:0010955 142 0.013
cellular response to oxidative stress GO:0034599 85 0.013
regulation of protein processing GO:0070613 150 0.013
cell fate determination GO:0001709 3 0.012
positive regulation of kinase activity GO:0033674 204 0.012
cell part morphogenesis GO:0032990 137 0.012
circulatory system development GO:0072359 262 0.012
response to external biotic stimulus GO:0043207 261 0.012
cell development GO:0048468 328 0.012
negative regulation of growth GO:0045926 97 0.012
response to axon injury GO:0048678 1 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
regulation of cytoskeleton organization GO:0051493 177 0.012
embryo development GO:0009790 123 0.012
small molecule biosynthetic process GO:0044283 157 0.012
lens development in camera type eye GO:0002088 2 0.012
positive regulation of immune response GO:0050778 159 0.012
positive regulation of organelle organization GO:0010638 195 0.012
cellular response to lipid GO:0071396 127 0.012
protein deubiquitination GO:0016579 79 0.012
cellular homeostasis GO:0019725 196 0.012
adult locomotory behavior GO:0008344 1 0.012
hematopoietic or lymphoid organ development GO:0048534 186 0.012
negative regulation of developmental process GO:0051093 247 0.012
modification dependent macromolecule catabolic process GO:0043632 212 0.012
protein localization to membrane GO:0072657 160 0.012
rna interference GO:0016246 4 0.012
anterior posterior axis specification GO:0009948 2 0.012
cilium morphogenesis GO:0060271 75 0.012
response to hypoxia GO:0001666 96 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
cell adhesion GO:0007155 325 0.012
cellular chemical homeostasis GO:0055082 180 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
regulation of small gtpase mediated signal transduction GO:0051056 156 0.012
positive regulation of mapk cascade GO:0043410 190 0.012
positive regulation of protein transport GO:0051222 135 0.012
regulation of cytoplasmic transport GO:1903649 149 0.012
hippocampus development GO:0021766 1 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
glycoprotein biosynthetic process GO:0009101 91 0.012
translation GO:0006412 132 0.012
mitochondrion organization GO:0007005 156 0.012
regulation of cell cycle phase transition GO:1901987 126 0.012
negative regulation of multicellular organismal process GO:0051241 317 0.012
phosphorylation of rna polymerase ii c terminal domain GO:0070816 3 0.012
Yeast
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.011
mitotic cell cycle process GO:1903047 286 0.011
morphogenesis of embryonic epithelium GO:0016331 4 0.011
oxidation reduction process GO:0055114 396 0.011
positive regulation of gtpase activity GO:0043547 166 0.011
secretion GO:0046903 254 0.011
immune effector process GO:0002252 159 0.011
double strand break repair GO:0006302 101 0.011
single organism cell adhesion GO:0098602 179 0.011
positive regulation of protein kinase activity GO:0045860 190 0.011
rna splicing GO:0008380 131 0.011
memory GO:0007613 3 0.011
neuron differentiation GO:0030182 138 0.011
leukocyte activation GO:0045321 164 0.011
negative regulation of chromosome organization GO:2001251 48 0.011
negative regulation of protein kinase activity GO:0006469 98 0.011
intrinsic apoptotic signaling pathway GO:0097193 127 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
developmental programmed cell death GO:0010623 3 0.011
regulation of protein complex assembly GO:0043254 147 0.011
glycoprotein metabolic process GO:0009100 110 0.011
cell morphogenesis involved in differentiation GO:0000904 144 0.011
activation of immune response GO:0002253 114 0.011
interspecies interaction between organisms GO:0044419 156 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
regulation of vesicle mediated transport GO:0060627 130 0.011
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.011
neurological system process GO:0050877 163 0.011
response to virus GO:0009615 126 0.011
receptor mediated endocytosis GO:0006898 84 0.011
regulation of defense response GO:0031347 154 0.011
response to growth factor GO:0070848 205 0.011
negative regulation of kinase activity GO:0033673 106 0.011
fatty acid metabolic process GO:0006631 115 0.011
blastocyst formation GO:0001825 3 0.011
reproductive process GO:0022414 106 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
neural tube formation GO:0001841 3 0.011
compound eye development GO:0048749 1 0.011
peptidyl serine phosphorylation GO:0018105 101 0.011
regulation of protein stability GO:0031647 87 0.011
regulation of cytokine production GO:0001817 232 0.011
regulation of cell adhesion GO:0030155 166 0.011
response to organic cyclic compound GO:0014070 204 0.011
cation homeostasis GO:0055080 189 0.010
cellular protein complex assembly GO:0043623 188 0.010
regulation of cell development GO:0060284 161 0.010
embryonic epithelial tube formation GO:0001838 4 0.010
sequestering of metal ion GO:0051238 24 0.010
motor neuron axon guidance GO:0008045 2 0.010
peptidyl serine modification GO:0018209 106 0.010
response to inorganic substance GO:0010035 127 0.010
epithelial cell differentiation GO:0030855 141 0.010
epithelial cell proliferation GO:0050673 128 0.010
cytokine production GO:0001816 247 0.010
positive regulation of cell proliferation GO:0008284 301 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.010
generation of precursor metabolites and energy GO:0006091 68 0.010
response to organonitrogen compound GO:0010243 156 0.010
cytokinesis GO:0000910 96 0.010
actin cytoskeleton organization GO:0030036 207 0.010
protein secretion GO:0009306 98 0.010
cytokine mediated signaling pathway GO:0019221 109 0.010
actin filament organization GO:0007015 128 0.010
response to hormone GO:0009725 175 0.010
regulation of ion transport GO:0043269 189 0.010
hindbrain development GO:0030902 3 0.010
negative regulation of cell cycle process GO:0010948 121 0.010
single organism reproductive process GO:0044702 98 0.010
protein acylation GO:0043543 138 0.010

ERCC2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.052
cancer DOID:162 167 0.050
organ system cancer DOID:0050686 164 0.036
disease of metabolism DOID:0014667 295 0.036
sensory system disease DOID:0050155 203 0.028
nervous system disease DOID:863 431 0.028
musculoskeletal system disease DOID:17 223 0.028
central nervous system disease DOID:331 186 0.026
inherited metabolic disorder DOID:655 242 0.020
eye and adnexa disease DOID:1492 150 0.019
eye disease DOID:5614 149 0.019
retinal disease DOID:5679 118 0.019
connective tissue disease DOID:65 109 0.017
immune system disease DOID:2914 155 0.015
neurodegenerative disease DOID:1289 102 0.015
epilepsy syndrome DOID:1826 41 0.014
brain disease DOID:936 73 0.014
electroclinical syndrome DOID:0050701 32 0.014
neonatal period electroclinical syndrome DOID:0050702 19 0.014
retinal degeneration DOID:8466 89 0.013
bone disease DOID:0080001 88 0.012
carbohydrate metabolic disorder DOID:2978 55 0.012
muscular disease DOID:0080000 114 0.010
muscle tissue disease DOID:66 113 0.010
xeroderma pigmentosum DOID:0050427 8 0.004
photosensitive trichothiodystrophy DOID:2960 3 0.001