Homo sapiens

103 known processes

ERCC4

excision repair cross-complementing rodent repair deficiency, complementation group 4

(Aliases: ERCC11,XPF,RAD1)

ERCC4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
double strand break repair via single strand annealing GO:0045002 4 0.603
nucleotide excision repair GO:0006289 31 0.479
nucleotide excision repair dna incision GO:0033683 7 0.191
cellular response to dna damage stimulus GO:0006974 379 0.186
cellular macromolecule catabolic process GO:0044265 380 0.157
regulation of telomere maintenance GO:0032204 13 0.140
response to cell cycle checkpoint signaling GO:0072396 4 0.133
post embryonic development GO:0009791 2 0.130
dna catabolic process endonucleolytic GO:0000737 37 0.112
dna recombination GO:0006310 77 0.111
regulation of mitotic cell cycle GO:0007346 189 0.102
dna repair GO:0006281 198 0.096
cellular amino acid metabolic process GO:0006520 116 0.089
negative regulation of cell cycle phase transition GO:1901988 89 0.080
dna catabolic process GO:0006308 49 0.077
negative regulation of mitotic cell cycle GO:0045930 102 0.073
regulation of cellular amine metabolic process GO:0033238 11 0.072
regulation of cell cycle GO:0051726 393 0.070
negative regulation of organelle organization GO:0010639 126 0.070
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.068
nucleoside triphosphate metabolic process GO:0009141 422 0.066
regulation of dna metabolic process GO:0051052 153 0.063
regulation of cellular ketone metabolic process GO:0010565 50 0.063
response to biotic stimulus GO:0009607 276 0.061
amine metabolic process GO:0009308 44 0.061
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.060
mitotic cell cycle GO:0000278 326 0.058
regulation of cellular amino acid metabolic process GO:0006521 6 0.058
positive regulation of cellular amine metabolic process GO:0033240 7 0.052
negative regulation of cell cycle process GO:0010948 121 0.052
cellular amine metabolic process GO:0044106 41 0.052
negative regulation of cell cycle GO:0045786 193 0.051
nucleotide catabolic process GO:0009166 408 0.047
negative regulation of dna metabolic process GO:0051053 57 0.047
cellular ketone metabolic process GO:0042180 80 0.047
nucleoside triphosphate catabolic process GO:0009143 394 0.045
dna integrity checkpoint GO:0031570 71 0.044
recombinational repair GO:0000725 50 0.043
response to dna integrity checkpoint signaling GO:0072402 4 0.043
positive regulation of catabolic process GO:0009896 310 0.042
oogenesis GO:0048477 2 0.041
protein catabolic process GO:0030163 325 0.040
multicellular organismal aging GO:0010259 3 0.039
female gamete generation GO:0007292 2 0.039
negative regulation of protein metabolic process GO:0051248 391 0.038
morphogenesis of embryonic epithelium GO:0016331 4 0.038
positive regulation of hydrolase activity GO:0051345 331 0.037
mitotic cell cycle checkpoint GO:0007093 68 0.035
negative regulation of homeostatic process GO:0032845 59 0.035
positive regulation of cell death GO:0010942 263 0.035
ribonucleoside triphosphate catabolic process GO:0009203 391 0.035
double strand break repair via homologous recombination GO:0000724 50 0.034
purine ribonucleotide catabolic process GO:0009154 404 0.034
purine nucleotide catabolic process GO:0006195 405 0.034
ribonucleoside triphosphate metabolic process GO:0009199 412 0.034
purine nucleoside triphosphate metabolic process GO:0009144 412 0.033
epithelium development GO:0060429 227 0.033
negative regulation of chromosome organization GO:2001251 48 0.032
nucleoside phosphate catabolic process GO:1901292 412 0.032
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.032
negative regulation of catalytic activity GO:0043086 335 0.031
organophosphate catabolic process GO:0046434 430 0.031
actomyosin contractile ring organization GO:0044837 1 0.031
negative regulation of programmed cell death GO:0043069 321 0.031
regulation of cell cycle process GO:0010564 266 0.031
purine ribonucleoside metabolic process GO:0046128 437 0.030
regulation of cellular component biogenesis GO:0044087 281 0.029
cellular protein complex assembly GO:0043623 188 0.029
ribonucleoside catabolic process GO:0042454 406 0.029
transmembrane transport GO:0055085 399 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.029
purine ribonucleoside catabolic process GO:0046130 398 0.029
cell cycle phase transition GO:0044770 173 0.028
determination of adult lifespan GO:0008340 2 0.028
anatomical structure homeostasis GO:0060249 100 0.028
purine nucleoside triphosphate catabolic process GO:0009146 392 0.028
response to radiation GO:0009314 151 0.027
protein localization to organelle GO:0033365 280 0.027
negative regulation of cell death GO:0060548 345 0.027
negative regulation of phosphorus metabolic process GO:0010563 267 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.027
actin filament based process GO:0030029 224 0.026
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
purine containing compound catabolic process GO:0072523 411 0.026
gtp metabolic process GO:0046039 239 0.026
oocyte differentiation GO:0009994 2 0.026
mitotic cell cycle process GO:1903047 286 0.026
protein maturation GO:0051604 233 0.026
intracellular protein transport GO:0006886 270 0.026
ubiquitin dependent protein catabolic process GO:0006511 206 0.026
negative regulation of catabolic process GO:0009895 104 0.026
glycosyl compound catabolic process GO:1901658 413 0.025
negative regulation of phosphate metabolic process GO:0045936 267 0.025
negative regulation of apoptotic process GO:0043066 316 0.025
ribonucleotide catabolic process GO:0009261 405 0.025
positive regulation of transport GO:0051050 336 0.025
response to oxygen containing compound GO:1901700 369 0.024
response to abiotic stimulus GO:0009628 336 0.024
regulation of proteolysis GO:0030162 293 0.024
cellular response to endogenous stimulus GO:0071495 336 0.024
i kappab kinase nf kappab signaling GO:0007249 166 0.024
regulation of protein kinase activity GO:0045859 289 0.024
positive regulation of cellular component organization GO:0051130 376 0.024
regulation of mitotic cell cycle phase transition GO:1901990 118 0.023
response to dna damage checkpoint signaling GO:0072423 4 0.023
cytoplasmic transport GO:0016482 379 0.023
regulation of cell differentiation GO:0045595 393 0.023
regulation of purine nucleotide catabolic process GO:0033121 205 0.023
regulation of kinase activity GO:0043549 314 0.023
dna catabolic process exonucleolytic GO:0000738 17 0.023
spermatid differentiation GO:0048515 4 0.023
positive regulation of protein phosphorylation GO:0001934 313 0.023
positive regulation of phosphorylation GO:0042327 394 0.023
dephosphorylation GO:0016311 209 0.022
dna double strand break processing GO:0000729 10 0.022
regulation of meiotic cell cycle GO:0051445 4 0.022
microtubule based process GO:0007017 210 0.022
regulation of nucleotide metabolic process GO:0006140 269 0.022
dna damage checkpoint GO:0000077 68 0.022
regulation of protein catabolic process GO:0042176 155 0.022
nucleoside catabolic process GO:0009164 408 0.022
guanosine containing compound metabolic process GO:1901068 244 0.022
regulation of transferase activity GO:0051338 355 0.022
positive regulation of apoptotic process GO:0043065 246 0.021
negative regulation of cellular catabolic process GO:0031330 83 0.021
embryonic epithelial tube formation GO:0001838 4 0.021
protein modification by small protein conjugation GO:0032446 342 0.021
positive regulation of cell cycle process GO:0090068 106 0.021
modification dependent macromolecule catabolic process GO:0043632 212 0.021
regulation of nucleotide catabolic process GO:0030811 205 0.021
biological adhesion GO:0022610 331 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
negative regulation of telomere maintenance GO:0032205 9 0.021
cellular response to biotic stimulus GO:0071216 71 0.021
negative regulation of proteolysis GO:0045861 132 0.021
protein ubiquitination GO:0016567 314 0.021
gtp catabolic process GO:0006184 237 0.021
regulation of protein processing GO:0070613 150 0.021
positive regulation of protein transport GO:0051222 135 0.020
rho protein signal transduction GO:0007266 26 0.020
guanosine containing compound catabolic process GO:1901069 239 0.020
neuroblast proliferation GO:0007405 4 0.020
vesicle mediated transport GO:0016192 371 0.020
immune response GO:0006955 307 0.020
mitotic cell cycle phase transition GO:0044772 162 0.020
regulation of cellular response to stress GO:0080135 244 0.020
positive regulation of nucleoside metabolic process GO:0045979 186 0.020
defense response GO:0006952 315 0.020
locomotory behavior GO:0007626 1 0.020
regulation of purine nucleotide metabolic process GO:1900542 264 0.020
signal transduction by phosphorylation GO:0023014 297 0.020
cell morphogenesis GO:0000902 296 0.020
ras protein signal transduction GO:0007265 73 0.020
proteasomal protein catabolic process GO:0010498 176 0.020
regulation of establishment of protein localization GO:0070201 242 0.020
single organism membrane organization GO:0044802 268 0.020
regulation of intracellular transport GO:0032386 195 0.020
regulation of cell cycle phase transition GO:1901987 126 0.020
nitrogen compound transport GO:0071705 191 0.019
anterior posterior axis specification GO:0009948 2 0.019
positive regulation of organelle organization GO:0010638 195 0.019
protein processing GO:0016485 226 0.019
segmentation GO:0035282 4 0.019
spermatid development GO:0007286 4 0.019
positive regulation of nucleotide metabolic process GO:0045981 230 0.019
purine nucleoside catabolic process GO:0006152 398 0.019
cellular component morphogenesis GO:0032989 314 0.019
mitotic dna damage checkpoint GO:0044773 28 0.019
regulation of protein transport GO:0051223 213 0.019
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.019
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.018
small gtpase mediated signal transduction GO:0007264 78 0.018
cell division GO:0051301 168 0.018
regulation of neural precursor cell proliferation GO:2000177 4 0.018
cellular protein catabolic process GO:0044257 261 0.018
ion transmembrane transport GO:0034220 338 0.018
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.018
meiosis i GO:0007127 4 0.018
regulation of meiosis GO:0040020 3 0.018
negative regulation of protein phosphorylation GO:0001933 140 0.018
negative regulation of protein modification process GO:0031400 200 0.018
g2 m transition of mitotic cell cycle GO:0000086 41 0.017
response to oxidative stress GO:0006979 121 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
cellular lipid metabolic process GO:0044255 303 0.017
metal ion transport GO:0030001 272 0.017
memory GO:0007613 3 0.017
regulation of nucleoside metabolic process GO:0009118 209 0.017
regulation of homeostatic process GO:0032844 121 0.017
mapk cascade GO:0000165 288 0.017
positive regulation of gtpase activity GO:0043547 166 0.017
regulation of cellular protein catabolic process GO:1903362 96 0.017
neuromuscular junction development GO:0007528 3 0.017
oocyte development GO:0048599 1 0.017
regulation of cytoskeleton organization GO:0051493 177 0.017
hindbrain development GO:0030902 3 0.017
response to wounding GO:0009611 168 0.017
cell cycle checkpoint GO:0000075 117 0.017
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
microtubule cytoskeleton organization GO:0000226 176 0.016
sex determination GO:0007530 3 0.016
negative regulation of phosphorylation GO:0042326 174 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.016
intra s dna damage checkpoint GO:0031573 4 0.016
regulation of gtp catabolic process GO:0033124 180 0.016
positive regulation of nucleotide catabolic process GO:0030813 185 0.016
cell adhesion GO:0007155 325 0.016
membrane organization GO:0061024 292 0.016
negative regulation of developmental process GO:0051093 247 0.016
cell type specific apoptotic process GO:0097285 125 0.015
peripheral nervous system development GO:0007422 2 0.015
negative regulation of protein processing GO:0010955 142 0.015
positive regulation of transferase activity GO:0051347 227 0.015
actin cytoskeleton organization GO:0030036 207 0.015
lipid metabolic process GO:0006629 381 0.015
ribonucleoside monophosphate metabolic process GO:0009161 187 0.015
cation transport GO:0006812 331 0.015
protein targeting GO:0006605 187 0.015
regulation of protein complex assembly GO:0043254 147 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
salivary gland morphogenesis GO:0007435 4 0.015
posttranscriptional regulation of gene expression GO:0010608 213 0.015
cell development GO:0048468 328 0.015
maintenance of location GO:0051235 112 0.015
negative regulation of cell proliferation GO:0008285 228 0.015
nervous system development GO:0007399 293 0.015
regulation of gtpase activity GO:0043087 180 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
system process GO:0003008 349 0.015
organelle fission GO:0048285 149 0.015
positive regulation of intracellular transport GO:0032388 104 0.015
negative regulation of multicellular organismal process GO:0051241 317 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
non recombinational repair GO:0000726 14 0.014
positive regulation of cell cycle GO:0045787 140 0.014
regulation of locomotion GO:0040012 329 0.014
regulation of response to external stimulus GO:0032101 222 0.014
single organism cellular localization GO:1902580 332 0.014
cell part morphogenesis GO:0032990 137 0.014
regulation of intracellular protein transport GO:0033157 123 0.014
negative regulation of protein maturation GO:1903318 142 0.014
positive regulation of gtp catabolic process GO:0033126 166 0.014
protein oligomerization GO:0051259 173 0.014
regulation of protein maturation GO:1903317 150 0.014
regulation of neuroblast proliferation GO:1902692 3 0.014
organelle assembly GO:0070925 176 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
regulation of transcription from rna polymerase ii promoter mitotic GO:0046021 1 0.014
regulation of protein localization GO:0032880 296 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.014
establishment of nucleus localization GO:0040023 1 0.014
regulation of cell migration GO:0030334 289 0.014
innate immune response GO:0045087 178 0.014
protein localization to nucleus GO:0034504 136 0.014
nucleoside monophosphate metabolic process GO:0009123 191 0.014
cell projection organization GO:0030030 252 0.014
regulation of cell motility GO:2000145 299 0.014
reciprocal dna recombination GO:0035825 4 0.014
regulation of mapk cascade GO:0043408 262 0.013
establishment of protein localization to organelle GO:0072594 172 0.013
negative regulation of transferase activity GO:0051348 124 0.013
epithelial cell differentiation GO:0030855 141 0.013
blastoderm segmentation GO:0007350 2 0.013
response to uv GO:0009411 73 0.013
primary neural tube formation GO:0014020 3 0.013
cellular macromolecular complex assembly GO:0034622 324 0.013
compound eye development GO:0048749 1 0.013
tripartite regional subdivision GO:0007351 2 0.013
positive regulation of cellular component biogenesis GO:0044089 158 0.013
negative regulation of stem cell proliferation GO:2000647 3 0.013
regulation of proteasomal protein catabolic process GO:0061136 87 0.013
metencephalon development GO:0022037 2 0.013
nucleus localization GO:0051647 1 0.013
reciprocal meiotic recombination GO:0007131 4 0.013
response to ionizing radiation GO:0010212 65 0.013
double strand break repair GO:0006302 101 0.013
photoreceptor cell differentiation GO:0046530 2 0.013
anatomical structure formation involved in morphogenesis GO:0048646 284 0.013
modification dependent protein catabolic process GO:0019941 209 0.013
response to lipid GO:0033993 206 0.013
regulation of cell development GO:0060284 161 0.013
inorganic ion transmembrane transport GO:0098660 231 0.013
regulation of protein stability GO:0031647 87 0.013
inner ear morphogenesis GO:0042472 4 0.013
neural tube closure GO:0001843 3 0.013
immune effector process GO:0002252 159 0.013
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.013
morphogenesis of a polarized epithelium GO:0001738 3 0.012
positive regulation of kinase activity GO:0033674 204 0.012
oxidation reduction process GO:0055114 396 0.012
regulation of ras gtpase activity GO:0032318 128 0.012
neurotransmitter secretion GO:0007269 4 0.012
endosomal transport GO:0016197 129 0.012
protein autophosphorylation GO:0046777 123 0.012
cell projection assembly GO:0030031 126 0.012
negative regulation of kinase activity GO:0033673 106 0.012
purine nucleoside monophosphate metabolic process GO:0009126 186 0.012
organophosphate biosynthetic process GO:0090407 163 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
negative regulation of cellular component organization GO:0051129 235 0.012
nucleocytoplasmic transport GO:0006913 176 0.012
peptidyl tyrosine modification GO:0018212 170 0.012
chemical homeostasis GO:0048878 306 0.012
peptidyl tyrosine phosphorylation GO:0018108 170 0.012
embryo development GO:0009790 123 0.012
taxis GO:0042330 157 0.012
male meiosis GO:0007140 1 0.012
regulation of synaptic plasticity GO:0048167 3 0.012
cytokinesis GO:0000910 96 0.012
regulation of cellular component movement GO:0051270 334 0.012
regulation of binding GO:0051098 111 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
negative regulation of transport GO:0051051 176 0.012
anterior posterior axis specification embryo GO:0008595 2 0.012
motor neuron axon guidance GO:0008045 2 0.012
anion transport GO:0006820 161 0.012
interspecies interaction between organisms GO:0044419 156 0.012
cellular homeostasis GO:0019725 196 0.012
cellular response to oxygen containing compound GO:1901701 276 0.011
peptidyl lysine modification GO:0018205 144 0.011
positive regulation of protein kinase activity GO:0045860 190 0.011
single organismal cell cell adhesion GO:0016337 148 0.011
response to cytokine GO:0034097 232 0.011
hematopoietic or lymphoid organ development GO:0048534 186 0.011
negative regulation of neural precursor cell proliferation GO:2000178 1 0.011
wnt signaling pathway GO:0016055 156 0.011
cilium morphogenesis GO:0060271 75 0.011
apoptotic signaling pathway GO:0097190 268 0.011
anion transmembrane transport GO:0098656 76 0.011
nuclear transport GO:0051169 179 0.011
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
regulation of immune response GO:0050776 201 0.011
generation of neurons GO:0048699 152 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.011
myosin filament assembly GO:0031034 2 0.011
response to axon injury GO:0048678 1 0.011
leukocyte activation GO:0045321 164 0.011
sequestering of metal ion GO:0051238 24 0.011
reproductive process GO:0022414 106 0.011
autophagy GO:0006914 88 0.011
negative regulation of protein kinase activity GO:0006469 98 0.011
sensory perception of pain GO:0019233 4 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
regulation of small gtpase mediated signal transduction GO:0051056 156 0.011
syncytium formation by plasma membrane fusion GO:0000768 2 0.011
telomere maintenance GO:0000723 32 0.011
response to external biotic stimulus GO:0043207 261 0.011
positive regulation of ras gtpase activity GO:0032320 117 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.011
single organism cell adhesion GO:0098602 179 0.011
sequestering of calcium ion GO:0051208 17 0.011
protein homooligomerization GO:0051260 100 0.011
visual behavior GO:0007632 2 0.011
cell activation GO:0001775 213 0.011
organ formation GO:0048645 3 0.011
regulation of protein binding GO:0043393 66 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
receptor metabolic process GO:0043112 81 0.011
negative regulation of synaptic transmission GO:0050805 2 0.011
regulation of reactive oxygen species metabolic process GO:2000377 41 0.011
positive regulation of immune system process GO:0002684 283 0.011
single organism nuclear import GO:1902593 104 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
neural tube formation GO:0001841 3 0.011
rna processing GO:0006396 255 0.011
rhythmic behavior GO:0007622 2 0.011
chromatin organization GO:0006325 351 0.011
long term memory GO:0007616 2 0.011
lung alveolus development GO:0048286 4 0.011
cerebellum development GO:0021549 2 0.010
lipid biosynthetic process GO:0008610 177 0.010
regulation of cell morphogenesis GO:0022604 153 0.010
protein localization to membrane GO:0072657 160 0.010
negative regulation of gliogenesis GO:0014014 3 0.010
cation homeostasis GO:0055080 189 0.010
hemopoiesis GO:0030097 180 0.010
negative regulation of jun kinase activity GO:0043508 4 0.010
adult locomotory behavior GO:0008344 1 0.010
positive regulation of intracellular protein transport GO:0090316 76 0.010
regulation of cytoplasmic transport GO:1903649 149 0.010
protein acylation GO:0043543 138 0.010
regulation of secretion GO:0051046 194 0.010
reactive nitrogen species metabolic process GO:2001057 3 0.010
inorganic cation transmembrane transport GO:0098662 194 0.010
endocytosis GO:0006897 159 0.010
regulation of response to wounding GO:1903034 101 0.010
response to light stimulus GO:0009416 87 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
positive regulation of cellular component movement GO:0051272 181 0.010
actin filament based movement GO:0030048 17 0.010
sensory perception GO:0007600 103 0.010
regulation of microtubule based process GO:0032886 74 0.010

ERCC4 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.333
aplastic anemia DOID:12449 30 0.333
bone marrow disease DOID:4961 31 0.333
anemia DOID:2355 55 0.333
hematopoietic system disease DOID:74 100 0.333
disease of metabolism DOID:0014667 295 0.032
cancer DOID:162 167 0.031
disease of cellular proliferation DOID:14566 174 0.031
organ system cancer DOID:0050686 164 0.026
sensory system disease DOID:0050155 203 0.025
nervous system disease DOID:863 431 0.025
musculoskeletal system disease DOID:17 223 0.022
connective tissue disease DOID:65 109 0.022
inherited metabolic disorder DOID:655 242 0.021
eye and adnexa disease DOID:1492 150 0.020
eye disease DOID:5614 149 0.020
central nervous system disease DOID:331 186 0.018
retinal disease DOID:5679 118 0.017
retinal degeneration DOID:8466 89 0.014
bone disease DOID:0080001 88 0.012
brain disease DOID:936 73 0.010
muscular disease DOID:0080000 114 0.010
cardiovascular system disease DOID:1287 106 0.010
congenital hypoplastic anemia DOID:1342 26 0.010
fanconi s anemia DOID:13636 16 0.010
xeroderma pigmentosum DOID:0050427 8 0.005