Homo sapiens

13 known processes

LOXL1

lysyl oxidase-like 1

(Aliases: LOXL,LOL)

LOXL1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of mesenchymal stem cell differentiation GO:2000741 4 0.888
elastic fiber assembly GO:0048251 3 0.744
positive regulation of cell differentiation GO:0045597 211 0.598
extracellular structure organization GO:0043062 41 0.557
Human
positive regulation of cell proliferation GO:0008284 301 0.529
connective tissue development GO:0061448 39 0.458
stem cell differentiation GO:0048863 93 0.457
Human
regulation of cell differentiation GO:0045595 393 0.456
positive regulation of developmental process GO:0051094 314 0.446
mesenchymal stem cell proliferation GO:0097168 1 0.416
negative regulation of developmental process GO:0051093 247 0.389
regulation of cartilage development GO:0061035 12 0.337
regulation of stem cell differentiation GO:2000736 56 0.296
positive regulation of stem cell differentiation GO:2000738 29 0.276
positive regulation of mesenchymal stem cell proliferation GO:1902462 1 0.236
transforming growth factor beta production GO:0071604 14 0.233
response to oxygen containing compound GO:1901700 369 0.233
Rat
enzyme linked receptor protein signaling pathway GO:0007167 303 0.225
negative regulation of multicellular organismal process GO:0051241 317 0.217
regulation of cellular response to oxidative stress GO:1900407 26 0.217
peptidyl tyrosine modification GO:0018212 170 0.176
cellular response to oxygen containing compound GO:1901701 276 0.166
regulation of cellular response to stress GO:0080135 244 0.147
skeletal system development GO:0001501 79 0.142
cell activation GO:0001775 213 0.108
transforming growth factor beta activation GO:0036363 1 0.104
regulation of proteolysis GO:0030162 293 0.103
cartilage development GO:0051216 31 0.097
biological adhesion GO:0022610 331 0.096
cell morphogenesis GO:0000902 296 0.094
Human
cellular response to oxidative stress GO:0034599 85 0.094
extracellular matrix organization GO:0030198 41 0.093
Human
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.092
detection of mechanical stimulus involved in sensory perception GO:0050974 1 0.091
mesenchymal stem cell differentiation GO:0072497 8 0.087
cytokine production GO:0001816 247 0.085
post embryonic development GO:0009791 2 0.081
regulation of chondrocyte differentiation GO:0032330 9 0.080
cellular response to endogenous stimulus GO:0071495 336 0.075
negative regulation of chondrocyte differentiation GO:0032331 5 0.075
peptidyl tyrosine phosphorylation GO:0018108 170 0.075
anatomical structure formation involved in morphogenesis GO:0048646 284 0.072
Human
negative regulation of cell differentiation GO:0045596 171 0.072
ossification GO:0001503 121 0.069
cellular response to reactive oxygen species GO:0034614 50 0.065
regulation of mesenchymal stem cell differentiation GO:2000739 6 0.064
cell development GO:0048468 328 0.062
Human
osteoblast differentiation GO:0001649 92 0.062
reactive oxygen species metabolic process GO:0072593 75 0.062
detection of mechanical stimulus GO:0050982 4 0.060
regulation of locomotion GO:0040012 329 0.057
cellular response to nitrogen compound GO:1901699 144 0.057
regulation of mesenchymal stem cell proliferation GO:1902460 1 0.056
negative regulation of cartilage development GO:0061037 5 0.056
cellular response to oxygen radical GO:0071450 6 0.056
regeneration GO:0031099 4 0.055
soft palate development GO:0060023 3 0.052
protein oligomerization GO:0051259 173 0.052
chondrocyte differentiation GO:0002062 17 0.051
morphogenesis of embryonic epithelium GO:0016331 4 0.050
regulation of anatomical structure morphogenesis GO:0022603 286 0.050
regulation of response to oxidative stress GO:1902882 26 0.048
sensory perception of light stimulus GO:0050953 35 0.048
negative regulation of protein metabolic process GO:0051248 391 0.047
rho protein signal transduction GO:0007266 26 0.044
epithelium development GO:0060429 227 0.044
neuromuscular junction development GO:0007528 3 0.042
cell morphogenesis involved in differentiation GO:0000904 144 0.041
Human
negative regulation of phosphate metabolic process GO:0045936 267 0.040
protein heterotrimerization GO:0070208 4 0.040
regulation of cell development GO:0060284 161 0.039
response to oxidative stress GO:0006979 121 0.039
regulation of response to reactive oxygen species GO:1901031 12 0.039
mesenchyme development GO:0060485 59 0.038
Human
negative regulation of protein modification process GO:0031400 200 0.037
tube development GO:0035295 125 0.037
response to inorganic substance GO:0010035 127 0.036
Human
vesicle mediated transport GO:0016192 371 0.036
cellular component morphogenesis GO:0032989 314 0.036
Human
regulation of cell migration GO:0030334 289 0.036
cell substrate adhesion GO:0031589 132 0.035
regulation of stem cell proliferation GO:0072091 15 0.034
positive regulation of cellular component organization GO:0051130 376 0.033
glycoprotein metabolic process GO:0009100 110 0.033
embryonic morphogenesis GO:0048598 85 0.032
response to reactive oxygen species GO:0000302 61 0.032
negative regulation of embryonic development GO:0045992 4 0.031
nervous system development GO:0007399 293 0.030
response to organic cyclic compound GO:0014070 204 0.030
tube morphogenesis GO:0035239 95 0.030
negative regulation of phosphorus metabolic process GO:0010563 267 0.030
neuron projection regeneration GO:0031102 1 0.030
response to organonitrogen compound GO:0010243 156 0.030
negative regulation of gastrulation GO:2000542 4 0.029
collagen metabolic process GO:0032963 28 0.029
negative regulation of endodermal cell differentiation GO:1903225 2 0.029
wound healing GO:0042060 115 0.028
nucleoside catabolic process GO:0009164 408 0.028
actin filament based process GO:0030029 224 0.028
neurogenesis GO:0022008 169 0.028
protein localization to cell surface GO:0034394 28 0.028
mesenchymal cell differentiation GO:0048762 52 0.027
Human
superoxide metabolic process GO:0006801 20 0.027
erbb signaling pathway GO:0038127 44 0.027
response to nitrogen compound GO:1901698 184 0.027
cell projection organization GO:0030030 252 0.027
growth GO:0040007 202 0.026
visual perception GO:0007601 27 0.026
regulation of superoxide metabolic process GO:0090322 6 0.026
endodermal cell differentiation GO:0035987 31 0.026
negative regulation of catalytic activity GO:0043086 335 0.025
female gamete generation GO:0007292 2 0.025
circulatory system development GO:0072359 262 0.025
Human Rat
cell adhesion GO:0007155 325 0.025
cellular amino acid metabolic process GO:0006520 116 0.025
regulation of peptidase activity GO:0052547 180 0.025
cellular response to growth factor stimulus GO:0071363 197 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.025
small gtpase mediated signal transduction GO:0007264 78 0.024
proteoglycan catabolic process GO:0030167 3 0.024
embryonic epithelial tube formation GO:0001838 4 0.024
positive regulation of immune system process GO:0002684 283 0.024
system process GO:0003008 349 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.023
regulation of cell motility GO:2000145 299 0.023
purine nucleotide catabolic process GO:0006195 405 0.023
regulation of muscle cell differentiation GO:0051147 31 0.023
removal of superoxide radicals GO:0019430 6 0.022
blastoderm segmentation GO:0007350 2 0.022
response to lipid GO:0033993 206 0.022
Rat
multicellular organismal aging GO:0010259 3 0.022
determination of adult lifespan GO:0008340 2 0.022
embryonic skeletal joint development GO:0072498 2 0.022
cell projection morphogenesis GO:0048858 129 0.022
multicellular organismal metabolic process GO:0044236 34 0.022
cell fate determination GO:0001709 3 0.022
vasculature development GO:0001944 181 0.022
Human Rat
compound eye development GO:0048749 1 0.022
chromatin modification GO:0016568 298 0.022
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
cellular response to organonitrogen compound GO:0071417 124 0.021
cellular macromolecular complex assembly GO:0034622 324 0.021
nucleotide catabolic process GO:0009166 408 0.021
response to abiotic stimulus GO:0009628 336 0.021
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.021
membrane organization GO:0061024 292 0.021
positive regulation of cell migration GO:0030335 172 0.021
regulation of cellular amine metabolic process GO:0033238 11 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.020
glycosyl compound catabolic process GO:1901658 413 0.020
stem cell proliferation GO:0072089 25 0.020
cellular protein complex assembly GO:0043623 188 0.020
cardiovascular system development GO:0072358 262 0.020
Human Rat
single organism carbohydrate metabolic process GO:0044723 193 0.020
endoderm development GO:0007492 33 0.020
negative regulation of phosphorylation GO:0042326 174 0.020
positive regulation of cellular component movement GO:0051272 181 0.020
basement membrane organization GO:0071711 3 0.020
purine containing compound catabolic process GO:0072523 411 0.020
regulation of endodermal cell differentiation GO:1903224 3 0.019
positive regulation of organelle organization GO:0010638 195 0.019
detection of stimulus GO:0051606 85 0.019
response to wounding GO:0009611 168 0.019
regulation of growth GO:0040008 165 0.019
apoptotic signaling pathway GO:0097190 268 0.019
syncytium formation by plasma membrane fusion GO:0000768 2 0.019
regulation of immune response GO:0050776 201 0.019
ribonucleotide catabolic process GO:0009261 405 0.018
generation of neurons GO:0048699 152 0.018
embryo development GO:0009790 123 0.018
Zebrafish
posttranscriptional regulation of gene expression GO:0010608 213 0.018
cellular macromolecule catabolic process GO:0044265 380 0.018
regulation of myoblast fusion GO:1901739 1 0.018
regulation of wnt signaling pathway GO:0030111 123 0.018
regulation of cellular ketone metabolic process GO:0010565 50 0.018
muscle structure development GO:0061061 98 0.018
cellular ketone metabolic process GO:0042180 80 0.018
sensory perception GO:0007600 103 0.018
ribonucleoside catabolic process GO:0042454 406 0.018
regulation of cell cycle GO:0051726 393 0.018
positive regulation of cell development GO:0010720 92 0.018
myoblast fusion GO:0007520 1 0.017
negative regulation of hydrolase activity GO:0051346 182 0.017
single organism membrane organization GO:0044802 268 0.017
carbohydrate derivative biosynthetic process GO:1901137 207 0.017
cerebellum development GO:0021549 2 0.017
regulation of cell adhesion GO:0030155 166 0.017
cellular response to dna damage stimulus GO:0006974 379 0.017
positive regulation of stem cell proliferation GO:2000648 10 0.017
covalent chromatin modification GO:0016569 254 0.017
Human
neurological system process GO:0050877 163 0.017
organophosphate catabolic process GO:0046434 430 0.017
nucleoside phosphate catabolic process GO:1901292 412 0.017
chondroitin sulfate metabolic process GO:0030204 7 0.017
segmentation GO:0035282 4 0.017
striated muscle cell differentiation GO:0051146 43 0.017
plasma membrane organization GO:0007009 115 0.017
carbohydrate metabolic process GO:0005975 207 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.017
negative regulation of cellular component organization GO:0051129 235 0.017
immune response GO:0006955 307 0.017
amine metabolic process GO:0009308 44 0.016
purine ribonucleoside metabolic process GO:0046128 437 0.016
negative regulation of cell proliferation GO:0008285 228 0.016
regulation of kinase activity GO:0043549 314 0.016
axon regeneration GO:0031103 1 0.016
detection of abiotic stimulus GO:0009582 15 0.016
nucleoside triphosphate metabolic process GO:0009141 422 0.016
response to radiation GO:0009314 151 0.016
primary neural tube formation GO:0014020 3 0.016
ribonucleoside triphosphate catabolic process GO:0009203 391 0.016
endomembrane system organization GO:0010256 196 0.016
positive regulation of cellular catabolic process GO:0031331 284 0.016
positive regulation of lymphocyte activation GO:0051251 73 0.016
purine ribonucleotide catabolic process GO:0009154 404 0.016
sulfur compound metabolic process GO:0006790 101 0.016
response to growth factor GO:0070848 205 0.016
metencephalon development GO:0022037 2 0.015
muscle organ development GO:0007517 56 0.015
protein catabolic process GO:0030163 325 0.015
gastrulation GO:0007369 51 0.015
regulation of cell cycle process GO:0010564 266 0.015
negative regulation of cellular component movement GO:0051271 106 0.015
regulation of nucleotide catabolic process GO:0030811 205 0.015
negative regulation of locomotion GO:0040013 118 0.015
purine nucleoside triphosphate metabolic process GO:0009144 412 0.015
small molecule biosynthetic process GO:0044283 157 0.015
limbic system development GO:0021761 3 0.015
positive regulation of phosphorylation GO:0042327 394 0.015
defense response GO:0006952 315 0.015
regulation of striated muscle cell differentiation GO:0051153 25 0.015
positive regulation of cell death GO:0010942 263 0.015
response to camp GO:0051591 25 0.015
sensory organ development GO:0007423 52 0.015
epidermal growth factor receptor signaling pathway GO:0007173 39 0.014
regulation of cellular component movement GO:0051270 334 0.014
pharynx development GO:0060465 1 0.014
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.014
protein localization to organelle GO:0033365 280 0.014
hindbrain development GO:0030902 3 0.014
digestive tract morphogenesis GO:0048546 56 0.014
mapk cascade GO:0000165 288 0.014
regulation of epithelial to mesenchymal transition GO:0010717 37 0.014
anterior posterior axis specification GO:0009948 2 0.014
multicellular organismal macromolecule metabolic process GO:0044259 29 0.014
cellular response to cytokine stimulus GO:0071345 181 0.014
positive regulation of wnt signaling pathway GO:0030177 54 0.014
ras protein signal transduction GO:0007265 73 0.014
response to axon injury GO:0048678 1 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
negative regulation of proteolysis GO:0045861 132 0.014
cellular response to organic cyclic compound GO:0071407 127 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.014
cell part morphogenesis GO:0032990 137 0.014
negative regulation of cellular protein metabolic process GO:0032269 353 0.014
monocarboxylic acid metabolic process GO:0032787 185 0.014
positive regulation of cellular amine metabolic process GO:0033240 7 0.014
negative regulation of cell adhesion GO:0007162 64 0.014
organonitrogen compound biosynthetic process GO:1901566 200 0.014
purine nucleoside triphosphate catabolic process GO:0009146 392 0.014
regulation of protein localization GO:0032880 296 0.013
nitrogen compound transport GO:0071705 191 0.013
secretion by cell GO:0032940 226 0.013
cell division GO:0051301 168 0.013
blood vessel morphogenesis GO:0048514 162 0.013
Human
multicellular organismal response to stress GO:0033555 1 0.013
positive regulation of keratinocyte migration GO:0051549 4 0.013
regulation of cellular amino acid metabolic process GO:0006521 6 0.013
peripheral nervous system development GO:0007422 2 0.013
positive regulation of locomotion GO:0040017 186 0.013
regulation of ossification GO:0030278 58 0.013
neuroblast proliferation GO:0007405 4 0.013
regulation of cysteine type endopeptidase activity GO:2000116 127 0.013
prostate gland development GO:0030850 3 0.013
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.013
innate immune response GO:0045087 178 0.013
head development GO:0060322 108 0.013
memory GO:0007613 3 0.013
ribonucleoside triphosphate metabolic process GO:0009199 412 0.013
regulation of ras gtpase activity GO:0032318 128 0.013
epithelial cell differentiation GO:0030855 141 0.012
mitotic cell cycle process GO:1903047 286 0.012
regulation of neural precursor cell proliferation GO:2000177 4 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
canonical wnt signaling pathway GO:0060070 116 0.012
neuron differentiation GO:0030182 138 0.012
microtubule based process GO:0007017 210 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
neural tube formation GO:0001841 3 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
response to superoxide GO:0000303 6 0.012
mitotic cell cycle GO:0000278 326 0.012
signal transduction by phosphorylation GO:0023014 297 0.012
regulation of secretion by cell GO:1903530 177 0.012
negative regulation of apoptotic process GO:0043066 316 0.012
cellular amine metabolic process GO:0044106 41 0.012
spermatid differentiation GO:0048515 4 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
negative regulation of peptidase activity GO:0010466 91 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.012
single organismal cell cell adhesion GO:0016337 148 0.012
guanosine containing compound metabolic process GO:1901068 244 0.012
muscle tissue development GO:0060537 62 0.012
nucleoside monophosphate metabolic process GO:0009123 191 0.012
positive regulation of catabolic process GO:0009896 310 0.012
cellular protein catabolic process GO:0044257 261 0.012
proteoglycan metabolic process GO:0006029 29 0.012
negative regulation of programmed cell death GO:0043069 321 0.011
tissue regeneration GO:0042246 3 0.011
organelle assembly GO:0070925 176 0.011
regulation of nervous system development GO:0051960 88 0.011
response to hyperoxia GO:0055093 4 0.011
central nervous system development GO:0007417 123 0.011
glycoprotein biosynthetic process GO:0009101 91 0.011
neuron development GO:0048666 113 0.011
transmembrane transport GO:0055085 399 0.011
tissue morphogenesis GO:0048729 96 0.011
response to oxygen radical GO:0000305 6 0.011
endocytosis GO:0006897 159 0.011
leukocyte activation GO:0045321 164 0.011
intracellular protein transport GO:0006886 270 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
striated muscle tissue development GO:0014706 59 0.011
dephosphorylation GO:0016311 209 0.011
immune system development GO:0002520 195 0.011
locomotory behavior GO:0007626 1 0.011
regulation of protein complex assembly GO:0043254 147 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.011
negative regulation of cell motility GO:2000146 104 0.011
maintenance of location GO:0051235 112 0.011
protein maturation GO:0051604 233 0.011
regulation of vesicle mediated transport GO:0060627 130 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
regulation of nucleotide metabolic process GO:0006140 269 0.011
negative regulation of cell death GO:0060548 345 0.011
regulation of leukocyte activation GO:0002694 115 0.011
nerve development GO:0021675 4 0.011
chondroitin sulfate proteoglycan metabolic process GO:0050654 10 0.011
regulation of cell growth GO:0001558 135 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
oxidation reduction process GO:0055114 396 0.011
Human Mouse
positive regulation of fibroblast migration GO:0010763 3 0.011
regulation of cellular component size GO:0032535 82 0.011
sprouting angiogenesis GO:0002040 29 0.010
Human
organ morphogenesis GO:0009887 147 0.010
cellular response to lipid GO:0071396 127 0.010
regulation of protein processing GO:0070613 150 0.010
biomineral tissue development GO:0031214 39 0.010
hemostasis GO:0007599 76 0.010
platelet activation GO:0030168 44 0.010
alpha amino acid metabolic process GO:1901605 72 0.010
muscle cell differentiation GO:0042692 63 0.010
regulation of cardiac muscle cell membrane potential GO:0086036 1 0.010
purine nucleoside catabolic process GO:0006152 398 0.010
negative regulation of organelle organization GO:0010639 126 0.010
regulation of gtpase activity GO:0043087 180 0.010
regulation of establishment of protein localization GO:0070201 242 0.010
angiogenesis involved in wound healing GO:0060055 4 0.010
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.010
positive regulation of synaptic transmission GO:0050806 4 0.010
cytoplasmic transport GO:0016482 379 0.010
regulation of cell activation GO:0050865 125 0.010
regulation of protein kinase activity GO:0045859 289 0.010
positive regulation of cytokine production GO:0001819 167 0.010
cellular response to nutrient levels GO:0031669 69 0.010
cellular amide metabolic process GO:0043603 69 0.010
negative regulation of transferase activity GO:0051348 124 0.010
actin mediated cell contraction GO:0070252 12 0.010
regulation of lymphocyte activation GO:0051249 103 0.010
cellular carbohydrate metabolic process GO:0044262 84 0.010
positive regulation of myotube differentiation GO:0010831 3 0.010
regulation of purine nucleotide metabolic process GO:1900542 264 0.010
ameboidal type cell migration GO:0001667 135 0.010
Human

LOXL1 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.671
eye and adnexa disease DOID:1492 150 0.671
nervous system disease DOID:863 431 0.671
eye disease DOID:5614 149 0.671
musculoskeletal system disease DOID:17 223 0.552
retinal disease DOID:5679 118 0.535
retinal degeneration DOID:8466 89 0.421
degeneration of macula and posterior pole DOID:2007 17 0.421
macular degeneration DOID:4448 20 0.421
age related macular degeneration DOID:10871 17 0.421
connective tissue disease DOID:65 109 0.225
muscular disease DOID:0080000 114 0.213
muscle tissue disease DOID:66 113 0.162
myopathy DOID:423 104 0.159
congenital muscular dystrophy DOID:0050557 22 0.159
muscular dystrophy DOID:9884 51 0.159
bone development disease DOID:0080006 55 0.038
bone disease DOID:0080001 88 0.038
osteochondrodysplasia DOID:2256 35 0.025
osteogenesis imperfecta DOID:12347 13 0.016
collagen disease DOID:854 9 0.014
ehlers danlos syndrome DOID:13359 9 0.014
central nervous system disease DOID:331 186 0.014
neurodegenerative disease DOID:1289 102 0.014
cardiovascular system disease DOID:1287 106 0.011
glaucoma DOID:1686 8 0.008
uveal disease DOID:3480 4 0.001