Homo sapiens

0 known processes

NGEF

neuronal guanine nucleotide exchange factor

(Aliases: EPHEXIN,ARHGEF27)

NGEF biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organophosphate catabolic process GO:0046434 430 0.116
Human Mouse Rat
ribonucleoside triphosphate metabolic process GO:0009199 412 0.108
Human Mouse Rat
regulation of gtpase activity GO:0043087 180 0.104
Human Mouse Rat
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.101
Human Mouse Rat
purine nucleoside triphosphate catabolic process GO:0009146 392 0.092
Human Mouse Rat
regulation of nucleotide metabolic process GO:0006140 269 0.091
Human Mouse Rat
glycosyl compound catabolic process GO:1901658 413 0.089
Human Mouse Rat
gtp catabolic process GO:0006184 237 0.086
Human Mouse Rat
purine ribonucleotide catabolic process GO:0009154 404 0.079
Human Mouse Rat
gtp metabolic process GO:0046039 239 0.077
Human Mouse Rat
purine ribonucleoside metabolic process GO:0046128 437 0.076
Human Mouse Rat
regulation of purine nucleotide metabolic process GO:1900542 264 0.069
Human Mouse Rat
ribonucleotide catabolic process GO:0009261 405 0.060
Human Mouse Rat
post embryonic development GO:0009791 2 0.057
nucleotide catabolic process GO:0009166 408 0.055
Human Mouse Rat
positive regulation of nucleotide catabolic process GO:0030813 185 0.054
Human
purine nucleoside catabolic process GO:0006152 398 0.053
Human Mouse Rat
rho protein signal transduction GO:0007266 26 0.051
guanosine containing compound catabolic process GO:1901069 239 0.051
Human Mouse Rat
regulation of nucleotide catabolic process GO:0030811 205 0.049
Human Mouse Rat
cellular amino acid metabolic process GO:0006520 116 0.047
nucleoside triphosphate catabolic process GO:0009143 394 0.047
Human Mouse Rat
regulation of cellular ketone metabolic process GO:0010565 50 0.046
ribonucleoside catabolic process GO:0042454 406 0.045
Human Mouse Rat
positive regulation of hydrolase activity GO:0051345 331 0.043
Human
positive regulation of catabolic process GO:0009896 310 0.042
Human
nucleoside catabolic process GO:0009164 408 0.042
Human Mouse Rat
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.042
Human Mouse Rat
positive regulation of protein phosphorylation GO:0001934 313 0.041
nucleoside phosphate catabolic process GO:1901292 412 0.039
Human Mouse Rat
nucleoside triphosphate metabolic process GO:0009141 422 0.039
Human Mouse Rat
positive regulation of ras gtpase activity GO:0032320 117 0.038
Human
neuromuscular junction development GO:0007528 3 0.038
regulation of nucleoside metabolic process GO:0009118 209 0.037
Human Mouse Rat
response to increased oxygen levels GO:0036296 4 0.037
regulation of cell cycle GO:0051726 393 0.037
ribonucleoside triphosphate catabolic process GO:0009203 391 0.037
Human Mouse Rat
small gtpase mediated signal transduction GO:0007264 78 0.037
purine nucleoside triphosphate metabolic process GO:0009144 412 0.035
Human Mouse Rat
regulation of ras gtpase activity GO:0032318 128 0.035
Human
negative regulation of catalytic activity GO:0043086 335 0.034
regeneration GO:0031099 4 0.033
positive regulation of nucleoside metabolic process GO:0045979 186 0.033
Human
immune response GO:0006955 307 0.032
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.032
positive regulation of gtp catabolic process GO:0033126 166 0.032
Human
transmembrane transport GO:0055085 399 0.032
regulation of cellular amine metabolic process GO:0033238 11 0.032
positive regulation of gtpase activity GO:0043547 166 0.032
Human
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.031
Human
regulation of cytoskeleton organization GO:0051493 177 0.031
Human
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.030
Human
anterior posterior axis specification embryo GO:0008595 2 0.030
lipid metabolic process GO:0006629 381 0.030
inner ear morphogenesis GO:0042472 4 0.029
amine metabolic process GO:0009308 44 0.029
cellular ketone metabolic process GO:0042180 80 0.029
purine containing compound catabolic process GO:0072523 411 0.029
Human Mouse Rat
regulation of actin filament based process GO:0032970 141 0.029
Human
cell adhesion GO:0007155 325 0.028
regulation of small gtpase mediated signal transduction GO:0051056 156 0.027
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.027
purine nucleotide catabolic process GO:0006195 405 0.026
Human Mouse Rat
anterior posterior axis specification GO:0009948 2 0.026
cellular amine metabolic process GO:0044106 41 0.026
regulation of protein localization GO:0032880 296 0.026
Human
regulation of actin cytoskeleton organization GO:0032956 116 0.026
Human
biological adhesion GO:0022610 331 0.025
regulation of ras protein signal transduction GO:0046578 155 0.024
Human
protein maturation GO:0051604 233 0.024
spermatid differentiation GO:0048515 4 0.024
regulation of actin filament polymerization GO:0030833 50 0.024
regulation of purine nucleotide catabolic process GO:0033121 205 0.024
Human Mouse Rat
regulation of cellular amino acid metabolic process GO:0006521 6 0.023
positive regulation of kinase activity GO:0033674 204 0.023
epithelium development GO:0060429 227 0.023
positive regulation of cellular catabolic process GO:0031331 284 0.023
Human
ras protein signal transduction GO:0007265 73 0.023
positive regulation of developmental process GO:0051094 314 0.023
cytoplasmic transport GO:0016482 379 0.023
system process GO:0003008 349 0.023
purine ribonucleoside catabolic process GO:0046130 398 0.023
Human Mouse Rat
microtubule cytoskeleton organization GO:0000226 176 0.023
positive regulation of cellular component organization GO:0051130 376 0.023
Human
positive regulation of protein kinase activity GO:0045860 190 0.022
response to oxygen containing compound GO:1901700 369 0.022
mitotic cell cycle GO:0000278 326 0.022
protein localization to organelle GO:0033365 280 0.022
regulation of establishment of protein localization GO:0070201 242 0.022
Human
positive regulation of nucleotide metabolic process GO:0045981 230 0.022
Human
actin filament based process GO:0030029 224 0.022
Human
regulation of transferase activity GO:0051338 355 0.022
microtubule based process GO:0007017 210 0.021
regulation of rho gtpase activity GO:0032319 66 0.021
Human
protein processing GO:0016485 226 0.021
single organism cellular localization GO:1902580 332 0.021
Human
cellular macromolecule catabolic process GO:0044265 380 0.021
actin filament organization GO:0007015 128 0.020
cdc42 protein signal transduction GO:0032488 4 0.020
cellular lipid metabolic process GO:0044255 303 0.020
defense response GO:0006952 315 0.020
small molecule biosynthetic process GO:0044283 157 0.020
mitochondrion organization GO:0007005 156 0.020
single organism carbohydrate metabolic process GO:0044723 193 0.020
tripartite regional subdivision GO:0007351 2 0.020
morphogenesis of embryonic epithelium GO:0016331 4 0.020
negative regulation of hydrolase activity GO:0051346 182 0.020
cerebral cortex cell migration GO:0021795 3 0.020
actin cytoskeleton organization GO:0030036 207 0.019
Human
regulation of cellular component biogenesis GO:0044087 281 0.019
innate immune response GO:0045087 178 0.019
cellular protein catabolic process GO:0044257 261 0.019
organonitrogen compound biosynthetic process GO:1901566 200 0.019
locomotory behavior GO:0007626 1 0.019
oogenesis GO:0048477 2 0.019
regulation of apoptotic signaling pathway GO:2001233 175 0.019
dna repair GO:0006281 198 0.019
cellular response to growth factor stimulus GO:0071363 197 0.018
positive regulation of cellular amine metabolic process GO:0033240 7 0.018
regulation of cell adhesion GO:0030155 166 0.018
regulation of growth GO:0040008 165 0.018
blastocyst development GO:0001824 3 0.018
compound eye development GO:0048749 1 0.018
apoptotic signaling pathway GO:0097190 268 0.018
positive regulation of phosphorylation GO:0042327 394 0.018
regulation of protein transport GO:0051223 213 0.018
regulation of kinase activity GO:0043549 314 0.018
protein ubiquitination GO:0016567 314 0.018
establishment of tissue polarity GO:0007164 3 0.018
positive regulation of organelle organization GO:0010638 195 0.018
embryonic epithelial tube formation GO:0001838 4 0.018
regulation of protein complex assembly GO:0043254 147 0.018
regulation of protein processing GO:0070613 150 0.018
forebrain generation of neurons GO:0021872 3 0.018
inorganic cation transmembrane transport GO:0098662 194 0.018
nucleocytoplasmic transport GO:0006913 176 0.017
regulation of protein kinase activity GO:0045859 289 0.017
negative regulation of cell proliferation GO:0008285 228 0.017
mating GO:0007618 1 0.017
regulation of protein serine threonine kinase activity GO:0071900 179 0.017
regulation of intracellular transport GO:0032386 195 0.017
dephosphorylation GO:0016311 209 0.017
regulation of protein polymerization GO:0032271 63 0.017
cellular response to endogenous stimulus GO:0071495 336 0.017
central nervous system development GO:0007417 123 0.017
regulation of actin polymerization or depolymerization GO:0008064 56 0.017
stem cell division GO:0017145 2 0.017
regulation of cell cycle process GO:0010564 266 0.016
vesicle mediated transport GO:0016192 371 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.016
establishment of planar polarity GO:0001736 3 0.016
negative regulation of cellular protein metabolic process GO:0032269 353 0.016
regulation of protein maturation GO:1903317 150 0.016
ribonucleoside monophosphate catabolic process GO:0009158 158 0.016
segmentation GO:0035282 4 0.016
positive regulation of transferase activity GO:0051347 227 0.016
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.016
nuclear transport GO:0051169 179 0.016
rhythmic behavior GO:0007622 2 0.016
positive regulation of protein complex assembly GO:0031334 86 0.016
positive regulation of cellular component biogenesis GO:0044089 158 0.016
negative regulation of protein processing GO:0010955 142 0.016
hindbrain development GO:0030902 3 0.015
regulation of multi organism process GO:0043900 157 0.015
memory GO:0007613 3 0.015
response to growth factor GO:0070848 205 0.015
inorganic ion transmembrane transport GO:0098660 231 0.015
mitotic cell cycle process GO:1903047 286 0.015
dna replication GO:0006260 116 0.015
actin mediated cell contraction GO:0070252 12 0.015
atp metabolic process GO:0046034 176 0.015
regulation of endopeptidase activity GO:0052548 170 0.015
blastoderm segmentation GO:0007350 2 0.015
negative regulation of proteolysis GO:0045861 132 0.015
negative regulation of phosphate metabolic process GO:0045936 267 0.014
viral process GO:0016032 146 0.014
anion transport GO:0006820 161 0.014
regulation of proteolysis GO:0030162 293 0.014
tissue regeneration GO:0042246 3 0.014
ion homeostasis GO:0050801 230 0.014
viral life cycle GO:0019058 132 0.014
mitotic spindle elongation GO:0000022 4 0.014
guanosine containing compound metabolic process GO:1901068 244 0.014
Human Mouse Rat
intracellular mrna localization GO:0008298 1 0.014
semaphorin plexin signaling pathway GO:0071526 4 0.014
multi organism cellular process GO:0044764 156 0.014
cation transport GO:0006812 331 0.014
female gamete generation GO:0007292 2 0.014
nervous system development GO:0007399 293 0.014
Mouse Rat
extrinsic apoptotic signaling pathway GO:0097191 119 0.014
regulation of cellular response to stress GO:0080135 244 0.014
monocarboxylic acid metabolic process GO:0032787 185 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
protein catabolic process GO:0030163 325 0.014
post embryonic organ development GO:0048569 1 0.013
regulation of gtp catabolic process GO:0033124 180 0.013
Human Mouse Rat
organ formation GO:0048645 3 0.013
response to abiotic stimulus GO:0009628 336 0.013
establishment of protein localization to membrane GO:0090150 121 0.013
Human
single organism cell adhesion GO:0098602 179 0.013
regulation of response to external stimulus GO:0032101 222 0.013
salivary gland morphogenesis GO:0007435 4 0.013
regulation of cell cell adhesion GO:0022407 57 0.013
neurological system process GO:0050877 163 0.013
ribonucleoprotein complex assembly GO:0022618 78 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
divalent metal ion transport GO:0070838 152 0.013
spermatid development GO:0007286 4 0.013
negative regulation of programmed cell death GO:0043069 321 0.013
negative regulation of cellular amine metabolic process GO:0033239 3 0.013
spindle elongation GO:0051231 4 0.013
interspecies interaction between organisms GO:0044419 156 0.013
cellular response to dna damage stimulus GO:0006974 379 0.013
cell projection organization GO:0030030 252 0.013
Mouse Rat
positive regulation of apoptotic signaling pathway GO:2001235 70 0.013
single organismal cell cell adhesion GO:0016337 148 0.013
regulation of intracellular protein transport GO:0033157 123 0.013
nitrogen compound transport GO:0071705 191 0.013
metencephalon development GO:0022037 2 0.013
negative regulation of protein maturation GO:1903318 142 0.013
positive regulation of synaptic transmission GO:0050806 4 0.013
determination of adult lifespan GO:0008340 2 0.013
positive regulation of programmed cell death GO:0043068 249 0.013
positive regulation of protein transport GO:0051222 135 0.013
forebrain neuron development GO:0021884 2 0.013
regulation of actin filament length GO:0030832 56 0.013
protein localization to nucleus GO:0034504 136 0.013
protein targeting GO:0006605 187 0.013
signal transduction by phosphorylation GO:0023014 297 0.012
myoblast fusion GO:0007520 1 0.012
protein modification by small protein conjugation GO:0032446 342 0.012
actin polymerization or depolymerization GO:0008154 56 0.012
taxis GO:0042330 157 0.012
Human
single organism reproductive process GO:0044702 98 0.012
cell division GO:0051301 168 0.012
growth GO:0040007 202 0.012
intracellular protein transport GO:0006886 270 0.012
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.012
positive regulation of transport GO:0051050 336 0.012
cardiac muscle cell contraction GO:0086003 4 0.012
cell morphogenesis GO:0000902 296 0.012
Mouse Rat
regulation of mapk cascade GO:0043408 262 0.012
positive regulation of mapk cascade GO:0043410 190 0.012
actin filament polymerization GO:0030041 45 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
response to axon injury GO:0048678 1 0.012
regulation of anatomical structure size GO:0090066 101 0.012
negative regulation of protein metabolic process GO:0051248 391 0.012
oocyte development GO:0048599 1 0.012
regulation of peptidase activity GO:0052547 180 0.012
rna interference GO:0016246 4 0.012
negative regulation of cell death GO:0060548 345 0.012
negative regulation of apoptotic process GO:0043066 316 0.012
regulation of synaptic plasticity GO:0048167 3 0.012
circadian behavior GO:0048512 2 0.012
protein polymerization GO:0051258 71 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
negative regulation of multicellular organismal process GO:0051241 317 0.012
Mouse Rat
negative regulation of endopeptidase activity GO:0010951 84 0.012
organic acid biosynthetic process GO:0016053 97 0.011
cation transmembrane transport GO:0098655 238 0.011
response to nitrogen compound GO:1901698 184 0.011
peripheral nervous system development GO:0007422 2 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
Mouse Rat
rab protein signal transduction GO:0032482 4 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.011
lipid biosynthetic process GO:0008610 177 0.011
nuclear import GO:0051170 106 0.011
cell projection assembly GO:0030031 126 0.011
neural tube formation GO:0001841 3 0.011
g protein coupled receptor signaling pathway GO:0007186 207 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
negative regulation of phosphatase activity GO:0010923 61 0.011
carbohydrate derivative biosynthetic process GO:1901137 207 0.011
regulation of mitotic cell cycle GO:0007346 189 0.011
protein oligomerization GO:0051259 173 0.011
maintenance of location GO:0051235 112 0.011
oocyte differentiation GO:0009994 2 0.011
cochlea development GO:0090102 1 0.011
mapk cascade GO:0000165 288 0.011
modification dependent protein catabolic process GO:0019941 209 0.011
organelle fission GO:0048285 149 0.011
metal ion transport GO:0030001 272 0.011
neural crest cell development GO:0014032 3 0.011
cuticle development GO:0042335 1 0.011
cellular response to abiotic stimulus GO:0071214 117 0.011
regulation of rho protein signal transduction GO:0035023 79 0.011
Human
endocytosis GO:0006897 159 0.011
nerve development GO:0021675 4 0.011
negative regulation of cell cycle GO:0045786 193 0.011
ion transmembrane transport GO:0034220 338 0.011
motor neuron axon guidance GO:0008045 2 0.011
adult locomotory behavior GO:0008344 1 0.011
skin development GO:0043588 76 0.011
endomembrane system organization GO:0010256 196 0.011
Human
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.011
single organism membrane organization GO:0044802 268 0.010
Human
epidermis morphogenesis GO:0048730 3 0.010
actin filament based movement GO:0030048 17 0.010
regulation of cellular component size GO:0032535 82 0.010
positive regulation of immune system process GO:0002684 283 0.010
carboxylic acid biosynthetic process GO:0046394 97 0.010
negative regulation of peptidase activity GO:0010466 91 0.010
negative regulation of growth GO:0045926 97 0.010
cerebellum development GO:0021549 2 0.010
positive regulation of map kinase activity GO:0043406 80 0.010
negative regulation of epidermal cell differentiation GO:0045605 4 0.010
regulation of protein targeting GO:1903533 91 0.010
rna localization GO:0006403 41 0.010
regulation of cell differentiation GO:0045595 393 0.010
Mouse Rat
mitotic nuclear division GO:0007067 119 0.010
positive regulation of rho gtpase activity GO:0032321 56 0.010
Human
regulation of phosphatase activity GO:0010921 81 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.010
protein targeting to nucleus GO:0044744 104 0.010
specification of organ identity GO:0010092 3 0.010
primary neural tube formation GO:0014020 3 0.010
sensory perception of pain GO:0019233 4 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.010
regulation of cell division GO:0051302 116 0.010
regulation of viral process GO:0050792 103 0.010
response to fungus GO:0009620 4 0.010
non canonical wnt signaling pathway via mapk cascade GO:0038030 4 0.010

NGEF disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.023
central nervous system disease DOID:331 186 0.022
nervous system disease DOID:863 431 0.022
musculoskeletal system disease DOID:17 223 0.017
urinary system disease DOID:18 40 0.016
connective tissue disease DOID:65 109 0.015
sensory system disease DOID:0050155 203 0.015
cancer DOID:162 167 0.014
disease of cellular proliferation DOID:14566 174 0.014
organ system cancer DOID:0050686 164 0.014
inherited metabolic disorder DOID:655 242 0.013
kidney disease DOID:557 36 0.011
bone disease DOID:0080001 88 0.011
eye and adnexa disease DOID:1492 150 0.011
retinal disease DOID:5679 118 0.011
retinal degeneration DOID:8466 89 0.011
eye disease DOID:5614 149 0.011
brain disease DOID:936 73 0.010