Homo sapiens

73 known processes

GAA

glucosidase, alpha; acid

(Aliases: LYAG)

GAA biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
epithelium development GO:0060429 227 0.148
negative regulation of multicellular organismal metabolic process GO:0044252 3 0.142
cellular amino acid metabolic process GO:0006520 116 0.135
cellular amine metabolic process GO:0044106 41 0.129
multicellular organismal homeostasis GO:0048871 67 0.104
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.100
multicellular organismal aging GO:0010259 3 0.098
urogenital system development GO:0001655 65 0.097
proteasomal protein catabolic process GO:0010498 176 0.096
anatomical structure homeostasis GO:0060249 100 0.090
Mouse
positive regulation of cellular amine metabolic process GO:0033240 7 0.089
regulation of cellular ketone metabolic process GO:0010565 50 0.084
cellular macromolecule catabolic process GO:0044265 380 0.083
cellular ketone metabolic process GO:0042180 80 0.077
positive regulation of epithelial cell proliferation GO:0050679 65 0.076
monosaccharide metabolic process GO:0005996 74 0.075
lipid metabolic process GO:0006629 381 0.073
defense response GO:0006952 315 0.073
amine metabolic process GO:0009308 44 0.071
regulation of cellular amine metabolic process GO:0033238 11 0.069
epithelial cell proliferation GO:0050673 128 0.067
regulation of cellular amino acid metabolic process GO:0006521 6 0.064
neurological system process GO:0050877 163 0.064
Mouse
cell development GO:0048468 328 0.062
determination of adult lifespan GO:0008340 2 0.059
positive regulation of developmental process GO:0051094 314 0.056
regulation of lipid metabolic process GO:0019216 96 0.055
response to hormone GO:0009725 175 0.055
circulatory system development GO:0072359 262 0.051
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.051
protein localization to organelle GO:0033365 280 0.051
cell morphogenesis GO:0000902 296 0.049
response to oxygen containing compound GO:1901700 369 0.048
negative regulation of elastin catabolic process GO:0060311 1 0.048
antigen processing and presentation GO:0019882 33 0.048
regulation of epithelial cell proliferation GO:0050678 113 0.048
post embryonic development GO:0009791 2 0.047
hexose metabolic process GO:0019318 55 0.046
regulation of transferase activity GO:0051338 355 0.046
neuron projection regeneration GO:0031102 1 0.046
protein processing GO:0016485 226 0.045
head development GO:0060322 108 0.044
immune response GO:0006955 307 0.044
negative regulation of developmental process GO:0051093 247 0.044
regulation of cell differentiation GO:0045595 393 0.044
signal transduction by phosphorylation GO:0023014 297 0.043
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.043
positive regulation of mapk cascade GO:0043410 190 0.043
negative regulation of cellular protein metabolic process GO:0032269 353 0.042
regulation of elastin catabolic process GO:0060310 1 0.042
positive regulation of cell differentiation GO:0045597 211 0.042
regulation of mapk cascade GO:0043408 262 0.041
system process GO:0003008 349 0.041
negative regulation of collagen catabolic process GO:0010711 1 0.041
transmembrane transport GO:0055085 399 0.040
membrane organization GO:0061024 292 0.040
positive regulation of cellular component organization GO:0051130 376 0.040
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.040
cell projection organization GO:0030030 252 0.038
cellular lipid metabolic process GO:0044255 303 0.038
protein maturation GO:0051604 233 0.036
cellular component morphogenesis GO:0032989 314 0.036
organic hydroxy compound transport GO:0015850 63 0.036
positive regulation of cytokine production GO:0001819 167 0.036
response to biotic stimulus GO:0009607 276 0.035
elastin catabolic process GO:0060309 1 0.035
negative regulation of blood vessel remodeling GO:0060313 1 0.035
negative regulation of multicellular organismal process GO:0051241 317 0.035
regulation of cellular response to stress GO:0080135 244 0.035
single organism membrane organization GO:0044802 268 0.035
regulation of secretion GO:0051046 194 0.034
response to wounding GO:0009611 168 0.034
carbohydrate metabolic process GO:0005975 207 0.033
negative regulation of proteolysis GO:0045861 132 0.033
negative regulation of catalytic activity GO:0043086 335 0.033
regulation of blood vessel remodeling GO:0060312 2 0.033
peptidyl tyrosine phosphorylation GO:0018108 170 0.033
negative regulation of cell death GO:0060548 345 0.032
nervous system development GO:0007399 293 0.031
negative regulation of protein maturation GO:1903318 142 0.031
detection of chemical stimulus GO:0009593 55 0.031
regulation of blood pressure GO:0008217 30 0.031
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.031
sensory perception of bitter taste GO:0050913 28 0.030
protein catabolic process GO:0030163 325 0.030
regulation of cell motility GO:2000145 299 0.030
lipid biosynthetic process GO:0008610 177 0.029
positive regulation of cell proliferation GO:0008284 301 0.029
positive regulation of protein phosphorylation GO:0001934 313 0.029
cellular amide metabolic process GO:0043603 69 0.029
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 22 0.029
single organism cellular localization GO:1902580 332 0.028
carbohydrate derivative biosynthetic process GO:1901137 207 0.028
regulation of hormone levels GO:0010817 125 0.028
regulation of anatomical structure morphogenesis GO:0022603 286 0.028
regulation of protein processing GO:0070613 150 0.028
cellular response to reactive oxygen species GO:0034614 50 0.027
organonitrogen compound biosynthetic process GO:1901566 200 0.027
actin filament based process GO:0030029 224 0.027
positive regulation of phosphorylation GO:0042327 394 0.027
regulation of protein maturation GO:1903317 150 0.027
protein modification by small protein conjugation GO:0032446 342 0.027
regulation of oxidative stress induced cell death GO:1903201 24 0.026
cellular protein catabolic process GO:0044257 261 0.026
response to lipid GO:0033993 206 0.026
single organism carbohydrate metabolic process GO:0044723 193 0.026
negative regulation of phosphorus metabolic process GO:0010563 267 0.025
mapk cascade GO:0000165 288 0.025
positive regulation of kinase activity GO:0033674 204 0.025
memory GO:0007613 3 0.025
negative regulation of hydrolase activity GO:0051346 182 0.025
sleep GO:0030431 2 0.024
intracellular protein transport GO:0006886 270 0.024
protein targeting GO:0006605 187 0.024
regulation of purine nucleotide metabolic process GO:1900542 264 0.024
regeneration GO:0031099 4 0.024
metal ion transport GO:0030001 272 0.024
alcohol metabolic process GO:0006066 114 0.024
organophosphate biosynthetic process GO:0090407 163 0.024
positive regulation of transferase activity GO:0051347 227 0.023
tube development GO:0035295 125 0.023
regulation of protein kinase activity GO:0045859 289 0.023
regulation of peptidase activity GO:0052547 180 0.023
cellular homeostasis GO:0019725 196 0.023
Mouse
secretion GO:0046903 254 0.023
regulation of kinase activity GO:0043549 314 0.022
anatomical structure formation involved in morphogenesis GO:0048646 284 0.022
central nervous system development GO:0007417 123 0.022
segmentation GO:0035282 4 0.022
chromatin organization GO:0006325 351 0.022
cell projection morphogenesis GO:0048858 129 0.022
cell growth GO:0016049 160 0.022
prostate gland development GO:0030850 3 0.022
ubiquitin dependent protein catabolic process GO:0006511 206 0.022
cellular response to growth factor stimulus GO:0071363 197 0.022
regulation of cellular component movement GO:0051270 334 0.022
vacuole organization GO:0007033 44 0.021
lymphocyte activation GO:0046649 133 0.021
regulation of establishment of protein localization GO:0070201 242 0.021
neuromuscular junction development GO:0007528 3 0.021
modification dependent macromolecule catabolic process GO:0043632 212 0.021
ossification GO:0001503 121 0.021
cell activation GO:0001775 213 0.021
regulation of defense response GO:0031347 154 0.021
lipid transport GO:0006869 90 0.021
negative regulation of peptidase activity GO:0010466 91 0.021
positive regulation of transport GO:0051050 336 0.021
regulation of endopeptidase activity GO:0052548 170 0.020
generation of neurons GO:0048699 152 0.020
rhythmic behavior GO:0007622 2 0.020
renal system development GO:0072001 63 0.020
organic hydroxy compound metabolic process GO:1901615 147 0.020
response to abiotic stimulus GO:0009628 336 0.020
peptidyl tyrosine modification GO:0018212 170 0.020
negative regulation of cellular component organization GO:0051129 235 0.020
innate immune response GO:0045087 178 0.020
chemotaxis GO:0006935 157 0.019
response to axon injury GO:0048678 1 0.019
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
sulfur compound metabolic process GO:0006790 101 0.019
regulation of proteolysis GO:0030162 293 0.019
cellular component disassembly GO:0022411 92 0.019
secretion by cell GO:0032940 226 0.019
sensory perception of chemical stimulus GO:0007606 38 0.019
monocarboxylic acid metabolic process GO:0032787 185 0.019
negative regulation of protein processing GO:0010955 142 0.019
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.019
cytoplasmic transport GO:0016482 379 0.019
cellular response to oxidative stress GO:0034599 85 0.019
cell division GO:0051301 168 0.019
camp metabolic process GO:0046058 61 0.019
ion homeostasis GO:0050801 230 0.019
negative regulation of protein phosphorylation GO:0001933 140 0.018
positive regulation of organelle organization GO:0010638 195 0.018
neuron projection development GO:0031175 106 0.018
epithelial cell differentiation GO:0030855 141 0.018
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.018
positive regulation of bone resorption GO:0045780 2 0.018
regulation of locomotion GO:0040012 329 0.018
cellular carbohydrate metabolic process GO:0044262 84 0.018
negative regulation of protein metabolic process GO:0051248 391 0.018
negative regulation of programmed cell death GO:0043069 321 0.018
regulation of vesicle mediated transport GO:0060627 130 0.018
glycerolipid biosynthetic process GO:0045017 51 0.018
neurogenesis GO:0022008 169 0.018
response to oxidative stress GO:0006979 121 0.018
cellular response to organic cyclic compound GO:0071407 127 0.018
glycerolipid metabolic process GO:0046486 107 0.018
negative regulation of cellular response to oxidative stress GO:1900408 18 0.018
response to hydrogen peroxide GO:0042542 40 0.018
regulation of cell migration GO:0030334 289 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.018
chemical homeostasis GO:0048878 306 0.018
positive regulation of cell motility GO:2000147 177 0.017
regulation of nucleotide metabolic process GO:0006140 269 0.017
peptidyl lysine modification GO:0018205 144 0.017
modification dependent protein catabolic process GO:0019941 209 0.017
regulation of erk1 and erk2 cascade GO:0070372 99 0.017
regulation of immune response GO:0050776 201 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.017
positive regulation of locomotion GO:0040017 186 0.017
pharynx development GO:0060465 1 0.017
response to reactive oxygen species GO:0000302 61 0.017
response to external biotic stimulus GO:0043207 261 0.017
cell adhesion GO:0007155 325 0.017
eye development GO:0001654 42 0.017
regulation of protein catabolic process GO:0042176 155 0.017
hematopoietic or lymphoid organ development GO:0048534 186 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
negative regulation of oxidative stress induced cell death GO:1903202 17 0.016
positive regulation of immune response GO:0050778 159 0.016
peripheral nervous system development GO:0007422 2 0.016
stem cell division GO:0017145 2 0.016
regulation of cell cycle process GO:0010564 266 0.016
small gtpase mediated signal transduction GO:0007264 78 0.016
endochondral bone morphogenesis GO:0060350 3 0.016
protein localization to membrane GO:0072657 160 0.016
hindbrain development GO:0030902 3 0.016
cellular response to endogenous stimulus GO:0071495 336 0.016
receptor metabolic process GO:0043112 81 0.016
organelle assembly GO:0070925 176 0.016
cellular response to hydrogen peroxide GO:0070301 37 0.016
response to oxygen levels GO:0070482 100 0.016
cytokine production GO:0001816 247 0.015
oxidation reduction process GO:0055114 396 0.015
cerebral cortex radially oriented cell migration GO:0021799 1 0.015
blastoderm segmentation GO:0007350 2 0.015
reactive oxygen species biosynthetic process GO:1903409 4 0.015
negative regulation of immune system process GO:0002683 136 0.015
leukocyte activation GO:0045321 164 0.015
protein ubiquitination GO:0016567 314 0.015
negative regulation of intracellular signal transduction GO:1902532 183 0.015
g protein coupled receptor signaling pathway GO:0007186 207 0.015
response to decreased oxygen levels GO:0036293 96 0.015
locomotory behavior GO:0007626 1 0.015
Mouse
response to other organism GO:0051707 261 0.015
regulation of intracellular transport GO:0032386 195 0.015
covalent chromatin modification GO:0016569 254 0.014
endothelial cell proliferation GO:0001935 65 0.014
regulation of immune effector process GO:0002697 91 0.014
nitrogen compound transport GO:0071705 191 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
posttranscriptional regulation of gene expression GO:0010608 213 0.014
ion transmembrane transport GO:0034220 338 0.014
glycerophospholipid metabolic process GO:0006650 84 0.014
metencephalon development GO:0022037 2 0.014
regulation of cytokine production GO:0001817 232 0.014
phosphatidylinositol metabolic process GO:0046488 53 0.014
response to bacterium GO:0009617 144 0.014
nuclear transport GO:0051169 179 0.014
glycoprotein metabolic process GO:0009100 110 0.014
mitotic cell cycle GO:0000278 326 0.014
regulation of protein transport GO:0051223 213 0.014
histone modification GO:0016570 251 0.014
regulation of cell activation GO:0050865 125 0.014
neuron differentiation GO:0030182 138 0.014
cellular lipid catabolic process GO:0044242 65 0.014
regulation of response to external stimulus GO:0032101 222 0.014
ribonucleoside catabolic process GO:0042454 406 0.014
cation transport GO:0006812 331 0.014
mannose metabolic process GO:0006013 1 0.014
positive regulation of immune system process GO:0002684 283 0.014
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.014
phospholipid metabolic process GO:0006644 99 0.013
immune system development GO:0002520 195 0.013
taxis GO:0042330 157 0.013
response to organic cyclic compound GO:0014070 204 0.013
response to hypoxia GO:0001666 96 0.013
cdc42 protein signal transduction GO:0032488 4 0.013
cellular protein complex assembly GO:0043623 188 0.013
negative regulation of transferase activity GO:0051348 124 0.013
response to cytokine GO:0034097 232 0.013
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
extracellular matrix disassembly GO:0022617 16 0.013
regulation of cell development GO:0060284 161 0.013
anion transport GO:0006820 161 0.013
negative regulation of cell differentiation GO:0045596 171 0.013
vasculature development GO:0001944 181 0.013
aminoglycan metabolic process GO:0006022 39 0.013
negative regulation of protein kinase activity GO:0006469 98 0.013
activation of protein kinase activity GO:0032147 90 0.013
cell part morphogenesis GO:0032990 137 0.013
regulation of secretion by cell GO:1903530 177 0.013
positive regulation of t cell tolerance induction GO:0002666 2 0.013
negative regulation of catabolic process GO:0009895 104 0.013
growth GO:0040007 202 0.013
blastocyst development GO:0001824 3 0.013
positive regulation of hydrolase activity GO:0051345 331 0.012
regulation of cellular response to growth factor stimulus GO:0090287 76 0.012
positive regulation of protein kinase activity GO:0045860 190 0.012
regulation of dna metabolic process GO:0051052 153 0.012
circadian behavior GO:0048512 2 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.012
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.012
regulation of dendritic cell differentiation GO:2001198 3 0.012
response to starvation GO:0042594 59 0.012
glycoprotein biosynthetic process GO:0009101 91 0.012
retina homeostasis GO:0001895 42 0.012
leukocyte mediated immunity GO:0002443 59 0.012
protein localization to nucleus GO:0034504 136 0.012
gland development GO:0048732 48 0.012
neuron development GO:0048666 113 0.012
regulation of leukocyte activation GO:0002694 115 0.012
neuroblast proliferation GO:0007405 4 0.012
negative regulation of apoptotic process GO:0043066 316 0.012
myeloid cell differentiation GO:0030099 117 0.012
cerebellum development GO:0021549 2 0.012
small molecule catabolic process GO:0044282 92 0.012
circulatory system process GO:0003013 113 0.012
immune response regulating signaling pathway GO:0002764 97 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
negative regulation of response to external stimulus GO:0032102 83 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.012
toxin transport GO:1901998 4 0.012
divalent inorganic cation transport GO:0072511 158 0.012
carboxylic acid catabolic process GO:0046395 71 0.012
regulation of protein localization GO:0032880 296 0.012
cellular response to extracellular stimulus GO:0031668 72 0.012
negative regulation of cellular catabolic process GO:0031330 83 0.012
regulation of lymphocyte mediated immunity GO:0002706 33 0.012
multicellular organismal metabolic process GO:0044236 34 0.011
regulation of neuron differentiation GO:0045664 70 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
glycerophospholipid biosynthetic process GO:0046474 40 0.011
vesicle mediated transport GO:0016192 371 0.011
sensory perception GO:0007600 103 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
cell morphogenesis involved in differentiation GO:0000904 144 0.011
lipid catabolic process GO:0016042 84 0.011
embryo development GO:0009790 123 0.011
tube closure GO:0060606 3 0.011
mucopolysaccharide metabolic process GO:1903510 27 0.011
regulation of angiotensin levels in blood GO:0002002 3 0.011
generation of precursor metabolites and energy GO:0006091 68 0.011
regulation of binding GO:0051098 111 0.011
membrane protein proteolysis GO:0033619 38 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.011
positive regulation of protein transport GO:0051222 135 0.011
regulation of cell cycle GO:0051726 393 0.011
positive regulation of cell migration GO:0030335 172 0.011
mononuclear cell proliferation GO:0032943 71 0.011
lung alveolus development GO:0048286 4 0.011
regulation of systemic arterial blood pressure by hormone GO:0001990 12 0.011
dephosphorylation GO:0016311 209 0.011
epithelial cell migration GO:0010631 119 0.011
angiogenesis GO:0001525 147 0.011
kidney development GO:0001822 53 0.011
cell substrate adhesion GO:0031589 132 0.011
regulation of neuron projection development GO:0010975 57 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
microtubule based process GO:0007017 210 0.011
positive regulation of secretion GO:0051047 116 0.011
cholesterol transport GO:0030301 39 0.011
cell chemotaxis GO:0060326 112 0.011
establishment of protein localization to organelle GO:0072594 172 0.010
lipid localization GO:0010876 106 0.010
macromolecule glycosylation GO:0043413 63 0.010
negative regulation of cell migration GO:0030336 102 0.010
bone remodeling GO:0046849 11 0.010
regulation of cell projection organization GO:0031344 107 0.010
female gamete generation GO:0007292 2 0.010
negative regulation of endopeptidase activity GO:0010951 84 0.010
immune effector process GO:0002252 159 0.010
regulation of endothelial cell proliferation GO:0001936 56 0.010
response to extracellular stimulus GO:0009991 85 0.010
protein import GO:0017038 130 0.010
negative regulation of protein modification process GO:0031400 200 0.010
regulation of protein binding GO:0043393 66 0.010
developmental programmed cell death GO:0010623 3 0.010
detection of stimulus involved in sensory perception GO:0050906 43 0.010
positive regulation of cell projection organization GO:0031346 64 0.010
skeletal system development GO:0001501 79 0.010
carboxylic acid biosynthetic process GO:0046394 97 0.010

GAA disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.952
inherited metabolic disorder DOID:655 242 0.911
lysosomal storage disease DOID:3211 47 0.892
lipid storage disease DOID:9455 28 0.416
central nervous system disease DOID:331 186 0.201
nervous system disease DOID:863 431 0.201
neurodegenerative disease DOID:1289 102 0.058
neuronal ceroid lipofuscinosis DOID:14503 11 0.053
dementia DOID:1307 19 0.043
alzheimer s disease DOID:10652 16 0.043
disease of mental health DOID:150 70 0.043
tauopathy DOID:680 16 0.043
cognitive disorder DOID:1561 29 0.043
retinal disease DOID:5679 118 0.027
retinal degeneration DOID:8466 89 0.027
sensory system disease DOID:0050155 203 0.027
eye and adnexa disease DOID:1492 150 0.027
eye disease DOID:5614 149 0.027
cerebral degeneration DOID:1443 16 0.025
brain disease DOID:936 73 0.025
leukodystrophy DOID:10579 8 0.025
sphingolipidosis DOID:1927 14 0.019
mucopolysaccharidosis DOID:12798 11 0.017
acquired metabolic disease DOID:0060158 58 0.015
developmental disorder of mental health DOID:0060037 29 0.011
cancer DOID:162 167 0.011
disease of cellular proliferation DOID:14566 174 0.011
organ system cancer DOID:0050686 164 0.011
kidney disease DOID:557 36 0.010
urinary system disease DOID:18 40 0.010
carbohydrate metabolic disorder DOID:2978 55 0.004
glycogen storage disease DOID:2747 10 0.002
glycogen metabolism disorder DOID:0050728 10 0.002