Homo sapiens

64 known processes

PLK4

polo-like kinase 4

(Aliases: SAK,STK18)

PLK4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleoside monophosphate metabolic process GO:0009123 191 0.527
chromosome segregation GO:0007059 114 0.498
cell division GO:0051301 168 0.427
mitotic cell cycle GO:0000278 326 0.415
Fly
regulation of cytoskeleton organization GO:0051493 177 0.392
nuclear division GO:0000280 128 0.353
Fly
microtubule cytoskeleton organization GO:0000226 176 0.316
regulation of cell cycle GO:0051726 393 0.308
meiotic chromosome segregation GO:0045132 4 0.293
somatic stem cell division GO:0048103 1 0.278
microtubule based process GO:0007017 210 0.277
centrosome organization GO:0051297 58 0.262
purine nucleotide catabolic process GO:0006195 405 0.245
nucleoside triphosphate metabolic process GO:0009141 422 0.241
mitotic nuclear division GO:0007067 119 0.224
organelle fission GO:0048285 149 0.221
Fly
nucleoside phosphate catabolic process GO:1901292 412 0.220
ribonucleotide catabolic process GO:0009261 405 0.215
microtubule polymerization or depolymerization GO:0031109 37 0.202
mitotic cell cycle process GO:1903047 286 0.176
Fly
microtubule organizing center organization GO:0031023 62 0.169
regulation of cell cycle process GO:0010564 266 0.165
purine nucleoside catabolic process GO:0006152 398 0.149
nucleoside triphosphate catabolic process GO:0009143 394 0.145
dna repair GO:0006281 198 0.138
organophosphate catabolic process GO:0046434 430 0.126
purine nucleoside triphosphate metabolic process GO:0009144 412 0.120
negative regulation of cell cycle process GO:0010948 121 0.120
cellular macromolecular complex assembly GO:0034622 324 0.120
purine nucleoside triphosphate catabolic process GO:0009146 392 0.119
ribonucleoside monophosphate catabolic process GO:0009158 158 0.113
nucleoside monophosphate catabolic process GO:0009125 159 0.111
ribonucleoside triphosphate catabolic process GO:0009203 391 0.110
purine ribonucleotide catabolic process GO:0009154 404 0.106
positive regulation of cell cycle GO:0045787 140 0.101
double strand break repair GO:0006302 101 0.101
regulation of microtubule cytoskeleton organization GO:0070507 61 0.096
regulation of mitotic cell cycle GO:0007346 189 0.095
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.095
ribonucleoside catabolic process GO:0042454 406 0.095
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.091
purine ribonucleoside metabolic process GO:0046128 437 0.089
mitotic cell cycle checkpoint GO:0007093 68 0.089
post embryonic development GO:0009791 2 0.086
nervous system development GO:0007399 293 0.086
cell cycle phase transition GO:0044770 173 0.084
organelle assembly GO:0070925 176 0.083
regeneration GO:0031099 4 0.081
regulation of protein localization GO:0032880 296 0.079
purine containing compound catabolic process GO:0072523 411 0.075
ribonucleoside monophosphate metabolic process GO:0009161 187 0.073
mitotic cell cycle phase transition GO:0044772 162 0.073
cellular macromolecule catabolic process GO:0044265 380 0.073
ribonucleoside triphosphate metabolic process GO:0009199 412 0.071
sister chromatid segregation GO:0000819 54 0.071
neuroblast division GO:0055057 1 0.070
purine ribonucleoside catabolic process GO:0046130 398 0.070
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.069
centrosome cycle GO:0007098 32 0.069
microtubule polymerization GO:0046785 18 0.066
mitotic sister chromatid segregation GO:0000070 53 0.064
nucleoside catabolic process GO:0009164 408 0.062
positive regulation of transferase activity GO:0051347 227 0.060
embryo development GO:0009790 123 0.058
Mouse Fly
positive regulation of protein phosphorylation GO:0001934 313 0.055
glycosyl compound catabolic process GO:1901658 413 0.055
atp catabolic process GO:0006200 157 0.055
protein catabolic process GO:0030163 325 0.053
Fly
dna conformation change GO:0071103 113 0.051
cell cycle checkpoint GO:0000075 117 0.050
negative regulation of cell cycle GO:0045786 193 0.050
stem cell division GO:0017145 2 0.049
dna recombination GO:0006310 77 0.049
double strand break repair via homologous recombination GO:0000724 50 0.049
regulation of protein kinase activity GO:0045859 289 0.048
negative regulation of protein metabolic process GO:0051248 391 0.047
regulation of transferase activity GO:0051338 355 0.047
regulation of cell division GO:0051302 116 0.046
regulation of kinase activity GO:0043549 314 0.046
regulation of protein catabolic process GO:0042176 155 0.045
Fly
regulation of mitotic sister chromatid segregation GO:0033047 27 0.045
regulation of proteasomal protein catabolic process GO:0061136 87 0.044
atp metabolic process GO:0046034 176 0.044
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.043
cytokinesis GO:0000910 96 0.042
regulation of cellular response to stress GO:0080135 244 0.042
neurogenesis GO:0022008 169 0.041
spindle assembly GO:0051225 29 0.040
neuronal stem cell division GO:0036445 1 0.039
mitotic spindle checkpoint GO:0071174 18 0.039
regulation of cell cycle phase transition GO:1901987 126 0.039
purine nucleoside monophosphate metabolic process GO:0009126 186 0.039
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.038
meiosis i GO:0007127 4 0.038
protein modification by small protein conjugation GO:0032446 342 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.036
microtubule anchoring GO:0034453 24 0.035
dna replication GO:0006260 116 0.035
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.035
spindle organization GO:0007051 53 0.035
Fly
meiotic cell cycle GO:0051321 13 0.034
Fly
modification dependent macromolecule catabolic process GO:0043632 212 0.034
cellular protein complex disassembly GO:0043624 36 0.034
maintenance of location GO:0051235 112 0.034
positive regulation of cell cycle process GO:0090068 106 0.034
establishment of organelle localization GO:0051656 59 0.034
regulation of purine nucleotide metabolic process GO:1900542 264 0.034
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.033
modification dependent protein catabolic process GO:0019941 209 0.033
regulation of cellular protein catabolic process GO:1903362 96 0.033
proteasomal protein catabolic process GO:0010498 176 0.032
nucleotide catabolic process GO:0009166 408 0.032
regulation of sister chromatid segregation GO:0033045 27 0.032
anatomical structure homeostasis GO:0060249 100 0.031
protein localization to organelle GO:0033365 280 0.031
regulation of dna metabolic process GO:0051052 153 0.031
positive regulation of kinase activity GO:0033674 204 0.030
asymmetric neuroblast division GO:0055059 1 0.030
chromatin organization GO:0006325 351 0.030
ubiquitin dependent protein catabolic process GO:0006511 206 0.029
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.029
cell development GO:0048468 328 0.029
Fly
protein polymerization GO:0051258 71 0.029
neuroblast proliferation GO:0007405 4 0.029
small gtpase mediated signal transduction GO:0007264 78 0.028
regulation of protein serine threonine kinase activity GO:0071900 179 0.028
cellular component disassembly GO:0022411 92 0.028
neural tube formation GO:0001841 3 0.028
regulation of chromosome segregation GO:0051983 44 0.028
cell fate determination GO:0001709 3 0.028
regulation of mitosis GO:0007088 63 0.028
mitotic spindle organization GO:0007052 27 0.027
Fly
purine nucleoside monophosphate catabolic process GO:0009128 158 0.027
cellular component morphogenesis GO:0032989 314 0.027
Fly
negative regulation of mitotic cell cycle GO:0045930 102 0.027
embryonic epithelial tube formation GO:0001838 4 0.027
cellular response to dna damage stimulus GO:0006974 379 0.027
spindle checkpoint GO:0031577 26 0.027
chromatin modification GO:0016568 298 0.026
dna dependent dna replication GO:0006261 44 0.026
endomembrane system organization GO:0010256 196 0.026
reproduction GO:0000003 63 0.026
Fly
blastocyst development GO:0001824 3 0.026
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.026
regulation of protein processing GO:0070613 150 0.026
growth GO:0040007 202 0.026
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.025
chromosome separation GO:0051304 23 0.025
ras protein signal transduction GO:0007265 73 0.025
protein processing GO:0016485 226 0.025
maintenance of location in cell GO:0051651 62 0.024
negative regulation of apoptotic process GO:0043066 316 0.024
negative regulation of organelle organization GO:0010639 126 0.024
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.024
cellular protein catabolic process GO:0044257 261 0.023
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.023
regulation of response to dna damage stimulus GO:2001020 94 0.023
regulation of establishment of protein localization GO:0070201 242 0.023
regulation of cell differentiation GO:0045595 393 0.023
negative regulation of cellular component organization GO:0051129 235 0.023
negative regulation of sister chromatid segregation GO:0033046 17 0.023
single organism reproductive process GO:0044702 98 0.023
Mouse Fly
protein ubiquitination GO:0016567 314 0.022
single organism cellular localization GO:1902580 332 0.022
cell projection morphogenesis GO:0048858 129 0.022
Fly
negative regulation of programmed cell death GO:0043069 321 0.022
positive regulation of mitotic cell cycle GO:0045931 60 0.022
negative regulation of cellular catabolic process GO:0031330 83 0.022
positive regulation of phosphorylation GO:0042327 394 0.022
regulation of cellular component biogenesis GO:0044087 281 0.022
mitotic sister chromatid separation GO:0051306 18 0.022
regulation of cytoplasmic transport GO:1903649 149 0.022
regulation of nuclear division GO:0051783 65 0.022
regulation of mitotic sister chromatid separation GO:0010965 27 0.021
regulation of proteolysis GO:0030162 293 0.021
mitotic centrosome separation GO:0007100 1 0.021
response to radiation GO:0009314 151 0.021
positive regulation of cell proliferation GO:0008284 301 0.020
regulation of dna repair GO:0006282 47 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
negative regulation of catabolic process GO:0009895 104 0.020
dna packaging GO:0006323 77 0.020
neuron differentiation GO:0030182 138 0.020
positive regulation of cell death GO:0010942 263 0.019
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.019
chromatin assembly or disassembly GO:0006333 78 0.019
negative regulation of cell cycle phase transition GO:1901988 89 0.019
centrosome duplication GO:0051298 28 0.019
negative regulation of intracellular signal transduction GO:1902532 183 0.019
regulation of cellular amino acid metabolic process GO:0006521 6 0.019
positive regulation of apoptotic process GO:0043065 246 0.019
positive regulation of organelle organization GO:0010638 195 0.019
cell part morphogenesis GO:0032990 137 0.019
Fly
positive regulation of cellular catabolic process GO:0031331 284 0.018
oogenesis GO:0048477 2 0.018
regulation of microtubule based process GO:0032886 74 0.018
negative regulation of proteolysis GO:0045861 132 0.018
anatomical structure formation involved in morphogenesis GO:0048646 284 0.018
Fly
positive regulation of neural precursor cell proliferation GO:2000179 2 0.018
positive regulation of dna metabolic process GO:0051054 73 0.017
negative regulation of cell death GO:0060548 345 0.017
regulation of centrosome duplication GO:0010824 14 0.017
regulation of nucleocytoplasmic transport GO:0046822 98 0.017
cellular ketone metabolic process GO:0042180 80 0.017
macromolecular complex disassembly GO:0032984 60 0.017
neural tube closure GO:0001843 3 0.017
intracellular protein transport GO:0006886 270 0.017
histone acetylation GO:0016573 93 0.017
regulation of cellular ketone metabolic process GO:0010565 50 0.017
regulation of nucleotide metabolic process GO:0006140 269 0.016
negative regulation of protein phosphorylation GO:0001933 140 0.016
protein autophosphorylation GO:0046777 123 0.016
Fly
negative regulation of catalytic activity GO:0043086 335 0.016
response to oxidative stress GO:0006979 121 0.016
positive regulation of cellular component organization GO:0051130 376 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.016
reproductive process GO:0022414 106 0.016
Mouse Fly
positive regulation of catabolic process GO:0009896 310 0.015
Fly
epithelium development GO:0060429 227 0.015
cell morphogenesis GO:0000902 296 0.015
Fly
positive regulation of programmed cell death GO:0043068 249 0.015
cellular protein complex assembly GO:0043623 188 0.015
regulation of cellular amine metabolic process GO:0033238 11 0.015
protein import GO:0017038 130 0.015
signal transduction by phosphorylation GO:0023014 297 0.015
sister chromatid cohesion GO:0007062 24 0.015
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.014
maintenance of protein location in cell GO:0032507 56 0.014
negative regulation of meiotic cell cycle GO:0051447 2 0.014
negative regulation of protein processing GO:0010955 142 0.014
negative regulation of transferase activity GO:0051348 124 0.014
regulation of organelle assembly GO:1902115 40 0.014
negative regulation of protein catabolic process GO:0042177 59 0.014
neuron development GO:0048666 113 0.014
centrosome separation GO:0051299 3 0.014
regulation of nucleotide catabolic process GO:0030811 205 0.013
positive regulation of transport GO:0051050 336 0.013
regulation of chromosome organization GO:0033044 103 0.013
internal peptidyl lysine acetylation GO:0018393 97 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
regulation of intracellular transport GO:0032386 195 0.013
primary neural tube formation GO:0014020 3 0.013
axoneme assembly GO:0035082 3 0.013
Fly
attachment of mitotic spindle microtubules to kinetochore GO:0051315 3 0.013
protein polyubiquitination GO:0000209 110 0.013
positive regulation of developmental process GO:0051094 314 0.013
response to abiotic stimulus GO:0009628 336 0.012
regulation of protein transport GO:0051223 213 0.012
regulation of centrosome cycle GO:0046605 15 0.012
cell activation GO:0001775 213 0.012
regulation of mitotic cell cycle phase transition GO:1901990 118 0.012
regulation of dna replication GO:0006275 68 0.012
protein maturation GO:0051604 233 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
positive regulation of nucleotide metabolic process GO:0045981 230 0.012
generation of neurons GO:0048699 152 0.012
positive regulation of gtp catabolic process GO:0033126 166 0.012
cellular response to radiation GO:0071478 65 0.012
cell fate commitment GO:0045165 27 0.012
cilium organization GO:0044782 68 0.012
Fly
negative regulation of protein modification process GO:0031400 200 0.012
recombinational repair GO:0000725 50 0.012
negative regulation of cellular protein catabolic process GO:1903363 38 0.012
organelle localization GO:0051640 84 0.012
cell projection organization GO:0030030 252 0.012
Fly
positive regulation of protein transport GO:0051222 135 0.012
reciprocal dna recombination GO:0035825 4 0.011
negative regulation of protein maturation GO:1903318 142 0.011
reproductive system development GO:0061458 56 0.011
Mouse
tissue regeneration GO:0042246 3 0.011
developmental process involved in reproduction GO:0003006 66 0.011
Mouse Fly
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 30 0.011
spindle assembly involved in mitosis GO:0090307 12 0.011
positive regulation of cytoplasmic transport GO:1903651 82 0.011
cytoplasmic transport GO:0016482 379 0.011
protein targeting GO:0006605 187 0.011
reciprocal meiotic recombination GO:0007131 4 0.010
positive regulation of intracellular transport GO:0032388 104 0.010
regulation of intracellular protein transport GO:0033157 123 0.010
wnt signaling pathway GO:0016055 156 0.010
tissue morphogenesis GO:0048729 96 0.010
determination of adult lifespan GO:0008340 2 0.010
regulation of apoptotic signaling pathway GO:2001233 175 0.010
biological adhesion GO:0022610 331 0.010
embryonic organ development GO:0048568 36 0.010
Mouse
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.010

PLK4 disease predictions

Disease DO term ID Size Probability Func Analog Org
physical disorder DOID:0080015 41 0.048
congenital nervous system abnormality DOID:2490 21 0.048
immune system disease DOID:2914 155 0.023
disease of cellular proliferation DOID:14566 174 0.014