Homo sapiens

64 known processes

ISG20

interferon stimulated exonuclease gene 20kDa

(Aliases: HEM45,CD25)

ISG20 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
defense response GO:0006952 315 0.404
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.379
response to other organism GO:0051707 261 0.293
response to external biotic stimulus GO:0043207 261 0.203
interleukin 4 biosynthetic process GO:0042097 2 0.142
response to biotic stimulus GO:0009607 276 0.132
positive regulation of interleukin 13 production GO:0032736 4 0.128
positive regulation of developmental process GO:0051094 314 0.107
positive regulation of defense response GO:0031349 87 0.101
response to abiotic stimulus GO:0009628 336 0.091
response to virus GO:0009615 126 0.090
positive regulation of interferon beta production GO:0032728 17 0.085
cytoplasmic transport GO:0016482 379 0.084
defense response to other organism GO:0098542 129 0.083
immune response activating signal transduction GO:0002757 90 0.081
chemical homeostasis GO:0048878 306 0.078
positive regulation of immune system process GO:0002684 283 0.078
regulation of immune response GO:0050776 201 0.075
positive regulation of interleukin 4 biosynthetic process GO:0045404 1 0.075
hematopoietic or lymphoid organ development GO:0048534 186 0.073
regulation of cytokine production GO:0001817 232 0.070
viral life cycle GO:0019058 132 0.067
negative regulation of hydrolase activity GO:0051346 182 0.065
purine nucleoside triphosphate catabolic process GO:0009146 392 0.065
positive regulation of cell death GO:0010942 263 0.062
hemopoiesis GO:0030097 180 0.061
immune response GO:0006955 307 0.061
biological adhesion GO:0022610 331 0.059
defense response to virus GO:0051607 71 0.057
negative regulation of apoptotic process GO:0043066 316 0.056
carbohydrate metabolic process GO:0005975 207 0.055
negative regulation of catalytic activity GO:0043086 335 0.055
nucleoside phosphate biosynthetic process GO:1901293 109 0.053
interleukin 13 production GO:0032616 7 0.053
negative regulation of cell death GO:0060548 345 0.052
cellular macromolecule catabolic process GO:0044265 380 0.051
glycosyl compound catabolic process GO:1901658 413 0.050
regulation of apoptotic signaling pathway GO:2001233 175 0.049
post embryonic development GO:0009791 2 0.048
cellular protein catabolic process GO:0044257 261 0.048
determination of adult lifespan GO:0008340 2 0.048
purine containing compound catabolic process GO:0072523 411 0.047
regulation of cell cycle GO:0051726 393 0.046
protein oligomerization GO:0051259 173 0.046
sensory perception of bitter taste GO:0050913 28 0.044
negative regulation of apoptotic signaling pathway GO:2001234 97 0.044
system process GO:0003008 349 0.043
activation of immune response GO:0002253 114 0.042
purine nucleoside triphosphate metabolic process GO:0009144 412 0.041
ribonucleoside triphosphate catabolic process GO:0009203 391 0.041
protein maturation GO:0051604 233 0.040
sensory perception GO:0007600 103 0.039
ribonucleoside triphosphate metabolic process GO:0009199 412 0.039
positive regulation of interleukin 4 production GO:0032753 3 0.039
ion homeostasis GO:0050801 230 0.039
positive regulation of apoptotic process GO:0043065 246 0.039
regulation of cell differentiation GO:0045595 393 0.038
nucleoside phosphate catabolic process GO:1901292 412 0.037
regulation of cell migration GO:0030334 289 0.036
immune system development GO:0002520 195 0.036
regulation of regulatory t cell differentiation GO:0045589 4 0.036
glucose metabolic process GO:0006006 45 0.036
response to cytokine GO:0034097 232 0.035
immune response regulating signaling pathway GO:0002764 97 0.035
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.035
negative regulation of programmed cell death GO:0043069 321 0.034
carbohydrate derivative biosynthetic process GO:1901137 207 0.034
cation transport GO:0006812 331 0.033
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.033
mitochondrion organization GO:0007005 156 0.033
cellular response to cytokine stimulus GO:0071345 181 0.032
extrinsic apoptotic signaling pathway GO:0097191 119 0.032
positive regulation of interferon alpha production GO:0032727 11 0.031
purine nucleotide biosynthetic process GO:0006164 84 0.031
amine metabolic process GO:0009308 44 0.030
cell adhesion GO:0007155 325 0.029
positive regulation of cell differentiation GO:0045597 211 0.029
cellular response to abiotic stimulus GO:0071214 117 0.029
regulation of immune effector process GO:0002697 91 0.029
cellular response to external stimulus GO:0071496 111 0.028
antigen processing and presentation via mhc class ib GO:0002475 3 0.028
negative regulation of protein metabolic process GO:0051248 391 0.028
purine nucleoside catabolic process GO:0006152 398 0.028
purine nucleoside monophosphate catabolic process GO:0009128 158 0.028
nucleoside triphosphate catabolic process GO:0009143 394 0.028
interferon alpha production GO:0032607 11 0.027
nucleotide catabolic process GO:0009166 408 0.027
purine ribonucleotide catabolic process GO:0009154 404 0.027
single organism carbohydrate metabolic process GO:0044723 193 0.027
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.027
response to peptidoglycan GO:0032494 3 0.027
organonitrogen compound biosynthetic process GO:1901566 200 0.027
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.027
ribonucleotide catabolic process GO:0009261 405 0.026
purine nucleotide catabolic process GO:0006195 405 0.026
cellular amine metabolic process GO:0044106 41 0.026
negative regulation of cell cycle GO:0045786 193 0.026
response to bacterium GO:0009617 144 0.026
interspecies interaction between organisms GO:0044419 156 0.025
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.025
nucleoside catabolic process GO:0009164 408 0.024
ribonucleoside catabolic process GO:0042454 406 0.024
regulation of adaptive immune response GO:0002819 33 0.024
regulation of cellular component movement GO:0051270 334 0.024
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.023
positive regulation of interleukin 2 production GO:0032743 11 0.023
regulation of cysteine type endopeptidase activity GO:2000116 127 0.023
leukocyte differentiation GO:0002521 98 0.023
regulation of defense response GO:0031347 154 0.023
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.023
activation of innate immune response GO:0002218 55 0.022
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
nucleoside triphosphate metabolic process GO:0009141 422 0.022
single organism cellular localization GO:1902580 332 0.022
multicellular organismal aging GO:0010259 3 0.022
apoptotic signaling pathway GO:0097190 268 0.022
positive regulation of immune response GO:0050778 159 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.022
pattern recognition receptor signaling pathway GO:0002221 48 0.021
glycoprotein biosynthetic process GO:0009101 91 0.021
positive regulation of natural killer cell mediated immunity GO:0002717 12 0.021
purine ribonucleoside metabolic process GO:0046128 437 0.021
anatomical structure homeostasis GO:0060249 100 0.021
regulation of cellular ketone metabolic process GO:0010565 50 0.021
regulation of interleukin 4 biosynthetic process GO:0045402 2 0.021
viral process GO:0016032 146 0.021
positive regulation of programmed cell death GO:0043068 249 0.021
cd8 positive alpha beta t cell proliferation GO:0035740 1 0.021
detection of stimulus involved in sensory perception GO:0050906 43 0.021
oogenesis GO:0048477 2 0.021
leukocyte activation GO:0045321 164 0.021
cellular response to mechanical stimulus GO:0071260 39 0.020
purine ribonucleoside catabolic process GO:0046130 398 0.020
single organism membrane organization GO:0044802 268 0.020
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.020
purine nucleoside monophosphate metabolic process GO:0009126 186 0.020
regulation of multi organism process GO:0043900 157 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.020
metal ion transport GO:0030001 272 0.020
protein processing GO:0016485 226 0.020
regulation of cell motility GO:2000145 299 0.020
regulation of interferon beta production GO:0032648 22 0.020
glycosylation GO:0070085 71 0.019
positive regulation of cytokine production GO:0001819 167 0.019
interleukin 10 biosynthetic process GO:0042091 2 0.019
glycoprotein metabolic process GO:0009100 110 0.019
proteasomal protein catabolic process GO:0010498 176 0.019
organophosphate catabolic process GO:0046434 430 0.019
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.019
cellular response to dna damage stimulus GO:0006974 379 0.019
protein catabolic process GO:0030163 325 0.018
ribonucleoside monophosphate catabolic process GO:0009158 158 0.018
cell cycle arrest GO:0007050 71 0.018
membrane organization GO:0061024 292 0.018
modification dependent protein catabolic process GO:0019941 209 0.018
protein acylation GO:0043543 138 0.018
innate immune response GO:0045087 178 0.018
negative regulation of immune system process GO:0002683 136 0.018
monosaccharide metabolic process GO:0005996 74 0.018
neurological system process GO:0050877 163 0.017
rna catabolic process GO:0006401 71 0.017
multi organism cellular process GO:0044764 156 0.017
atp metabolic process GO:0046034 176 0.017
leukocyte mediated immunity GO:0002443 59 0.017
regulation of protein maturation GO:1903317 150 0.017
protein localization to organelle GO:0033365 280 0.017
antigen processing and presentation GO:0019882 33 0.017
ribonucleoside monophosphate metabolic process GO:0009161 187 0.017
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.017
negative regulation of developmental process GO:0051093 247 0.017
regulation of interferon alpha production GO:0032647 11 0.017
negative regulation of multicellular organismal process GO:0051241 317 0.017
sensory perception of taste GO:0050909 36 0.017
lymphocyte mediated immunity GO:0002449 48 0.017
modification dependent macromolecule catabolic process GO:0043632 212 0.017
nucleoside monophosphate metabolic process GO:0009123 191 0.016
regulation of viral genome replication GO:0045069 48 0.016
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.016
lipoprotein biosynthetic process GO:0042158 33 0.016
protein localization to membrane GO:0072657 160 0.016
organophosphate biosynthetic process GO:0090407 163 0.016
regulation of protein processing GO:0070613 150 0.016
purine containing compound biosynthetic process GO:0072522 88 0.016
regulation of membrane potential GO:0042391 95 0.016
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.016
mitotic cell cycle GO:0000278 326 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.015
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.015
detection of stimulus GO:0051606 85 0.015
negative regulation of cell differentiation GO:0045596 171 0.015
regulation of anatomical structure morphogenesis GO:0022603 286 0.015
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.015
negative regulation of protein maturation GO:1903318 142 0.015
sensory perception of chemical stimulus GO:0007606 38 0.015
type i interferon biosynthetic process GO:0045351 4 0.015
regulation of proteolysis GO:0030162 293 0.015
cellular ketone metabolic process GO:0042180 80 0.014
negative regulation of phosphorus metabolic process GO:0010563 267 0.014
positive regulation of type i interferon production GO:0032481 20 0.014
positive regulation of regulatory t cell differentiation GO:0045591 3 0.014
regeneration GO:0031099 4 0.014
negative regulation of multi organism process GO:0043901 92 0.014
negative regulation of cellular protein metabolic process GO:0032269 353 0.014
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.014
regulation of intracellular transport GO:0032386 195 0.014
response to interferon gamma GO:0034341 39 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.014
regulation of innate immune response GO:0045088 97 0.014
intrinsic apoptotic signaling pathway GO:0097193 127 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.013
positive regulation of innate immune response GO:0045089 79 0.013
intracellular protein transport GO:0006886 270 0.013
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.013
negative regulation of endopeptidase activity GO:0010951 84 0.013
negative regulation of protein modification process GO:0031400 200 0.013
regulation of gtp catabolic process GO:0033124 180 0.013
tissue migration GO:0090130 119 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.013
growth GO:0040007 202 0.013
detection of chemical stimulus GO:0009593 55 0.013
macromolecule glycosylation GO:0043413 63 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.013
negative regulation of peptidase activity GO:0010466 91 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.012
anatomical structure formation involved in morphogenesis GO:0048646 284 0.012
response to mechanical stimulus GO:0009612 51 0.012
regulation of cell growth GO:0001558 135 0.012
negative regulation of cell motility GO:2000146 104 0.012
taxis GO:0042330 157 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
nucleoside monophosphate catabolic process GO:0009125 159 0.012
regulation of peptidase activity GO:0052547 180 0.012
cell projection organization GO:0030030 252 0.012
plasma membrane organization GO:0007009 115 0.012
anion transport GO:0006820 161 0.012
interferon beta production GO:0032608 23 0.012
t cell differentiation in thymus GO:0033077 4 0.012
actin filament based process GO:0030029 224 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.012
negative regulation of proteolysis GO:0045861 132 0.012
immune response inhibiting cell surface receptor signaling pathway GO:0002767 4 0.012
cytokine metabolic process GO:0042107 38 0.012
regulation of small gtpase mediated signal transduction GO:0051056 156 0.012
positive regulation of transport GO:0051050 336 0.011
regulation of leukocyte activation GO:0002694 115 0.011
defense response to fungus GO:0050832 4 0.011
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.011
cell growth GO:0016049 160 0.011
protein lipidation GO:0006497 33 0.011
mitotic cell cycle process GO:1903047 286 0.011
lymphocyte differentiation GO:0030098 35 0.011
regulation of cd8 positive alpha beta t cell proliferation GO:2000564 1 0.011
regulation of nuclease activity GO:0032069 11 0.011
response to organonitrogen compound GO:0010243 156 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
secretion GO:0046903 254 0.011
positive regulation of cellular component organization GO:0051130 376 0.011
regulation of homeostatic process GO:0032844 121 0.011
interleukin 13 biosynthetic process GO:0042231 1 0.011
positive regulation of lymphocyte differentiation GO:0045621 13 0.011
cytokine mediated signaling pathway GO:0019221 109 0.011
regulation of cell adhesion GO:0030155 166 0.011
positive regulation of locomotion GO:0040017 186 0.011
regulation of binding GO:0051098 111 0.011
retina homeostasis GO:0001895 42 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
posttranscriptional regulation of gene expression GO:0010608 213 0.011
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 24 0.011
positive regulation of interleukin 13 biosynthetic process GO:0045368 1 0.011
response to oxygen containing compound GO:1901700 369 0.011
cell activation GO:0001775 213 0.011
lipoprotein metabolic process GO:0042157 42 0.011
regulation of viral process GO:0050792 103 0.010
cation homeostasis GO:0055080 189 0.010
ras protein signal transduction GO:0007265 73 0.010
vesicle mediated transport GO:0016192 371 0.010
protein modification by small protein conjugation GO:0032446 342 0.010
endomembrane system organization GO:0010256 196 0.010
response to nitrogen compound GO:1901698 184 0.010
establishment of protein localization to membrane GO:0090150 121 0.010
nitrogen compound transport GO:0071705 191 0.010
syncytium formation by plasma membrane fusion GO:0000768 2 0.010
epithelial cell migration GO:0010631 119 0.010
cytokine production GO:0001816 247 0.010
cellular homeostasis GO:0019725 196 0.010
leukocyte proliferation GO:0070661 74 0.010
immune response inhibiting signal transduction GO:0002765 4 0.010

ISG20 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.031
disease of cellular proliferation DOID:14566 174 0.025
cancer DOID:162 167 0.025
organ system cancer DOID:0050686 164 0.023
immune system disease DOID:2914 155 0.013
gastrointestinal system cancer DOID:3119 52 0.011