Homo sapiens

43 known processes

HACL1

2-hydroxyacyl-CoA lyase 1

(Aliases: HPCL2,HPCL,FLJ55041,2-HPCL,PHYH2)

HACL1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitochondrion organization GO:0007005 156 0.199
post embryonic development GO:0009791 2 0.139
organophosphate catabolic process GO:0046434 430 0.088
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.073
glycosyl compound catabolic process GO:1901658 413 0.071
lipid metabolic process GO:0006629 381 0.068
purine nucleoside catabolic process GO:0006152 398 0.067
nucleoside phosphate catabolic process GO:1901292 412 0.064
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.058
ribonucleoside triphosphate catabolic process GO:0009203 391 0.056
cellular lipid metabolic process GO:0044255 303 0.054
purine nucleotide catabolic process GO:0006195 405 0.054
multicellular organismal aging GO:0010259 3 0.050
purine ribonucleoside catabolic process GO:0046130 398 0.047
ribonucleoside catabolic process GO:0042454 406 0.047
ribonucleoside triphosphate metabolic process GO:0009199 412 0.046
purine ribonucleotide catabolic process GO:0009154 404 0.045
purine nucleoside triphosphate metabolic process GO:0009144 412 0.041
purine ribonucleoside metabolic process GO:0046128 437 0.041
purine containing compound catabolic process GO:0072523 411 0.041
nucleoside catabolic process GO:0009164 408 0.038
ribonucleotide catabolic process GO:0009261 405 0.037
nucleotide catabolic process GO:0009166 408 0.037
nucleoside triphosphate metabolic process GO:0009141 422 0.037
cellular ketone metabolic process GO:0042180 80 0.036
determination of adult lifespan GO:0008340 2 0.036
cellular amino acid metabolic process GO:0006520 116 0.035
protein processing GO:0016485 226 0.035
transmembrane transport GO:0055085 399 0.033
intracellular protein transport GO:0006886 270 0.032
guanosine containing compound metabolic process GO:1901068 244 0.030
carbohydrate metabolic process GO:0005975 207 0.030
single organism cellular localization GO:1902580 332 0.030
cellular protein complex assembly GO:0043623 188 0.029
regulation of cellular ketone metabolic process GO:0010565 50 0.029
system process GO:0003008 349 0.029
protein maturation GO:0051604 233 0.029
positive regulation of catabolic process GO:0009896 310 0.029
purine nucleoside monophosphate metabolic process GO:0009126 186 0.028
nucleoside triphosphate catabolic process GO:0009143 394 0.028
oxidation reduction process GO:0055114 396 0.027
locomotory behavior GO:0007626 1 0.027
protein localization to organelle GO:0033365 280 0.027
protein oligomerization GO:0051259 173 0.026
modification dependent macromolecule catabolic process GO:0043632 212 0.026
female gamete generation GO:0007292 2 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.025
protein catabolic process GO:0030163 325 0.025
guanosine containing compound catabolic process GO:1901069 239 0.025
regeneration GO:0031099 4 0.025
single organism carbohydrate metabolic process GO:0044723 193 0.024
fatty acid metabolic process GO:0006631 115 0.023
purine nucleoside triphosphate catabolic process GO:0009146 392 0.023
carbohydrate derivative biosynthetic process GO:1901137 207 0.023
gtp metabolic process GO:0046039 239 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
lipid biosynthetic process GO:0008610 177 0.022
response to abiotic stimulus GO:0009628 336 0.022
monocarboxylic acid metabolic process GO:0032787 185 0.022
cellular homeostasis GO:0019725 196 0.022
modification dependent protein catabolic process GO:0019941 209 0.021
negative regulation of intracellular signal transduction GO:1902532 183 0.021
response to organic cyclic compound GO:0014070 204 0.021
regulation of cellular amino acid metabolic process GO:0006521 6 0.021
cofactor metabolic process GO:0051186 87 0.021
secretion by cell GO:0032940 226 0.020
regulation of proteolysis GO:0030162 293 0.020
cellular amine metabolic process GO:0044106 41 0.020
ras protein signal transduction GO:0007265 73 0.020
cytoplasmic transport GO:0016482 379 0.020
ribonucleoside monophosphate catabolic process GO:0009158 158 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.020
amine metabolic process GO:0009308 44 0.020
organelle fission GO:0048285 149 0.020
neuromuscular junction development GO:0007528 3 0.019
nucleoside monophosphate catabolic process GO:0009125 159 0.019
apoptotic signaling pathway GO:0097190 268 0.019
chemical homeostasis GO:0048878 306 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
protein modification by small protein conjugation GO:0032446 342 0.019
vesicle mediated transport GO:0016192 371 0.019
purine nucleoside monophosphate catabolic process GO:0009128 158 0.019
regulation of nucleotide metabolic process GO:0006140 269 0.019
positive regulation of hydrolase activity GO:0051345 331 0.019
positive regulation of cell death GO:0010942 263 0.019
cellular protein catabolic process GO:0044257 261 0.019
cellular response to dna damage stimulus GO:0006974 379 0.019
protein targeting GO:0006605 187 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.018
growth GO:0040007 202 0.018
organelle assembly GO:0070925 176 0.018
single organism membrane organization GO:0044802 268 0.017
immune response GO:0006955 307 0.017
small molecule biosynthetic process GO:0044283 157 0.017
small molecule catabolic process GO:0044282 92 0.017
secretion GO:0046903 254 0.017
cytokine production GO:0001816 247 0.017
positive regulation of cellular component organization GO:0051130 376 0.017
response to cytokine GO:0034097 232 0.017
oogenesis GO:0048477 2 0.017
nucleoside monophosphate metabolic process GO:0009123 191 0.017
positive regulation of cellular catabolic process GO:0031331 284 0.017
translation GO:0006412 132 0.017
atp catabolic process GO:0006200 157 0.017
negative regulation of cellular component organization GO:0051129 235 0.017
positive regulation of programmed cell death GO:0043068 249 0.017
regulation of cytokine production GO:0001817 232 0.017
negative regulation of protein metabolic process GO:0051248 391 0.017
regulation of cell cycle GO:0051726 393 0.016
gtp catabolic process GO:0006184 237 0.016
protein import GO:0017038 130 0.016
regulation of gtpase activity GO:0043087 180 0.016
negative regulation of cell death GO:0060548 345 0.015
organophosphate biosynthetic process GO:0090407 163 0.015
positive regulation of developmental process GO:0051094 314 0.015
actin filament based process GO:0030029 224 0.015
endomembrane system organization GO:0010256 196 0.015
protein localization to membrane GO:0072657 160 0.015
positive regulation of nucleoside metabolic process GO:0045979 186 0.015
atp metabolic process GO:0046034 176 0.015
meiotic chromosome segregation GO:0045132 4 0.015
tissue regeneration GO:0042246 3 0.015
regulation of cellular amine metabolic process GO:0033238 11 0.014
negative regulation of cellular protein metabolic process GO:0032269 353 0.014
organonitrogen compound biosynthetic process GO:1901566 200 0.014
positive regulation of apoptotic process GO:0043065 246 0.014
coenzyme metabolic process GO:0006732 65 0.014
chromosome segregation GO:0007059 114 0.014
cofactor biosynthetic process GO:0051188 31 0.014
membrane organization GO:0061024 292 0.014
posttranscriptional regulation of gene expression GO:0010608 213 0.014
peripheral nervous system development GO:0007422 2 0.014
nervous system development GO:0007399 293 0.014
cellular chemical homeostasis GO:0055082 180 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.014
cellular macromolecular complex assembly GO:0034622 324 0.014
maintenance of location GO:0051235 112 0.014
positive regulation of cellular amine metabolic process GO:0033240 7 0.014
neurological system process GO:0050877 163 0.014
positive regulation of nucleotide catabolic process GO:0030813 185 0.014
ion homeostasis GO:0050801 230 0.014
cell growth GO:0016049 160 0.014
positive regulation of transport GO:0051050 336 0.013
cell development GO:0048468 328 0.013
negative regulation of programmed cell death GO:0043069 321 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
regulation of protein localization GO:0032880 296 0.013
cell morphogenesis GO:0000902 296 0.013
carboxylic acid biosynthetic process GO:0046394 97 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
organic acid biosynthetic process GO:0016053 97 0.013
proteasomal protein catabolic process GO:0010498 176 0.012
negative regulation of catalytic activity GO:0043086 335 0.012
cation homeostasis GO:0055080 189 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.012
actin mediated cell contraction GO:0070252 12 0.012
cellular ion homeostasis GO:0006873 168 0.012
cellular carbohydrate metabolic process GO:0044262 84 0.012
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
trna processing GO:0008033 23 0.012
regulation of cellular response to stress GO:0080135 244 0.012
actin filament based movement GO:0030048 17 0.012
cellular cation homeostasis GO:0030003 163 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
rna processing GO:0006396 255 0.012
ribonucleoside monophosphate metabolic process GO:0009161 187 0.012
cellular amide metabolic process GO:0043603 69 0.012
protein homooligomerization GO:0051260 100 0.012
positive regulation of gtpase activity GO:0043547 166 0.011
cilium morphogenesis GO:0060271 75 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
defense response GO:0006952 315 0.011
adult locomotory behavior GO:0008344 1 0.011
response to oxygen containing compound GO:1901700 369 0.011
regulation of peptidase activity GO:0052547 180 0.011
phospholipid metabolic process GO:0006644 99 0.011
regulation of purine nucleotide metabolic process GO:1900542 264 0.011
glycerol metabolic process GO:0006071 4 0.011
mitotic cell cycle GO:0000278 326 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
regulation of cell cycle process GO:0010564 266 0.011
cell projection organization GO:0030030 252 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
dephosphorylation GO:0016311 209 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
negative regulation of apoptotic process GO:0043066 316 0.011
ion transmembrane transport GO:0034220 338 0.011
negative regulation of developmental process GO:0051093 247 0.011
neurotransmitter secretion GO:0007269 4 0.011
response to biotic stimulus GO:0009607 276 0.011
ncrna metabolic process GO:0034660 108 0.011
regulation of response to external stimulus GO:0032101 222 0.011
cellular response to endogenous stimulus GO:0071495 336 0.011
positive regulation of immune system process GO:0002684 283 0.010
cellular response to oxygen containing compound GO:1901701 276 0.010
cardiac muscle cell contraction GO:0086003 4 0.010
nitrogen compound transport GO:0071705 191 0.010
protein dephosphorylation GO:0006470 81 0.010
small gtpase mediated signal transduction GO:0007264 78 0.010
regulation of transferase activity GO:0051338 355 0.010
enzyme linked receptor protein signaling pathway GO:0007167 303 0.010
response to growth factor GO:0070848 205 0.010
response to hormone GO:0009725 175 0.010
peptidyl serine modification GO:0018209 106 0.010
regulation of establishment of protein localization GO:0070201 242 0.010
regulation of mitochondrion organization GO:0010821 54 0.010
response to metal ion GO:0010038 84 0.010

HACL1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.081
inherited metabolic disorder DOID:655 242 0.066
musculoskeletal system disease DOID:17 223 0.021
amino acid metabolic disorder DOID:9252 50 0.018
central nervous system disease DOID:331 186 0.016
nervous system disease DOID:863 431 0.016
sensory system disease DOID:0050155 203 0.014
retinal disease DOID:5679 118 0.014
eye and adnexa disease DOID:1492 150 0.014
eye disease DOID:5614 149 0.014
cancer DOID:162 167 0.011
disease of cellular proliferation DOID:14566 174 0.011
organ system cancer DOID:0050686 164 0.011