Homo sapiens

0 known processes

TTK

TTK protein kinase

(Aliases: MPS1L1,FLJ38280,PYT,MPS1,CT96,ESK)

TTK biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
microtubule cytoskeleton organization GO:0000226 176 0.863
Yeast
microtubule based process GO:0007017 210 0.820
Yeast
sister chromatid segregation GO:0000819 54 0.703
Yeast
nuclear division GO:0000280 128 0.577
Yeast Zebrafish
organelle fission GO:0048285 149 0.566
Yeast Zebrafish
chromosome segregation GO:0007059 114 0.533
Yeast Zebrafish
spindle assembly GO:0051225 29 0.532
Yeast
spindle assembly involved in mitosis GO:0090307 12 0.511
mitotic sister chromatid segregation GO:0000070 53 0.481
Yeast
regulation of microtubule based process GO:0032886 74 0.478
Yeast
mitotic cell cycle GO:0000278 326 0.471
Yeast Zebrafish
organelle assembly GO:0070925 176 0.469
Yeast
spindle organization GO:0007051 53 0.405
Yeast
cell division GO:0051301 168 0.402
Yeast
attachment of spindle microtubules to kinetochore GO:0008608 17 0.371
Yeast
regulation of cell cycle process GO:0010564 266 0.320
Yeast Zebrafish
maintenance of location in cell GO:0051651 62 0.312
Yeast
regulation of spindle organization GO:0090224 10 0.310
maintenance of location GO:0051235 112 0.305
Yeast
regulation of cell cycle GO:0051726 393 0.299
Yeast Zebrafish
stem cell division GO:0017145 2 0.294
centrosome organization GO:0051297 58 0.290
positive regulation of cell cycle GO:0045787 140 0.204
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.204
Yeast
negative regulation of cellular component organization GO:0051129 235 0.196
Yeast
microtubule anchoring GO:0034453 24 0.187
Yeast
mitotic spindle midzone assembly GO:0051256 4 0.174
regulation of mitosis GO:0007088 63 0.170
Yeast
mitotic nuclear division GO:0007067 119 0.166
Yeast
organophosphate catabolic process GO:0046434 430 0.159
microtubule organizing center organization GO:0031023 62 0.159
Yeast
regulation of mitotic spindle organization GO:0060236 6 0.150
glycosyl compound catabolic process GO:1901658 413 0.148
regulation of cytoskeleton organization GO:0051493 177 0.132
Yeast
ribonucleoside triphosphate catabolic process GO:0009203 391 0.131
regulation of proteasomal protein catabolic process GO:0061136 87 0.130
Yeast
maintenance of protein location in cell GO:0032507 56 0.120
Yeast
mitotic cell cycle process GO:1903047 286 0.117
Yeast Zebrafish
protein depolymerization GO:0051261 30 0.115
organelle localization GO:0051640 84 0.114
Yeast
positive regulation of cell cycle process GO:0090068 106 0.111
ribonucleoside catabolic process GO:0042454 406 0.111
cellular macromolecular complex assembly GO:0034622 324 0.110
meiosis i GO:0007127 4 0.106
regulation of chromosome segregation GO:0051983 44 0.105
Yeast
oogenesis GO:0048477 2 0.104
mitotic spindle organization GO:0007052 27 0.103
microtubule based movement GO:0007018 32 0.103
microtubule polymerization or depolymerization GO:0031109 37 0.100
nucleoside triphosphate metabolic process GO:0009141 422 0.099
cytoskeleton dependent cytokinesis GO:0061640 22 0.097
purine nucleoside catabolic process GO:0006152 398 0.094
chromatin modification GO:0016568 298 0.091
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.088
Yeast
histone serine phosphorylation GO:0035404 4 0.087
protein processing GO:0016485 226 0.086
Yeast
cellular protein complex assembly GO:0043623 188 0.082
spindle midzone assembly GO:0051255 4 0.081
positive regulation of organelle organization GO:0010638 195 0.081
negative regulation of proteolysis GO:0045861 132 0.079
Yeast
centrosome separation GO:0051299 3 0.077
blastocyst development GO:0001824 3 0.077
post embryonic development GO:0009791 2 0.077
meiotic chromosome segregation GO:0045132 4 0.074
Zebrafish
posttranscriptional regulation of gene expression GO:0010608 213 0.073
nervous system development GO:0007399 293 0.071
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.070
Yeast
mitotic spindle elongation GO:0000022 4 0.068
spindle elongation GO:0051231 4 0.068
negative regulation of protein metabolic process GO:0051248 391 0.068
Yeast
somatic stem cell division GO:0048103 1 0.068
regulation of cell division GO:0051302 116 0.067
Yeast
mitotic centrosome separation GO:0007100 1 0.067
neurogenesis GO:0022008 169 0.067
regulation of mitotic cell cycle GO:0007346 189 0.066
Yeast Zebrafish
protein polymerization GO:0051258 71 0.066
proteasomal protein catabolic process GO:0010498 176 0.066
Yeast
ribonucleotide catabolic process GO:0009261 405 0.066
regulation of protein localization GO:0032880 296 0.065
Yeast
nucleoside phosphate catabolic process GO:1901292 412 0.063
nucleoside triphosphate catabolic process GO:0009143 394 0.062
ras protein signal transduction GO:0007265 73 0.062
regulation of wnt signaling pathway GO:0030111 123 0.061
small gtpase mediated signal transduction GO:0007264 78 0.061
single organism cellular localization GO:1902580 332 0.061
regulation of attachment of spindle microtubules to kinetochore GO:0051988 9 0.060
Yeast
nucleoside monophosphate catabolic process GO:0009125 159 0.059
cellular macromolecule catabolic process GO:0044265 380 0.058
Yeast
purine nucleoside triphosphate metabolic process GO:0009144 412 0.058
neuroblast division GO:0055057 1 0.058
regulation of binding GO:0051098 111 0.058
protein autophosphorylation GO:0046777 123 0.058
purine containing compound catabolic process GO:0072523 411 0.057
negative regulation of apoptotic process GO:0043066 316 0.056
regulation of mitotic sister chromatid separation GO:0010965 27 0.056
Yeast
peptidyl serine phosphorylation GO:0018105 101 0.055
purine ribonucleotide catabolic process GO:0009154 404 0.055
establishment of organelle localization GO:0051656 59 0.053
Yeast
regulation of protein catabolic process GO:0042176 155 0.052
Yeast
positive regulation of catabolic process GO:0009896 310 0.052
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.051
Yeast
negative regulation of organelle organization GO:0010639 126 0.051
Yeast
regulation of transferase activity GO:0051338 355 0.051
regulation of mitotic sister chromatid segregation GO:0033047 27 0.051
Yeast
protein ubiquitination GO:0016567 314 0.050
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.049
Yeast
positive regulation of protein catabolic process GO:0045732 75 0.048
protein catabolic process GO:0030163 325 0.048
Yeast
cell fate determination GO:0001709 3 0.048
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.047
Yeast
neuroblast proliferation GO:0007405 4 0.047
canonical wnt signaling pathway GO:0060070 116 0.046
cellular amino acid metabolic process GO:0006520 116 0.046
regulation of microtubule cytoskeleton organization GO:0070507 61 0.046
Yeast
positive regulation of protein phosphorylation GO:0001934 313 0.045
maintenance of protein location GO:0045185 57 0.045
Yeast
wnt signaling pathway GO:0016055 156 0.043
cellular protein catabolic process GO:0044257 261 0.043
Yeast
regulation of proteolysis GO:0030162 293 0.043
Yeast
peptidyl serine modification GO:0018209 106 0.043
cytokinesis GO:0000910 96 0.043
regeneration GO:0031099 4 0.042
Zebrafish
ribonucleoside monophosphate catabolic process GO:0009158 158 0.042
regulation of sister chromatid segregation GO:0033045 27 0.041
Yeast
chromatin organization GO:0006325 351 0.041
positive regulation of mitosis GO:0045840 25 0.041
positive regulation of cellular component organization GO:0051130 376 0.040
negative regulation of protein processing GO:0010955 142 0.040
Yeast
ribonucleoside triphosphate metabolic process GO:0009199 412 0.040
regulation of nuclear division GO:0051783 65 0.038
Yeast
centrosome cycle GO:0007098 32 0.038
negative regulation of mitotic anaphase promoting complex activity GO:0060564 4 0.037
meiotic nuclear division GO:0007126 10 0.037
Zebrafish
negative regulation of programmed cell death GO:0043069 321 0.037
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.037
Yeast
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.037
Yeast
positive regulation of phosphorylation GO:0042327 394 0.036
cardiovascular system development GO:0072358 262 0.035
regulation of cellular protein catabolic process GO:1903362 96 0.035
Yeast
anatomical structure formation involved in morphogenesis GO:0048646 284 0.035
regulation of cellular amine metabolic process GO:0033238 11 0.035
protein maturation GO:0051604 233 0.034
Yeast
negative regulation of cell cycle GO:0045786 193 0.034
Yeast Zebrafish
purine nucleoside triphosphate catabolic process GO:0009146 392 0.034
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.034
modification dependent protein catabolic process GO:0019941 209 0.034
Yeast
mitotic cytokinesis GO:0000281 19 0.034
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.034
modification dependent macromolecule catabolic process GO:0043632 212 0.033
Yeast
negative regulation of microtubule polymerization or depolymerization GO:0031111 17 0.033
protein localization to organelle GO:0033365 280 0.033
mitotic sister chromatid separation GO:0051306 18 0.033
Yeast
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.033
Yeast Zebrafish
microtubule polymerization GO:0046785 18 0.032
cell development GO:0048468 328 0.032
cellular component morphogenesis GO:0032989 314 0.032
embryo development GO:0009790 123 0.032
Zebrafish
regulation of cell differentiation GO:0045595 393 0.032
regulation of cellular amino acid metabolic process GO:0006521 6 0.032
purine ribonucleoside catabolic process GO:0046130 398 0.032
negative regulation of cell division GO:0051782 31 0.031
Yeast
response to abiotic stimulus GO:0009628 336 0.031
negative regulation of cell death GO:0060548 345 0.031
nucleus localization GO:0051647 1 0.031
negative regulation of cell cycle process GO:0010948 121 0.031
Yeast Zebrafish
neuron differentiation GO:0030182 138 0.030
cellular protein complex disassembly GO:0043624 36 0.030
dna repair GO:0006281 198 0.030
regulation of cytoplasmic transport GO:1903649 149 0.030
positive regulation of cytoskeleton organization GO:0051495 83 0.030
nucleoside monophosphate metabolic process GO:0009123 191 0.030
positive regulation of apoptotic process GO:0043065 246 0.029
asymmetric neuroblast division GO:0055059 1 0.029
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.029
circulatory system development GO:0072359 262 0.029
regulation of intracellular protein transport GO:0033157 123 0.029
centrosome duplication GO:0051298 28 0.029
generation of neurons GO:0048699 152 0.028
regulation of cell development GO:0060284 161 0.028
positive regulation of proteolysis GO:0045862 142 0.027
covalent chromatin modification GO:0016569 254 0.027
regulation of nervous system development GO:0051960 88 0.027
positive regulation of cellular catabolic process GO:0031331 284 0.027
histone modification GO:0016570 251 0.026
regulation of meiosis GO:0040020 3 0.026
determination of adult lifespan GO:0008340 2 0.026
female gamete generation GO:0007292 2 0.026
cell morphogenesis GO:0000902 296 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.026
negative regulation of protein ubiquitination GO:0031397 35 0.025
purine nucleoside monophosphate metabolic process GO:0009126 186 0.025
regulation of kinase activity GO:0043549 314 0.025
regulation of small gtpase mediated signal transduction GO:0051056 156 0.024
sister chromatid biorientation GO:0031134 2 0.024
Yeast
multicellular organismal aging GO:0010259 3 0.024
cellular response to oxygen containing compound GO:1901701 276 0.024
cilium morphogenesis GO:0060271 75 0.024
protein modification by small protein conjugation GO:0032446 342 0.024
cellular response to dna damage stimulus GO:0006974 379 0.023
enzyme linked receptor protein signaling pathway GO:0007167 303 0.023
regulation of protein processing GO:0070613 150 0.023
Yeast
purine nucleoside monophosphate catabolic process GO:0009128 158 0.023
negative regulation of protein modification process GO:0031400 200 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.022
cellular ketone metabolic process GO:0042180 80 0.022
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.022
clearance of foreign intracellular dna by conversion of dna cytidine to uridine GO:0044356 1 0.022
positive regulation of chromosome organization GO:2001252 41 0.022
regulation of cellular ketone metabolic process GO:0010565 50 0.022
positive regulation of nuclear division GO:0051785 27 0.021
nucleoside catabolic process GO:0009164 408 0.021
negative regulation of cell differentiation GO:0045596 171 0.020
attachment of mitotic spindle microtubules to kinetochore GO:0051315 3 0.020
Yeast
positive regulation of programmed cell death GO:0043068 249 0.020
negative regulation of ubiquitin protein ligase activity involved in mitotic cell cycle GO:0051436 4 0.020
negative regulation of ubiquitin protein transferase activity GO:0051444 8 0.020
mitotic spindle checkpoint GO:0071174 18 0.020
Yeast
mitotic cell cycle phase transition GO:0044772 162 0.019
Yeast Zebrafish
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.019
positive regulation of mitotic sister chromatid separation GO:1901970 6 0.019
establishment of chromosome localization GO:0051303 20 0.019
Yeast
positive regulation of transport GO:0051050 336 0.019
positive regulation of hydrolase activity GO:0051345 331 0.019
atp metabolic process GO:0046034 176 0.019
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.019
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.019
Yeast
spindle stabilization GO:0043146 4 0.019
regulation of nucleocytoplasmic transport GO:0046822 98 0.019
regulation of cell cycle phase transition GO:1901987 126 0.019
Yeast Zebrafish
photoreceptor cell differentiation GO:0046530 2 0.019
ribosome assembly GO:0042255 9 0.018
forebrain development GO:0030900 26 0.018
negative regulation of protein maturation GO:1903318 142 0.018
Yeast
positive regulation of protein transport GO:0051222 135 0.018
negative regulation of catalytic activity GO:0043086 335 0.018
regulation of establishment of protein localization GO:0070201 242 0.018
positive regulation of gtp catabolic process GO:0033126 166 0.018
protein complex disassembly GO:0043241 52 0.018
positive regulation of protein kinase activity GO:0045860 190 0.018
regulation of chromosome organization GO:0033044 103 0.017
Yeast
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.017
Yeast
regulation of protein transport GO:0051223 213 0.017
regulation of meiotic cell cycle GO:0051445 4 0.017
negative regulation of cellular protein metabolic process GO:0032269 353 0.017
Yeast
spindle checkpoint GO:0031577 26 0.017
Yeast
head development GO:0060322 108 0.017
positive regulation of cell development GO:0010720 92 0.017
embryonic epithelial tube formation GO:0001838 4 0.017
mitotic metaphase plate congression GO:0007080 14 0.017
Yeast
regulation of protein stability GO:0031647 87 0.017
regulation of intracellular transport GO:0032386 195 0.017
protein targeting GO:0006605 187 0.017
ubiquitin dependent protein catabolic process GO:0006511 206 0.017
Yeast
protein dephosphorylation GO:0006470 81 0.016
central nervous system development GO:0007417 123 0.016
positive regulation of mitotic cell cycle GO:0045931 60 0.016
macromolecular complex disassembly GO:0032984 60 0.016
purine nucleotide catabolic process GO:0006195 405 0.016
regulation of response to dna damage stimulus GO:2001020 94 0.016
cell projection organization GO:0030030 252 0.016
chordate embryonic development GO:0043009 34 0.016
biological adhesion GO:0022610 331 0.016
positive regulation of cell division GO:0051781 59 0.016
regulation of dna binding GO:0051101 37 0.015
regulation of protein complex assembly GO:0043254 147 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.015
microtubule bundle formation GO:0001578 15 0.015
brain development GO:0007420 97 0.015
positive regulation of cell differentiation GO:0045597 211 0.015
negative regulation of chromosome organization GO:2001251 48 0.015
Yeast
positive regulation of gtpase activity GO:0043547 166 0.015
nucleotide catabolic process GO:0009166 408 0.015
guanosine containing compound catabolic process GO:1901069 239 0.015
brain morphogenesis GO:0048854 1 0.015
positive regulation of nucleotide metabolic process GO:0045981 230 0.014
positive regulation of kinase activity GO:0033674 204 0.014
kinetochore organization GO:0051383 8 0.014
positive regulation of transferase activity GO:0051347 227 0.014
meiotic cell cycle process GO:1903046 8 0.014
Zebrafish
intracellular protein transport GO:0006886 270 0.014
regulation of cysteine type endopeptidase activity GO:2000116 127 0.014
double strand break repair via homologous recombination GO:0000724 50 0.014
positive regulation of cellular protein catabolic process GO:1903364 37 0.014
establishment of spindle localization GO:0051293 12 0.014
regulation of double strand break repair GO:2000779 22 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.014
cellular component disassembly GO:0022411 92 0.014
response to organic cyclic compound GO:0014070 204 0.014
protein oligomerization GO:0051259 173 0.014
regulation of dna metabolic process GO:0051052 153 0.014
negative regulation of cellular protein catabolic process GO:1903363 38 0.014
Yeast
regulation of cellular component biogenesis GO:0044087 281 0.013
spindle assembly checkpoint GO:0071173 17 0.013
Yeast
response to oxidative stress GO:0006979 121 0.013
cdc42 protein signal transduction GO:0032488 4 0.013
regulation of protein localization to nucleus GO:1900180 85 0.013
primary neural tube formation GO:0014020 3 0.013
telencephalon development GO:0021537 17 0.013
regulation of ras protein signal transduction GO:0046578 155 0.013
regulation of cellular component movement GO:0051270 334 0.013
cell cycle checkpoint GO:0000075 117 0.013
Yeast Zebrafish
growth GO:0040007 202 0.013
Zebrafish
actin filament based process GO:0030029 224 0.013
protein import GO:0017038 130 0.013
oocyte maturation GO:0001556 1 0.013
cell part morphogenesis GO:0032990 137 0.013
cellular amine metabolic process GO:0044106 41 0.013
spermatid differentiation GO:0048515 4 0.013
regulation of protein ubiquitination GO:0031396 95 0.013
regulation of protein serine threonine kinase activity GO:0071900 179 0.012
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.012
regulation of canonical wnt signaling pathway GO:0060828 88 0.012
establishment of protein localization to organelle GO:0072594 172 0.012
negative regulation of cytoskeleton organization GO:0051494 45 0.012
cellular response to endogenous stimulus GO:0071495 336 0.012
positive regulation of cytoplasmic transport GO:1903651 82 0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.012
positive regulation of protein import into nucleus GO:0042307 46 0.012
positive regulation of ras gtpase activity GO:0032320 117 0.012
atp catabolic process GO:0006200 157 0.012
regulation of nucleotide metabolic process GO:0006140 269 0.012
ribonucleoside monophosphate metabolic process GO:0009161 187 0.012
regulation of protein targeting GO:1903533 91 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
regulation of protein import into nucleus GO:0042306 78 0.011
negative regulation of chromosome segregation GO:0051985 18 0.011
Yeast
cell morphogenesis involved in differentiation GO:0000904 144 0.011
endomembrane system organization GO:0010256 196 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
regulation of endopeptidase activity GO:0052548 170 0.011
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.011
Yeast
regulation of neural precursor cell proliferation GO:2000177 4 0.011
reproduction GO:0000003 63 0.011
Zebrafish
negative regulation of catabolic process GO:0009895 104 0.011
Yeast
peptidyl lysine modification GO:0018205 144 0.011
cell adhesion GO:0007155 325 0.011
cellular response to oxidative stress GO:0034599 85 0.011
cell cycle phase transition GO:0044770 173 0.011
Yeast Zebrafish
vesicle transport along microtubule GO:0047496 4 0.011
centromeric sister chromatid cohesion GO:0070601 3 0.011
negative regulation of mitotic cell cycle GO:0045930 102 0.011
Yeast Zebrafish
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.011
regulation of neurogenesis GO:0050767 82 0.011
apoptotic signaling pathway GO:0097190 268 0.011
intrinsic apoptotic signaling pathway GO:0097193 127 0.011
regulation of protein maturation GO:1903317 150 0.011
Yeast
regulation of cellular response to stress GO:0080135 244 0.011
cell projection morphogenesis GO:0048858 129 0.010
double strand break repair GO:0006302 101 0.010
regulation of peptidase activity GO:0052547 180 0.010
aging GO:0007568 66 0.010
positive regulation of intracellular transport GO:0032388 104 0.010
chromosome condensation GO:0030261 15 0.010
nuclear import GO:0051170 106 0.010
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 17 0.010
Yeast
guanosine containing compound metabolic process GO:1901068 244 0.010
amine metabolic process GO:0009308 44 0.010
cellular response to abiotic stimulus GO:0071214 117 0.010

TTK disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.031
physical disorder DOID:0080015 41 0.027
congenital nervous system abnormality DOID:2490 21 0.027
cancer DOID:162 167 0.015
organ system cancer DOID:0050686 164 0.015