Homo sapiens

36 known processes

MSL2

male-specific lethal 2 homolog (Drosophila)

(Aliases: FLJ54913,MSL-2,RNF184,KIAA1585,FLJ10546,MSL2L1)

MSL2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
covalent chromatin modification GO:0016569 254 0.413
histone modification GO:0016570 251 0.362
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.238
cellular amine metabolic process GO:0044106 41 0.225
chromatin organization GO:0006325 351 0.196
histone acetylation GO:0016573 93 0.191
internal peptidyl lysine acetylation GO:0018393 97 0.169
peptidyl lysine acetylation GO:0018394 101 0.154
protein acylation GO:0043543 138 0.153
chromatin modification GO:0016568 298 0.129
negative regulation of chromatin silencing GO:0031936 4 0.118
cellular amino acid metabolic process GO:0006520 116 0.111
regulation of cellular amino acid metabolic process GO:0006521 6 0.106
protein ubiquitination GO:0016567 314 0.097
Fly
peptidyl lysine modification GO:0018205 144 0.090
protein modification by small protein conjugation GO:0032446 342 0.089
Fly
cellular response to dna damage stimulus GO:0006974 379 0.089
regulation of cellular amine metabolic process GO:0033238 11 0.085
blood vessel development GO:0001568 172 0.081
regulation of cell cycle GO:0051726 393 0.079
regulation of cellular ketone metabolic process GO:0010565 50 0.079
protein acetylation GO:0006473 116 0.076
cell development GO:0048468 328 0.074
negative regulation of protein metabolic process GO:0051248 391 0.071
modification dependent protein catabolic process GO:0019941 209 0.070
cellular ketone metabolic process GO:0042180 80 0.065
internal protein amino acid acetylation GO:0006475 101 0.061
vasculature development GO:0001944 181 0.060
cardiovascular system development GO:0072358 262 0.059
blood vessel morphogenesis GO:0048514 162 0.058
myeloid cell differentiation GO:0030099 117 0.057
memory GO:0007613 3 0.055
ubiquitin dependent protein catabolic process GO:0006511 206 0.055
carbohydrate metabolic process GO:0005975 207 0.054
determination of adult lifespan GO:0008340 2 0.053
negative regulation of cell death GO:0060548 345 0.053
nucleosome organization GO:0034728 66 0.050
amine metabolic process GO:0009308 44 0.049
anatomical structure formation involved in morphogenesis GO:0048646 284 0.045
regulation of cell differentiation GO:0045595 393 0.045
multicellular organismal aging GO:0010259 3 0.044
single organism carbohydrate metabolic process GO:0044723 193 0.044
macromolecule methylation GO:0043414 97 0.044
circulatory system development GO:0072359 262 0.044
hemopoiesis GO:0030097 180 0.043
post embryonic development GO:0009791 2 0.041
negative regulation of developmental process GO:0051093 247 0.040
pericardium development GO:0060039 2 0.040
negative regulation of cell cycle process GO:0010948 121 0.039
cellular macromolecular complex assembly GO:0034622 324 0.039
mitotic cell cycle phase transition GO:0044772 162 0.038
angiogenesis GO:0001525 147 0.038
female gamete generation GO:0007292 2 0.038
defense response GO:0006952 315 0.037
carbohydrate derivative biosynthetic process GO:1901137 207 0.036
embryonic placenta development GO:0001892 1 0.036
stem cell differentiation GO:0048863 93 0.035
cellular carbohydrate metabolic process GO:0044262 84 0.035
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.034
regulation of chromatin organization GO:1902275 56 0.034
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.034
neural tube formation GO:0001841 3 0.034
positive regulation of catabolic process GO:0009896 310 0.034
cell division GO:0051301 168 0.033
cellular component morphogenesis GO:0032989 314 0.033
response to oxygen containing compound GO:1901700 369 0.033
morphogenesis of embryonic epithelium GO:0016331 4 0.032
positive regulation of developmental process GO:0051094 314 0.032
long term memory GO:0007616 2 0.032
mitotic cell cycle process GO:1903047 286 0.032
regulation of protein processing GO:0070613 150 0.031
epithelium development GO:0060429 227 0.031
nervous system development GO:0007399 293 0.030
negative regulation of apoptotic process GO:0043066 316 0.030
dephosphorylation GO:0016311 209 0.030
negative regulation of cellular protein metabolic process GO:0032269 353 0.030
cellular protein catabolic process GO:0044257 261 0.030
negative regulation of programmed cell death GO:0043069 321 0.029
cellular macromolecule catabolic process GO:0044265 380 0.029
dna damage checkpoint GO:0000077 68 0.029
proteasomal protein catabolic process GO:0010498 176 0.029
enzyme linked receptor protein signaling pathway GO:0007167 303 0.029
tube closure GO:0060606 3 0.028
male meiosis GO:0007140 1 0.028
cytoplasmic transport GO:0016482 379 0.028
system process GO:0003008 349 0.028
positive regulation of cellular component organization GO:0051130 376 0.028
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.027
histone lysine methylation GO:0034968 50 0.027
glycoprotein metabolic process GO:0009100 110 0.027
regulation of response to external stimulus GO:0032101 222 0.026
regulation of chromatin silencing GO:0031935 8 0.026
mrna metabolic process GO:0016071 175 0.026
histone methylation GO:0016571 60 0.026
rna splicing GO:0008380 131 0.026
negative regulation of hydrolase activity GO:0051346 182 0.026
wnt signaling pathway GO:0016055 156 0.026
oogenesis GO:0048477 2 0.026
neurological system process GO:0050877 163 0.026
protein processing GO:0016485 226 0.026
nucleoside phosphate catabolic process GO:1901292 412 0.026
immune response GO:0006955 307 0.025
histone h4 acetylation GO:0043967 47 0.025
modification dependent macromolecule catabolic process GO:0043632 212 0.025
regulation of intracellular transport GO:0032386 195 0.025
lipid metabolic process GO:0006629 381 0.025
dna repair GO:0006281 198 0.025
neuroblast proliferation GO:0007405 4 0.024
protein catabolic process GO:0030163 325 0.024
vesicle mediated transport GO:0016192 371 0.024
mitotic cell cycle GO:0000278 326 0.024
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.023
protein maturation GO:0051604 233 0.023
intracellular receptor signaling pathway GO:0030522 104 0.023
central nervous system development GO:0007417 123 0.023
cellular response to oxygen containing compound GO:1901701 276 0.023
apoptotic signaling pathway GO:0097190 268 0.023
innate immune response GO:0045087 178 0.023
canonical wnt signaling pathway GO:0060070 116 0.023
anterior posterior axis specification GO:0009948 2 0.023
protein monoubiquitination GO:0006513 39 0.023
regulation of cellular response to stress GO:0080135 244 0.023
oocyte differentiation GO:0009994 2 0.023
negative regulation of cellular amine metabolic process GO:0033239 3 0.023
positive regulation of cell death GO:0010942 263 0.023
cell projection organization GO:0030030 252 0.023
tube development GO:0035295 125 0.022
negative regulation of catalytic activity GO:0043086 335 0.022
protein deacylation GO:0035601 39 0.022
cell cycle checkpoint GO:0000075 117 0.022
regulation of cell cycle process GO:0010564 266 0.022
macromolecule glycosylation GO:0043413 63 0.022
spermatid differentiation GO:0048515 4 0.021
negative regulation of protein processing GO:0010955 142 0.021
cell cycle phase transition GO:0044770 173 0.021
nucleotide catabolic process GO:0009166 408 0.021
embryonic camera type eye morphogenesis GO:0048596 2 0.021
histone deacetylation GO:0016575 32 0.021
glycoprotein biosynthetic process GO:0009101 91 0.021
single organism membrane organization GO:0044802 268 0.021
negative regulation of proteolysis GO:0045861 132 0.021
positive regulation of cellular amine metabolic process GO:0033240 7 0.021
ribonucleotide catabolic process GO:0009261 405 0.020
regulation of nucleotide metabolic process GO:0006140 269 0.020
locomotory behavior GO:0007626 1 0.020
positive regulation of transferase activity GO:0051347 227 0.020
rna processing GO:0006396 255 0.020
cyclic nucleotide metabolic process GO:0009187 82 0.020
cellular lipid metabolic process GO:0044255 303 0.020
protein glycosylation GO:0006486 62 0.020
protein methylation GO:0006479 74 0.020
embryonic epithelial tube formation GO:0001838 4 0.020
protein localization to organelle GO:0033365 280 0.020
oxidation reduction process GO:0055114 396 0.019
regulation of mitotic cell cycle GO:0007346 189 0.019
photoreceptor cell differentiation GO:0046530 2 0.019
neurotransmitter secretion GO:0007269 4 0.019
regulation of anatomical structure morphogenesis GO:0022603 286 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
negative regulation of cell differentiation GO:0045596 171 0.019
embryonic forelimb morphogenesis GO:0035115 4 0.019
sensory perception GO:0007600 103 0.019
epithelial cell differentiation GO:0030855 141 0.019
response to lipid GO:0033993 206 0.019
rho protein signal transduction GO:0007266 26 0.019
regulation of canonical wnt signaling pathway GO:0060828 88 0.019
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.018
ribonucleoside triphosphate catabolic process GO:0009203 391 0.018
double strand break repair GO:0006302 101 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.018
neuromuscular junction development GO:0007528 3 0.018
adult locomotory behavior GO:0008344 1 0.018
negative regulation of cell cycle GO:0045786 193 0.018
neuron development GO:0048666 113 0.018
regulation of protein maturation GO:1903317 150 0.018
response to abiotic stimulus GO:0009628 336 0.018
positive regulation of transport GO:0051050 336 0.018
negative regulation of protein maturation GO:1903318 142 0.018
glycosylation GO:0070085 71 0.017
negative regulation of multicellular organismal process GO:0051241 317 0.017
segmentation GO:0035282 4 0.017
regulation of purine nucleotide metabolic process GO:1900542 264 0.017
positive regulation of cell proliferation GO:0008284 301 0.017
histone h4 k8 acetylation GO:0043982 15 0.017
regulation of protein transport GO:0051223 213 0.017
cellular response to cytokine stimulus GO:0071345 181 0.017
neurogenesis GO:0022008 169 0.017
heart morphogenesis GO:0003007 48 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
regulation of neural precursor cell proliferation GO:2000177 4 0.017
organ morphogenesis GO:0009887 147 0.017
reproductive process GO:0022414 106 0.017
hematopoietic or lymphoid organ development GO:0048534 186 0.017
camp metabolic process GO:0046058 61 0.017
regulation of cysteine type endopeptidase activity GO:2000116 127 0.017
regulation of proteolysis GO:0030162 293 0.017
protein oligomerization GO:0051259 173 0.017
cell projection morphogenesis GO:0048858 129 0.017
membrane organization GO:0061024 292 0.016
chemotaxis GO:0006935 157 0.016
cell type specific apoptotic process GO:0097285 125 0.016
regulation of locomotion GO:0040012 329 0.016
ras protein signal transduction GO:0007265 73 0.016
cellular response to endogenous stimulus GO:0071495 336 0.016
androgen receptor signaling pathway GO:0030521 34 0.016
small gtpase mediated signal transduction GO:0007264 78 0.016
primary neural tube formation GO:0014020 3 0.016
positive regulation of programmed cell death GO:0043068 249 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.016
cellular response to lipid GO:0071396 127 0.016
regulation of gene expression epigenetic GO:0040029 73 0.016
Fly
embryonic eye morphogenesis GO:0048048 2 0.016
response to hormone GO:0009725 175 0.016
positive regulation of organelle organization GO:0010638 195 0.016
small molecule biosynthetic process GO:0044283 157 0.016
nucleoside triphosphate metabolic process GO:0009141 422 0.016
growth GO:0040007 202 0.016
negative regulation of protein catabolic process GO:0042177 59 0.016
positive regulation of phosphorylation GO:0042327 394 0.015
negative regulation of catabolic process GO:0009895 104 0.015
response to cytokine GO:0034097 232 0.015
positive regulation of apoptotic process GO:0043065 246 0.015
negative regulation of cellular component organization GO:0051129 235 0.015
cellular protein complex assembly GO:0043623 188 0.015
regulation of carbohydrate metabolic process GO:0006109 54 0.015
response to external biotic stimulus GO:0043207 261 0.015
mapk cascade GO:0000165 288 0.015
purine nucleoside triphosphate metabolic process GO:0009144 412 0.015
heart development GO:0007507 95 0.015
tissue morphogenesis GO:0048729 96 0.015
regulation of apoptotic signaling pathway GO:2001233 175 0.015
regulation of cellular component movement GO:0051270 334 0.015
protein deacetylation GO:0006476 38 0.015
muscle contraction GO:0006936 73 0.015
protein dephosphorylation GO:0006470 81 0.015
protein polyubiquitination GO:0000209 110 0.015
regulation of cytokine production GO:0001817 232 0.015
negative regulation of cell cycle phase transition GO:1901988 89 0.015
histone h4 k5 acetylation GO:0043981 15 0.015
behavioral response to ethanol GO:0048149 2 0.015
spermatid development GO:0007286 4 0.015
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.015
regulation of mapk cascade GO:0043408 262 0.015
patterning of blood vessels GO:0001569 2 0.015
cell growth GO:0016049 160 0.015
positive regulation of immune system process GO:0002684 283 0.015
regulation of cell cycle phase transition GO:1901987 126 0.015
macromolecule deacylation GO:0098732 41 0.015
oocyte development GO:0048599 1 0.014
ribonucleoside catabolic process GO:0042454 406 0.014
regulation of endopeptidase activity GO:0052548 170 0.014
neural tube closure GO:0001843 3 0.014
nitrogen compound transport GO:0071705 191 0.014
purine ribonucleoside metabolic process GO:0046128 437 0.014
organophosphate catabolic process GO:0046434 430 0.014
organonitrogen compound biosynthetic process GO:1901566 200 0.014
intrinsic apoptotic signaling pathway GO:0097193 127 0.014
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.014
metencephalon development GO:0022037 2 0.014
positive regulation of protein kinase activity GO:0045860 190 0.014
purine containing compound catabolic process GO:0072523 411 0.014
cell morphogenesis GO:0000902 296 0.014
neuron differentiation GO:0030182 138 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.014
negative regulation of phosphorus metabolic process GO:0010563 267 0.014
regulation of transferase activity GO:0051338 355 0.014
cellular response to abiotic stimulus GO:0071214 117 0.014
actin filament based process GO:0030029 224 0.014
regulation of cell growth GO:0001558 135 0.014
g1 s transition of mitotic cell cycle GO:0000082 78 0.014
response to other organism GO:0051707 261 0.014
protein alkylation GO:0008213 74 0.014
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.014
meiotic chromosome segregation GO:0045132 4 0.014
rna splicing via transesterification reactions GO:0000375 90 0.014
regulation of reactive oxygen species metabolic process GO:2000377 41 0.014
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.014
peptidyl tyrosine modification GO:0018212 170 0.014
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.014
positive regulation of hydrolase activity GO:0051345 331 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.014
generation of neurons GO:0048699 152 0.014
ribonucleoprotein complex assembly GO:0022618 78 0.014
negative regulation of transport GO:0051051 176 0.013
head development GO:0060322 108 0.013
mrna splicing via spliceosome GO:0000398 89 0.013
nucleoside triphosphate catabolic process GO:0009143 394 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
ribonucleoprotein complex biogenesis GO:0022613 116 0.013
cerebellum development GO:0021549 2 0.013
embryo development GO:0009790 123 0.013
protein modification by small protein removal GO:0070646 92 0.013
negative regulation of protein modification process GO:0031400 200 0.013
regulation of gene silencing GO:0060968 24 0.013
neuron projection development GO:0031175 106 0.013
regulation of cytoplasmic transport GO:1903649 149 0.013
regulation of protein kinase activity GO:0045859 289 0.013
ameboidal type cell migration GO:0001667 135 0.013
negative regulation of cellular catabolic process GO:0031330 83 0.013
regulation of growth GO:0040008 165 0.013
regulation of protein catabolic process GO:0042176 155 0.013
regulation of dephosphorylation GO:0035303 96 0.013
cellular response to organic cyclic compound GO:0071407 127 0.013
response to radiation GO:0009314 151 0.013
secretion GO:0046903 254 0.013
regulation of meiosis GO:0040020 3 0.013
cell part morphogenesis GO:0032990 137 0.013
transmembrane transport GO:0055085 399 0.013
cell morphogenesis involved in differentiation GO:0000904 144 0.013
stem cell development GO:0048864 69 0.013
mitotic cell cycle checkpoint GO:0007093 68 0.013
forelimb morphogenesis GO:0035136 4 0.012
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.012
organelle fission GO:0048285 149 0.012
reactive oxygen species metabolic process GO:0072593 75 0.012
regulation of protein localization GO:0032880 296 0.012
tube morphogenesis GO:0035239 95 0.012
response to biotic stimulus GO:0009607 276 0.012
striated muscle contraction GO:0006941 52 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
dna integrity checkpoint GO:0031570 71 0.012
secretion by cell GO:0032940 226 0.012
negative regulation of synaptic transmission GO:0050805 2 0.012
glycosyl compound catabolic process GO:1901658 413 0.012
cell adhesion GO:0007155 325 0.012
single organism reproductive process GO:0044702 98 0.012
cytokine production GO:0001816 247 0.012
regulation of cell migration GO:0030334 289 0.012
regulation of synaptic plasticity GO:0048167 3 0.012
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.012
embryonic morphogenesis GO:0048598 85 0.012
taxis GO:0042330 157 0.012
trophectodermal cell differentiation GO:0001829 3 0.012
regulation of response to dna damage stimulus GO:2001020 94 0.012
glycerolipid metabolic process GO:0046486 107 0.012
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.012
regulation of ras protein signal transduction GO:0046578 155 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
negative regulation of cellular protein catabolic process GO:1903363 38 0.012
monocarboxylic acid metabolic process GO:0032787 185 0.012
interspecies interaction between organisms GO:0044419 156 0.012
dosage compensation GO:0007549 3 0.012
Fly
peptidyl serine phosphorylation GO:0018105 101 0.012
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.012
purine nucleotide catabolic process GO:0006195 405 0.012
regulation of neurogenesis GO:0050767 82 0.012
regulation of peptidase activity GO:0052547 180 0.012
purine ribonucleoside catabolic process GO:0046130 398 0.012
negative regulation of intracellular signal transduction GO:1902532 183 0.012
purine ribonucleotide catabolic process GO:0009154 404 0.012
hindbrain development GO:0030902 3 0.011
extrinsic apoptotic signaling pathway GO:0097191 119 0.011
peptidyl lysine methylation GO:0018022 37 0.011
sleep GO:0030431 2 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.011
regulation of chromatin modification GO:1903308 51 0.011
positive regulation of proteolysis GO:0045862 142 0.011
nucleoside catabolic process GO:0009164 408 0.011
nuclear transport GO:0051169 179 0.011
associative learning GO:0008306 1 0.011
regulation of dna metabolic process GO:0051052 153 0.011
limbic system development GO:0021761 3 0.011
rhythmic behavior GO:0007622 2 0.011
dna packaging GO:0006323 77 0.011
positive regulation of protein phosphorylation GO:0001934 313 0.011
regulation of small gtpase mediated signal transduction GO:0051056 156 0.011
syncytium formation by plasma membrane fusion GO:0000768 2 0.011
protein demethylation GO:0006482 17 0.011
cellular response to radiation GO:0071478 65 0.011
regulation of nucleocytoplasmic transport GO:0046822 98 0.011
regulation of cellular component biogenesis GO:0044087 281 0.011
response to fungus GO:0009620 4 0.011
response to nutrient levels GO:0031667 81 0.011
signal transduction by phosphorylation GO:0023014 297 0.011
purine nucleoside catabolic process GO:0006152 398 0.011
negative regulation of mitotic cell cycle GO:0045930 102 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
regulation of cell development GO:0060284 161 0.011
regulation of hormone levels GO:0010817 125 0.011
peptidyl tyrosine phosphorylation GO:0018108 170 0.011
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
protein targeting GO:0006605 187 0.011
response to organic cyclic compound GO:0014070 204 0.011
engulfment of apoptotic cell GO:0043652 2 0.011
ossification GO:0001503 121 0.010
protein localization to nucleus GO:0034504 136 0.010
adipose tissue development GO:0060612 2 0.010
i kappab kinase nf kappab signaling GO:0007249 166 0.010
gtp metabolic process GO:0046039 239 0.010
visual behavior GO:0007632 2 0.010
reproduction GO:0000003 63 0.010
regulation of cell division GO:0051302 116 0.010
tissue migration GO:0090130 119 0.010
cation transmembrane transport GO:0098655 238 0.010
endomembrane system organization GO:0010256 196 0.010
immune system development GO:0002520 195 0.010
response to dietary excess GO:0002021 2 0.010
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.010
regulation of rna splicing GO:0043484 62 0.010
regulation of cell morphogenesis GO:0022604 153 0.010

MSL2 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.048
nervous system disease DOID:863 431 0.048
eye and adnexa disease DOID:1492 150 0.030
central nervous system disease DOID:331 186 0.024
neurodegenerative disease DOID:1289 102 0.024
cancer DOID:162 167 0.022
disease of cellular proliferation DOID:14566 174 0.022
organ system cancer DOID:0050686 164 0.022
eye disease DOID:5614 149 0.019
musculoskeletal system disease DOID:17 223 0.016
retinal disease DOID:5679 118 0.012
retinal degeneration DOID:8466 89 0.012
connective tissue disease DOID:65 109 0.011
disease of mental health DOID:150 70 0.010