Homo sapiens

139 known processes

FXN

frataxin

(Aliases: MGC57199,FRDA,CyaY,FA,FARR,X25)

FXN biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.201
cellular amino acid metabolic process GO:0006520 116 0.122
cellular ketone metabolic process GO:0042180 80 0.080
ribonucleoside monophosphate metabolic process GO:0009161 187 0.074
Mouse
ion transmembrane transport GO:0034220 338 0.070
purine ribonucleoside metabolic process GO:0046128 437 0.068
Mouse
organonitrogen compound biosynthetic process GO:1901566 200 0.065
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.064
Mouse
transmembrane transport GO:0055085 399 0.062
locomotory behavior GO:0007626 1 0.058
Mouse
nucleoside phosphate biosynthetic process GO:1901293 109 0.052
single organism membrane organization GO:0044802 268 0.048
amine metabolic process GO:0009308 44 0.047
determination of adult lifespan GO:0008340 2 0.046
nucleoside triphosphate metabolic process GO:0009141 422 0.046
Mouse
cellular amine metabolic process GO:0044106 41 0.045
purine nucleoside monophosphate metabolic process GO:0009126 186 0.039
Mouse
vesicle mediated transport GO:0016192 371 0.039
nucleotide biosynthetic process GO:0009165 109 0.038
atp metabolic process GO:0046034 176 0.038
Mouse
ribonucleoside triphosphate metabolic process GO:0009199 412 0.037
Mouse
female gamete generation GO:0007292 2 0.037
lipid metabolic process GO:0006629 381 0.037
multicellular organismal aging GO:0010259 3 0.036
regulation of cellular ketone metabolic process GO:0010565 50 0.036
cellular component morphogenesis GO:0032989 314 0.036
cation transmembrane transport GO:0098655 238 0.036
mitochondrion organization GO:0007005 156 0.034
purine nucleoside triphosphate metabolic process GO:0009144 412 0.033
Mouse
response to oxygen containing compound GO:1901700 369 0.032
membrane organization GO:0061024 292 0.032
nucleoside monophosphate metabolic process GO:0009123 191 0.032
Mouse
protein maturation GO:0051604 233 0.031
regulation of cellular amino acid metabolic process GO:0006521 6 0.029
cellular macromolecule catabolic process GO:0044265 380 0.029
regulation of nucleotide metabolic process GO:0006140 269 0.028
response to abiotic stimulus GO:0009628 336 0.028
regulation of cellular amine metabolic process GO:0033238 11 0.027
positive regulation of cellular component organization GO:0051130 376 0.027
protein localization to organelle GO:0033365 280 0.026
alpha amino acid metabolic process GO:1901605 72 0.026
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.026
nucleoside triphosphate catabolic process GO:0009143 394 0.026
positive regulation of hydrolase activity GO:0051345 331 0.026
generation of precursor metabolites and energy GO:0006091 68 0.026
Mouse
glutamine family amino acid metabolic process GO:0009064 17 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.026
positive regulation of transport GO:0051050 336 0.026
intracellular protein transport GO:0006886 270 0.025
secretion by cell GO:0032940 226 0.025
anterior posterior axis specification GO:0009948 2 0.024
negative regulation of cell proliferation GO:0008285 228 0.024
carbohydrate metabolic process GO:0005975 207 0.024
negative regulation of multicellular organismal process GO:0051241 317 0.024
Mouse
nucleoside phosphate catabolic process GO:1901292 412 0.024
response to oxygen levels GO:0070482 100 0.023
regulation of kinase activity GO:0043549 314 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.023
Mouse
regeneration GO:0031099 4 0.023
inorganic cation transmembrane transport GO:0098662 194 0.023
negative regulation of cellular protein metabolic process GO:0032269 353 0.023
cofactor metabolic process GO:0051186 87 0.023
response to decreased oxygen levels GO:0036293 96 0.023
regulation of cell growth GO:0001558 135 0.022
positive regulation of cell proliferation GO:0008284 301 0.022
nitrogen compound transport GO:0071705 191 0.022
negative regulation of protein metabolic process GO:0051248 391 0.022
single organism cellular localization GO:1902580 332 0.022
regulation of nucleoside metabolic process GO:0009118 209 0.022
small molecule biosynthetic process GO:0044283 157 0.022
regulation of proteolysis GO:0030162 293 0.022
negative regulation of programmed cell death GO:0043069 321 0.022
actin filament based process GO:0030029 224 0.022
small molecule catabolic process GO:0044282 92 0.022
covalent chromatin modification GO:0016569 254 0.022
organophosphate biosynthetic process GO:0090407 163 0.022
cellular macromolecular complex assembly GO:0034622 324 0.021
single organism carbohydrate metabolic process GO:0044723 193 0.021
protein catabolic process GO:0030163 325 0.021
positive regulation of developmental process GO:0051094 314 0.021
cytoplasmic transport GO:0016482 379 0.021
negative regulation of cell death GO:0060548 345 0.021
purine containing compound biosynthetic process GO:0072522 88 0.021
purine containing compound catabolic process GO:0072523 411 0.021
nucleotide catabolic process GO:0009166 408 0.021
organophosphate catabolic process GO:0046434 430 0.020
immune response GO:0006955 307 0.020
cellular lipid metabolic process GO:0044255 303 0.020
ribonucleoside triphosphate catabolic process GO:0009203 391 0.020
negative regulation of catalytic activity GO:0043086 335 0.020
positive regulation of cell death GO:0010942 263 0.020
oxidation reduction process GO:0055114 396 0.020
positive regulation of organelle organization GO:0010638 195 0.020
positive regulation of programmed cell death GO:0043068 249 0.020
regulation of growth GO:0040008 165 0.019
cellular response to dna damage stimulus GO:0006974 379 0.019
oogenesis GO:0048477 2 0.019
carbohydrate derivative biosynthetic process GO:1901137 207 0.019
biological adhesion GO:0022610 331 0.019
posttranscriptional regulation of gene expression GO:0010608 213 0.019
mitotic cell cycle process GO:1903047 286 0.019
purine nucleotide biosynthetic process GO:0006164 84 0.019
inorganic ion transmembrane transport GO:0098660 231 0.019
growth GO:0040007 202 0.018
histone modification GO:0016570 251 0.018
embryo development GO:0009790 123 0.018
Mouse
adult locomotory behavior GO:0008344 1 0.018
Mouse
negative regulation of protein modification process GO:0031400 200 0.018
apoptotic signaling pathway GO:0097190 268 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.018
nervous system development GO:0007399 293 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
establishment of protein localization to organelle GO:0072594 172 0.018
anion transmembrane transport GO:0098656 76 0.018
segmentation GO:0035282 4 0.018
protein homooligomerization GO:0051260 100 0.018
ribonucleotide catabolic process GO:0009261 405 0.018
protein localization to membrane GO:0072657 160 0.018
regulation of peptidase activity GO:0052547 180 0.018
protein processing GO:0016485 226 0.017
cell growth GO:0016049 160 0.017
actin cytoskeleton organization GO:0030036 207 0.017
cation transport GO:0006812 331 0.017
monovalent inorganic cation transport GO:0015672 128 0.017
ribose phosphate biosynthetic process GO:0046390 82 0.017
positive regulation of cellular amine metabolic process GO:0033240 7 0.017
coenzyme metabolic process GO:0006732 65 0.017
cytokine production GO:0001816 247 0.017
cell projection organization GO:0030030 252 0.017
negative regulation of hydrolase activity GO:0051346 182 0.017
response to cytokine GO:0034097 232 0.017
protein ubiquitination GO:0016567 314 0.017
nucleocytoplasmic transport GO:0006913 176 0.017
organic acid transport GO:0015849 65 0.017
purine ribonucleoside catabolic process GO:0046130 398 0.017
intracellular receptor signaling pathway GO:0030522 104 0.016
ribonucleoside catabolic process GO:0042454 406 0.016
regulation of cell differentiation GO:0045595 393 0.016
positive regulation of apoptotic process GO:0043065 246 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
negative regulation of organelle organization GO:0010639 126 0.016
defense response GO:0006952 315 0.016
mitochondrial membrane organization GO:0007006 40 0.016
mitotic cell cycle GO:0000278 326 0.016
lipid biosynthetic process GO:0008610 177 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.016
nuclear transport GO:0051169 179 0.016
regulation of cellular response to stress GO:0080135 244 0.016
metal ion transport GO:0030001 272 0.016
protein targeting GO:0006605 187 0.016
neuromuscular junction development GO:0007528 3 0.016
regulation of transmembrane transport GO:0034762 139 0.016
regulation of anatomical structure morphogenesis GO:0022603 286 0.016
negative regulation of cellular component organization GO:0051129 235 0.016
regulation of purine nucleotide metabolic process GO:1900542 264 0.015
regulation of cellular component movement GO:0051270 334 0.015
regulation of immune response GO:0050776 201 0.015
regulation of feeding behavior GO:0060259 3 0.015
myosin filament assembly GO:0031034 2 0.015
protein oligomerization GO:0051259 173 0.015
response to external biotic stimulus GO:0043207 261 0.015
regulation of ion transport GO:0043269 189 0.015
cell adhesion GO:0007155 325 0.015
regulation of membrane potential GO:0042391 95 0.015
secretion GO:0046903 254 0.015
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.015
carboxylic acid biosynthetic process GO:0046394 97 0.015
purine nucleoside triphosphate catabolic process GO:0009146 392 0.015
regulation of cytokine production GO:0001817 232 0.015
cellular response to oxygen levels GO:0071453 55 0.015
cellular metal ion homeostasis GO:0006875 146 0.015
regulation of endopeptidase activity GO:0052548 170 0.015
positive regulation of locomotion GO:0040017 186 0.015
endocytosis GO:0006897 159 0.014
cell morphogenesis GO:0000902 296 0.014
response to other organism GO:0051707 261 0.014
cellular response to oxygen containing compound GO:1901701 276 0.014
organic acid biosynthetic process GO:0016053 97 0.014
nucleoside catabolic process GO:0009164 408 0.014
cellular response to decreased oxygen levels GO:0036294 51 0.014
maintenance of location GO:0051235 112 0.014
response to oxidative stress GO:0006979 121 0.014
organic anion transport GO:0015711 103 0.014
divalent metal ion transport GO:0070838 152 0.014
negative regulation of cell cycle GO:0045786 193 0.014
cellular response to cytokine stimulus GO:0071345 181 0.014
translation GO:0006412 132 0.014
small gtpase mediated signal transduction GO:0007264 78 0.014
purine nucleoside catabolic process GO:0006152 398 0.014
blastoderm segmentation GO:0007350 2 0.014
organic acid catabolic process GO:0016054 71 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.013
response to organic cyclic compound GO:0014070 204 0.013
regulation of protein localization GO:0032880 296 0.013
hindbrain development GO:0030902 3 0.013
positive regulation of cellular catabolic process GO:0031331 284 0.013
hemopoiesis GO:0030097 180 0.013
dna conformation change GO:0071103 113 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
cell development GO:0048468 328 0.013
response to biotic stimulus GO:0009607 276 0.013
developmental programmed cell death GO:0010623 3 0.013
cell cell signaling GO:0007267 155 0.013
positive regulation of cell migration GO:0030335 172 0.013
glycosyl compound catabolic process GO:1901658 413 0.012
protein tetramerization GO:0051262 47 0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.012
pharynx development GO:0060465 1 0.012
ion homeostasis GO:0050801 230 0.012
regulation of oxidative phosphorylation GO:0002082 3 0.012
cellular amino acid biosynthetic process GO:0008652 30 0.012
positive regulation of immune response GO:0050778 159 0.012
cellular protein complex assembly GO:0043623 188 0.012
cell substrate adhesion GO:0031589 132 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
ras protein signal transduction GO:0007265 73 0.012
cellular homeostasis GO:0019725 196 0.012
positive regulation of immune system process GO:0002684 283 0.012
regulation of defense response GO:0031347 154 0.012
tripartite regional subdivision GO:0007351 2 0.012
regulation of protein kinase activity GO:0045859 289 0.012
regulation of dna metabolic process GO:0051052 153 0.012
cell activation GO:0001775 213 0.012
oocyte differentiation GO:0009994 2 0.012
nucleoside monophosphate catabolic process GO:0009125 159 0.012
regulation of behavior GO:0050795 82 0.012
positive regulation of catabolic process GO:0009896 310 0.012
regulation of generation of precursor metabolites and energy GO:0043467 27 0.012
positive regulation of cell differentiation GO:0045597 211 0.012
carboxylic acid catabolic process GO:0046395 71 0.012
central nervous system development GO:0007417 123 0.012
protein autophosphorylation GO:0046777 123 0.012
regulation of response to external stimulus GO:0032101 222 0.012
innate immune response GO:0045087 178 0.012
purine ribonucleotide catabolic process GO:0009154 404 0.012
phospholipid metabolic process GO:0006644 99 0.012
regulation of protein stability GO:0031647 87 0.012
ribonucleotide biosynthetic process GO:0009260 81 0.012
anterior posterior axis specification embryo GO:0008595 2 0.011
regulation of protein catabolic process GO:0042176 155 0.011
cofactor biosynthetic process GO:0051188 31 0.011
receptor metabolic process GO:0043112 81 0.011
modification dependent macromolecule catabolic process GO:0043632 212 0.011
monocarboxylic acid metabolic process GO:0032787 185 0.011
oocyte development GO:0048599 1 0.011
immune system development GO:0002520 195 0.011
chemical homeostasis GO:0048878 306 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
lymphocyte activation GO:0046649 133 0.011
regulation of intracellular transport GO:0032386 195 0.011
response to nitrogen compound GO:1901698 184 0.011
zymogen activation GO:0031638 70 0.011
negative regulation of growth GO:0045926 97 0.011
Mouse
cellular cation homeostasis GO:0030003 163 0.011
regulation of protein processing GO:0070613 150 0.011
protein modification by small protein conjugation GO:0032446 342 0.011
mitochondrial transport GO:0006839 60 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
spermatid differentiation GO:0048515 4 0.011
regulation of transferase activity GO:0051338 355 0.011
activation of immune response GO:0002253 114 0.011
cell type specific apoptotic process GO:0097285 125 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
regulation of ion transmembrane transport GO:0034765 132 0.011
ossification GO:0001503 121 0.011
positive regulation of peptidase activity GO:0010952 88 0.011
protein secretion GO:0009306 98 0.011
organelle assembly GO:0070925 176 0.011
negative regulation of immune system process GO:0002683 136 0.011
negative regulation of cell growth GO:0030308 83 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.010
regulation of protein maturation GO:1903317 150 0.010
cellular amino acid catabolic process GO:0009063 31 0.010
negative regulation of transport GO:0051051 176 0.010
positive regulation of cytokine production GO:0001819 167 0.010
endomembrane system organization GO:0010256 196 0.010
cellular protein catabolic process GO:0044257 261 0.010
hematopoietic or lymphoid organ development GO:0048534 186 0.010
regulation of response to wounding GO:1903034 101 0.010
cell part morphogenesis GO:0032990 137 0.010
dephosphorylation GO:0016311 209 0.010
i kappab kinase nf kappab signaling GO:0007249 166 0.010
cellular component disassembly GO:0022411 92 0.010
response to hypoxia GO:0001666 96 0.010
protein homotetramerization GO:0051289 28 0.010
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.010
reactive oxygen species metabolic process GO:0072593 75 0.010
compound eye development GO:0048749 1 0.010
positive regulation of endopeptidase activity GO:0010950 84 0.010
response to organonitrogen compound GO:0010243 156 0.010
immune response regulating signaling pathway GO:0002764 97 0.010

FXN disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.383
inherited metabolic disorder DOID:655 242 0.383
cancer DOID:162 167 0.043
disease of cellular proliferation DOID:14566 174 0.043
central nervous system disease DOID:331 186 0.041
nervous system disease DOID:863 431 0.041
organ system cancer DOID:0050686 164 0.040
amino acid metabolic disorder DOID:9252 50 0.037
sensory system disease DOID:0050155 203 0.010
neurodegenerative disease DOID:1289 102 0.010
spinocerebellar degeneration DOID:2478 27 0.003
spinocerebellar ataxia DOID:1441 26 0.003