Homo sapiens

42 known processes

HDAC8

histone deacetylase 8

(Aliases: HDACL1,RPD3,HD8)

HDAC8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
female gamete generation GO:0007292 2 0.112
post embryonic development GO:0009791 2 0.102
segmentation GO:0035282 4 0.097
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.082
blastoderm segmentation GO:0007350 2 0.080
oogenesis GO:0048477 2 0.077
regulation of cellular component biogenesis GO:0044087 281 0.075
cardiac muscle contraction GO:0060048 34 0.061
oocyte differentiation GO:0009994 2 0.059
cellular ketone metabolic process GO:0042180 80 0.058
multicellular organismal aging GO:0010259 3 0.057
determination of adult lifespan GO:0008340 2 0.051
cellular amino acid metabolic process GO:0006520 116 0.049
locomotory behavior GO:0007626 1 0.047
oocyte development GO:0048599 1 0.047
anterior posterior axis specification embryo GO:0008595 2 0.046
regulation of cellular ketone metabolic process GO:0010565 50 0.045
tripartite regional subdivision GO:0007351 2 0.045
regulation of cellular amine metabolic process GO:0033238 11 0.045
membrane organization GO:0061024 292 0.043
cellular amine metabolic process GO:0044106 41 0.043
single organism cellular localization GO:1902580 332 0.042
amine metabolic process GO:0009308 44 0.042
system process GO:0003008 349 0.041
regulation of cellular amino acid metabolic process GO:0006521 6 0.041
regulation of cell differentiation GO:0045595 393 0.039
purine ribonucleoside metabolic process GO:0046128 437 0.038
ribonucleoside triphosphate metabolic process GO:0009199 412 0.037
mitochondrion organization GO:0007005 156 0.037
cell development GO:0048468 328 0.037
single organism membrane organization GO:0044802 268 0.037
nucleoside triphosphate metabolic process GO:0009141 422 0.036
cell morphogenesis GO:0000902 296 0.035
organophosphate catabolic process GO:0046434 430 0.035
nucleotide catabolic process GO:0009166 408 0.034
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.034
purine ribonucleotide catabolic process GO:0009154 404 0.034
organelle assembly GO:0070925 176 0.033
cellular component morphogenesis GO:0032989 314 0.033
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.033
ribonucleoside triphosphate catabolic process GO:0009203 391 0.032
cell projection organization GO:0030030 252 0.032
protein localization to organelle GO:0033365 280 0.032
purine nucleoside triphosphate metabolic process GO:0009144 412 0.032
response to oxidative stress GO:0006979 121 0.031
actin cytoskeleton organization GO:0030036 207 0.031
nervous system development GO:0007399 293 0.031
purine nucleoside catabolic process GO:0006152 398 0.031
cell projection assembly GO:0030031 126 0.031
ribonucleotide catabolic process GO:0009261 405 0.030
cellular response to dna damage stimulus GO:0006974 379 0.030
purine nucleoside triphosphate catabolic process GO:0009146 392 0.030
cellular response to oxidative stress GO:0034599 85 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.029
muscle system process GO:0003012 81 0.029
striated muscle contraction GO:0006941 52 0.029
muscle contraction GO:0006936 73 0.029
ribonucleoside catabolic process GO:0042454 406 0.028
neuromuscular junction development GO:0007528 3 0.028
circulatory system development GO:0072359 262 0.028
histone modification GO:0016570 251 0.028
neuron differentiation GO:0030182 138 0.028
purine ribonucleoside catabolic process GO:0046130 398 0.028
regulation of cell cycle GO:0051726 393 0.028
purine containing compound catabolic process GO:0072523 411 0.028
actin filament based process GO:0030029 224 0.027
vesicle mediated transport GO:0016192 371 0.027
nucleoside triphosphate catabolic process GO:0009143 394 0.026
anatomical structure formation involved in morphogenesis GO:0048646 284 0.026
negative regulation of protein metabolic process GO:0051248 391 0.026
cardiovascular system development GO:0072358 262 0.026
lipid biosynthetic process GO:0008610 177 0.026
cellular component assembly involved in morphogenesis GO:0010927 73 0.025
cellular macromolecular complex assembly GO:0034622 324 0.025
single organism reproductive process GO:0044702 98 0.025
cellular lipid metabolic process GO:0044255 303 0.025
positive regulation of catabolic process GO:0009896 310 0.025
cellular protein catabolic process GO:0044257 261 0.025
blood circulation GO:0008015 113 0.024
cell part morphogenesis GO:0032990 137 0.024
brain development GO:0007420 97 0.024
regulation of protein localization GO:0032880 296 0.024
positive regulation of cellular amine metabolic process GO:0033240 7 0.024
cytoplasmic transport GO:0016482 379 0.024
neuron projection development GO:0031175 106 0.023
response to oxygen containing compound GO:1901700 369 0.023
ossification GO:0001503 121 0.023
response to abiotic stimulus GO:0009628 336 0.023
cellular response to oxygen containing compound GO:1901701 276 0.023
lipid metabolic process GO:0006629 381 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
positive regulation of cellular component organization GO:0051130 376 0.022
nucleoside phosphate catabolic process GO:1901292 412 0.022
covalent chromatin modification GO:0016569 254 0.022
intracellular mrna localization GO:0008298 1 0.022
protein catabolic process GO:0030163 325 0.022
regulation of proteolysis GO:0030162 293 0.022
nucleoside catabolic process GO:0009164 408 0.021
purine nucleotide catabolic process GO:0006195 405 0.021
cellular homeostasis GO:0019725 196 0.021
mating GO:0007618 1 0.021
meiosis i GO:0007127 4 0.021
negative regulation of developmental process GO:0051093 247 0.021
protein processing GO:0016485 226 0.021
reproductive process GO:0022414 106 0.020
positive regulation of apoptotic process GO:0043065 246 0.020
organophosphate biosynthetic process GO:0090407 163 0.020
regulation of protein catabolic process GO:0042176 155 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
osteoblast differentiation GO:0001649 92 0.020
ubiquitin dependent protein catabolic process GO:0006511 206 0.020
adult locomotory behavior GO:0008344 1 0.020
cellular component disassembly GO:0022411 92 0.020
regulation of cellular response to stress GO:0080135 244 0.020
positive regulation of hydrolase activity GO:0051345 331 0.019
generation of neurons GO:0048699 152 0.019
protein maturation GO:0051604 233 0.019
regulation of cell cycle process GO:0010564 266 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
modification dependent protein catabolic process GO:0019941 209 0.019
central nervous system development GO:0007417 123 0.019
transmembrane transport GO:0055085 399 0.019
signal transduction by phosphorylation GO:0023014 297 0.019
atp metabolic process GO:0046034 176 0.018
positive regulation of transport GO:0051050 336 0.018
protein targeting GO:0006605 187 0.018
cell projection morphogenesis GO:0048858 129 0.018
peripheral nervous system development GO:0007422 2 0.018
apoptotic signaling pathway GO:0097190 268 0.018
negative regulation of catalytic activity GO:0043086 335 0.018
chromatin organization GO:0006325 351 0.018
positive regulation of phosphorylation GO:0042327 394 0.018
cell morphogenesis involved in differentiation GO:0000904 144 0.018
carbohydrate metabolic process GO:0005975 207 0.018
microtubule based process GO:0007017 210 0.017
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.017
negative regulation of organelle organization GO:0010639 126 0.017
single organism membrane fusion GO:0044801 37 0.017
circulatory system process GO:0003013 113 0.017
dna repair GO:0006281 198 0.017
glycosyl compound catabolic process GO:1901658 413 0.017
ras protein signal transduction GO:0007265 73 0.017
small gtpase mediated signal transduction GO:0007264 78 0.017
microtubule cytoskeleton organization GO:0000226 176 0.017
dephosphorylation GO:0016311 209 0.017
cellular response to reactive oxygen species GO:0034614 50 0.017
regulation of nucleotide metabolic process GO:0006140 269 0.017
regulation of purine nucleotide metabolic process GO:1900542 264 0.017
negative regulation of cellular component organization GO:0051129 235 0.017
anterior posterior axis specification GO:0009948 2 0.017
ribonucleoside monophosphate metabolic process GO:0009161 187 0.017
neuron development GO:0048666 113 0.016
chromosome segregation GO:0007059 114 0.016
negative regulation of cell cycle GO:0045786 193 0.016
regulation of protein transport GO:0051223 213 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
dna replication GO:0006260 116 0.016
regulation of binding GO:0051098 111 0.016
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.016
rho protein signal transduction GO:0007266 26 0.016
regulation of transferase activity GO:0051338 355 0.016
memory GO:0007613 3 0.016
cation homeostasis GO:0055080 189 0.016
protein acylation GO:0043543 138 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.016
heart morphogenesis GO:0003007 48 0.016
meiotic chromosome segregation GO:0045132 4 0.016
posttranscriptional regulation of gene expression GO:0010608 213 0.016
regulation of cytoskeleton organization GO:0051493 177 0.015
mapk cascade GO:0000165 288 0.015
purine nucleoside monophosphate metabolic process GO:0009126 186 0.015
regulation of anatomical structure morphogenesis GO:0022603 286 0.015
nucleoside monophosphate metabolic process GO:0009123 191 0.015
negative regulation of apoptotic process GO:0043066 316 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
endosomal transport GO:0016197 129 0.015
developmental process involved in reproduction GO:0003006 66 0.015
single organism carbohydrate metabolic process GO:0044723 193 0.015
regulation of nucleoside metabolic process GO:0009118 209 0.015
small molecule biosynthetic process GO:0044283 157 0.015
regulation of chromosome organization GO:0033044 103 0.015
positive regulation of transferase activity GO:0051347 227 0.015
guanosine containing compound catabolic process GO:1901069 239 0.015
regulation of intracellular transport GO:0032386 195 0.015
mitochondrial membrane organization GO:0007006 40 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
monocarboxylic acid metabolic process GO:0032787 185 0.015
intracellular protein transport GO:0006886 270 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
regulation of protein kinase activity GO:0045859 289 0.015
positive regulation of cellular component biogenesis GO:0044089 158 0.014
organelle fusion GO:0048284 36 0.014
proteasomal protein catabolic process GO:0010498 176 0.014
protein modification by small protein conjugation GO:0032446 342 0.014
regulation of protein maturation GO:1903317 150 0.014
hindbrain development GO:0030902 3 0.014
spermatid development GO:0007286 4 0.014
regulation of cellular component movement GO:0051270 334 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
regulation of mapk cascade GO:0043408 262 0.014
endomembrane system organization GO:0010256 196 0.014
cellular protein complex assembly GO:0043623 188 0.014
response to radiation GO:0009314 151 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
glial cell migration GO:0008347 4 0.014
endocytosis GO:0006897 159 0.014
mitotic cell cycle GO:0000278 326 0.014
spermatid differentiation GO:0048515 4 0.014
regulation of nucleotide catabolic process GO:0030811 205 0.014
secretion by cell GO:0032940 226 0.014
compound eye development GO:0048749 1 0.014
negative regulation of cell death GO:0060548 345 0.014
defense response GO:0006952 315 0.014
metal ion transport GO:0030001 272 0.014
innate immune response GO:0045087 178 0.014
cellular cation homeostasis GO:0030003 163 0.014
secretion GO:0046903 254 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.014
negative regulation of protein modification process GO:0031400 200 0.014
response to other organism GO:0051707 261 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.013
reactive nitrogen species metabolic process GO:2001057 3 0.013
sensory perception of pain GO:0019233 4 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
reproduction GO:0000003 63 0.013
protein localization to membrane GO:0072657 160 0.013
organ morphogenesis GO:0009887 147 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
regulation of cytokine production GO:0001817 232 0.013
chemical homeostasis GO:0048878 306 0.013
ion homeostasis GO:0050801 230 0.013
organonitrogen compound biosynthetic process GO:1901566 200 0.013
organic acid biosynthetic process GO:0016053 97 0.013
negative regulation of protein processing GO:0010955 142 0.013
negative regulation of transport GO:0051051 176 0.013
associative learning GO:0008306 1 0.013
protein oligomerization GO:0051259 173 0.013
heart contraction GO:0060047 62 0.013
response to cytokine GO:0034097 232 0.013
maintenance of location GO:0051235 112 0.013
positive regulation of protein transport GO:0051222 135 0.013
protein acetylation GO:0006473 116 0.013
protein ubiquitination GO:0016567 314 0.013
chromatin modification GO:0016568 298 0.013
somatic muscle development GO:0007525 1 0.013
macromolecular complex disassembly GO:0032984 60 0.013
positive regulation of proteolysis GO:0045862 142 0.013
reciprocal meiotic recombination GO:0007131 4 0.013
regulation of protein processing GO:0070613 150 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.012
negative regulation of intracellular signal transduction GO:1902532 183 0.012
cellular metal ion homeostasis GO:0006875 146 0.012
regulation of secretion GO:0051046 194 0.012
carboxylic acid biosynthetic process GO:0046394 97 0.012
peptidyl lysine modification GO:0018205 144 0.012
pattern specification process GO:0007389 43 0.012
regeneration GO:0031099 4 0.012
regulation of kinase activity GO:0043549 314 0.012
regulation of reactive oxygen species metabolic process GO:2000377 41 0.012
regulation of cell migration GO:0030334 289 0.012
positive regulation of protein catabolic process GO:0045732 75 0.012
heart process GO:0003015 62 0.012
reactive oxygen species biosynthetic process GO:1903409 4 0.012
regulation of membrane potential GO:0042391 95 0.012
response to reactive oxygen species GO:0000302 61 0.012
anatomical structure homeostasis GO:0060249 100 0.012
cell division GO:0051301 168 0.012
negative regulation of cell proliferation GO:0008285 228 0.012
nucleoside monophosphate catabolic process GO:0009125 159 0.012
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
muscle tissue development GO:0060537 62 0.012
protein autophosphorylation GO:0046777 123 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
regulation of multi organism process GO:0043900 157 0.012
macromolecule methylation GO:0043414 97 0.012
cellular ion homeostasis GO:0006873 168 0.012
regulation of secretion by cell GO:1903530 177 0.012
organelle localization GO:0051640 84 0.012
protein methylation GO:0006479 74 0.012
regulation of locomotion GO:0040012 329 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.012
positive regulation of immune system process GO:0002684 283 0.012
photoreceptor cell differentiation GO:0046530 2 0.012
regulation of small gtpase mediated signal transduction GO:0051056 156 0.012
regulation of cytoplasmic transport GO:1903649 149 0.012
positive regulation of synaptic transmission GO:0050806 4 0.012
intrinsic apoptotic signaling pathway GO:0097193 127 0.012
positive regulation of organelle organization GO:0010638 195 0.012
double strand break repair GO:0006302 101 0.012
negative regulation of cytoskeleton organization GO:0051494 45 0.011
gtp metabolic process GO:0046039 239 0.011
cell cycle phase transition GO:0044770 173 0.011
guanosine containing compound metabolic process GO:1901068 244 0.011
regulation of intracellular protein transport GO:0033157 123 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
embryo development GO:0009790 123 0.011
negative regulation of cell cycle process GO:0010948 121 0.011
regulation of cell motility GO:2000145 299 0.011
regulation of protein complex assembly GO:0043254 147 0.011
nitrogen compound transport GO:0071705 191 0.011
neurogenesis GO:0022008 169 0.011
immune response GO:0006955 307 0.011
autophagy GO:0006914 88 0.011
motor neuron axon guidance GO:0008045 2 0.011
methylation GO:0032259 106 0.011
morphogenesis of embryonic epithelium GO:0016331 4 0.011
positive regulation of protein kinase activity GO:0045860 190 0.011
cellular response to cytokine stimulus GO:0071345 181 0.011
positive regulation of kinase activity GO:0033674 204 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
nerve development GO:0021675 4 0.011
regulation of immune response GO:0050776 201 0.011
phospholipid metabolic process GO:0006644 99 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
regulation of protein stability GO:0031647 87 0.011
long term memory GO:0007616 2 0.011
cell growth GO:0016049 160 0.011
nuclear transport GO:0051169 179 0.011
negative regulation of programmed cell death GO:0043069 321 0.011
cellular chemical homeostasis GO:0055082 180 0.011
biological adhesion GO:0022610 331 0.011
regulation of protein serine threonine kinase activity GO:0071900 179 0.011
response to uv GO:0009411 73 0.011
rna interference GO:0016246 4 0.011
cytokine production GO:0001816 247 0.011
negative regulation of phosphorylation GO:0042326 174 0.011
positive regulation of protein phosphorylation GO:0001934 313 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
regulation of cell projection organization GO:0031344 107 0.011
cardiac muscle cell contraction GO:0086003 4 0.011
heart development GO:0007507 95 0.011
regulation of protein binding GO:0043393 66 0.011
positive regulation of gtp catabolic process GO:0033126 166 0.011
head development GO:0060322 108 0.010
response to fungus GO:0009620 4 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.010
regulation of cell morphogenesis GO:0022604 153 0.010
reproductive system development GO:0061458 56 0.010
oxidation reduction process GO:0055114 396 0.010
pharynx development GO:0060465 1 0.010
negative regulation of protein maturation GO:1903318 142 0.010
cellular response to endogenous stimulus GO:0071495 336 0.010
regulation of synaptic plasticity GO:0048167 3 0.010
inorganic ion transmembrane transport GO:0098660 231 0.010
regulation of dna metabolic process GO:0051052 153 0.010
atp catabolic process GO:0006200 157 0.010
cellular amide metabolic process GO:0043603 69 0.010
response to axon injury GO:0048678 1 0.010
regulation of hormone levels GO:0010817 125 0.010
protein modification by small protein removal GO:0070646 92 0.010
establishment of protein localization to organelle GO:0072594 172 0.010
neuron remodeling GO:0016322 2 0.010
dna dependent dna replication GO:0006261 44 0.010
hemopoiesis GO:0030097 180 0.010
negative regulation of kinase activity GO:0033673 106 0.010
peptidyl lysine acetylation GO:0018394 101 0.010
stress activated mapk cascade GO:0051403 93 0.010
regulation of defense response GO:0031347 154 0.010
positive regulation of cell cycle GO:0045787 140 0.010
negative regulation of multicellular organismal process GO:0051241 317 0.010
internal protein amino acid acetylation GO:0006475 101 0.010
response to wounding GO:0009611 168 0.010
mrna metabolic process GO:0016071 175 0.010
establishment of protein localization to membrane GO:0090150 121 0.010
gtp catabolic process GO:0006184 237 0.010
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.010
positive regulation of cell cycle process GO:0090068 106 0.010
melanin metabolic process GO:0006582 1 0.010

HDAC8 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.032
sensory system disease DOID:0050155 203 0.029
nervous system disease DOID:863 431 0.029
cancer DOID:162 167 0.026
disease of cellular proliferation DOID:14566 174 0.026
organ system cancer DOID:0050686 164 0.026
central nervous system disease DOID:331 186 0.025
eye and adnexa disease DOID:1492 150 0.020
musculoskeletal system disease DOID:17 223 0.019
inherited metabolic disorder DOID:655 242 0.017
eye disease DOID:5614 149 0.016
retinal disease DOID:5679 118 0.015
neurodegenerative disease DOID:1289 102 0.014
retinal degeneration DOID:8466 89 0.013
immune system disease DOID:2914 155 0.013
connective tissue disease DOID:65 109 0.012
brain disease DOID:936 73 0.011
bone disease DOID:0080001 88 0.011
disease of mental health DOID:150 70 0.011
muscular disease DOID:0080000 114 0.011
muscle tissue disease DOID:66 113 0.011
cornelia de lange syndrome DOID:11725 5 0.001