Homo sapiens

93 known processes

CDK12

cyclin-dependent kinase 12

(Aliases: CRKR,CRKRS,hCDK12,CRK7,KIAA0904)

CDK12 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
determination of adult lifespan GO:0008340 2 0.118
vesicle mediated transport GO:0016192 371 0.115
Worm Fly
rna processing GO:0006396 255 0.101
Rat
regulation of anatomical structure morphogenesis GO:0022603 286 0.096
organic hydroxy compound metabolic process GO:1901615 147 0.088
post embryonic development GO:0009791 2 0.085
Worm
positive regulation of mapk cascade GO:0043410 190 0.082
Fly
androgen biosynthetic process GO:0006702 3 0.080
immune system development GO:0002520 195 0.074
Human
erk1 and erk2 cascade GO:0070371 104 0.073
Fly
activation of store operated calcium channel activity GO:0032237 4 0.067
actin filament based process GO:0030029 224 0.062
positive regulation of cellular component organization GO:0051130 376 0.060
ion transmembrane transport GO:0034220 338 0.059
cellular divalent inorganic cation homeostasis GO:0072503 128 0.056
regulation of transferase activity GO:0051338 355 0.056
organophosphate catabolic process GO:0046434 430 0.054
multicellular organismal aging GO:0010259 3 0.053
regulation of ras protein signal transduction GO:0046578 155 0.052
Fly
protein modification by small protein conjugation GO:0032446 342 0.052
histone modification GO:0016570 251 0.051
signal transduction by phosphorylation GO:0023014 297 0.051
regulation of cell cycle GO:0051726 393 0.051
cellular amino acid metabolic process GO:0006520 116 0.051
metal ion transport GO:0030001 272 0.050
cell morphogenesis GO:0000902 296 0.049
small gtpase mediated signal transduction GO:0007264 78 0.049
Fly
protein ubiquitination GO:0016567 314 0.048
lens development in camera type eye GO:0002088 2 0.048
purine nucleoside triphosphate metabolic process GO:0009144 412 0.048
cellular component morphogenesis GO:0032989 314 0.048
cellular response to histamine GO:0071420 3 0.047
cellular macromolecule catabolic process GO:0044265 380 0.046
cellular amine metabolic process GO:0044106 41 0.046
chromatin modification GO:0016568 298 0.045
regulation of cellular amine metabolic process GO:0033238 11 0.045
positive regulation of developmental process GO:0051094 314 0.044
positive regulation of immune system process GO:0002684 283 0.044
negative regulation of hydrolase activity GO:0051346 182 0.044
ras protein signal transduction GO:0007265 73 0.044
Fly
negative regulation of programmed cell death GO:0043069 321 0.042
system process GO:0003008 349 0.042
calcium ion homeostasis GO:0055074 122 0.041
compound eye development GO:0048749 1 0.040
metal ion homeostasis GO:0055065 169 0.040
phosphorylation of rna polymerase ii c terminal domain GO:0070816 3 0.039
mitotic cell cycle GO:0000278 326 0.039
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.038
positive regulation of transport GO:0051050 336 0.038
regulation of protein localization GO:0032880 296 0.037
nervous system development GO:0007399 293 0.037
Fly
regulation of cellular amino acid metabolic process GO:0006521 6 0.037
actin cytoskeleton organization GO:0030036 207 0.036
immune response GO:0006955 307 0.036
regulation of proteolysis GO:0030162 293 0.036
cardiovascular system development GO:0072358 262 0.036
regulation of purine nucleotide metabolic process GO:1900542 264 0.036
cytoplasmic transport GO:0016482 379 0.036
secretion GO:0046903 254 0.035
positive regulation of cellular catabolic process GO:0031331 284 0.035
regulation of mapk cascade GO:0043408 262 0.035
reproductive process GO:0022414 106 0.035
Worm
cellular cation homeostasis GO:0030003 163 0.034
embryo development GO:0009790 123 0.033
Worm
blood vessel development GO:0001568 172 0.033
mitotic cell cycle phase transition GO:0044772 162 0.032
protein autophosphorylation GO:0046777 123 0.032
locomotory behavior GO:0007626 1 0.032
regulation of map kinase activity GO:0043405 108 0.032
response to organic cyclic compound GO:0014070 204 0.032
ion homeostasis GO:0050801 230 0.031
membrane organization GO:0061024 292 0.031
cellular response to growth factor stimulus GO:0071363 197 0.031
cation transport GO:0006812 331 0.030
innate immune response GO:0045087 178 0.030
intracellular protein transport GO:0006886 270 0.030
amine metabolic process GO:0009308 44 0.030
regulation of cell morphogenesis GO:0022604 153 0.030
regulation of kinase activity GO:0043549 314 0.030
regulation of protein kinase activity GO:0045859 289 0.029
negative regulation of apoptotic process GO:0043066 316 0.029
purine ribonucleoside catabolic process GO:0046130 398 0.029
cellular response to dna damage stimulus GO:0006974 379 0.029
hemopoiesis GO:0030097 180 0.028
Human
growth GO:0040007 202 0.027
ncrna metabolic process GO:0034660 108 0.027
regulation of cell cycle process GO:0010564 266 0.027
cellular protein catabolic process GO:0044257 261 0.027
regulation of cellular protein catabolic process GO:1903362 96 0.026
cellular macromolecular complex assembly GO:0034622 324 0.026
cation homeostasis GO:0055080 189 0.026
glycosyl compound catabolic process GO:1901658 413 0.026
regulation of actin filament length GO:0030832 56 0.026
guanosine containing compound metabolic process GO:1901068 244 0.026
cytokinesis GO:0000910 96 0.025
protein acylation GO:0043543 138 0.025
segmentation GO:0035282 4 0.025
methylation GO:0032259 106 0.025
purine nucleoside triphosphate catabolic process GO:0009146 392 0.025
chromatin organization GO:0006325 351 0.025
regulation of response to external stimulus GO:0032101 222 0.025
negative regulation of cell death GO:0060548 345 0.025
actin mediated cell contraction GO:0070252 12 0.025
positive regulation of phosphorylation GO:0042327 394 0.025
Fly
regulation of nucleotide metabolic process GO:0006140 269 0.025
regulation of histone modification GO:0031056 47 0.025
purine ribonucleotide catabolic process GO:0009154 404 0.024
positive regulation of cell differentiation GO:0045597 211 0.024
nucleoside phosphate catabolic process GO:1901292 412 0.024
neurogenesis GO:0022008 169 0.024
Fly
lipid biosynthetic process GO:0008610 177 0.024
positive regulation of cell cycle process GO:0090068 106 0.024
nucleotide catabolic process GO:0009166 408 0.024
cation transmembrane transport GO:0098655 238 0.024
chemical homeostasis GO:0048878 306 0.024
protein targeting GO:0006605 187 0.023
regulation of ion transport GO:0043269 189 0.023
ribonucleoside triphosphate metabolic process GO:0009199 412 0.023
cellular response to organic cyclic compound GO:0071407 127 0.023
calcium ion transport GO:0006816 147 0.023
hematopoietic or lymphoid organ development GO:0048534 186 0.023
Human
regulation of intracellular transport GO:0032386 195 0.023
cellular ketone metabolic process GO:0042180 80 0.023
negative regulation of protein metabolic process GO:0051248 391 0.023
mapk cascade GO:0000165 288 0.023
response to growth factor GO:0070848 205 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
purine ribonucleoside metabolic process GO:0046128 437 0.022
inorganic ion transmembrane transport GO:0098660 231 0.022
neurological system process GO:0050877 163 0.022
ubiquitin dependent protein catabolic process GO:0006511 206 0.022
positive regulation of protein import into nucleus GO:0042307 46 0.022
sequestering of metal ion GO:0051238 24 0.022
tripartite regional subdivision GO:0007351 2 0.022
regulation of protein serine threonine kinase activity GO:0071900 179 0.022
positive regulation of organelle organization GO:0010638 195 0.022
positive regulation of store operated calcium channel activity GO:1901341 4 0.022
positive regulation of peroxisome proliferator activated receptor signaling pathway GO:0035360 4 0.022
spermatid differentiation GO:0048515 4 0.022
defense response GO:0006952 315 0.021
maturation of ssu rrna GO:0030490 3 0.021
transmembrane transport GO:0055085 399 0.021
divalent inorganic cation homeostasis GO:0072507 136 0.021
negative regulation of protein modification process GO:0031400 200 0.021
regulation of cytoplasmic transport GO:1903649 149 0.021
regulation of apoptotic signaling pathway GO:2001233 175 0.021
actin filament based movement GO:0030048 17 0.021
protein localization to organelle GO:0033365 280 0.021
internal protein amino acid acetylation GO:0006475 101 0.021
cellular homeostasis GO:0019725 196 0.021
negative regulation of catalytic activity GO:0043086 335 0.021
g2 m transition of mitotic cell cycle GO:0000086 41 0.021
ribonucleoside triphosphate catabolic process GO:0009203 391 0.021
blood vessel morphogenesis GO:0048514 162 0.020
purine nucleoside catabolic process GO:0006152 398 0.020
anterior posterior axis specification GO:0009948 2 0.020
mitotic cell cycle process GO:1903047 286 0.020
organelle fission GO:0048285 149 0.020
divalent inorganic cation transport GO:0072511 158 0.020
cell growth GO:0016049 160 0.020
anatomical structure formation involved in morphogenesis GO:0048646 284 0.020
inorganic cation transmembrane transport GO:0098662 194 0.020
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.020
regulation of proteasomal protein catabolic process GO:0061136 87 0.020
protein catabolic process GO:0030163 325 0.020
neuromuscular junction development GO:0007528 3 0.020
ribonucleoside catabolic process GO:0042454 406 0.020
regulation of cellular component biogenesis GO:0044087 281 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.019
angiogenesis GO:0001525 147 0.019
peptidyl lysine acetylation GO:0018394 101 0.019
regulation of hormone levels GO:0010817 125 0.019
purine nucleotide catabolic process GO:0006195 405 0.019
ncrna processing GO:0034470 83 0.019
regulation of metal ion transport GO:0010959 120 0.019
female gamete generation GO:0007292 2 0.019
purine containing compound catabolic process GO:0072523 411 0.019
regulation of protein transport GO:0051223 213 0.019
divalent metal ion transport GO:0070838 152 0.019
lung alveolus development GO:0048286 4 0.019
regulation of cellular ketone metabolic process GO:0010565 50 0.018
nucleoside triphosphate catabolic process GO:0009143 394 0.018
positive regulation of intracellular protein transport GO:0090316 76 0.018
negative regulation of cellular protein metabolic process GO:0032269 353 0.018
regulation of nucleoside metabolic process GO:0009118 209 0.018
lipid metabolic process GO:0006629 381 0.018
positive regulation of cellular amine metabolic process GO:0033240 7 0.018
cellular calcium ion homeostasis GO:0006874 117 0.018
organonitrogen compound biosynthetic process GO:1901566 200 0.018
meiosis i GO:0007127 4 0.018
regulation of calcium ion transport GO:0051924 79 0.018
regulation of cell projection organization GO:0031344 107 0.018
negative regulation of cellular amine metabolic process GO:0033239 3 0.018
single organism membrane organization GO:0044802 268 0.018
regulation of cell differentiation GO:0045595 393 0.018
cell cycle phase transition GO:0044770 173 0.018
rho protein signal transduction GO:0007266 26 0.018
rna catabolic process GO:0006401 71 0.017
organophosphate biosynthetic process GO:0090407 163 0.017
single organism cellular localization GO:1902580 332 0.017
cellular ion homeostasis GO:0006873 168 0.017
vasculature development GO:0001944 181 0.017
positive regulation of nucleotide metabolic process GO:0045981 230 0.017
histone acetylation GO:0016573 93 0.017
regulation of multi organism process GO:0043900 157 0.017
positive regulation of protein transport GO:0051222 135 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
spermatid development GO:0007286 4 0.017
response to wounding GO:0009611 168 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
mrna metabolic process GO:0016071 175 0.017
blastoderm segmentation GO:0007350 2 0.017
rna interference GO:0016246 4 0.017
apoptotic signaling pathway GO:0097190 268 0.017
embryonic eye morphogenesis GO:0048048 2 0.017
nucleocytoplasmic transport GO:0006913 176 0.017
axon cargo transport GO:0008088 2 0.017
regulation of protein targeting GO:1903533 91 0.017
regulation of small gtpase mediated signal transduction GO:0051056 156 0.017
Fly
internal peptidyl lysine acetylation GO:0018393 97 0.017
maintenance of location GO:0051235 112 0.017
gtp metabolic process GO:0046039 239 0.017
regulation of cell shape GO:0008360 48 0.016
positive regulation of chromosome organization GO:2001252 41 0.016
guanosine containing compound catabolic process GO:1901069 239 0.016
positive regulation of cell cycle GO:0045787 140 0.016
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.016
Fly
organelle assembly GO:0070925 176 0.016
regulation of response to wounding GO:1903034 101 0.016
negative regulation of cellular component organization GO:0051129 235 0.016
cell division GO:0051301 168 0.016
regulation of chromosome organization GO:0033044 103 0.016
cellular lipid metabolic process GO:0044255 303 0.016
positive regulation of mitotic cell cycle GO:0045931 60 0.016
neuron differentiation GO:0030182 138 0.016
sequestering of calcium ion GO:0051208 17 0.016
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.016
protein import GO:0017038 130 0.015
ribonucleotide catabolic process GO:0009261 405 0.015
anterior posterior axis specification embryo GO:0008595 2 0.015
cell projection assembly GO:0030031 126 0.015
gtp catabolic process GO:0006184 237 0.015
carbohydrate metabolic process GO:0005975 207 0.015
myeloid cell differentiation GO:0030099 117 0.015
cellular response to cytokine stimulus GO:0071345 181 0.015
positive regulation of gtp catabolic process GO:0033126 166 0.015
proteasomal protein catabolic process GO:0010498 176 0.015
phospholipid metabolic process GO:0006644 99 0.015
regulation of protein ubiquitination GO:0031396 95 0.015
positive regulation of catabolic process GO:0009896 310 0.015
nuclear transport GO:0051169 179 0.015
covalent chromatin modification GO:0016569 254 0.015
regeneration GO:0031099 4 0.015
rna splicing GO:0008380 131 0.015
Rat
chromosome segregation GO:0007059 114 0.015
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.015
regulation of defense response GO:0031347 154 0.014
calcium ion transmembrane transport GO:0070588 76 0.014
regulation of nucleotide catabolic process GO:0030811 205 0.014
regulation of axon guidance GO:1902667 3 0.014
embryonic camera type eye development GO:0031076 2 0.014
rrna metabolic process GO:0016072 40 0.014
photoreceptor cell differentiation GO:0046530 2 0.014
epithelium development GO:0060429 227 0.014
cytokine mediated signaling pathway GO:0019221 109 0.014
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.014
cell projection organization GO:0030030 252 0.014
cytokine production GO:0001816 247 0.014
pharynx development GO:0060465 1 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
regulation of protein import into nucleus GO:0042306 78 0.014
regulation of biomineral tissue development GO:0070167 31 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.014
positive regulation of cellular component biogenesis GO:0044089 158 0.014
regulation of protein localization to nucleus GO:1900180 85 0.014
regulation of chromatin organization GO:1902275 56 0.014
melanin metabolic process GO:0006582 1 0.014
regulation of immune response GO:0050776 201 0.014
carbohydrate derivative biosynthetic process GO:1901137 207 0.014
leukocyte differentiation GO:0002521 98 0.014
regulation of homeostatic process GO:0032844 121 0.013
cellular hormone metabolic process GO:0034754 41 0.013
cellular metal ion homeostasis GO:0006875 146 0.013
actin filament organization GO:0007015 128 0.013
regulation of cellular component size GO:0032535 82 0.013
hindlimb morphogenesis GO:0035137 2 0.013
oogenesis GO:0048477 2 0.013
reproduction GO:0000003 63 0.013
Worm
regulation of meiotic cell cycle GO:0051445 4 0.013
regulation of protein complex assembly GO:0043254 147 0.013
cellular response to endogenous stimulus GO:0071495 336 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
positive regulation of cell proliferation GO:0008284 301 0.013
regulation of protein maturation GO:1903317 150 0.013
regulation of vasculature development GO:1901342 97 0.013
embryonic morphogenesis GO:0048598 85 0.013
positive regulation of protein complex assembly GO:0031334 86 0.013
regulation of binding GO:0051098 111 0.013
response to cytokine GO:0034097 232 0.013
immune effector process GO:0002252 159 0.013
regulation of anatomical structure size GO:0090066 101 0.013
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.013
regulation of dna metabolic process GO:0051052 153 0.013
cardiac muscle cell contraction GO:0086003 4 0.013
generation of neurons GO:0048699 152 0.013
nuclear import GO:0051170 106 0.013
intracellular receptor signaling pathway GO:0030522 104 0.013
regulation of purine nucleotide catabolic process GO:0033121 205 0.013
positive regulation of intracellular transport GO:0032388 104 0.013
hormone metabolic process GO:0042445 61 0.013
regulation of establishment of protein localization GO:0070201 242 0.013
single organism nuclear import GO:1902593 104 0.012
memory GO:0007613 3 0.012
regulation of cellular response to stress GO:0080135 244 0.012
embryonic camera type eye morphogenesis GO:0048596 2 0.012
negative regulation of protein processing GO:0010955 142 0.012
modification dependent protein catabolic process GO:0019941 209 0.012
intrinsic apoptotic signaling pathway GO:0097193 127 0.012
protein oligomerization GO:0051259 173 0.012
nucleoside catabolic process GO:0009164 408 0.012
negative regulation of protein maturation GO:1903318 142 0.012
response to abiotic stimulus GO:0009628 336 0.012
regulation of nucleocytoplasmic transport GO:0046822 98 0.012
protein targeting to nucleus GO:0044744 104 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
oocyte development GO:0048599 1 0.012
regulation of response to oxidative stress GO:1902882 26 0.012
cellular response to ammonium ion GO:0071242 4 0.012
response to nitrogen compound GO:1901698 184 0.012
regulation of cellular component movement GO:0051270 334 0.012
positive regulation of cytokine production GO:0001819 167 0.012
branch elongation of an epithelium GO:0060602 3 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
protein dna complex subunit organization GO:0071824 80 0.012
head development GO:0060322 108 0.012
single organism reproductive process GO:0044702 98 0.012
Worm
macromolecule methylation GO:0043414 97 0.012
nerve development GO:0021675 4 0.012
regulation of protein catabolic process GO:0042176 155 0.012
regulation of leukocyte differentiation GO:1902105 61 0.012
myeloid leukocyte differentiation GO:0002573 60 0.012
response to histamine GO:0034776 6 0.012
protein glycosylation GO:0006486 62 0.012
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
positive regulation of defense response GO:0031349 87 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
developmental growth GO:0048589 48 0.011
central nervous system development GO:0007417 123 0.011
visual behavior GO:0007632 2 0.011
regulation of mitotic cell cycle phase transition GO:1901990 118 0.011
cellular protein complex assembly GO:0043623 188 0.011
enzyme linked receptor protein signaling pathway GO:0007167 303 0.011
somitogenesis GO:0001756 2 0.011
sensory perception of mechanical stimulus GO:0050954 37 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.011
regulation of dephosphorylation GO:0035303 96 0.011
dephosphorylation GO:0016311 209 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
blastocyst development GO:0001824 3 0.011
vitamin d receptor signaling pathway GO:0070561 4 0.011
regulation of ion transmembrane transporter activity GO:0032412 72 0.011
regulation of actin filament based process GO:0032970 141 0.011
protein processing GO:0016485 226 0.011
negative regulation of phosphatase activity GO:0010923 61 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
regulation of transporter activity GO:0032409 82 0.011
regulation of actin cytoskeleton organization GO:0032956 116 0.011
detection of chemical stimulus GO:0009593 55 0.011
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.011
regulation of ion transmembrane transport GO:0034765 132 0.011
protein import into nucleus GO:0006606 104 0.011
actin polymerization or depolymerization GO:0008154 56 0.011
glycerolipid metabolic process GO:0046486 107 0.011
regulation of intracellular protein transport GO:0033157 123 0.011
phagocytosis GO:0006909 42 0.011
Fly
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.010
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.010
adult locomotory behavior GO:0008344 1 0.010
cellular modified amino acid metabolic process GO:0006575 64 0.010
regulation of meiosis GO:0040020 3 0.010
endomembrane system organization GO:0010256 196 0.010
sensory perception GO:0007600 103 0.010
tissue morphogenesis GO:0048729 96 0.010
single organism carbohydrate metabolic process GO:0044723 193 0.010
histone h3 acetylation GO:0043966 45 0.010
positive regulation of immune response GO:0050778 159 0.010
nuclear division GO:0000280 128 0.010
regulation of protein polymerization GO:0032271 63 0.010
negative regulation of intracellular signal transduction GO:1902532 183 0.010

CDK12 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.054
cancer DOID:162 167 0.041
organ system cancer DOID:0050686 164 0.037
central nervous system disease DOID:331 186 0.033
nervous system disease DOID:863 431 0.033
auditory system disease DOID:2742 53 0.025
sensory system disease DOID:0050155 203 0.025
neurodegenerative disease DOID:1289 102 0.024
endocrine gland cancer DOID:170 26 0.021
nonsyndromic deafness DOID:0050563 50 0.020
musculoskeletal system disease DOID:17 223 0.020
connective tissue disease DOID:65 109 0.014
cardiovascular system disease DOID:1287 106 0.014
bone disease DOID:0080001 88 0.013
physical disorder DOID:0080015 41 0.012
congenital nervous system abnormality DOID:2490 21 0.012
eye and adnexa disease DOID:1492 150 0.011
eye disease DOID:5614 149 0.011
immune system disease DOID:2914 155 0.011
hematopoietic system disease DOID:74 100 0.011
myopathy DOID:423 104 0.010
muscular disease DOID:0080000 114 0.010
muscle tissue disease DOID:66 113 0.010