Homo sapiens

43 known processes

AKR1C4

aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

(Aliases: CHDR,DD4,HAKRA,3-alpha-HSD,CDR,C11,MGC22581)

AKR1C4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
vitamin e metabolic process GO:0042360 1 0.302
cellular lipid metabolic process GO:0044255 303 0.209
Human
vitamin k catabolic process GO:0042377 2 0.203
testosterone biosynthetic process GO:0061370 2 0.191
Human
monocarboxylic acid metabolic process GO:0032787 185 0.183
Human
cellular amino acid metabolic process GO:0006520 116 0.172
negative regulation of icosanoid secretion GO:0032304 2 0.151
lipid metabolic process GO:0006629 381 0.147
Human Mouse Rat
phylloquinone metabolic process GO:0042374 2 0.129
oxidation reduction process GO:0055114 396 0.120
regulation of cellular ketone metabolic process GO:0010565 50 0.112
Human
fatty acid derivative catabolic process GO:1901569 2 0.111
ketone catabolic process GO:0042182 3 0.111
fatty acid omega oxidation GO:0010430 2 0.109
cellular ketone metabolic process GO:0042180 80 0.106
leukotriene b4 metabolic process GO:0036102 2 0.092
cellular amine metabolic process GO:0044106 41 0.090
organic hydroxy compound metabolic process GO:1901615 147 0.088
Human
primary alcohol metabolic process GO:0034308 17 0.087
Human
menaquinone metabolic process GO:0009233 3 0.086
amine metabolic process GO:0009308 44 0.084
retinoic acid biosynthetic process GO:0002138 2 0.083
Human
icosanoid catabolic process GO:1901523 2 0.082
androgen biosynthetic process GO:0006702 3 0.080
Human
negative regulation of protein metabolic process GO:0051248 391 0.078
modulation of molecular function in other organism involved in symbiotic interaction GO:0052205 2 0.075
fatty acid metabolic process GO:0006631 115 0.074
Human
defense response GO:0006952 315 0.073
epoxygenase p450 pathway GO:0019373 3 0.071
response to oxygen containing compound GO:1901700 369 0.071
regulation of cellular amine metabolic process GO:0033238 11 0.070
post embryonic development GO:0009791 2 0.069
single organism carbohydrate metabolic process GO:0044723 193 0.068
cellular lipid catabolic process GO:0044242 65 0.068
Human
protein maturation GO:0051604 233 0.066
regulation of cellular amino acid metabolic process GO:0006521 6 0.062
leukotriene catabolic process GO:0036100 2 0.062
cellular response to oxygen containing compound GO:1901701 276 0.058
carboxylic acid biosynthetic process GO:0046394 97 0.058
Human
menaquinone catabolic process GO:0042361 2 0.057
alcohol metabolic process GO:0006066 114 0.057
Human
organic acid biosynthetic process GO:0016053 97 0.057
Human
quinone catabolic process GO:1901662 2 0.056
regulation of testosterone biosynthetic process GO:2000224 2 0.055
Human
cofactor metabolic process GO:0051186 87 0.054
positive regulation of cellular amine metabolic process GO:0033240 7 0.054
secretion GO:0046903 254 0.053
small molecule biosynthetic process GO:0044283 157 0.053
Human
immune response GO:0006955 307 0.052
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.051
diterpenoid metabolic process GO:0016101 20 0.051
Human
pressure natriuresis GO:0003095 2 0.050
nitrogen cycle metabolic process GO:0071941 3 0.050
9 cis retinoic acid metabolic process GO:0042905 1 0.050
negative regulation of cellular protein metabolic process GO:0032269 353 0.049
steroid metabolic process GO:0008202 94 0.049
Human Mouse Rat
urea metabolic process GO:0019627 3 0.049
positive regulation of transport GO:0051050 336 0.048
regulation of cellular component movement GO:0051270 334 0.048
regulation of locomotion GO:0040012 329 0.048
phylloquinone catabolic process GO:0042376 2 0.048
chemical homeostasis GO:0048878 306 0.047
lipid catabolic process GO:0016042 84 0.046
Human
anion transport GO:0006820 161 0.045
ion homeostasis GO:0050801 230 0.045
negative regulation by host of viral glycoprotein metabolic process GO:0044871 2 0.044
protein processing GO:0016485 226 0.043
carbohydrate metabolic process GO:0005975 207 0.043
regulation of response to external stimulus GO:0032101 222 0.042
response to wounding GO:0009611 168 0.041
small molecule catabolic process GO:0044282 92 0.040
Human
negative regulation of catalytic activity GO:0043086 335 0.040
negative regulation of cell death GO:0060548 345 0.040
innate immune response GO:0045087 178 0.039
response to organic cyclic compound GO:0014070 204 0.039
Human Rat
regulation of hormone levels GO:0010817 125 0.039
Human Rat
regulation of cell motility GO:2000145 299 0.039
response to biotic stimulus GO:0009607 276 0.038
modulation of molecular function in other organism GO:0044359 2 0.038
cytoplasmic transport GO:0016482 379 0.038
Human
cellular response to prostaglandin stimulus GO:0071379 4 0.038
Human
system process GO:0003008 349 0.037
regeneration GO:0031099 4 0.037
regulation of cell migration GO:0030334 289 0.036
organic anion transport GO:0015711 103 0.036
organophosphate catabolic process GO:0046434 430 0.036
interspecies interaction between organisms GO:0044419 156 0.036
cellular response to endogenous stimulus GO:0071495 336 0.035
regulation of proteolysis GO:0030162 293 0.035
regulation of cell differentiation GO:0045595 393 0.035
multicellular organismal aging GO:0010259 3 0.035
determination of adult lifespan GO:0008340 2 0.035
transmembrane transport GO:0055085 399 0.035
negative regulation of apoptotic process GO:0043066 316 0.035
vitamin k biosynthetic process GO:0042371 2 0.034
negative regulation of protein maturation GO:1903318 142 0.034
response to other organism GO:0051707 261 0.033
cellular response to genistein GO:0071412 1 0.033
nitrogen compound transport GO:0071705 191 0.033
negative regulation of programmed cell death GO:0043069 321 0.033
lipid biosynthetic process GO:0008610 177 0.033
Human Mouse Rat
renal water homeostasis GO:0003091 4 0.033
negative regulation of multicellular organismal process GO:0051241 317 0.033
purine ribonucleoside metabolic process GO:0046128 437 0.032
nucleotide catabolic process GO:0009166 408 0.031
terpenoid metabolic process GO:0006721 27 0.031
Human
regulation of establishment of protein localization GO:0070201 242 0.031
carboxylic acid catabolic process GO:0046395 71 0.031
negative regulation of developmental process GO:0051093 247 0.030
viral life cycle GO:0019058 132 0.030
cellular organohalogen metabolic process GO:0090345 2 0.030
regulation of protein localization GO:0032880 296 0.030
response to cytokine GO:0034097 232 0.030
nucleoside triphosphate metabolic process GO:0009141 422 0.030
maintenance of location GO:0051235 112 0.029
regulation of high density lipoprotein particle clearance GO:0010982 2 0.029
response to external biotic stimulus GO:0043207 261 0.029
multi organism cellular process GO:0044764 156 0.029
unsaturated fatty acid metabolic process GO:0033559 37 0.029
Human
metal ion homeostasis GO:0055065 169 0.029
positive regulation of protein phosphorylation GO:0001934 313 0.028
lipid transport GO:0006869 90 0.028
positive regulation of immune system process GO:0002684 283 0.028
alkaloid metabolic process GO:0009820 4 0.028
organonitrogen compound biosynthetic process GO:1901566 200 0.028
regulation of protein maturation GO:1903317 150 0.028
viral process GO:0016032 146 0.028
monocarboxylic acid biosynthetic process GO:0072330 67 0.028
Human
urate transport GO:0015747 3 0.028
regulation of secretion by cell GO:1903530 177 0.028
immune effector process GO:0002252 159 0.028
regulation of secretion GO:0051046 194 0.028
icosanoid metabolic process GO:0006690 35 0.027
Human
nucleoside catabolic process GO:0009164 408 0.027
vesicle mediated transport GO:0016192 371 0.027
regulation of immune response GO:0050776 201 0.027
female gamete generation GO:0007292 2 0.027
protein oligomerization GO:0051259 173 0.027
Human
regulation of protein processing GO:0070613 150 0.027
ribonucleoside catabolic process GO:0042454 406 0.027
secretion by cell GO:0032940 226 0.027
ribonucleoside triphosphate catabolic process GO:0009203 391 0.026
nucleoside phosphate catabolic process GO:1901292 412 0.026
purine containing compound catabolic process GO:0072523 411 0.026
negative regulation of protein processing GO:0010955 142 0.026
isoquinoline alkaloid metabolic process GO:0033076 1 0.026
organic acid transport GO:0015849 65 0.026
purine nucleotide catabolic process GO:0006195 405 0.026
response to hormone GO:0009725 175 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.026
cellular homeostasis GO:0019725 196 0.026
glycosyl compound catabolic process GO:1901658 413 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.025
purine nucleoside triphosphate catabolic process GO:0009146 392 0.025
fatty acid derivative metabolic process GO:1901568 35 0.025
Human
sulfur compound metabolic process GO:0006790 101 0.025
positive regulation of cellular component organization GO:0051130 376 0.025
single organism cellular localization GO:1902580 332 0.025
Human
positive regulation of programmed cell death GO:0043068 249 0.025
Human
cellular response to growth factor stimulus GO:0071363 197 0.025
locomotory behavior GO:0007626 1 0.025
regulation of anatomical structure morphogenesis GO:0022603 286 0.025
regulation of endopeptidase activity GO:0052548 170 0.025
regulation of transferase activity GO:0051338 355 0.025
negative regulation of locomotion GO:0040013 118 0.025
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.025
protein localization to organelle GO:0033365 280 0.024
Human
positive regulation of cell proliferation GO:0008284 301 0.024
Human
regulation of response to wounding GO:1903034 101 0.024
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.024
positive regulation of cell death GO:0010942 263 0.024
Human
positive regulation of catabolic process GO:0009896 310 0.024
negative regulation of proteolysis GO:0045861 132 0.024
regulation of protein transport GO:0051223 213 0.024
neutral lipid catabolic process GO:0046461 12 0.024
regulation of cytokine production GO:0001817 232 0.024
ribonucleotide catabolic process GO:0009261 405 0.024
oogenesis GO:0048477 2 0.024
positive regulation of hydrolase activity GO:0051345 331 0.024
response to inorganic substance GO:0010035 127 0.024
Human
response to nitrogen compound GO:1901698 184 0.024
apoptotic signaling pathway GO:0097190 268 0.023
cell adhesion GO:0007155 325 0.023
reactive oxygen species metabolic process GO:0072593 75 0.023
Human
negative regulation of hydrolase activity GO:0051346 182 0.023
purine nucleoside catabolic process GO:0006152 398 0.023
isoprenoid metabolic process GO:0006720 39 0.023
Human
response to abiotic stimulus GO:0009628 336 0.023
purine nucleoside triphosphate metabolic process GO:0009144 412 0.023
carboxylic acid transport GO:0046942 63 0.023
neuromuscular junction development GO:0007528 3 0.023
naphthalene metabolic process GO:0018931 1 0.023
long chain fatty acid metabolic process GO:0001676 30 0.023
oxidative demethylation GO:0070989 11 0.023
purine ribonucleoside catabolic process GO:0046130 398 0.022
intracellular protein transport GO:0006886 270 0.022
Human
protein catabolic process GO:0030163 325 0.022
biological adhesion GO:0022610 331 0.022
cation transport GO:0006812 331 0.022
segmentation GO:0035282 4 0.022
morphogenesis of embryonic epithelium GO:0016331 4 0.022
purine ribonucleotide catabolic process GO:0009154 404 0.022
organic acid catabolic process GO:0016054 71 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
regulation of lipid metabolic process GO:0019216 96 0.022
Human Rat
actin filament based process GO:0030029 224 0.021
regulation of phospholipase c activating g protein coupled receptor signaling pathway GO:1900736 1 0.021
enzyme linked receptor protein signaling pathway GO:0007167 303 0.021
response to growth factor GO:0070848 205 0.021
nucleoside monophosphate metabolic process GO:0009123 191 0.021
glycoprotein metabolic process GO:0009100 110 0.021
regulation of apoptotic signaling pathway GO:2001233 175 0.021
ribonucleoside triphosphate metabolic process GO:0009199 412 0.021
positive regulation of fibrinolysis GO:0051919 4 0.021
limbic system development GO:0021761 3 0.021
Rat
cellular macromolecular complex assembly GO:0034622 324 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
purine nucleoside monophosphate metabolic process GO:0009126 186 0.021
positive regulation of cell migration GO:0030335 172 0.021
lipid localization GO:0010876 106 0.021
tissue regeneration GO:0042246 3 0.021
cytokine production GO:0001816 247 0.021
arachidonic acid metabolic process GO:0019369 14 0.021
cation homeostasis GO:0055080 189 0.021
negative regulation of cell differentiation GO:0045596 171 0.021
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.020
response to lipid GO:0033993 206 0.020
Human Rat
response to drug GO:0042493 81 0.020
Rat
nucleoside triphosphate catabolic process GO:0009143 394 0.020
positive regulation of apoptotic process GO:0043065 246 0.020
Human
ribonucleoside monophosphate metabolic process GO:0009161 187 0.020
regulation of cellular response to stress GO:0080135 244 0.020
salivary gland morphogenesis GO:0007435 4 0.020
sensory perception of smell GO:0007608 2 0.020
chemotaxis GO:0006935 157 0.020
regulation of peptidase activity GO:0052547 180 0.020
positive regulation of organic acid transport GO:0032892 3 0.020
long chain fatty acid catabolic process GO:0042758 3 0.019
negative regulation of cellular component organization GO:0051129 235 0.019
metal ion transport GO:0030001 272 0.019
cell morphogenesis GO:0000902 296 0.019
naphthalene containing compound metabolic process GO:0090420 1 0.019
peptidyl tyrosine modification GO:0018212 170 0.019
peripheral nervous system development GO:0007422 2 0.019
positive regulation of phosphorylation GO:0042327 394 0.019
negative regulation of endopeptidase activity GO:0010951 84 0.019
nucleocytoplasmic transport GO:0006913 176 0.019
Human
peptidyl tyrosine phosphorylation GO:0018108 170 0.019
positive regulation of cellular component movement GO:0051272 181 0.019
regulation of cell cycle GO:0051726 393 0.019
cellular chemical homeostasis GO:0055082 180 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
positive regulation of secretion GO:0051047 116 0.019
response to metal ion GO:0010038 84 0.019
Human
mitotic cell cycle GO:0000278 326 0.018
carbohydrate derivative biosynthetic process GO:1901137 207 0.018
regulation of kinase activity GO:0043549 314 0.018
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.018
glycerolipid metabolic process GO:0046486 107 0.018
regulation of viral process GO:0050792 103 0.018
negative regulation of protein modification process GO:0031400 200 0.018
cellular protein catabolic process GO:0044257 261 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.018
negative regulation of immune system process GO:0002683 136 0.018
nervous system development GO:0007399 293 0.018
Rat
sterol catabolic process GO:0016127 3 0.018
Human
ion transmembrane transport GO:0034220 338 0.018
anatomical structure formation involved in morphogenesis GO:0048646 284 0.018
single organism membrane organization GO:0044802 268 0.018
spermatid differentiation GO:0048515 4 0.018
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.018
negative regulation of cellular amine metabolic process GO:0033239 3 0.018
coenzyme metabolic process GO:0006732 65 0.018
taxis GO:0042330 157 0.018
memory GO:0007613 3 0.018
regulation of cell cycle process GO:0010564 266 0.018
alpha amino acid metabolic process GO:1901605 72 0.017
regulation of cellular component biogenesis GO:0044087 281 0.017
immune system development GO:0002520 195 0.017
t helper 2 cell cytokine production GO:0035745 3 0.017
positive regulation of peptidyl serine phosphorylation of stat protein GO:0033141 3 0.017
inner ear morphogenesis GO:0042472 4 0.017
actin filament based movement GO:0030048 17 0.017
cellular response to cytokine stimulus GO:0071345 181 0.017
negative regulation of peptidase activity GO:0010466 91 0.017
epithelial cell differentiation GO:0030855 141 0.017
Human
regulation of defense response GO:0031347 154 0.017
epithelium development GO:0060429 227 0.017
Human
cellular response to organic cyclic compound GO:0071407 127 0.017
Human
negative regulation of phosphate metabolic process GO:0045936 267 0.017
lipid modification GO:0030258 84 0.017
positive regulation of vasoconstriction GO:0045907 3 0.017
hematopoietic or lymphoid organ development GO:0048534 186 0.017
circulatory system development GO:0072359 262 0.017
protein targeting GO:0006605 187 0.016
Human
small gtpase mediated signal transduction GO:0007264 78 0.016
negative regulation of monocyte differentiation GO:0045656 3 0.016
nuclear transport GO:0051169 179 0.016
Human
protein import GO:0017038 130 0.016
Human
establishment of protein localization to organelle GO:0072594 172 0.016
Human
cellular cation homeostasis GO:0030003 163 0.016
protein secretion GO:0009306 98 0.016
negative regulation of response to external stimulus GO:0032102 83 0.016
activation of immune response GO:0002253 114 0.016
cardiac muscle cell contraction GO:0086003 4 0.016
response to nutrient levels GO:0031667 81 0.016
Human
adult locomotory behavior GO:0008344 1 0.016
atp metabolic process GO:0046034 176 0.016
mapk cascade GO:0000165 288 0.016
ras protein signal transduction GO:0007265 73 0.016
cellular component morphogenesis GO:0032989 314 0.016
regulation of protein secretion GO:0050708 86 0.016
response to oxidative stress GO:0006979 121 0.016
Human
inflammatory response GO:0006954 79 0.016
hemopoiesis GO:0030097 180 0.016
posttranscriptional regulation of gene expression GO:0010608 213 0.016
positive regulation of locomotion GO:0040017 186 0.016
ribonucleoside monophosphate catabolic process GO:0009158 158 0.016
wound healing GO:0042060 115 0.016
cellular protein complex assembly GO:0043623 188 0.016
regulation of intracellular transport GO:0032386 195 0.016
cardiovascular system development GO:0072358 262 0.016
rna processing GO:0006396 255 0.016
Mouse
protein ubiquitination GO:0016567 314 0.016
growth GO:0040007 202 0.016
reactive oxygen species biosynthetic process GO:1903409 4 0.016
negative regulation of cell motility GO:2000146 104 0.016
hormone metabolic process GO:0042445 61 0.016
Human Rat
regulation of reactive oxygen species metabolic process GO:2000377 41 0.016
Human
dephosphorylation GO:0016311 209 0.016
cellular amide metabolic process GO:0043603 69 0.016
positive regulation of protein transport GO:0051222 135 0.016
response to fungus GO:0009620 4 0.016
vitamin metabolic process GO:0006766 26 0.016
Human
protein modification by small protein conjugation GO:0032446 342 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
positive regulation of transferase activity GO:0051347 227 0.016
blood circulation GO:0008015 113 0.016
regulation of nucleotide metabolic process GO:0006140 269 0.015
response to axon injury GO:0048678 1 0.015
regulation of system process GO:0044057 101 0.015
purine nucleoside monophosphate catabolic process GO:0009128 158 0.015
positive regulation of nucleotide metabolic process GO:0045981 230 0.015
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.015
Human
hemostasis GO:0007599 76 0.015
terpenoid biosynthetic process GO:0016114 2 0.015
Human
oocyte development GO:0048599 1 0.015
spermatid development GO:0007286 4 0.015
motor neuron axon guidance GO:0008045 2 0.015
atp catabolic process GO:0006200 157 0.015
regulation of multi organism process GO:0043900 157 0.015
g protein coupled receptor signaling pathway GO:0007186 207 0.015
Human
hormone catabolic process GO:0042447 4 0.015
chromatin organization GO:0006325 351 0.015
cellular response to hydroxyisoflavone GO:0071413 1 0.015
negative regulation of interleukin 13 secretion GO:2000666 1 0.015
leukocyte migration GO:0050900 107 0.015
regulation of cell adhesion GO:0030155 166 0.015
defense response to fungus GO:0050832 4 0.015
retinoid metabolic process GO:0001523 18 0.015
Human
cell substrate adhesion GO:0031589 132 0.015
nucleoside monophosphate catabolic process GO:0009125 159 0.015
vasculature development GO:0001944 181 0.015
negative regulation of phosphorylation GO:0042326 174 0.015
blastoderm segmentation GO:0007350 2 0.015
anterior posterior axis specification GO:0009948 2 0.015
neurological system process GO:0050877 163 0.015
negative regulation of multi organism process GO:0043901 92 0.015
embryonic epithelial tube formation GO:0001838 4 0.015
positive regulation of developmental process GO:0051094 314 0.015
circulatory system process GO:0003013 113 0.015
protein localization to nucleus GO:0034504 136 0.015
Human
hindbrain development GO:0030902 3 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.014
drug metabolic process GO:0017144 19 0.014
coumarin metabolic process GO:0009804 2 0.014
reproductive process GO:0022414 106 0.014
Human
regulation of protein kinase activity GO:0045859 289 0.014
positive regulation of organelle organization GO:0010638 195 0.014
regulation of binding GO:0051098 111 0.014
cellular calcium ion homeostasis GO:0006874 117 0.014
negative regulation of cellular component movement GO:0051271 106 0.014
cellular response to hormone stimulus GO:0032870 125 0.014
associative learning GO:0008306 1 0.014
carnitine transmembrane transport GO:1902603 3 0.014
cell activation GO:0001775 213 0.014
cellular response to dna damage stimulus GO:0006974 379 0.014
response to acid chemical GO:0001101 66 0.014
cell development GO:0048468 328 0.014
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.014
negative regulation of cellular organohalogen metabolic process GO:0090349 1 0.014
cell chemotaxis GO:0060326 112 0.014
positive regulation of response to external stimulus GO:0032103 88 0.014
negative regulation of viral process GO:0048525 66 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.014
cell growth GO:0016049 160 0.014
photoreceptor cell differentiation GO:0046530 2 0.014
cellular response to reactive oxygen species GO:0034614 50 0.014
Human
chromatin modification GO:0016568 298 0.014
response to extracellular stimulus GO:0009991 85 0.014
Human
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.014
tissue migration GO:0090130 119 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.014
angiogenesis GO:0001525 147 0.014
toxin metabolic process GO:0009404 4 0.014
regulation of growth GO:0040008 165 0.014
myeloid cell differentiation GO:0030099 117 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.014
negative regulation of apoptotic signaling pathway GO:2001234 97 0.014
positive regulation of immune response GO:0050778 159 0.014
glial cell migration GO:0008347 4 0.014
regulation of ion transport GO:0043269 189 0.014
behavior GO:0007610 112 0.014
regulation of cellular organohalogen metabolic process GO:0090347 1 0.014
negative regulation of transport GO:0051051 176 0.014
regulation of body fluid levels GO:0050878 99 0.014
organic hydroxy compound catabolic process GO:1901616 22 0.014
Human
rhythmic behavior GO:0007622 2 0.014
cellular response to nitrogen compound GO:1901699 144 0.014
leukotriene b4 catabolic process GO:0036101 2 0.014
cellular response to external stimulus GO:0071496 111 0.014
Human
renal system process involved in regulation of blood volume GO:0001977 4 0.014
negative regulation of intracellular signal transduction GO:1902532 183 0.014
negative regulation of cell proliferation GO:0008285 228 0.014
alpha ketoglutarate transport GO:0015742 1 0.014
positive regulation of cell differentiation GO:0045597 211 0.014
regulation of cytoplasmic transport GO:1903649 149 0.014
response to bacterium GO:0009617 144 0.014
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.014
cholesterol metabolic process GO:0008203 28 0.013
Human
negative regulation of cell migration GO:0030336 102 0.013
actin mediated cell contraction GO:0070252 12 0.013
negative regulation of molecular function in other organism involved in symbiotic interaction GO:0052204 2 0.013
oocyte differentiation GO:0009994 2 0.013
sequestering of metal ion GO:0051238 24 0.013
positive regulation of cell motility GO:2000147 177 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
epithelial cell proliferation GO:0050673 128 0.013
cell projection organization GO:0030030 252 0.013
membrane organization GO:0061024 292 0.013
organ formation GO:0048645 3 0.013
regulation of immune effector process GO:0002697 91 0.013
response to organonitrogen compound GO:0010243 156 0.013
cellular organofluorine metabolic process GO:0090346 2 0.013
positive regulation of synaptic transmission GO:0050806 4 0.013
cell type specific apoptotic process GO:0097285 125 0.013
Human
reactive nitrogen species metabolic process GO:2001057 3 0.013
circadian behavior GO:0048512 2 0.013
tripartite regional subdivision GO:0007351 2 0.013
regulation of mapk cascade GO:0043408 262 0.013
estrogen catabolic process GO:0006711 1 0.013
regulation of cysteine type endopeptidase activity GO:2000116 127 0.013
cation transmembrane transport GO:0098655 238 0.013
monosaccharide metabolic process GO:0005996 74 0.013
compound eye development GO:0048749 1 0.013
negative regulation of gliogenesis GO:0014014 3 0.013
intracellular receptor signaling pathway GO:0030522 104 0.013
Human
regulation of glial cell differentiation GO:0045685 3 0.013
phospholipid metabolic process GO:0006644 99 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
stem cell division GO:0017145 2 0.013
organ morphogenesis GO:0009887 147 0.013
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.013
negative regulation of cellular organofluorine metabolic process GO:0090350 1 0.013
endocytosis GO:0006897 159 0.013
farnesol catabolic process GO:0016488 2 0.013
Human
calcium ion homeostasis GO:0055074 122 0.013
cellular response to lipid GO:0071396 127 0.013
Human
regulation of transmission of nerve impulse GO:0051969 2 0.013
regulation of vesicle mediated transport GO:0060627 130 0.013
positive regulation of fatty acid transport GO:2000193 3 0.013
ameboidal type cell migration GO:0001667 135 0.013
hippocampus development GO:0021766 1 0.013
Rat
defense response to other organism GO:0098542 129 0.013
alkaloid catabolic process GO:0009822 3 0.012
mitotic cell cycle process GO:1903047 286 0.012
embryonic viscerocranium morphogenesis GO:0048703 1 0.012

AKR1C4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.081
Human
inherited metabolic disorder DOID:655 242 0.060
Human
immune system disease DOID:2914 155 0.028
amino acid metabolic disorder DOID:9252 50 0.026
hematopoietic system disease DOID:74 100 0.023
sensory system disease DOID:0050155 203 0.020
nervous system disease DOID:863 431 0.020
disease of cellular proliferation DOID:14566 174 0.019
cancer DOID:162 167 0.019
organ system cancer DOID:0050686 164 0.018
central nervous system disease DOID:331 186 0.017
musculoskeletal system disease DOID:17 223 0.015
acquired metabolic disease DOID:0060158 58 0.014
neurodegenerative disease DOID:1289 102 0.014
eye and adnexa disease DOID:1492 150 0.013
eye disease DOID:5614 149 0.013
cardiovascular system disease DOID:1287 106 0.012