Homo sapiens

48 known processes

USP49

ubiquitin specific peptidase 49

(Aliases: MGC20741)

USP49 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein deubiquitination GO:0016579 79 0.194
protein modification by small protein removal GO:0070646 92 0.131
post embryonic development GO:0009791 2 0.104
protein catabolic process GO:0030163 325 0.096
Human
chromatin organization GO:0006325 351 0.096
cellular macromolecule catabolic process GO:0044265 380 0.095
Human
chromatin modification GO:0016568 298 0.088
protein modification by small protein conjugation GO:0032446 342 0.081
Human
histone modification GO:0016570 251 0.070
negative regulation of protein metabolic process GO:0051248 391 0.063
Human
rna processing GO:0006396 255 0.063
protein processing GO:0016485 226 0.060
Human
modification dependent macromolecule catabolic process GO:0043632 212 0.060
Human
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.058
Human
cellular protein catabolic process GO:0044257 261 0.053
Human
protein ubiquitination GO:0016567 314 0.053
Human
dna repair GO:0006281 198 0.049
Human
organelle fission GO:0048285 149 0.048
Human
regulation of transferase activity GO:0051338 355 0.047
Human
mitotic cell cycle GO:0000278 326 0.046
Human
regulation of mitosis GO:0007088 63 0.046
Human
segmentation GO:0035282 4 0.045
regulation of proteasomal protein catabolic process GO:0061136 87 0.045
Human
system process GO:0003008 349 0.042
proteasomal protein catabolic process GO:0010498 176 0.042
Human
cytoplasmic transport GO:0016482 379 0.042
regulation of cell cycle process GO:0010564 266 0.040
Human
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.040
Human
regulation of protein processing GO:0070613 150 0.040
Human
mrna metabolic process GO:0016071 175 0.038
regulation of protein maturation GO:1903317 150 0.037
Human
negative regulation of protein maturation GO:1903318 142 0.037
Human
regulation of proteolysis GO:0030162 293 0.037
Human
multicellular organismal aging GO:0010259 3 0.037
oogenesis GO:0048477 2 0.036
regulation of cell cycle GO:0051726 393 0.036
Human
regulation of ligase activity GO:0051340 29 0.035
Human
negative regulation of protein modification process GO:0031400 200 0.035
Human
nuclear transport GO:0051169 179 0.034
negative regulation of catalytic activity GO:0043086 335 0.034
Human
nucleocytoplasmic transport GO:0006913 176 0.033
regulation of cell migration GO:0030334 289 0.033
locomotory behavior GO:0007626 1 0.033
cell division GO:0051301 168 0.033
Human
mitotic sister chromatid separation GO:0051306 18 0.031
Human
determination of adult lifespan GO:0008340 2 0.031
female gamete generation GO:0007292 2 0.031
rhythmic behavior GO:0007622 2 0.030
histone deubiquitination GO:0016578 16 0.029
associative learning GO:0008306 1 0.029
chromosome segregation GO:0007059 114 0.028
Human
regulation of cell motility GO:2000145 299 0.028
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.028
Human
regulation of cell division GO:0051302 116 0.028
Human
response to abiotic stimulus GO:0009628 336 0.028
chromosome separation GO:0051304 23 0.027
Human
cell cycle phase transition GO:0044770 173 0.027
Human
intracellular protein transport GO:0006886 270 0.027
amine metabolic process GO:0009308 44 0.027
metal ion transport GO:0030001 272 0.027
single organism cellular localization GO:1902580 332 0.027
negative regulation of organelle organization GO:0010639 126 0.026
Human
regulation of mitotic cell cycle GO:0007346 189 0.026
Human
mrna splicing via spliceosome GO:0000398 89 0.026
regulation of intracellular transport GO:0032386 195 0.026
blastoderm segmentation GO:0007350 2 0.026
regulation of ion transport GO:0043269 189 0.025
cellular amino acid metabolic process GO:0006520 116 0.025
regulation of neural precursor cell proliferation GO:2000177 4 0.025
regulation of protein localization GO:0032880 296 0.025
negative regulation of cell death GO:0060548 345 0.025
nuclear division GO:0000280 128 0.025
Human
regulation of nuclear division GO:0051783 65 0.025
Human
posttranscriptional regulation of gene expression GO:0010608 213 0.025
Human
regulation of ubiquitin protein transferase activity GO:0051438 28 0.025
Human
negative regulation of gliogenesis GO:0014014 3 0.025
dephosphorylation GO:0016311 209 0.025
regulation of locomotion GO:0040012 329 0.024
regulation of protein catabolic process GO:0042176 155 0.024
Human
spermatid development GO:0007286 4 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
regulation of chromosome segregation GO:0051983 44 0.024
Human
neuromuscular junction development GO:0007528 3 0.024
mitotic cell cycle phase transition GO:0044772 162 0.024
Human
negative regulation of cell cycle GO:0045786 193 0.024
Human
regulation of cellular component movement GO:0051270 334 0.023
ras protein signal transduction GO:0007265 73 0.023
anterior posterior axis specification GO:0009948 2 0.023
histone h2b conserved c terminal lysine deubiquitination GO:0035616 1 0.023
negative regulation of catabolic process GO:0009895 104 0.023
Human
regulation of protein stability GO:0031647 87 0.023
Human
regeneration GO:0031099 4 0.023
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.023
Human
positive regulation of phosphorylation GO:0042327 394 0.022
protein localization to organelle GO:0033365 280 0.022
positive regulation of immune system process GO:0002684 283 0.022
neurological system process GO:0050877 163 0.022
rna splicing GO:0008380 131 0.022
circadian behavior GO:0048512 2 0.022
oocyte differentiation GO:0009994 2 0.022
regulation of glial cell differentiation GO:0045685 3 0.022
cation transport GO:0006812 331 0.022
regulation of chromosome organization GO:0033044 103 0.021
Human
negative regulation of proteolysis GO:0045861 132 0.021
Human
spermatid differentiation GO:0048515 4 0.021
negative regulation of chromosome organization GO:2001251 48 0.021
Human
positive regulation of cellular component organization GO:0051130 376 0.021
cellular homeostasis GO:0019725 196 0.021
regulation of protein ubiquitination GO:0031396 95 0.021
Human
negative regulation of cellular protein metabolic process GO:0032269 353 0.021
Human
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.021
Human
metaphase anaphase transition of cell cycle GO:0044784 21 0.021
Human
ribonucleoside catabolic process GO:0042454 406 0.021
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.021
Human
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.021
Human
positive regulation of transport GO:0051050 336 0.021
sister chromatid segregation GO:0000819 54 0.021
Human
spindle assembly checkpoint GO:0071173 17 0.020
inorganic ion transmembrane transport GO:0098660 231 0.020
negative regulation of programmed cell death GO:0043069 321 0.020
purine ribonucleoside metabolic process GO:0046128 437 0.020
enzyme linked receptor protein signaling pathway GO:0007167 303 0.020
adult locomotory behavior GO:0008344 1 0.020
cellular response to dna damage stimulus GO:0006974 379 0.020
Human
negative regulation of cell cycle phase transition GO:1901988 89 0.020
Human
cellular ketone metabolic process GO:0042180 80 0.020
regulation of protein transport GO:0051223 213 0.020
regulation of cellular amino acid metabolic process GO:0006521 6 0.020
ribonucleoside triphosphate metabolic process GO:0009199 412 0.020
negative regulation of cellular protein catabolic process GO:1903363 38 0.020
Human
nitrogen compound transport GO:0071705 191 0.020
memory GO:0007613 3 0.020
regulation of cell differentiation GO:0045595 393 0.020
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.020
Human
transmembrane transport GO:0055085 399 0.020
regulation of cellular amine metabolic process GO:0033238 11 0.020
cation homeostasis GO:0055080 189 0.020
glycosyl compound catabolic process GO:1901658 413 0.020
negative regulation of apoptotic process GO:0043066 316 0.020
membrane organization GO:0061024 292 0.019
peripheral nervous system development GO:0007422 2 0.019
sensory perception GO:0007600 103 0.019
positive regulation of cellular amine metabolic process GO:0033240 7 0.019
protein maturation GO:0051604 233 0.019
Human
cation transmembrane transport GO:0098655 238 0.019
response to oxygen containing compound GO:1901700 369 0.019
regulation of purine nucleotide metabolic process GO:1900542 264 0.019
protein targeting GO:0006605 187 0.019
regulation of cytoplasmic transport GO:1903649 149 0.019
ion transmembrane transport GO:0034220 338 0.019
regulation of mitotic cell cycle phase transition GO:1901990 118 0.019
Human
nervous system development GO:0007399 293 0.019
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.018
Human
sleep GO:0030431 2 0.018
nucleoside phosphate catabolic process GO:1901292 412 0.018
regulation of cell development GO:0060284 161 0.018
regulation of establishment of protein localization GO:0070201 242 0.018
actin filament based process GO:0030029 224 0.018
cardiac muscle cell contraction GO:0086003 4 0.018
nerve development GO:0021675 4 0.018
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.018
morphogenesis of embryonic epithelium GO:0016331 4 0.018
regulation of mitotic sister chromatid segregation GO:0033047 27 0.018
Human
cellular chemical homeostasis GO:0055082 180 0.018
tripartite regional subdivision GO:0007351 2 0.018
circadian sleep wake cycle GO:0042745 2 0.018
immune response GO:0006955 307 0.017
protein localization to nucleus GO:0034504 136 0.017
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.017
Human
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.017
Human
regulation of cellular response to stress GO:0080135 244 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.017
cell morphogenesis GO:0000902 296 0.017
oocyte development GO:0048599 1 0.017
establishment of protein localization to organelle GO:0072594 172 0.017
anterior posterior axis specification embryo GO:0008595 2 0.017
inorganic cation transmembrane transport GO:0098662 194 0.017
positive regulation of hydrolase activity GO:0051345 331 0.017
regulation of meiotic cell cycle GO:0051445 4 0.017
maintenance of location GO:0051235 112 0.017
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
ubiquitin dependent protein catabolic process GO:0006511 206 0.016
Human
chemical homeostasis GO:0048878 306 0.016
regulation of nucleotide catabolic process GO:0030811 205 0.016
regulation of reactive oxygen species metabolic process GO:2000377 41 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
positive regulation of protein phosphorylation GO:0001934 313 0.016
reactive oxygen species metabolic process GO:0072593 75 0.016
neurogenesis GO:0022008 169 0.016
negative regulation of wnt signaling pathway GO:0030178 69 0.016
negative regulation of protein processing GO:0010955 142 0.016
Human
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.016
small gtpase mediated signal transduction GO:0007264 78 0.016
divalent inorganic cation transport GO:0072511 158 0.016
negative regulation of developmental process GO:0051093 247 0.016
calcium ion transport GO:0006816 147 0.016
positive regulation of intracellular transport GO:0032388 104 0.016
positive regulation of nucleotide catabolic process GO:0030813 185 0.016
mitotic cell cycle process GO:1903047 286 0.016
Human
response to nitrogen compound GO:1901698 184 0.016
divalent metal ion transport GO:0070838 152 0.016
positive regulation of apoptotic process GO:0043065 246 0.016
stem cell division GO:0017145 2 0.016
cellular response to endogenous stimulus GO:0071495 336 0.016
ncrna metabolic process GO:0034660 108 0.016
cell projection organization GO:0030030 252 0.015
protein polyubiquitination GO:0000209 110 0.015
forebrain neuron differentiation GO:0021879 3 0.015
regulation of purine nucleotide catabolic process GO:0033121 205 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
protein import GO:0017038 130 0.015
regulation of protein kinase activity GO:0045859 289 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.015
oxidation reduction process GO:0055114 396 0.015
negative regulation of multicellular organismal process GO:0051241 317 0.015
anion transport GO:0006820 161 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
negative regulation of phosphate metabolic process GO:0045936 267 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
cellular amine metabolic process GO:0044106 41 0.015
apoptotic signaling pathway GO:0097190 268 0.015
multicellular organismal signaling GO:0035637 34 0.015
tissue regeneration GO:0042246 3 0.015
spinal cord development GO:0021510 4 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.015
generation of neurons GO:0048699 152 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.015
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.015
biological adhesion GO:0022610 331 0.015
protein oligomerization GO:0051259 173 0.015
regulation of sister chromatid segregation GO:0033045 27 0.015
Human
negative regulation of protein catabolic process GO:0042177 59 0.015
Human
cellular response to organic cyclic compound GO:0071407 127 0.015
reactive nitrogen species metabolic process GO:2001057 3 0.015
negative regulation of protein ubiquitination GO:0031397 35 0.015
Human
endomembrane system organization GO:0010256 196 0.014
sensory perception of smell GO:0007608 2 0.014
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.014
startle response GO:0001964 3 0.014
multi organism cellular process GO:0044764 156 0.014
protein targeting to nucleus GO:0044744 104 0.014
regulation of intracellular protein transport GO:0033157 123 0.014
detection of stimulus GO:0051606 85 0.014
positive regulation of cytoplasmic transport GO:1903651 82 0.014
meiotic chromosome segregation GO:0045132 4 0.014
embryonic epithelial tube formation GO:0001838 4 0.014
metal ion homeostasis GO:0055065 169 0.014
reactive oxygen species biosynthetic process GO:1903409 4 0.014
regulation of synaptic plasticity GO:0048167 3 0.014
wnt signaling pathway GO:0016055 156 0.014
regulation of odontogenesis GO:0042481 4 0.014
cellular macromolecular complex assembly GO:0034622 324 0.014
cellular lipid metabolic process GO:0044255 303 0.014
lipid metabolic process GO:0006629 381 0.014
cellular metal ion homeostasis GO:0006875 146 0.014
actin mediated cell contraction GO:0070252 12 0.014
cell adhesion GO:0007155 325 0.014
covalent chromatin modification GO:0016569 254 0.014
positive regulation of protein transport GO:0051222 135 0.014
regulation of ras protein signal transduction GO:0046578 155 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.014
sequestering of metal ion GO:0051238 24 0.014
mitotic cell cycle checkpoint GO:0007093 68 0.014
response to fungus GO:0009620 4 0.014
circadian sleep wake cycle sleep GO:0050802 2 0.014
hindbrain development GO:0030902 3 0.014
response to other organism GO:0051707 261 0.014
secretion by cell GO:0032940 226 0.014
secretion GO:0046903 254 0.014
regulation of membrane potential GO:0042391 95 0.014
microtubule based process GO:0007017 210 0.014
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.014
Human
forebrain generation of neurons GO:0021872 3 0.014
regulation of nucleotide metabolic process GO:0006140 269 0.013
positive regulation of cell differentiation GO:0045597 211 0.013
response to organic cyclic compound GO:0014070 204 0.013
monovalent inorganic cation transport GO:0015672 128 0.013
regulation of cell cycle phase transition GO:1901987 126 0.013
Human
rna interference GO:0016246 4 0.013
regulation of dephosphorylation GO:0035303 96 0.013
compound eye development GO:0048749 1 0.013
positive regulation of programmed cell death GO:0043068 249 0.013
ion homeostasis GO:0050801 230 0.013
single organism nuclear import GO:1902593 104 0.013
positive regulation of cell death GO:0010942 263 0.013
vesicle mediated transport GO:0016192 371 0.013
negative regulation of cell differentiation GO:0045596 171 0.013
response to external biotic stimulus GO:0043207 261 0.013
organelle assembly GO:0070925 176 0.013
rho protein signal transduction GO:0007266 26 0.013
protein k48 linked ubiquitination GO:0070936 38 0.013
regulation of kinase activity GO:0043549 314 0.013
negative regulation of cell division GO:0051782 31 0.013
Human
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.013
actin filament based movement GO:0030048 17 0.013
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.013
cell development GO:0048468 328 0.013
regulation of cellular ketone metabolic process GO:0010565 50 0.013
purine ribonucleoside catabolic process GO:0046130 398 0.013
ribonucleoprotein complex biogenesis GO:0022613 116 0.013
negative regulation of cell proliferation GO:0008285 228 0.013
regulation of metal ion transport GO:0010959 120 0.013
regulation of response to external stimulus GO:0032101 222 0.013
microtubule cytoskeleton organization GO:0000226 176 0.012
cerebellum development GO:0021549 2 0.012
positive regulation of organelle organization GO:0010638 195 0.012
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.012
Human
purine ribonucleotide catabolic process GO:0009154 404 0.012
nuclear import GO:0051170 106 0.012
lipid biosynthetic process GO:0008610 177 0.012
positive regulation of developmental process GO:0051094 314 0.012
innate immune response GO:0045087 178 0.012
anatomical structure formation involved in morphogenesis GO:0048646 284 0.012
syncytium formation by plasma membrane fusion GO:0000768 2 0.012
neural tube closure GO:0001843 3 0.012
tube closure GO:0060606 3 0.012
defense response GO:0006952 315 0.012
regulation of transmembrane transport GO:0034762 139 0.012
purine nucleoside triphosphate metabolic process GO:0009144 412 0.012
regulation of dna metabolic process GO:0051052 153 0.012
cellular component morphogenesis GO:0032989 314 0.012
regulation of cell growth GO:0001558 135 0.012
neural tube formation GO:0001841 3 0.012
metencephalon development GO:0022037 2 0.012
response to fibroblast growth factor GO:0071774 39 0.012
sensory perception of pain GO:0019233 4 0.012
limbic system development GO:0021761 3 0.012
epidermis morphogenesis GO:0048730 3 0.012
regulation of cytokine production GO:0001817 232 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
regulation of circadian sleep wake cycle GO:0042749 2 0.012
negative regulation of hydrolase activity GO:0051346 182 0.011
photoreceptor cell differentiation GO:0046530 2 0.011
sequestering of calcium ion GO:0051208 17 0.011
mating GO:0007618 1 0.011
cell projection morphogenesis GO:0048858 129 0.011
cell part morphogenesis GO:0032990 137 0.011
methylation GO:0032259 106 0.011
protein import into nucleus GO:0006606 104 0.011
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.011
embryo development GO:0009790 123 0.011
protein autophosphorylation GO:0046777 123 0.011
regulation of cell adhesion GO:0030155 166 0.011
positive regulation of nucleoside metabolic process GO:0045979 186 0.011
single organism membrane organization GO:0044802 268 0.011
regulation of gtpase activity GO:0043087 180 0.011
circadian sleep wake cycle process GO:0022410 2 0.011
cellular calcium ion homeostasis GO:0006874 117 0.011
hair follicle morphogenesis GO:0031069 2 0.011
negative regulation of transferase activity GO:0051348 124 0.011
Human
negative regulation of smoothened signaling pathway GO:0045879 3 0.011
response to axon injury GO:0048678 1 0.011
neural crest cell development GO:0014032 3 0.011
ventral spinal cord development GO:0021517 1 0.011
response to growth factor GO:0070848 205 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
response to organonitrogen compound GO:0010243 156 0.011
ncrna processing GO:0034470 83 0.011
cytokine production GO:0001816 247 0.011
neurotransmitter secretion GO:0007269 4 0.011
i kappab kinase nf kappab signaling GO:0007249 166 0.011
regulation of immune response GO:0050776 201 0.011
positive regulation of cellular component biogenesis GO:0044089 158 0.011
negative regulation of mitotic sister chromatid separation GO:2000816 17 0.011
Human
macromolecule methylation GO:0043414 97 0.011
endosomal transport GO:0016197 129 0.011
response to hypoxia GO:0001666 96 0.011
rna phosphodiester bond hydrolysis GO:0090501 35 0.011
regulation of calcium ion transport GO:0051924 79 0.011
interspecies interaction between organisms GO:0044419 156 0.011
primary neural tube formation GO:0014020 3 0.011
negative regulation of chromosome segregation GO:0051985 18 0.010
Human
mitochondrion organization GO:0007005 156 0.010
modification dependent protein catabolic process GO:0019941 209 0.010
Human
cell differentiation in spinal cord GO:0021515 1 0.010
cell fate determination GO:0001709 3 0.010
regulation of cellular protein catabolic process GO:1903362 96 0.010
Human
response to biotic stimulus GO:0009607 276 0.010
sensory perception of light stimulus GO:0050953 35 0.010
regulation of endopeptidase activity GO:0052548 170 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
negative regulation of response to external stimulus GO:0032102 83 0.010
regulation of meiosis GO:0040020 3 0.010
regulation of cytoskeleton organization GO:0051493 177 0.010
positive regulation of transferase activity GO:0051347 227 0.010
response to virus GO:0009615 126 0.010
calcium ion homeostasis GO:0055074 122 0.010
motor neuron axon guidance GO:0008045 2 0.010
positive regulation of synaptic transmission GO:0050806 4 0.010
response to nutrient levels GO:0031667 81 0.010
cellular response to abiotic stimulus GO:0071214 117 0.010
cellular cation homeostasis GO:0030003 163 0.010
visual behavior GO:0007632 2 0.010
organ formation GO:0048645 3 0.010
myoblast fusion GO:0007520 1 0.010
positive regulation of cytokine production GO:0001819 167 0.010

USP49 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.024
nervous system disease DOID:863 431 0.024
disease of mental health DOID:150 70 0.023
disease of cellular proliferation DOID:14566 174 0.023
cancer DOID:162 167 0.022
organ system cancer DOID:0050686 164 0.022
musculoskeletal system disease DOID:17 223 0.021
disease of metabolism DOID:0014667 295 0.020
central nervous system disease DOID:331 186 0.019
eye and adnexa disease DOID:1492 150 0.019
eye disease DOID:5614 149 0.019
retinal disease DOID:5679 118 0.016
inherited metabolic disorder DOID:655 242 0.015
bone disease DOID:0080001 88 0.012
connective tissue disease DOID:65 109 0.012
myopathy DOID:423 104 0.011
muscular disease DOID:0080000 114 0.011
muscle tissue disease DOID:66 113 0.011
brain disease DOID:936 73 0.011
retinal degeneration DOID:8466 89 0.011