Homo sapiens

17 known processes

USP46

ubiquitin specific peptidase 46

(Aliases: FLJ39393,FLJ14283,FLJ11850,FLJ12552)

USP46 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
limbic system development GO:0021761 3 0.777
hippocampus development GO:0021766 1 0.620
protein dephosphorylation GO:0006470 81 0.243
protein deubiquitination GO:0016579 79 0.205
cellular amino acid metabolic process GO:0006520 116 0.195
cellular amino acid biosynthetic process GO:0008652 30 0.159
protein modification by small protein removal GO:0070646 92 0.125
pallium development GO:0021543 10 0.119
cellular response to dna damage stimulus GO:0006974 379 0.113
negative regulation of intracellular signal transduction GO:1902532 183 0.111
purine ribonucleotide catabolic process GO:0009154 404 0.107
organonitrogen compound biosynthetic process GO:1901566 200 0.099
organophosphate catabolic process GO:0046434 430 0.097
forebrain development GO:0030900 26 0.096
carboxylic acid biosynthetic process GO:0046394 97 0.081
dephosphorylation GO:0016311 209 0.081
glycosyl compound catabolic process GO:1901658 413 0.078
female gamete generation GO:0007292 2 0.077
response to unfolded protein GO:0006986 24 0.073
head development GO:0060322 108 0.072
double strand break repair GO:0006302 101 0.071
purine ribonucleoside metabolic process GO:0046128 437 0.069
nucleoside triphosphate catabolic process GO:0009143 394 0.067
organic acid biosynthetic process GO:0016053 97 0.066
regulation of epithelial cell proliferation GO:0050678 113 0.064
ribonucleoside catabolic process GO:0042454 406 0.064
negative regulation of cellular protein metabolic process GO:0032269 353 0.064
nervous system development GO:0007399 293 0.063
positive regulation of epithelial cell proliferation GO:0050679 65 0.062
purine nucleoside catabolic process GO:0006152 398 0.062
purine containing compound catabolic process GO:0072523 411 0.057
morphogenesis of embryonic epithelium GO:0016331 4 0.056
nucleoside triphosphate metabolic process GO:0009141 422 0.055
positive regulation of cell proliferation GO:0008284 301 0.054
brain development GO:0007420 97 0.053
positive regulation of cell size GO:0045793 3 0.051
ribonucleotide catabolic process GO:0009261 405 0.051
central nervous system development GO:0007417 123 0.050
dna repair GO:0006281 198 0.050
protein ubiquitination GO:0016567 314 0.049
small molecule biosynthetic process GO:0044283 157 0.048
positive regulation of catabolic process GO:0009896 310 0.047
negative regulation of protein metabolic process GO:0051248 391 0.045
cell cycle checkpoint GO:0000075 117 0.045
telencephalon development GO:0021537 17 0.044
post embryonic development GO:0009791 2 0.042
oogenesis GO:0048477 2 0.042
regulation of cellular component size GO:0032535 82 0.041
guanosine containing compound metabolic process GO:1901068 244 0.041
regulation of anatomical structure size GO:0090066 101 0.041
regulation of dna metabolic process GO:0051052 153 0.041
posttranscriptional regulation of gene expression GO:0010608 213 0.041
translation GO:0006412 132 0.040
amine metabolic process GO:0009308 44 0.039
cellular homeostasis GO:0019725 196 0.039
cytoplasmic transport GO:0016482 379 0.039
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.039
dna integrity checkpoint GO:0031570 71 0.038
purine nucleoside triphosphate catabolic process GO:0009146 392 0.038
locomotory behavior GO:0007626 1 0.037
neuromuscular junction development GO:0007528 3 0.035
response to radiation GO:0009314 151 0.035
cellular response to external stimulus GO:0071496 111 0.035
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.035
protein modification by small protein conjugation GO:0032446 342 0.034
memory GO:0007613 3 0.034
cellular response to nutrient levels GO:0031669 69 0.033
ribonucleoside triphosphate metabolic process GO:0009199 412 0.033
secretion by cell GO:0032940 226 0.033
response to topologically incorrect protein GO:0035966 29 0.032
response to extracellular stimulus GO:0009991 85 0.032
organ morphogenesis GO:0009887 147 0.032
positive regulation of apoptotic process GO:0043065 246 0.031
purine ribonucleoside catabolic process GO:0046130 398 0.031
cell morphogenesis GO:0000902 296 0.031
regulation of cellular amino acid metabolic process GO:0006521 6 0.031
cellular response to topologically incorrect protein GO:0035967 19 0.031
nucleoside phosphate catabolic process GO:1901292 412 0.031
negative regulation of catalytic activity GO:0043086 335 0.030
mitotic cell cycle GO:0000278 326 0.030
gtp metabolic process GO:0046039 239 0.030
purine nucleotide catabolic process GO:0006195 405 0.030
positive regulation of cellular component organization GO:0051130 376 0.030
regulation of purine nucleotide metabolic process GO:1900542 264 0.030
system process GO:0003008 349 0.030
cell aging GO:0007569 52 0.030
growth GO:0040007 202 0.029
regulation of cellular response to stress GO:0080135 244 0.029
cellular response to starvation GO:0009267 58 0.029
multicellular organismal aging GO:0010259 3 0.029
translational initiation GO:0006413 48 0.029
regulation of protein kinase b signaling GO:0051896 61 0.028
chronological cell aging GO:0001300 2 0.028
regulation of protein kinase activity GO:0045859 289 0.028
regulation of translational initiation GO:0006446 24 0.028
positive regulation of programmed cell death GO:0043068 249 0.028
negative regulation of growth GO:0045926 97 0.028
positive regulation of hydrolase activity GO:0051345 331 0.028
response to endoplasmic reticulum stress GO:0034976 49 0.027
secretion GO:0046903 254 0.027
nucleotide catabolic process GO:0009166 408 0.027
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.026
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.026
regulation of purine nucleotide catabolic process GO:0033121 205 0.026
ribonucleoside triphosphate catabolic process GO:0009203 391 0.026
regulation of cell cycle process GO:0010564 266 0.026
positive regulation of cell death GO:0010942 263 0.026
response to abiotic stimulus GO:0009628 336 0.025
regulation of kinase activity GO:0043549 314 0.025
positive regulation of phosphorylation GO:0042327 394 0.025
cellular response to extracellular stimulus GO:0031668 72 0.025
cellular ketone metabolic process GO:0042180 80 0.025
cell development GO:0048468 328 0.025
positive regulation of nucleotide metabolic process GO:0045981 230 0.025
proteasomal protein catabolic process GO:0010498 176 0.025
regulation of protein localization GO:0032880 296 0.025
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.025
membrane organization GO:0061024 292 0.024
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.024
protein kinase c signaling GO:0070528 17 0.024
cellular amine metabolic process GO:0044106 41 0.024
purine nucleoside triphosphate metabolic process GO:0009144 412 0.024
regulation of growth GO:0040008 165 0.024
regulation of translation GO:0006417 89 0.024
regulation of transferase activity GO:0051338 355 0.024
endomembrane system organization GO:0010256 196 0.024
guanosine containing compound catabolic process GO:1901069 239 0.024
regulation of cytoskeleton organization GO:0051493 177 0.023
oocyte development GO:0048599 1 0.023
regulation of cell differentiation GO:0045595 393 0.023
regulation of nucleotide metabolic process GO:0006140 269 0.023
regulation of protein ubiquitination GO:0031396 95 0.023
regulation of mapk cascade GO:0043408 262 0.023
regulation of cell growth GO:0001558 135 0.023
positive regulation of cellular amine metabolic process GO:0033240 7 0.023
positive regulation of gtpase activity GO:0043547 166 0.022
negative regulation of protein modification process GO:0031400 200 0.022
regulation of cellular amine metabolic process GO:0033238 11 0.022
vesicle mediated transport GO:0016192 371 0.022
atp catabolic process GO:0006200 157 0.022
regulation of ras protein signal transduction GO:0046578 155 0.022
negative regulation of multicellular organismal process GO:0051241 317 0.022
negative regulation of phosphorus metabolic process GO:0010563 267 0.022
cell adhesion GO:0007155 325 0.021
cellular component morphogenesis GO:0032989 314 0.021
macromolecular complex disassembly GO:0032984 60 0.021
Yeast
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.021
anterior posterior axis specification GO:0009948 2 0.021
transmembrane transport GO:0055085 399 0.021
regulation of cell morphogenesis GO:0022604 153 0.020
regulation of nucleoside metabolic process GO:0009118 209 0.020
regulation of anatomical structure morphogenesis GO:0022603 286 0.020
regulation of nucleotide catabolic process GO:0030811 205 0.020
positive regulation of immune system process GO:0002684 283 0.020
determination of adult lifespan GO:0008340 2 0.020
protein processing GO:0016485 226 0.020
long term memory GO:0007616 2 0.020
plasma membrane organization GO:0007009 115 0.020
ras protein signal transduction GO:0007265 73 0.020
oocyte differentiation GO:0009994 2 0.020
neurotransmitter secretion GO:0007269 4 0.020
ribonucleoside monophosphate catabolic process GO:0009158 158 0.020
regulation of small gtpase mediated signal transduction GO:0051056 156 0.020
regulation of cell motility GO:2000145 299 0.019
cation transport GO:0006812 331 0.019
signal transduction by phosphorylation GO:0023014 297 0.019
inner ear morphogenesis GO:0042472 4 0.019
cellular macromolecular complex assembly GO:0034622 324 0.019
cellular protein catabolic process GO:0044257 261 0.019
negative regulation of cellular component organization GO:0051129 235 0.019
immune response GO:0006955 307 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
regulation of gtp catabolic process GO:0033124 180 0.019
positive regulation of cell differentiation GO:0045597 211 0.019
negative regulation of cell growth GO:0030308 83 0.019
positive regulation of nucleoside metabolic process GO:0045979 186 0.019
positive regulation of protein kinase activity GO:0045860 190 0.019
lipid metabolic process GO:0006629 381 0.018
chemical homeostasis GO:0048878 306 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.018
tripartite regional subdivision GO:0007351 2 0.018
regulation of cellular ketone metabolic process GO:0010565 50 0.018
mitotic cell cycle process GO:1903047 286 0.018
segmentation GO:0035282 4 0.018
regulation of cell cycle GO:0051726 393 0.018
gtp catabolic process GO:0006184 237 0.018
cellular component disassembly GO:0022411 92 0.018
Yeast
cellular macromolecule catabolic process GO:0044265 380 0.018
purine nucleoside monophosphate metabolic process GO:0009126 186 0.018
protein catabolic process GO:0030163 325 0.018
negative regulation of protein kinase b signaling GO:0051898 17 0.018
single organism membrane organization GO:0044802 268 0.018
ion transmembrane transport GO:0034220 338 0.018
metal ion transport GO:0030001 272 0.018
positive regulation of kinase activity GO:0033674 204 0.018
embryonic organ development GO:0048568 36 0.018
regulation of homeostatic process GO:0032844 121 0.018
Yeast
establishment of tissue polarity GO:0007164 3 0.018
intracellular protein transport GO:0006886 270 0.018
mapk cascade GO:0000165 288 0.017
adult locomotory behavior GO:0008344 1 0.017
endoplasmic reticulum unfolded protein response GO:0030968 16 0.017
cellular response to radiation GO:0071478 65 0.017
establishment of planar polarity GO:0001736 3 0.017
cytokine production GO:0001816 247 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.017
response to nutrient levels GO:0031667 81 0.017
negative regulation of programmed cell death GO:0043069 321 0.017
carbohydrate metabolic process GO:0005975 207 0.017
er nucleus signaling pathway GO:0006984 23 0.017
protein kinase b signaling GO:0043491 69 0.017
positive regulation of cellular component biogenesis GO:0044089 158 0.017
cell growth GO:0016049 160 0.017
generation of neurons GO:0048699 152 0.017
regulation of cellular component movement GO:0051270 334 0.016
regulation of rho protein signal transduction GO:0035023 79 0.016
microtubule based process GO:0007017 210 0.016
positive regulation of ras gtpase activity GO:0032320 117 0.016
negative regulation of phosphorylation GO:0042326 174 0.016
epithelium development GO:0060429 227 0.016
oxidation reduction process GO:0055114 396 0.016
negative regulation of cell death GO:0060548 345 0.016
positive regulation of gtp catabolic process GO:0033126 166 0.016
response to starvation GO:0042594 59 0.016
regulation of protein transport GO:0051223 213 0.016
ribonucleoside monophosphate metabolic process GO:0009161 187 0.016
cation transmembrane transport GO:0098655 238 0.016
blastoderm segmentation GO:0007350 2 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
nucleoside monophosphate metabolic process GO:0009123 191 0.016
nucleoside catabolic process GO:0009164 408 0.016
monocarboxylic acid metabolic process GO:0032787 185 0.016
double strand break repair via homologous recombination GO:0000724 50 0.016
carbohydrate derivative biosynthetic process GO:1901137 207 0.016
positive regulation of developmental process GO:0051094 314 0.016
regulation of ras gtpase activity GO:0032318 128 0.016
cell division GO:0051301 168 0.016
hair cell differentiation GO:0035315 2 0.016
response to other organism GO:0051707 261 0.016
cardiovascular system development GO:0072358 262 0.016
negative regulation of translation GO:0017148 37 0.015
regulation of cell projection organization GO:0031344 107 0.015
rho protein signal transduction GO:0007266 26 0.015
microtubule cytoskeleton organization GO:0000226 176 0.015
spermatid differentiation GO:0048515 4 0.015
protein polyubiquitination GO:0000209 110 0.015
purine nucleoside monophosphate catabolic process GO:0009128 158 0.015
regulation of secretion GO:0051046 194 0.015
rhythmic process GO:0048511 31 0.015
cellular response to abiotic stimulus GO:0071214 117 0.015
nucleoside monophosphate catabolic process GO:0009125 159 0.015
protein monoubiquitination GO:0006513 39 0.015
cerebral cortex cell migration GO:0021795 3 0.015
single organism cellular localization GO:1902580 332 0.015
protein oligomerization GO:0051259 173 0.015
innate immune response GO:0045087 178 0.015
nucleus localization GO:0051647 1 0.015
single organism cell adhesion GO:0098602 179 0.015
male sex differentiation GO:0046661 25 0.014
positive regulation of organelle organization GO:0010638 195 0.014
cell projection organization GO:0030030 252 0.014
positive regulation of rho gtpase activity GO:0032321 56 0.014
dna recombination GO:0006310 77 0.014
negative regulation of apoptotic process GO:0043066 316 0.014
positive regulation of transferase activity GO:0051347 227 0.014
cellular lipid metabolic process GO:0044255 303 0.014
stem cell division GO:0017145 2 0.014
tube closure GO:0060606 3 0.014
neural tube closure GO:0001843 3 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
sulfur compound metabolic process GO:0006790 101 0.014
regulation of cell development GO:0060284 161 0.014
neurological system process GO:0050877 163 0.014
regulation of locomotion GO:0040012 329 0.014
glycoprotein metabolic process GO:0009100 110 0.014
peptidyl tyrosine phosphorylation GO:0018108 170 0.014
spermatid development GO:0007286 4 0.014
cell substrate adhesion GO:0031589 132 0.014
glial cell migration GO:0008347 4 0.013
cerebral cortex radially oriented cell migration GO:0021799 1 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
cellular chemical homeostasis GO:0055082 180 0.013
cation homeostasis GO:0055080 189 0.013
neurogenesis GO:0022008 169 0.013
peripheral nervous system development GO:0007422 2 0.013
negative regulation of cell cycle GO:0045786 193 0.013
single organismal cell cell adhesion GO:0016337 148 0.013
defense response GO:0006952 315 0.013
Mouse
multi organism cellular process GO:0044764 156 0.013
cell morphogenesis involved in differentiation GO:0000904 144 0.013
cell part morphogenesis GO:0032990 137 0.013
regulation of protein complex assembly GO:0043254 147 0.013
regulation of secretion by cell GO:1903530 177 0.013
cell projection assembly GO:0030031 126 0.013
ion homeostasis GO:0050801 230 0.013
rhythmic behavior GO:0007622 2 0.013
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
actin cytoskeleton organization GO:0030036 207 0.012
associative learning GO:0008306 1 0.012
regulation of response to external stimulus GO:0032101 222 0.012
chromatin modification GO:0016568 298 0.012
regulation of cell adhesion GO:0030155 166 0.012
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.012
regulation of circadian rhythm GO:0042752 11 0.012
negative regulation of cell proliferation GO:0008285 228 0.012
inorganic cation transmembrane transport GO:0098662 194 0.012
maintenance of cell polarity GO:0030011 2 0.012
jnk cascade GO:0007254 80 0.012
convergent extension GO:0060026 1 0.012
cell junction organization GO:0034330 79 0.012
circulatory system development GO:0072359 262 0.012
peptidyl tyrosine modification GO:0018212 170 0.012
monovalent inorganic cation transport GO:0015672 128 0.012
modification dependent protein catabolic process GO:0019941 209 0.012
regeneration GO:0031099 4 0.012
regulation of cytokine production GO:0001817 232 0.012
response to external biotic stimulus GO:0043207 261 0.012
inorganic ion transmembrane transport GO:0098660 231 0.012
response to light stimulus GO:0009416 87 0.012
response to oxygen containing compound GO:1901700 369 0.012
Mouse
anterior posterior axis specification embryo GO:0008595 2 0.012
motor neuron axon guidance GO:0008045 2 0.012
regulation of rho gtpase activity GO:0032319 66 0.012
positive regulation of cytoskeleton organization GO:0051495 83 0.012
maintenance of location in cell GO:0051651 62 0.011
organelle localization GO:0051640 84 0.011
positive regulation of protein phosphorylation GO:0001934 313 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
tube development GO:0035295 125 0.011
i kappab kinase nf kappab signaling GO:0007249 166 0.011
reactive oxygen species biosynthetic process GO:1903409 4 0.011
receptor metabolic process GO:0043112 81 0.011
behavior GO:0007610 112 0.011
Mouse
hemopoiesis GO:0030097 180 0.011
cell projection morphogenesis GO:0048858 129 0.011
regulation of membrane potential GO:0042391 95 0.011
sequestering of metal ion GO:0051238 24 0.011
negative regulation of synaptic transmission GO:0050805 2 0.011
regulation of protein processing GO:0070613 150 0.011
endosomal transport GO:0016197 129 0.011
reproductive process GO:0022414 106 0.011
stress activated protein kinase signaling cascade GO:0031098 94 0.011
positive regulation of cell cycle GO:0045787 140 0.011
regulation of protein serine threonine kinase activity GO:0071900 179 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
rna processing GO:0006396 255 0.011
small gtpase mediated signal transduction GO:0007264 78 0.011
positive regulation of synaptic transmission GO:0050806 4 0.011
maintenance of location GO:0051235 112 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
apoptotic signaling pathway GO:0097190 268 0.011
sleep GO:0030431 2 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.011
developmental programmed cell death GO:0010623 3 0.011
interspecies interaction between organisms GO:0044419 156 0.011
protein localization to organelle GO:0033365 280 0.010
embryo development GO:0009790 123 0.010
regulation of microtubule cytoskeleton organization GO:0070507 61 0.010
morphogenesis of an epithelium GO:0002009 60 0.010
regulation of vesicle mediated transport GO:0060627 130 0.010
protein homooligomerization GO:0051260 100 0.010
protein maturation GO:0051604 233 0.010
organelle assembly GO:0070925 176 0.010
regulation of multi organism process GO:0043900 157 0.010
positive regulation of protein transport GO:0051222 135 0.010
nuclear migration GO:0007097 1 0.010
protein k48 linked ubiquitination GO:0070936 38 0.010
regulation of response to dna damage stimulus GO:2001020 94 0.010
immune system development GO:0002520 195 0.010
regulation of immune response GO:0050776 201 0.010
organic hydroxy compound metabolic process GO:1901615 147 0.010
single organism carbohydrate metabolic process GO:0044723 193 0.010
dna replication GO:0006260 116 0.010
muscle contraction GO:0006936 73 0.010
reactive oxygen species metabolic process GO:0072593 75 0.010
regulation of actin filament based process GO:0032970 141 0.010
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.010

USP46 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.023
nervous system disease DOID:863 431 0.023
musculoskeletal system disease DOID:17 223 0.018
sensory system disease DOID:0050155 203 0.017
cancer DOID:162 167 0.016
disease of cellular proliferation DOID:14566 174 0.016
organ system cancer DOID:0050686 164 0.016
disease of metabolism DOID:0014667 295 0.014
bone disease DOID:0080001 88 0.013
connective tissue disease DOID:65 109 0.013