Homo sapiens

254 known processes

BLM

Bloom syndrome, RecQ helicase-like

(Aliases: RECQL3,RECQL2,MGC131618,MGC131620,RECQ2,BS,MGC126616)

BLM biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair via homologous recombination GO:0000724 50 1.000
Fly
dna repair GO:0006281 198 1.000
dna recombination GO:0006310 77 1.000
cellular response to dna damage stimulus GO:0006974 379 1.000
double strand break repair GO:0006302 101 1.000
recombinational repair GO:0000725 50 1.000
Fly
telomere maintenance GO:0000723 32 0.999
Mouse
dna replication GO:0006260 116 0.999
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.996
dna conformation change GO:0071103 113 0.995
meiosis i GO:0007127 4 0.995
Worm Fly
anatomical structure homeostasis GO:0060249 100 0.992
Mouse
meiotic chromosome segregation GO:0045132 4 0.987
Worm
nucleotide excision repair GO:0006289 31 0.986
dna dependent dna replication GO:0006261 44 0.986
non recombinational repair GO:0000726 14 0.985
Fly
ribonucleoside monophosphate catabolic process GO:0009158 158 0.982
nucleoside monophosphate catabolic process GO:0009125 159 0.966
ribonucleoside monophosphate metabolic process GO:0009161 187 0.962
purine nucleoside catabolic process GO:0006152 398 0.959
purine nucleoside monophosphate catabolic process GO:0009128 158 0.956
telomere organization GO:0032200 33 0.949
Mouse
organelle fission GO:0048285 149 0.910
Worm Fly
reciprocal meiotic recombination GO:0007131 4 0.910
Worm Fly
purine nucleoside monophosphate metabolic process GO:0009126 186 0.907
dna geometric change GO:0032392 32 0.905
mitotic recombination GO:0006312 8 0.888
Mouse
atp metabolic process GO:0046034 176 0.886
ribonucleotide catabolic process GO:0009261 405 0.884
purine ribonucleoside catabolic process GO:0046130 398 0.882
dna double strand break processing GO:0000729 10 0.870
base excision repair GO:0006284 21 0.869
nucleoside monophosphate metabolic process GO:0009123 191 0.862
atp catabolic process GO:0006200 157 0.849
purine nucleoside triphosphate catabolic process GO:0009146 392 0.827
regulation of double strand break repair via homologous recombination GO:0010569 11 0.821
regulation of dna metabolic process GO:0051052 153 0.816
telomere maintenance via recombination GO:0000722 4 0.816
mismatch repair GO:0006298 15 0.799
glycosyl compound catabolic process GO:1901658 413 0.790
negative regulation of cell cycle process GO:0010948 121 0.780
purine containing compound catabolic process GO:0072523 411 0.765
g2 dna damage checkpoint GO:0031572 26 0.755
mitotic dna damage checkpoint GO:0044773 28 0.722
mitotic cell cycle process GO:1903047 286 0.704
purine nucleotide catabolic process GO:0006195 405 0.694
mitotic cell cycle phase transition GO:0044772 162 0.677
nucleoside phosphate catabolic process GO:1901292 412 0.672
regulation of cell cycle process GO:0010564 266 0.669
nucleotide catabolic process GO:0009166 408 0.637
regulation of cell cycle phase transition GO:1901987 126 0.633
purine nucleoside triphosphate metabolic process GO:0009144 412 0.629
replication fork processing GO:0031297 13 0.621
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.611
nucleoside triphosphate catabolic process GO:0009143 394 0.602
cell cycle phase transition GO:0044770 173 0.600
ribonucleoside catabolic process GO:0042454 406 0.572
purine ribonucleoside metabolic process GO:0046128 437 0.542
nucleoside triphosphate metabolic process GO:0009141 422 0.537
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.523
nuclear division GO:0000280 128 0.498
Worm Fly
dna catabolic process GO:0006308 49 0.497
reciprocal dna recombination GO:0035825 4 0.496
Worm Fly
double strand break repair via nonhomologous end joining GO:0006303 10 0.492
Fly
positive regulation of dna metabolic process GO:0051054 73 0.481
nucleoside catabolic process GO:0009164 408 0.474
response to radiation GO:0009314 151 0.470
g2 m transition of mitotic cell cycle GO:0000086 41 0.468
response to abiotic stimulus GO:0009628 336 0.466
ribonucleoside triphosphate metabolic process GO:0009199 412 0.454
chromosome segregation GO:0007059 114 0.441
Worm
ribonucleoside triphosphate catabolic process GO:0009203 391 0.441
regulation of dna replication GO:0006275 68 0.423
regulation of cell cycle GO:0051726 393 0.419
negative regulation of mitotic cell cycle GO:0045930 102 0.417
organophosphate catabolic process GO:0046434 430 0.398
negative regulation of dna metabolic process GO:0051053 57 0.391
rna dependent dna replication GO:0006278 16 0.386
dna damage checkpoint GO:0000077 68 0.380
meiotic chromosome separation GO:0051307 3 0.359
Worm
response to ionizing radiation GO:0010212 65 0.350
regulation of mitotic cell cycle GO:0007346 189 0.342
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.339
regeneration GO:0031099 4 0.335
telomere capping GO:0016233 5 0.330
regulation of double strand break repair GO:2000779 22 0.324
Fly
growth GO:0040007 202 0.310
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.305
meiotic cell cycle GO:0051321 13 0.298
Worm Fly
mitochondrion organization GO:0007005 156 0.283
meiotic nuclear division GO:0007126 10 0.282
Worm Fly
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.252
mitotic dna integrity checkpoint GO:0044774 30 0.244
positive regulation of cell proliferation GO:0008284 301 0.237
Mouse
meiotic cell cycle process GO:1903046 8 0.231
Worm Fly
negative regulation of dna biosynthetic process GO:2000279 11 0.230
mitotic sister chromatid segregation GO:0000070 53 0.221
dna integrity checkpoint GO:0031570 71 0.214
purine ribonucleotide catabolic process GO:0009154 404 0.211
response to dietary excess GO:0002021 2 0.202
sister chromatid segregation GO:0000819 54 0.200
developmental growth GO:0048589 48 0.192
negative regulation of cell cycle GO:0045786 193 0.176
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.175
regulation of response to dna damage stimulus GO:2001020 94 0.173
Fly
chemical homeostasis GO:0048878 306 0.171
double strand break repair via single strand annealing GO:0045002 4 0.165
Fly
mitotic cell cycle checkpoint GO:0007093 68 0.161
male meiosis GO:0007140 1 0.160
ubiquitin dependent protein catabolic process GO:0006511 206 0.159
microtubule based process GO:0007017 210 0.158
regulation of mitotic cell cycle phase transition GO:1901990 118 0.154
regulation of dna repair GO:0006282 47 0.154
Fly
gene conversion GO:0035822 1 0.151
cellular macromolecular complex assembly GO:0034622 324 0.145
positive regulation of organelle organization GO:0010638 195 0.144
negative regulation of cell cycle phase transition GO:1901988 89 0.143
mitotic nuclear division GO:0007067 119 0.142
Worm
cell cycle checkpoint GO:0000075 117 0.140
protein dna complex subunit organization GO:0071824 80 0.140
response to alkaloid GO:0043279 20 0.140
immune system development GO:0002520 195 0.136
Mouse
regulation of dna dependent dna replication GO:0090329 19 0.136
positive regulation of mitotic cell cycle GO:0045931 60 0.135
mitotic cell cycle GO:0000278 326 0.129
dna duplex unwinding GO:0032508 30 0.127
positive regulation of telomere maintenance GO:0032206 4 0.125
telomere maintenance via telomere lengthening GO:0010833 9 0.124
response to oxygen containing compound GO:1901700 369 0.123
mitotic dna replication checkpoint GO:0033314 2 0.120
cellular response to abiotic stimulus GO:0071214 117 0.115
protein ubiquitination GO:0016567 314 0.114
cell development GO:0048468 328 0.113
replicative cell aging GO:0001302 3 0.112
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.110
negative regulation of organelle organization GO:0010639 126 0.108
regulation of cellular amino acid metabolic process GO:0006521 6 0.107
cellular protein catabolic process GO:0044257 261 0.106
response to uv GO:0009411 73 0.104
cell division GO:0051301 168 0.104
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.104
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.102
tissue regeneration GO:0042246 3 0.101
strand invasion GO:0042148 2 0.100
telomere maintenance via telomerase GO:0007004 8 0.095
cellular amine metabolic process GO:0044106 41 0.094
behavior GO:0007610 112 0.092
response to organic cyclic compound GO:0014070 204 0.091
negative regulation of developmental process GO:0051093 247 0.088
multicellular organism growth GO:0035264 8 0.085
cell aging GO:0007569 52 0.084
regulation of cellular amine metabolic process GO:0033238 11 0.083
somatic diversification of immune receptors via somatic mutation GO:0002566 1 0.082
positive regulation of chromosome organization GO:2001252 41 0.081
positive regulation of programmed cell death GO:0043068 249 0.081
positive regulation of hydrolase activity GO:0051345 331 0.080
embryo development GO:0009790 123 0.077
protein dna complex assembly GO:0065004 64 0.075
regulation of mitosis GO:0007088 63 0.075
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.073
response to wounding GO:0009611 168 0.073
protein modification by small protein conjugation GO:0032446 342 0.071
lymphocyte activation GO:0046649 133 0.069
Mouse
immune response GO:0006955 307 0.066
cellular response to ionizing radiation GO:0071479 32 0.062
reproduction GO:0000003 63 0.061
Worm Fly
dna dependent dna replication maintenance of fidelity GO:0045005 14 0.060
cellular response to external stimulus GO:0071496 111 0.060
cellular amino acid metabolic process GO:0006520 116 0.059
positive regulation of phosphorylation GO:0042327 394 0.058
wound healing GO:0042060 115 0.058
dna biosynthetic process GO:0071897 40 0.058
Fly
intrinsic apoptotic signaling pathway GO:0097193 127 0.057
negative regulation of cellular component organization GO:0051129 235 0.056
chromatin modification GO:0016568 298 0.056
response to purine containing compound GO:0014074 40 0.055
histone threonine phosphorylation GO:0035405 7 0.055
b cell activation GO:0042113 33 0.055
regulation of cell division GO:0051302 116 0.054
establishment of organelle localization GO:0051656 59 0.053
negative regulation of cellular protein metabolic process GO:0032269 353 0.053
response to organonitrogen compound GO:0010243 156 0.053
amine metabolic process GO:0009308 44 0.052
microtubule polymerization GO:0046785 18 0.052
signal transduction in response to dna damage GO:0042770 57 0.050
cellular macromolecule catabolic process GO:0044265 380 0.049
adaptive immune response GO:0002250 49 0.049
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.049
regulation of cellular ketone metabolic process GO:0010565 50 0.048
regulation of cytoskeleton organization GO:0051493 177 0.047
female gamete generation GO:0007292 2 0.047
maintenance of dna repeat elements GO:0043570 4 0.046
positive regulation of developmental process GO:0051094 314 0.046
cellular component disassembly GO:0022411 92 0.046
response to gamma radiation GO:0010332 14 0.046
hematopoietic or lymphoid organ development GO:0048534 186 0.045
Mouse
lagging strand elongation GO:0006273 3 0.045
sex determination GO:0007530 3 0.044
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.043
metaphase plate congression GO:0051310 18 0.043
determination of adult lifespan GO:0008340 2 0.043
Worm
apoptotic signaling pathway GO:0097190 268 0.043
negative regulation of dna replication GO:0008156 29 0.042
regulation of transcription from rna polymerase ii promoter in response to uv induced dna damage GO:0010767 1 0.040
regulation of dna recombination GO:0000018 23 0.040
cellular response to endogenous stimulus GO:0071495 336 0.040
post embryonic development GO:0009791 2 0.040
dna damage induced protein phosphorylation GO:0006975 5 0.039
protein catabolic process GO:0030163 325 0.038
regulation of cell cycle g2 m phase transition GO:1902749 22 0.038
positive regulation of cell cycle process GO:0090068 106 0.038
negative regulation of cell cycle g2 m phase transition GO:1902750 10 0.038
cellular ketone metabolic process GO:0042180 80 0.037
head development GO:0060322 108 0.035
positive regulation of response to dna damage stimulus GO:2001022 43 0.035
modification dependent protein catabolic process GO:0019941 209 0.034
peptidyl serine modification GO:0018209 106 0.033
protein polymerization GO:0051258 71 0.033
humoral immune response GO:0006959 49 0.033
regulation of chromatin organization GO:1902275 56 0.032
regulation of microtubule based process GO:0032886 74 0.032
single organism reproductive process GO:0044702 98 0.032
positive regulation of cellular component organization GO:0051130 376 0.031
leukocyte activation GO:0045321 164 0.030
Mouse
dna unwinding involved in dna replication GO:0006268 2 0.029
cellular response to nitrogen compound GO:1901699 144 0.029
response to oxidative stress GO:0006979 121 0.029
intracellular mrna localization GO:0008298 1 0.029
regulation of chromosome organization GO:0033044 103 0.029
defense response GO:0006952 315 0.028
circulatory system development GO:0072359 262 0.028
carbohydrate metabolic process GO:0005975 207 0.028
cellular response to radiation GO:0071478 65 0.028
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.027
aging GO:0007568 66 0.027
Worm
peptidyl serine phosphorylation GO:0018105 101 0.027
microtubule cytoskeleton organization GO:0000226 176 0.027
interstrand cross link repair GO:0036297 3 0.026
regulation of transferase activity GO:0051338 355 0.026
protein autophosphorylation GO:0046777 123 0.026
carbohydrate derivative biosynthetic process GO:1901137 207 0.026
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.025
cellular response to organonitrogen compound GO:0071417 124 0.025
regulation of cellular response to stress GO:0080135 244 0.025
Fly
negative regulation of cell division GO:0051782 31 0.025
response to carbohydrate GO:0009743 21 0.025
response to light stimulus GO:0009416 87 0.025
rna catabolic process GO:0006401 71 0.025
regulation of protein ubiquitination GO:0031396 95 0.024
positive regulation of dna replication GO:0045740 35 0.024
negative regulation of telomere maintenance GO:0032205 9 0.023
response to extracellular stimulus GO:0009991 85 0.023
negative regulation of apoptotic process GO:0043066 316 0.023
Mouse Worm
regulation of cell differentiation GO:0045595 393 0.023
nervous system development GO:0007399 293 0.023
positive regulation of kinase activity GO:0033674 204 0.022
cell cycle g2 m phase transition GO:0044839 43 0.022
regulation of nuclear division GO:0051783 65 0.022
multicellular organism reproduction GO:0032504 42 0.022
positive regulation of cellular amine metabolic process GO:0033240 7 0.022
negative regulation of transferase activity GO:0051348 124 0.022
multicellular organismal aging GO:0010259 3 0.020
Worm
oocyte maturation GO:0001556 1 0.020
response to nutrient levels GO:0031667 81 0.020
dna catabolic process endonucleolytic GO:0000737 37 0.020
protein acetylation GO:0006473 116 0.020
regulation of nucleoside metabolic process GO:0009118 209 0.019
stem cell differentiation GO:0048863 93 0.019
organelle localization GO:0051640 84 0.019
negative regulation of programmed cell death GO:0043069 321 0.019
Mouse Worm
positive regulation of cell cycle GO:0045787 140 0.019
energy homeostasis GO:0097009 3 0.019
blastocyst development GO:0001824 3 0.019
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 9 0.019
oocyte development GO:0048599 1 0.019
positive regulation of catabolic process GO:0009896 310 0.019
cellular response to alkaloid GO:0071312 11 0.018
central nervous system development GO:0007417 123 0.018
locomotory behavior GO:0007626 1 0.018
rna processing GO:0006396 255 0.018
protein oligomerization GO:0051259 173 0.018
regulation of protein catabolic process GO:0042176 155 0.018
multi organism reproductive process GO:0044703 54 0.017
mrna metabolic process GO:0016071 175 0.017
negative regulation of protein maturation GO:1903318 142 0.017
covalent chromatin modification GO:0016569 254 0.017
response to reactive oxygen species GO:0000302 61 0.017
proteasomal protein catabolic process GO:0010498 176 0.017
response to growth factor GO:0070848 205 0.016
protein localization to chromosome telomeric region GO:0070198 6 0.016
regulation of growth GO:0040008 165 0.016
peptidyl lysine modification GO:0018205 144 0.016
spermatid development GO:0007286 4 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
leukocyte mediated immunity GO:0002443 59 0.016
response to caffeine GO:0031000 3 0.016
epithelium development GO:0060429 227 0.016
negative regulation of telomere maintenance via telomerase GO:0032211 5 0.015
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.015
negative regulation of cellular catabolic process GO:0031330 83 0.015
positive regulation of growth GO:0045927 58 0.015
carbohydrate homeostasis GO:0033500 31 0.015
regulation of gene expression epigenetic GO:0040029 73 0.015
immune effector process GO:0002252 159 0.015
response to inorganic substance GO:0010035 127 0.015
mitotic g2 dna damage checkpoint GO:0007095 7 0.014
response to nitrogen compound GO:1901698 184 0.014
negative regulation of telomerase activity GO:0051974 6 0.014
leukocyte proliferation GO:0070661 74 0.014
Mouse
positive regulation of apoptotic process GO:0043065 246 0.014
regulation of lymphocyte activation GO:0051249 103 0.014
Mouse
regulation of protein maturation GO:1903317 150 0.014
chromosome condensation GO:0030261 15 0.014
positive regulation of homeostatic process GO:0032846 47 0.014
g1 s transition of mitotic cell cycle GO:0000082 78 0.014
cell activation involved in immune response GO:0002263 30 0.014
negative regulation of protein metabolic process GO:0051248 391 0.014
regulation of cytoplasmic transport GO:1903649 149 0.014
resolution of meiotic recombination intermediates GO:0000712 3 0.014
negative regulation of cellular protein catabolic process GO:1903363 38 0.013
regulation of nuclease activity GO:0032069 11 0.013
cell activation GO:0001775 213 0.013
Mouse
macromolecule glycosylation GO:0043413 63 0.013
reproductive process GO:0022414 106 0.013
peptidyl threonine phosphorylation GO:0018107 41 0.013
regulation of sister chromatid segregation GO:0033045 27 0.013
histone modification GO:0016570 251 0.013
regulation of proteolysis GO:0030162 293 0.013
regulation of mitotic sister chromatid segregation GO:0033047 27 0.013
dna packaging GO:0006323 77 0.013
regulation of kinase activity GO:0043549 314 0.013
dna strand elongation involved in dna replication GO:0006271 3 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
regulation of peptidyl lysine acetylation GO:2000756 22 0.012
cell morphogenesis GO:0000902 296 0.012
cardiovascular system development GO:0072358 262 0.012
negative regulation of mitosis GO:0045839 24 0.012
brain development GO:0007420 97 0.012
system process GO:0003008 349 0.012
microtubule organizing center organization GO:0031023 62 0.012
cellular response to oxygen containing compound GO:1901701 276 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.012
modification dependent macromolecule catabolic process GO:0043632 212 0.012
regulation of nucleocytoplasmic transport GO:0046822 98 0.011
cellular lipid metabolic process GO:0044255 303 0.011
regulation of meiotic cell cycle GO:0051445 4 0.011
neural crest cell migration GO:0001755 2 0.011
neurogenesis GO:0022008 169 0.011
nucleosome assembly GO:0006334 50 0.011
protein dephosphorylation GO:0006470 81 0.011
cellular component morphogenesis GO:0032989 314 0.011
negative regulation of protein processing GO:0010955 142 0.011
regulation of helicase activity GO:0051095 8 0.011
enzyme linked receptor protein signaling pathway GO:0007167 303 0.011
isotype switching GO:0045190 3 0.011
glycosylation GO:0070085 71 0.011
response to activity GO:0014823 0 0.011
secretion by cell GO:0032940 226 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.011
positive regulation of mapk cascade GO:0043410 190 0.011
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 5 0.010
single organism carbohydrate metabolic process GO:0044723 193 0.010
regulation of mitotic recombination GO:0000019 1 0.010
Mouse
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.010
cellular homeostasis GO:0019725 196 0.010
translesion synthesis GO:0019985 8 0.010
cellular response to cytokine stimulus GO:0071345 181 0.010
regulation of microtubule cytoskeleton organization GO:0070507 61 0.010
actin filament based process GO:0030029 224 0.010

BLM disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.973
bone marrow disease DOID:4961 31 0.929
hematopoietic system disease DOID:74 100 0.929
disease of cellular proliferation DOID:14566 174 0.766
breast cancer DOID:1612 21 0.621
thoracic cancer DOID:5093 21 0.621
cancer DOID:162 167 0.621
organ system cancer DOID:0050686 164 0.621
aplastic anemia DOID:12449 30 0.351
anemia DOID:2355 55 0.351
congenital hypoplastic anemia DOID:1342 26 0.299
fanconi s anemia DOID:13636 16 0.299
endocrine gland cancer DOID:170 26 0.046
pancreatic cancer DOID:1793 8 0.046
reproductive organ cancer DOID:193 23 0.014