Homo sapiens

0 known processes

HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

(Aliases: MGC90332,HMGCS)

HMGCS1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
steroid metabolic process GO:0008202 94 0.997
small molecule biosynthetic process GO:0044283 157 0.988
alcohol metabolic process GO:0006066 114 0.987
lipid biosynthetic process GO:0008610 177 0.979
lipid metabolic process GO:0006629 381 0.979
sterol metabolic process GO:0016125 28 0.967
organic hydroxy compound metabolic process GO:1901615 147 0.926
sterol biosynthetic process GO:0016126 10 0.919
steroid biosynthetic process GO:0006694 46 0.893
monocarboxylic acid biosynthetic process GO:0072330 67 0.892
organic hydroxy compound biosynthetic process GO:1901617 71 0.859
alcohol biosynthetic process GO:0046165 52 0.845
cellular lipid metabolic process GO:0044255 303 0.792
cholesterol metabolic process GO:0008203 28 0.729
associative learning GO:0008306 1 0.447
visual behavior GO:0007632 2 0.362
acylglycerol metabolic process GO:0006639 27 0.342
response to phenylpropanoid GO:0080184 1 0.308
carboxylic acid biosynthetic process GO:0046394 97 0.276
fatty acid biosynthetic process GO:0006633 46 0.263
inner ear morphogenesis GO:0042472 4 0.263
organophosphate biosynthetic process GO:0090407 163 0.238
triglyceride metabolic process GO:0006641 23 0.207
regulation of vesicle mediated transport GO:0060627 130 0.202
response to light stimulus GO:0009416 87 0.195
Rat
negative regulation of phosphate metabolic process GO:0045936 267 0.172
terpenoid metabolic process GO:0006721 27 0.168
amine metabolic process GO:0009308 44 0.161
cellular ketone body metabolic process GO:0046950 3 0.159
negative regulation of protein metabolic process GO:0051248 391 0.155
vesicle mediated transport GO:0016192 371 0.150
regulation of protein kinase activity GO:0045859 289 0.144
response to abiotic stimulus GO:0009628 336 0.144
Rat
phospholipid catabolic process GO:0009395 12 0.135
fatty acid elongation polyunsaturated fatty acid GO:0034626 4 0.129
regulation of cytoplasmic transport GO:1903649 149 0.128
cholesterol biosynthetic process GO:0006695 10 0.123
regulation of protein serine threonine kinase activity GO:0071900 179 0.123
regulation of transferase activity GO:0051338 355 0.117
post embryonic development GO:0009791 2 0.117
phosphatidylcholine metabolic process GO:0046470 19 0.106
head development GO:0060322 108 0.102
Rat
regulation of cellular ketone metabolic process GO:0010565 50 0.101
negative regulation of lipid metabolic process GO:0045833 38 0.091
single organism membrane budding GO:1902591 10 0.088
signal transduction by phosphorylation GO:0023014 297 0.086
negative regulation of growth of symbiont in host GO:0044130 1 0.086
glycerolipid metabolic process GO:0046486 107 0.085
positive regulation of cholesterol storage GO:0010886 4 0.084
phospholipid metabolic process GO:0006644 99 0.083
intestinal cholesterol absorption GO:0030299 4 0.076
sensory organ morphogenesis GO:0090596 21 0.073
negative regulation of endopeptidase activity GO:0010951 84 0.072
long chain fatty acid biosynthetic process GO:0042759 4 0.068
long chain fatty acid metabolic process GO:0001676 30 0.068
ketone body metabolic process GO:1902224 2 0.063
sphingolipid metabolic process GO:0006665 38 0.062
phospholipid biosynthetic process GO:0008654 44 0.062
membrane budding GO:0006900 28 0.059
golgi vesicle transport GO:0048193 80 0.056
terpenoid biosynthetic process GO:0016114 2 0.055
regulation of cellular amino acid metabolic process GO:0006521 6 0.053
monocarboxylic acid metabolic process GO:0032787 185 0.052
negative regulation of catalytic activity GO:0043086 335 0.051
phosphatidylcholine catabolic process GO:0034638 3 0.050
cellular alcohol metabolic process GO:0044107 7 0.048
srebp signaling pathway GO:0032933 4 0.045
cholesterol transport GO:0030301 39 0.044
growth GO:0040007 202 0.044
response to lipid GO:0033993 206 0.043
Rat
phospholipid transport GO:0015914 23 0.042
response to radiation GO:0009314 151 0.041
Rat
cellular amine metabolic process GO:0044106 41 0.040
fatty acid metabolic process GO:0006631 115 0.040
regulation of mapk cascade GO:0043408 262 0.040
regulation of kinase activity GO:0043549 314 0.039
single organism cellular localization GO:1902580 332 0.037
negative regulation of cellular protein metabolic process GO:0032269 353 0.036
multicellular organismal aging GO:0010259 3 0.036
response to sterol depletion GO:0006991 4 0.034
male genitalia development GO:0030539 1 0.033
fatty acid elongation monounsaturated fatty acid GO:0034625 3 0.033
acetylcholine transport GO:0015870 1 0.033
innate immune response GO:0045087 178 0.032
cellular biogenic amine metabolic process GO:0006576 34 0.031
maintenance of location GO:0051235 112 0.031
cellular ketone metabolic process GO:0042180 80 0.031
neutral lipid metabolic process GO:0006638 27 0.029
regulation of cellular amine metabolic process GO:0033238 11 0.029
cellular protein complex assembly GO:0043623 188 0.029
isoprenoid biosynthetic process GO:0008299 9 0.028
negative regulation of protein processing GO:0010955 142 0.028
cellular amino acid metabolic process GO:0006520 116 0.028
determination of adult lifespan GO:0008340 2 0.027
female gamete generation GO:0007292 2 0.026
negative regulation of kinase activity GO:0033673 106 0.026
fat cell differentiation GO:0045444 32 0.025
cellular response to sterol depletion GO:0071501 4 0.025
positive regulation of triglyceride biosynthetic process GO:0010867 4 0.025
membrane organization GO:0061024 292 0.024
negative regulation of protein phosphorylation GO:0001933 140 0.024
visual learning GO:0008542 1 0.024
regulation of intracellular transport GO:0032386 195 0.024
neuromuscular junction development GO:0007528 3 0.023
negative regulation of multi organism process GO:0043901 92 0.023
cognition GO:0050890 43 0.023
small molecule catabolic process GO:0044282 92 0.023
regulation of er to golgi vesicle mediated transport GO:0060628 5 0.023
lipid catabolic process GO:0016042 84 0.023
organophosphate catabolic process GO:0046434 430 0.023
mapk cascade GO:0000165 288 0.023
oogenesis GO:0048477 2 0.023
response to external biotic stimulus GO:0043207 261 0.022
isoprenoid metabolic process GO:0006720 39 0.022
vesicle organization GO:0016050 62 0.022
system process GO:0003008 349 0.021
multicellular organismal response to stress GO:0033555 1 0.020
defense response GO:0006952 315 0.020
response to biotic stimulus GO:0009607 276 0.020
ras protein signal transduction GO:0007265 73 0.020
mitotic cell cycle process GO:1903047 286 0.020
negative regulation of transferase activity GO:0051348 124 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.019
negative regulation of intracellular signal transduction GO:1902532 183 0.019
lipid storage GO:0019915 28 0.019
negative regulation of protein complex assembly GO:0031333 43 0.019
response to organic cyclic compound GO:0014070 204 0.018
Rat
sterol transport GO:0015918 39 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.018
cytoplasmic transport GO:0016482 379 0.018
skin development GO:0043588 76 0.018
cellular macromolecule catabolic process GO:0044265 380 0.017
long chain fatty acid import GO:0044539 5 0.017
bone morphogenesis GO:0060349 10 0.017
regulation of cellular component biogenesis GO:0044087 281 0.017
regulation of lipid metabolic process GO:0019216 96 0.017
er nucleus signaling pathway GO:0006984 23 0.017
regulation of proteolysis GO:0030162 293 0.017
immune system development GO:0002520 195 0.017
anterior posterior axis specification GO:0009948 2 0.017
icosanoid secretion GO:0032309 11 0.017
endocytosis GO:0006897 159 0.016
locomotory behavior GO:0007626 1 0.016
dephosphorylation GO:0016311 209 0.016
rho protein signal transduction GO:0007266 26 0.016
response to fungus GO:0009620 4 0.016
mitotic cell cycle GO:0000278 326 0.016
negative regulation of protein modification process GO:0031400 200 0.016
negative regulation of hydrolase activity GO:0051346 182 0.016
positive regulation of nucleoside metabolic process GO:0045979 186 0.016
purine containing compound catabolic process GO:0072523 411 0.016
chemical homeostasis GO:0048878 306 0.016
regulation of map kinase activity GO:0043405 108 0.016
regulation of nucleotide metabolic process GO:0006140 269 0.016
ribonucleoside triphosphate metabolic process GO:0009199 412 0.016
cellular macromolecular complex assembly GO:0034622 324 0.016
regulation of synaptic plasticity GO:0048167 3 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
protein processing GO:0016485 226 0.015
negative regulation of growth of symbiont involved in interaction with host GO:0044146 2 0.015
immune response GO:0006955 307 0.015
negative regulation of proteolysis GO:0045861 132 0.015
positive regulation of cellular component organization GO:0051130 376 0.015
neurotransmitter secretion GO:0007269 4 0.015
response to nutrient GO:0007584 20 0.014
Rat
morphogenesis of embryonic epithelium GO:0016331 4 0.014
photoreceptor cell differentiation GO:0046530 2 0.014
blastoderm segmentation GO:0007350 2 0.014
cholesterol import GO:0070508 4 0.014
cardiovascular system development GO:0072358 262 0.014
positive regulation of nucleotide metabolic process GO:0045981 230 0.014
regulation of response to external stimulus GO:0032101 222 0.014
ear morphogenesis GO:0042471 7 0.014
regulation of cell cycle GO:0051726 393 0.014
peripheral nervous system development GO:0007422 2 0.014
lipid localization GO:0010876 106 0.014
cardiac muscle cell contraction GO:0086003 4 0.014
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.014
transmembrane transport GO:0055085 399 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
regulation of cell differentiation GO:0045595 393 0.014
purine nucleoside monophosphate metabolic process GO:0009126 186 0.014
response to oxygen levels GO:0070482 100 0.014
negative regulation of map kinase activity GO:0043407 27 0.014
negative regulation of phosphorylation GO:0042326 174 0.014
actin filament based process GO:0030029 224 0.014
protein oligomerization GO:0051259 173 0.014
protein localization to membrane GO:0072657 160 0.014
regulation of protein localization to plasma membrane GO:1903076 40 0.014
regulation of cell motility GO:2000145 299 0.014
regulation of protein localization GO:0032880 296 0.014
glycosyl compound catabolic process GO:1901658 413 0.014
cell fate determination GO:0001709 3 0.014
cellular alcohol biosynthetic process GO:0044108 7 0.013
anion transport GO:0006820 161 0.013
protein catabolic process GO:0030163 325 0.013
regulation of cytokine production GO:0001817 232 0.013
positive regulation of secretion GO:0051047 116 0.013
embryonic organ morphogenesis GO:0048562 24 0.013
negative regulation of protein kinase activity GO:0006469 98 0.013
spermatid differentiation GO:0048515 4 0.013
circulatory system development GO:0072359 262 0.013
nerve development GO:0021675 4 0.013
negative regulation of developmental process GO:0051093 247 0.013
memory GO:0007613 3 0.013
positive regulation of cellular amine metabolic process GO:0033240 7 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.013
intracellular protein transport GO:0006886 270 0.013
hindbrain development GO:0030902 3 0.013
brain development GO:0007420 97 0.013
Rat
regulation of growth of symbiont in host GO:0044126 1 0.013
atp metabolic process GO:0046034 176 0.013
negative regulation of cytoplasmic transport GO:1903650 46 0.012
purine ribonucleoside metabolic process GO:0046128 437 0.012
nucleoside triphosphate metabolic process GO:0009141 422 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.012
positive regulation of catabolic process GO:0009896 310 0.012
regulation of nucleoside metabolic process GO:0009118 209 0.012
purine ribonucleoside catabolic process GO:0046130 398 0.012
fatty acid elongation saturated fatty acid GO:0019367 5 0.012
oocyte development GO:0048599 1 0.012
negative regulation of programmed cell death GO:0043069 321 0.012
positive regulation of intracellular transport GO:0032388 104 0.012
ion homeostasis GO:0050801 230 0.012
segmentation GO:0035282 4 0.012
regulation of steroid biosynthetic process GO:0050810 23 0.012
regulation of establishment of protein localization GO:0070201 242 0.012
ribonucleoside triphosphate catabolic process GO:0009203 391 0.012
regulation of protein complex assembly GO:0043254 147 0.012
spinal cord development GO:0021510 4 0.012
endomembrane system organization GO:0010256 196 0.012
organonitrogen compound biosynthetic process GO:1901566 200 0.012
cation transmembrane transport GO:0098655 238 0.012
regulation of immune response GO:0050776 201 0.012
response to other organism GO:0051707 261 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
cation homeostasis GO:0055080 189 0.012
response to axon injury GO:0048678 1 0.012
positive regulation of cytoplasmic transport GO:1903651 82 0.012
rhythmic behavior GO:0007622 2 0.012
interspecies interaction between organisms GO:0044419 156 0.012
growth involved in symbiotic interaction GO:0044110 2 0.012
apoptotic signaling pathway GO:0097190 268 0.011
negative regulation of organelle organization GO:0010639 126 0.011
mating GO:0007618 1 0.011
regulation of protein maturation GO:1903317 150 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
limbic system development GO:0021761 3 0.011
embryo development GO:0009790 123 0.011
positive regulation of transport GO:0051050 336 0.011
purine nucleotide catabolic process GO:0006195 405 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
calcium ion homeostasis GO:0055074 122 0.011
fatty acyl coa metabolic process GO:0035337 9 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
lipoprotein metabolic process GO:0042157 42 0.011
actin mediated cell contraction GO:0070252 12 0.011
cell growth GO:0016049 160 0.011
negative regulation of protein maturation GO:1903318 142 0.011
adult locomotory behavior GO:0008344 1 0.011
nucleoside phosphate catabolic process GO:1901292 412 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
er to golgi vesicle mediated transport GO:0006888 19 0.011
negative regulation of intracellular transport GO:0032387 60 0.011
response to cytokine GO:0034097 232 0.011
fatty acid elongation unsaturated fatty acid GO:0019368 5 0.011
ribonucleotide catabolic process GO:0009261 405 0.011
demethylation GO:0070988 37 0.011
positive regulation of organelle organization GO:0010638 195 0.011
positive regulation of immune system process GO:0002684 283 0.011
purine nucleoside triphosphate metabolic process GO:0009144 412 0.011
nucleotide catabolic process GO:0009166 408 0.011
cellular response to cytokine stimulus GO:0071345 181 0.011
vasculature development GO:0001944 181 0.011
secretion GO:0046903 254 0.011
sensory perception of smell GO:0007608 2 0.011
cholesterol homeostasis GO:0042632 28 0.010
diterpenoid metabolic process GO:0016101 20 0.010
cellular response to dna damage stimulus GO:0006974 379 0.010
small gtpase mediated signal transduction GO:0007264 78 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.010
positive regulation of hydrolase activity GO:0051345 331 0.010
regulation of purine nucleotide metabolic process GO:1900542 264 0.010
embryonic morphogenesis GO:0048598 85 0.010
regulation of peptidase activity GO:0052547 180 0.010
acetyl coa metabolic process GO:0006084 8 0.010
motor neuron axon guidance GO:0008045 2 0.010
oxidation reduction process GO:0055114 396 0.010
lipid transport GO:0006869 90 0.010
regeneration GO:0031099 4 0.010
regulation of cysteine type endopeptidase activity GO:2000116 127 0.010
purine ribonucleotide catabolic process GO:0009154 404 0.010
oocyte differentiation GO:0009994 2 0.010
hippocampus development GO:0021766 1 0.010
protein maturation GO:0051604 233 0.010
ribonucleoside catabolic process GO:0042454 406 0.010
copii coated vesicle budding GO:0090114 5 0.010
cell division GO:0051301 168 0.010
positive regulation of phosphorylation GO:0042327 394 0.010
single organism membrane organization GO:0044802 268 0.010
positive regulation of programmed cell death GO:0043068 249 0.010
neurological system process GO:0050877 163 0.010

HMGCS1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.048
lipid metabolism disorder DOID:3146 26 0.048
inherited metabolic disorder DOID:655 242 0.048
musculoskeletal system disease DOID:17 223 0.019
sensory system disease DOID:0050155 203 0.018
nervous system disease DOID:863 431 0.018
disease of cellular proliferation DOID:14566 174 0.014
myopathy DOID:423 104 0.014
muscular disease DOID:0080000 114 0.014
muscle tissue disease DOID:66 113 0.014
cancer DOID:162 167 0.013
immune system disease DOID:2914 155 0.012
eye and adnexa disease DOID:1492 150 0.012
eye disease DOID:5614 149 0.012
retinal disease DOID:5679 118 0.011
retinal degeneration DOID:8466 89 0.011