Homo sapiens

27 known processes

ACO2

aconitase 2, mitochondrial

(Aliases: MGC20605,ACONM,MGC33908)

ACO2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dicarboxylic acid metabolic process GO:0043648 29 0.760
oxidation reduction process GO:0055114 396 0.469
citrate metabolic process GO:0006101 2 0.414
isocitrate metabolic process GO:0006102 1 0.382
Rat
post embryonic development GO:0009791 2 0.281
Worm
tricarboxylic acid metabolic process GO:0072350 4 0.246
energy derivation by oxidation of organic compounds GO:0015980 43 0.197
2 oxoglutarate metabolic process GO:0006103 4 0.181
coenzyme metabolic process GO:0006732 65 0.179
generation of precursor metabolites and energy GO:0006091 68 0.147
tricarboxylic acid cycle GO:0006099 4 0.098
multicellular organismal aging GO:0010259 3 0.091
Worm
determination of adult lifespan GO:0008340 2 0.085
Worm
carboxylic acid catabolic process GO:0046395 71 0.083
lipid catabolic process GO:0016042 84 0.080
organic acid catabolic process GO:0016054 71 0.075
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.069
lipid metabolic process GO:0006629 381 0.066
ribonucleoside monophosphate metabolic process GO:0009161 187 0.065
female gamete generation GO:0007292 2 0.064
purine nucleoside triphosphate metabolic process GO:0009144 412 0.061
cation transmembrane transport GO:0098655 238 0.061
small molecule catabolic process GO:0044282 92 0.058
cation transport GO:0006812 331 0.057
small molecule biosynthetic process GO:0044283 157 0.055
nadh metabolic process GO:0006734 1 0.054
nucleoside monophosphate metabolic process GO:0009123 191 0.053
ribonucleoside triphosphate metabolic process GO:0009199 412 0.051
inorganic ion transmembrane transport GO:0098660 231 0.049
nucleoside triphosphate metabolic process GO:0009141 422 0.049
response to oxygen containing compound GO:1901700 369 0.048
purine ribonucleoside metabolic process GO:0046128 437 0.047
oogenesis GO:0048477 2 0.047
oxidoreduction coenzyme metabolic process GO:0006733 19 0.046
monocarboxylic acid metabolic process GO:0032787 185 0.044
aerobic respiration GO:0009060 7 0.044
atp metabolic process GO:0046034 176 0.043
fatty acid metabolic process GO:0006631 115 0.043
purine nucleoside monophosphate metabolic process GO:0009126 186 0.043
transmembrane transport GO:0055085 399 0.041
mitotic cell cycle process GO:1903047 286 0.041
cellular protein complex assembly GO:0043623 188 0.041
cellular macromolecular complex assembly GO:0034622 324 0.039
cofactor metabolic process GO:0051186 87 0.039
response to hormone GO:0009725 175 0.038
maintenance of location GO:0051235 112 0.038
cellular lipid catabolic process GO:0044242 65 0.037
anatomical structure formation involved in morphogenesis GO:0048646 284 0.037
membrane organization GO:0061024 292 0.036
chemical homeostasis GO:0048878 306 0.036
vesicle mediated transport GO:0016192 371 0.035
lipid modification GO:0030258 84 0.035
carbohydrate metabolic process GO:0005975 207 0.035
ion transmembrane transport GO:0034220 338 0.034
nucleoside phosphate biosynthetic process GO:1901293 109 0.033
organic acid biosynthetic process GO:0016053 97 0.033
amine metabolic process GO:0009308 44 0.032
response to abiotic stimulus GO:0009628 336 0.032
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.031
microtubule based process GO:0007017 210 0.031
pyridine nucleotide metabolic process GO:0019362 14 0.031
regulation of cellular ketone metabolic process GO:0010565 50 0.030
dicarboxylic acid biosynthetic process GO:0043650 4 0.030
organonitrogen compound biosynthetic process GO:1901566 200 0.030
organic hydroxy compound metabolic process GO:1901615 147 0.029
single organism cellular localization GO:1902580 332 0.029
mitochondrion organization GO:0007005 156 0.029
regulation of cellular amino acid metabolic process GO:0006521 6 0.028
cellular amino acid metabolic process GO:0006520 116 0.028
negative regulation of programmed cell death GO:0043069 321 0.027
purine containing compound biosynthetic process GO:0072522 88 0.027
mitotic cell cycle GO:0000278 326 0.027
secretion GO:0046903 254 0.027
regulation of transferase activity GO:0051338 355 0.027
lipid oxidation GO:0034440 33 0.027
organophosphate biosynthetic process GO:0090407 163 0.026
carbohydrate derivative biosynthetic process GO:1901137 207 0.026
single organism carbohydrate metabolic process GO:0044723 193 0.025
regulation of proteolysis GO:0030162 293 0.025
single organism membrane organization GO:0044802 268 0.025
cell development GO:0048468 328 0.025
negative regulation of multicellular organismal process GO:0051241 317 0.025
nucleotide catabolic process GO:0009166 408 0.025
negative regulation of apoptotic process GO:0043066 316 0.024
positive regulation of hydrolase activity GO:0051345 331 0.024
cellular component morphogenesis GO:0032989 314 0.024
cellular lipid metabolic process GO:0044255 303 0.024
positive regulation of cell death GO:0010942 263 0.024
response to organonitrogen compound GO:0010243 156 0.024
ribose phosphate biosynthetic process GO:0046390 82 0.024
cellular amine metabolic process GO:0044106 41 0.023
organelle assembly GO:0070925 176 0.023
growth GO:0040007 202 0.023
nucleotide biosynthetic process GO:0009165 109 0.023
negative regulation of catalytic activity GO:0043086 335 0.023
system process GO:0003008 349 0.023
purine ribonucleoside catabolic process GO:0046130 398 0.022
negative regulation of cell death GO:0060548 345 0.022
myosin filament assembly GO:0031034 2 0.022
lipid localization GO:0010876 106 0.022
cellular macromolecule catabolic process GO:0044265 380 0.022
protein maturation GO:0051604 233 0.022
cellular chemical homeostasis GO:0055082 180 0.022
embryo development GO:0009790 123 0.022
Worm
neuromuscular junction development GO:0007528 3 0.021
carboxylic acid biosynthetic process GO:0046394 97 0.021
inorganic cation transmembrane transport GO:0098662 194 0.021
organic hydroxy compound biosynthetic process GO:1901617 71 0.021
purine nucleotide catabolic process GO:0006195 405 0.021
ion homeostasis GO:0050801 230 0.021
regulation of purine nucleotide metabolic process GO:1900542 264 0.021
nucleoside diphosphate metabolic process GO:0009132 16 0.021
locomotory behavior GO:0007626 1 0.021
cellular response to dna damage stimulus GO:0006974 379 0.021
positive regulation of programmed cell death GO:0043068 249 0.020
regulation of cellular amine metabolic process GO:0033238 11 0.020
nicotinamide nucleotide metabolic process GO:0046496 14 0.020
purine nucleotide biosynthetic process GO:0006164 84 0.020
protein processing GO:0016485 226 0.020
cellular respiration GO:0045333 21 0.020
actin filament based process GO:0030029 224 0.020
ribonucleotide biosynthetic process GO:0009260 81 0.020
mitochondrial transport GO:0006839 60 0.020
segmentation GO:0035282 4 0.019
microtubule cytoskeleton organization GO:0000226 176 0.019
dephosphorylation GO:0016311 209 0.019
alcohol metabolic process GO:0006066 114 0.019
protein localization to membrane GO:0072657 160 0.019
regulation of peptidase activity GO:0052547 180 0.019
ribonucleotide catabolic process GO:0009261 405 0.018
single organism reproductive process GO:0044702 98 0.018
Worm
response to nitrogen compound GO:1901698 184 0.018
neuroblast proliferation GO:0007405 4 0.018
purine ribonucleotide catabolic process GO:0009154 404 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.018
nervous system development GO:0007399 293 0.018
response to metal ion GO:0010038 84 0.018
spermatid differentiation GO:0048515 4 0.018
cellular ketone metabolic process GO:0042180 80 0.018
response to organic cyclic compound GO:0014070 204 0.018
wnt signaling pathway GO:0016055 156 0.018
glycosyl compound catabolic process GO:1901658 413 0.018
purine ribonucleoside biosynthetic process GO:0046129 23 0.018
response to axon injury GO:0048678 1 0.018
spermatid development GO:0007286 4 0.018
positive regulation of phosphorylation GO:0042327 394 0.017
metal ion transport GO:0030001 272 0.017
secretion by cell GO:0032940 226 0.017
biological adhesion GO:0022610 331 0.017
cation homeostasis GO:0055080 189 0.017
protein catabolic process GO:0030163 325 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
regulation of neural precursor cell proliferation GO:2000177 4 0.017
ribonucleoside catabolic process GO:0042454 406 0.017
purine nucleoside triphosphate catabolic process GO:0009146 392 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
regulation of kinase activity GO:0043549 314 0.016
purine containing compound catabolic process GO:0072523 411 0.016
cellular ion homeostasis GO:0006873 168 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
rna interference GO:0016246 4 0.016
Worm
regulation of mapk cascade GO:0043408 262 0.016
cytoplasmic transport GO:0016482 379 0.016
dicarboxylic acid catabolic process GO:0043649 9 0.016
intracellular protein transport GO:0006886 270 0.016
negative regulation of cellular component organization GO:0051129 235 0.016
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.016
regulation of endopeptidase activity GO:0052548 170 0.016
endocytosis GO:0006897 159 0.016
reproductive process GO:0022414 106 0.016
Worm
response to external biotic stimulus GO:0043207 261 0.016
nucleoside phosphate catabolic process GO:1901292 412 0.016
ribonucleoside monophosphate catabolic process GO:0009158 158 0.016
cellular homeostasis GO:0019725 196 0.016
cell cycle phase transition GO:0044770 173 0.016
regulation of purine nucleotide catabolic process GO:0033121 205 0.016
protein targeting GO:0006605 187 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
adult locomotory behavior GO:0008344 1 0.015
negative regulation of cellular protein metabolic process GO:0032269 353 0.015
fatty acid catabolic process GO:0009062 29 0.015
nitrogen compound transport GO:0071705 191 0.015
negative regulation of protein metabolic process GO:0051248 391 0.015
regulation of cell differentiation GO:0045595 393 0.015
negative regulation of developmental process GO:0051093 247 0.015
protein homooligomerization GO:0051260 100 0.015
tube development GO:0035295 125 0.015
ubiquitin dependent protein catabolic process GO:0006511 206 0.015
apoptotic signaling pathway GO:0097190 268 0.015
negative regulation of growth GO:0045926 97 0.015
pyridine containing compound metabolic process GO:0072524 18 0.015
regeneration GO:0031099 4 0.015
modification dependent protein catabolic process GO:0019941 209 0.015
generation of neurons GO:0048699 152 0.015
peripheral nervous system development GO:0007422 2 0.015
regulation of synaptic plasticity GO:0048167 3 0.015
internal protein amino acid acetylation GO:0006475 101 0.014
negative regulation of hydrolase activity GO:0051346 182 0.014
regulation of neuroblast proliferation GO:1902692 3 0.014
reactive oxygen species metabolic process GO:0072593 75 0.014
response to fungus GO:0009620 4 0.014
response to decreased oxygen levels GO:0036293 96 0.014
cell morphogenesis GO:0000902 296 0.014
regulation of secretion GO:0051046 194 0.014
proteasomal protein catabolic process GO:0010498 176 0.014
memory GO:0007613 3 0.014
fatty acid oxidation GO:0019395 31 0.014
lipid biosynthetic process GO:0008610 177 0.014
striated muscle myosin thick filament assembly GO:0071688 2 0.014
negative regulation of cell proliferation GO:0008285 228 0.014
positive regulation of apoptotic process GO:0043065 246 0.014
negative regulation of apoptotic signaling pathway GO:2001234 97 0.014
protein localization to organelle GO:0033365 280 0.014
negative regulation of transport GO:0051051 176 0.014
myosin filament organization GO:0031033 2 0.014
cell projection organization GO:0030030 252 0.013
endomembrane system organization GO:0010256 196 0.013
negative regulation of protein modification process GO:0031400 200 0.013
aspartate metabolic process GO:0006531 4 0.013
cellular response to oxygen containing compound GO:1901701 276 0.013
modification dependent macromolecule catabolic process GO:0043632 212 0.013
steroid metabolic process GO:0008202 94 0.013
protein oligomerization GO:0051259 173 0.013
epithelium development GO:0060429 227 0.013
cellular amino acid catabolic process GO:0009063 31 0.013
response to hypoxia GO:0001666 96 0.013
embryonic morphogenesis GO:0048598 85 0.013
neurogenesis GO:0022008 169 0.013
monocarboxylic acid catabolic process GO:0072329 37 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
protein acetylation GO:0006473 116 0.013
positive regulation of developmental process GO:0051094 314 0.012
divalent metal ion transport GO:0070838 152 0.012
ribonucleoside triphosphate catabolic process GO:0009203 391 0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.012
mitochondrial membrane organization GO:0007006 40 0.012
glycerol metabolic process GO:0006071 4 0.012
positive regulation of proteolysis GO:0045862 142 0.012
response to oxidative stress GO:0006979 121 0.012
purine nucleoside monophosphate catabolic process GO:0009128 158 0.012
regulation of ion transmembrane transport GO:0034765 132 0.012
cell cell signaling GO:0007267 155 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
reactive nitrogen species metabolic process GO:2001057 3 0.012
neuron differentiation GO:0030182 138 0.012
cellular protein catabolic process GO:0044257 261 0.012
regulation of cysteine type endopeptidase activity GO:2000116 127 0.012
histone modification GO:0016570 251 0.012
response to nutrient levels GO:0031667 81 0.012
mating GO:0007618 1 0.012
purine nucleoside catabolic process GO:0006152 398 0.012
regulation of secretion by cell GO:1903530 177 0.012
regulation of cell cycle GO:0051726 393 0.012
ossification GO:0001503 121 0.012
calcium ion transmembrane transport GO:0070588 76 0.012
positive regulation of cellular amine metabolic process GO:0033240 7 0.012
regulation of growth GO:0040008 165 0.012
reproductive structure development GO:0048608 55 0.012
Worm
positive regulation of protein kinase activity GO:0045860 190 0.012
covalent chromatin modification GO:0016569 254 0.012
divalent inorganic cation transport GO:0072511 158 0.012
positive regulation of immune system process GO:0002684 283 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.012
organophosphate catabolic process GO:0046434 430 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
circulatory system development GO:0072359 262 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
cellular cation homeostasis GO:0030003 163 0.011
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.011
regulation of cellular component movement GO:0051270 334 0.011
cellular carbohydrate metabolic process GO:0044262 84 0.011
cellular response to endogenous stimulus GO:0071495 336 0.011
regulation of intracellular transport GO:0032386 195 0.011
ras protein signal transduction GO:0007265 73 0.011
brain development GO:0007420 97 0.011
regulation of wnt signaling pathway GO:0030111 123 0.011
developmental process involved in reproduction GO:0003006 66 0.011
Worm
regulation of nucleoside metabolic process GO:0009118 209 0.011
positive regulation of catabolic process GO:0009896 310 0.011
calcium ion transport GO:0006816 147 0.011
mitotic cell cycle phase transition GO:0044772 162 0.011
syncytium formation by plasma membrane fusion GO:0000768 2 0.011
chromatin modification GO:0016568 298 0.011
mitochondrial atp synthesis coupled electron transport GO:0042775 4 0.011
protein autophosphorylation GO:0046777 123 0.011
head development GO:0060322 108 0.011
regulation of transmembrane transport GO:0034762 139 0.011
response to biotic stimulus GO:0009607 276 0.011
nucleoside catabolic process GO:0009164 408 0.011
positive regulation of secretion by cell GO:1903532 108 0.011
negative regulation of transferase activity GO:0051348 124 0.011
small gtpase mediated signal transduction GO:0007264 78 0.011
muscle system process GO:0003012 81 0.011
response to lipid GO:0033993 206 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
monocarboxylic acid biosynthetic process GO:0072330 67 0.011
response to drug GO:0042493 81 0.011
regulation of cellular component biogenesis GO:0044087 281 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
nucleoside triphosphate catabolic process GO:0009143 394 0.011
negative regulation of cell cycle GO:0045786 193 0.011
cell part morphogenesis GO:0032990 137 0.010
aspartate family amino acid catabolic process GO:0009068 5 0.010
positive regulation of protein phosphorylation GO:0001934 313 0.010
blastoderm segmentation GO:0007350 2 0.010
negative regulation of proteolysis GO:0045861 132 0.010
somitogenesis GO:0001756 2 0.010
protein dephosphorylation GO:0006470 81 0.010
regulation of nucleotide metabolic process GO:0006140 269 0.010
chromatin organization GO:0006325 351 0.010
regulation of cellular response to stress GO:0080135 244 0.010
positive regulation of kinase activity GO:0033674 204 0.010
intrinsic apoptotic signaling pathway GO:0097193 127 0.010
neurological system process GO:0050877 163 0.010
monovalent inorganic cation transport GO:0015672 128 0.010
regulation of homeostatic process GO:0032844 121 0.010
cell adhesion GO:0007155 325 0.010
sensory perception of pain GO:0019233 4 0.010
response to peptide GO:1901652 65 0.010
anion transport GO:0006820 161 0.010
rna processing GO:0006396 255 0.010
nerve development GO:0021675 4 0.010
immune response GO:0006955 307 0.010
response to other organism GO:0051707 261 0.010
actin cytoskeleton organization GO:0030036 207 0.010
negative regulation of cell differentiation GO:0045596 171 0.010
regulation of protein kinase activity GO:0045859 289 0.010
response to starvation GO:0042594 59 0.010
actin mediated cell contraction GO:0070252 12 0.010

ACO2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.170
inherited metabolic disorder DOID:655 242 0.170
immune system disease DOID:2914 155 0.084
cancer DOID:162 167 0.035
disease of cellular proliferation DOID:14566 174 0.035
cardiovascular system disease DOID:1287 106 0.030
retinal disease DOID:5679 118 0.030
sensory system disease DOID:0050155 203 0.030
eye and adnexa disease DOID:1492 150 0.030
nervous system disease DOID:863 431 0.030
eye disease DOID:5614 149 0.030
hematopoietic system disease DOID:74 100 0.028
muscular disease DOID:0080000 114 0.028
musculoskeletal system disease DOID:17 223 0.028
muscle tissue disease DOID:66 113 0.028
hemolytic anemia DOID:583 20 0.025
normocytic anemia DOID:720 20 0.025
anemia DOID:2355 55 0.025
mitochondrial metabolism disease DOID:700 29 0.022
organ system cancer DOID:0050686 164 0.021
central nervous system disease DOID:331 186 0.020
amino acid metabolic disorder DOID:9252 50 0.020
heart disease DOID:114 68 0.015
neurodegenerative disease DOID:1289 102 0.015
carbohydrate metabolic disorder DOID:2978 55 0.014
retinal degeneration DOID:8466 89 0.013
retinitis pigmentosa DOID:10584 51 0.012
myopathy DOID:423 104 0.011
cardiomyopathy DOID:0050700 50 0.011
intrinsic cardiomyopathy DOID:0060036 50 0.011
dilated cardiomyopathy DOID:12930 32 0.010