Homo sapiens

107 known processes

COMMD1

copper metabolism (Murr1) domain containing 1

(Aliases: C2orf5,MURR1,MGC27155)

COMMD1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.921
activation of jak2 kinase activity GO:0042977 5 0.804
regulation of activation of jak2 kinase activity GO:0010534 5 0.804
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.596
regulation of activation of janus kinase activity GO:0010533 6 0.585
negative regulation of response to interferon gamma GO:0060331 2 0.373
tripartite regional subdivision GO:0007351 2 0.300
cellular amino acid metabolic process GO:0006520 116 0.292
regulation of protein catabolic process GO:0042176 155 0.256
regulation of cytokine production GO:0001817 232 0.250
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.249
intracellular protein transport GO:0006886 270 0.221
segmentation GO:0035282 4 0.188
anterior posterior axis specification GO:0009948 2 0.187
cellular amine metabolic process GO:0044106 41 0.184
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 6 0.179
positive regulation of proteolysis GO:0045862 142 0.159
cytokine production GO:0001816 247 0.141
negative regulation of catalytic activity GO:0043086 335 0.140
amine metabolic process GO:0009308 44 0.138
intrinsic apoptotic signaling pathway GO:0097193 127 0.124
anterior posterior axis specification embryo GO:0008595 2 0.122
activation of janus kinase activity GO:0042976 7 0.121
negative regulation of tyrosine phosphorylation of stat3 protein GO:0042518 2 0.113
cellular ketone metabolic process GO:0042180 80 0.113
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.105
negative regulation of defense response GO:0031348 47 0.103
proteasomal protein catabolic process GO:0010498 176 0.103
positive regulation of meiotic cell cycle GO:0051446 2 0.098
cellular macromolecule catabolic process GO:0044265 380 0.097
cellular response to oxygen containing compound GO:1901701 276 0.097
response to cytokine GO:0034097 232 0.093
regulation of apoptotic signaling pathway GO:2001233 175 0.093
regulation of cellular ketone metabolic process GO:0010565 50 0.090
regulation of transferase activity GO:0051338 355 0.089
regulation of protein localization GO:0032880 296 0.085
regulation of cellular amino acid metabolic process GO:0006521 6 0.083
protein targeting GO:0006605 187 0.080
cytokine mediated signaling pathway GO:0019221 109 0.079
chemical homeostasis GO:0048878 306 0.077
cellular response to cytokine stimulus GO:0071345 181 0.075
positive regulation of cellular catabolic process GO:0031331 284 0.073
metaphase anaphase transition of cell cycle GO:0044784 21 0.070
negative regulation of jak stat cascade GO:0046426 4 0.067
regeneration GO:0031099 4 0.066
negative regulation of protein metabolic process GO:0051248 391 0.064
ubiquitin dependent protein catabolic process GO:0006511 206 0.062
positive regulation of protein catabolic process GO:0045732 75 0.062
protein catabolic process GO:0030163 325 0.061
locomotory behavior GO:0007626 1 0.060
negative regulation of programmed cell death GO:0043069 321 0.059
regulation of chromosome segregation GO:0051983 44 0.059
blastoderm segmentation GO:0007350 2 0.058
nerve development GO:0021675 4 0.058
cellular response to dna damage stimulus GO:0006974 379 0.056
metal ion homeostasis GO:0055065 169 0.056
mitotic sister chromatid segregation GO:0000070 53 0.055
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.055
regulation of secretion GO:0051046 194 0.054
negative regulation of immune system process GO:0002683 136 0.053
regulation of cysteine type endopeptidase activity GO:2000116 127 0.050
regulation of kinase activity GO:0043549 314 0.050
modification dependent protein catabolic process GO:0019941 209 0.049
positive regulation of peptidase activity GO:0010952 88 0.049
response to abiotic stimulus GO:0009628 336 0.049
Mouse
cytoplasmic transport GO:0016482 379 0.047
positive regulation of catabolic process GO:0009896 310 0.047
sister chromatid segregation GO:0000819 54 0.046
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.046
regulation of secretion by cell GO:1903530 177 0.046
response to acid chemical GO:0001101 66 0.046
cellular response to acid chemical GO:0071229 44 0.045
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.045
positive regulation of transferase activity GO:0051347 227 0.045
ion homeostasis GO:0050801 230 0.045
peptidyl tyrosine modification GO:0018212 170 0.044
regulation of innate immune response GO:0045088 97 0.043
regulation of nucleoside metabolic process GO:0009118 209 0.043
negative regulation of epidermal growth factor activated receptor activity GO:0007175 6 0.043
secretion GO:0046903 254 0.042
post embryonic development GO:0009791 2 0.041
response to nitrogen compound GO:1901698 184 0.041
regulation of proteolysis GO:0030162 293 0.041
purine nucleoside triphosphate metabolic process GO:0009144 412 0.040
positive regulation of apoptotic process GO:0043065 246 0.040
protein maturation GO:0051604 233 0.040
regulation of establishment of protein localization GO:0070201 242 0.040
response to salt stress GO:0009651 3 0.039
regulation of cell adhesion GO:0030155 166 0.039
regulation of cytokine secretion GO:0050707 57 0.039
regulation of ligase activity GO:0051340 29 0.038
protein modification by small protein conjugation GO:0032446 342 0.038
positive regulation of kinase activity GO:0033674 204 0.038
regulation of protein processing GO:0070613 150 0.038
protein ubiquitination GO:0016567 314 0.037
response to organic cyclic compound GO:0014070 204 0.037
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.037
cellular response to organic cyclic compound GO:0071407 127 0.037
regulation of chromosome organization GO:0033044 103 0.037
response to lipid GO:0033993 206 0.036
cellular response to nitrogen compound GO:1901699 144 0.035
regulation of cellular protein catabolic process GO:1903362 96 0.035
regulation of nucleotide metabolic process GO:0006140 269 0.035
neurogenesis GO:0022008 169 0.034
mitochondrion organization GO:0007005 156 0.033
response to other organism GO:0051707 261 0.033
inflammatory response GO:0006954 79 0.033
innate immune response GO:0045087 178 0.032
cellular response to amino acid stimulus GO:0071230 12 0.032
response to oxygen containing compound GO:1901700 369 0.032
female gamete generation GO:0007292 2 0.031
regulation of mitotic sister chromatid segregation GO:0033047 27 0.031
chromosome segregation GO:0007059 114 0.031
positive regulation of cytokine production GO:0001819 167 0.031
defense response GO:0006952 315 0.031
negative regulation of intracellular signal transduction GO:1902532 183 0.031
negative regulation of phosphorus metabolic process GO:0010563 267 0.030
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.030
negative regulation of apoptotic process GO:0043066 316 0.030
protein secretion GO:0009306 98 0.030
negative regulation of cellular protein metabolic process GO:0032269 353 0.030
sensory perception of taste GO:0050909 36 0.029
lipid metabolic process GO:0006629 381 0.029
regulation of ubiquitin protein transferase activity GO:0051438 28 0.029
inorganic cation transmembrane transport GO:0098662 194 0.029
negative regulation of protein kinase activity GO:0006469 98 0.029
positive regulation of protein phosphorylation GO:0001934 313 0.029
protein import into nucleus GO:0006606 104 0.029
regulation of protein kinase activity GO:0045859 289 0.029
negative regulation of cytokine mediated signaling pathway GO:0001960 22 0.029
regulation of immune response GO:0050776 201 0.029
regulation of response to external stimulus GO:0032101 222 0.029
regulation of protein targeting GO:1903533 91 0.028
organophosphate catabolic process GO:0046434 430 0.028
response to organonitrogen compound GO:0010243 156 0.028
cellular protein catabolic process GO:0044257 261 0.028
response to bacterium GO:0009617 144 0.028
regulation of nucleocytoplasmic transport GO:0046822 98 0.027
negative regulation of transferase activity GO:0051348 124 0.027
positive regulation of cellular amine metabolic process GO:0033240 7 0.027
gtp catabolic process GO:0006184 237 0.027
mitotic sister chromatid separation GO:0051306 18 0.026
negative regulation of cellular amine metabolic process GO:0033239 3 0.026
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.026
regulation of endopeptidase activity GO:0052548 170 0.026
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.025
cellular response to interferon gamma GO:0071346 24 0.025
cation transport GO:0006812 331 0.025
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.025
monovalent inorganic cation transport GO:0015672 128 0.025
negative regulation of feeding behavior GO:2000252 1 0.025
regulation of cellular amine metabolic process GO:0033238 11 0.025
posttranscriptional regulation of gene expression GO:0010608 213 0.025
Mouse
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.024
positive regulation of protein kinase activity GO:0045860 190 0.024
regulation of meiotic cell cycle GO:0051445 4 0.024
negative regulation of response to cytokine stimulus GO:0060761 25 0.024
positive regulation of cell death GO:0010942 263 0.024
protein import GO:0017038 130 0.024
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 11 0.024
regulation of purine nucleotide metabolic process GO:1900542 264 0.024
nucleus localization GO:0051647 1 0.023
positive regulation of nucleoside metabolic process GO:0045979 186 0.023
protein targeting to nucleus GO:0044744 104 0.023
regulation of sister chromatid segregation GO:0033045 27 0.023
cellular homeostasis GO:0019725 196 0.023
apoptotic signaling pathway GO:0097190 268 0.023
purine ribonucleoside metabolic process GO:0046128 437 0.023
cell morphogenesis GO:0000902 296 0.023
oogenesis GO:0048477 2 0.023
purine ribonucleoside catabolic process GO:0046130 398 0.023
regulation of proteasomal protein catabolic process GO:0061136 87 0.023
drinking behavior GO:0042756 1 0.022
negative regulation of kinase activity GO:0033673 106 0.022
extrinsic apoptotic signaling pathway GO:0097191 119 0.022
cytokine secretion GO:0050663 64 0.022
single organism cellular localization GO:1902580 332 0.022
response to inorganic substance GO:0010035 127 0.022
protein localization to nucleus GO:0034504 136 0.022
nervous system development GO:0007399 293 0.022
response to external biotic stimulus GO:0043207 261 0.022
mitochondrial membrane organization GO:0007006 40 0.022
tyrosine phosphorylation of stat3 protein GO:0042503 20 0.022
positive regulation of transport GO:0051050 336 0.022
secretion by cell GO:0032940 226 0.021
steroid metabolic process GO:0008202 94 0.021
microtubule based movement GO:0007018 32 0.020
cation homeostasis GO:0055080 189 0.020
regulation of defense response GO:0031347 154 0.020
regulation of receptor activity GO:0010469 47 0.020
regulation of protein transport GO:0051223 213 0.020
negative regulation of developmental process GO:0051093 247 0.020
regulation of mitotic cell cycle GO:0007346 189 0.020
negative regulation of multicellular organismal process GO:0051241 317 0.020
chromosome separation GO:0051304 23 0.020
neurological system process GO:0050877 163 0.020
immune system development GO:0002520 195 0.019
positive regulation of nucleotide metabolic process GO:0045981 230 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
cellular response to oxidative stress GO:0034599 85 0.019
reactive oxygen species metabolic process GO:0072593 75 0.019
protein localization to organelle GO:0033365 280 0.019
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 11 0.019
regulation of cell cycle process GO:0010564 266 0.019
organonitrogen compound biosynthetic process GO:1901566 200 0.019
immune effector process GO:0002252 159 0.019
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 18 0.019
microtubule based process GO:0007017 210 0.018
ribonucleoside triphosphate catabolic process GO:0009203 391 0.018
determination of adult lifespan GO:0008340 2 0.018
regulation of cell cycle GO:0051726 393 0.018
response to peptide GO:1901652 65 0.018
establishment of protein localization to organelle GO:0072594 172 0.018
regulation of cell differentiation GO:0045595 393 0.018
cellular divalent inorganic cation homeostasis GO:0072503 128 0.017
regulation of erbb signaling pathway GO:1901184 27 0.017
regulation of protein localization to nucleus GO:1900180 85 0.017
multicellular organismal aging GO:0010259 3 0.017
interferon gamma mediated signaling pathway GO:0060333 7 0.017
immune response GO:0006955 307 0.017
cellular response to endogenous stimulus GO:0071495 336 0.017
hematopoietic or lymphoid organ development GO:0048534 186 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.017
intracellular receptor signaling pathway GO:0030522 104 0.016
transmembrane transport GO:0055085 399 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.016
system process GO:0003008 349 0.016
maintenance of location GO:0051235 112 0.016
regulation of gtp catabolic process GO:0033124 180 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.016
negative regulation of response to external stimulus GO:0032102 83 0.016
negative regulation of immune response GO:0050777 40 0.016
negative regulation of protein modification process GO:0031400 200 0.016
organelle localization GO:0051640 84 0.015
fat cell differentiation GO:0045444 32 0.015
nucleotide catabolic process GO:0009166 408 0.015
response to tumor necrosis factor GO:0034612 76 0.015
stem cell division GO:0017145 2 0.015
positive regulation of hydrolase activity GO:0051345 331 0.015
positive regulation of cell cycle process GO:0090068 106 0.015
release of cytochrome c from mitochondria GO:0001836 35 0.015
small molecule biosynthetic process GO:0044283 157 0.015
cation transmembrane transport GO:0098655 238 0.015
positive regulation of programmed cell death GO:0043068 249 0.015
ribonucleoside triphosphate metabolic process GO:0009199 412 0.015
nuclear migration GO:0007097 1 0.015
peptidyl tyrosine phosphorylation GO:0018108 170 0.015
mitotic nuclear division GO:0007067 119 0.015
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.015
regulation of mitosis GO:0007088 63 0.014
mitotic cell cycle process GO:1903047 286 0.014
carbohydrate biosynthetic process GO:0016051 42 0.014
response to drug GO:0042493 81 0.014
cellular cation homeostasis GO:0030003 163 0.014
detection of mechanical stimulus involved in sensory perception GO:0050974 1 0.014
single organism membrane organization GO:0044802 268 0.014
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.014
regulation of response to interferon gamma GO:0060330 7 0.014
calcium ion homeostasis GO:0055074 122 0.014
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 4 0.014
response to progesterone GO:0032570 5 0.014
alcohol metabolic process GO:0006066 114 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.014
protein acetylation GO:0006473 116 0.014
negative regulation of receptor activity GO:2000272 15 0.014
response to radiation GO:0009314 151 0.014
negative regulation of protein localization to nucleus GO:1900181 34 0.014
biological adhesion GO:0022610 331 0.014
cellular response to organonitrogen compound GO:0071417 124 0.013
response to interferon gamma GO:0034341 39 0.013
peptidyl lysine modification GO:0018205 144 0.013
regulation of cell division GO:0051302 116 0.013
negative regulation of innate immune response GO:0045824 18 0.013
cell projection organization GO:0030030 252 0.013
regulation of protein maturation GO:1903317 150 0.013
regulation of mitochondrion organization GO:0010821 54 0.013
transcription factor import into nucleus GO:0042991 40 0.013
regulation of cellular response to stress GO:0080135 244 0.013
Mouse
hemopoiesis GO:0030097 180 0.013
meiotic chromosome segregation GO:0045132 4 0.013
ossification GO:0001503 121 0.013
positive regulation of gtp catabolic process GO:0033126 166 0.013
lipid localization GO:0010876 106 0.013
regionalization GO:0003002 29 0.013
memory GO:0007613 3 0.013
negative regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061428 4 0.013
protein autophosphorylation GO:0046777 123 0.013
growth GO:0040007 202 0.013
positive regulation of cellular component movement GO:0051272 181 0.013
cellular response to hypoxia GO:0071456 51 0.012
Mouse
cellular response to lipid GO:0071396 127 0.012
activation of protein kinase activity GO:0032147 90 0.012
positive regulation of mitochondrion organization GO:0010822 30 0.012
positive regulation of ras gtpase activity GO:0032320 117 0.012
positive regulation of nucleotide catabolic process GO:0030813 185 0.012
cyclin catabolic process GO:0008054 6 0.012
rho protein signal transduction GO:0007266 26 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
negative regulation of transport GO:0051051 176 0.012
positive regulation of phosphorylation GO:0042327 394 0.012
asymmetric neuroblast division GO:0055059 1 0.012
nucleoside phosphate catabolic process GO:1901292 412 0.012
spindle organization GO:0007051 53 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.012
negative regulation of cell death GO:0060548 345 0.012
regulation of mitotic cell cycle phase transition GO:1901990 118 0.012
regulation of cell activation GO:0050865 125 0.012
response to lipopolysaccharide GO:0032496 70 0.012
cell cycle checkpoint GO:0000075 117 0.012
mrna metabolic process GO:0016071 175 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
regulation of epidermal growth factor activated receptor activity GO:0007176 14 0.012
carbohydrate metabolic process GO:0005975 207 0.012
cellular response to water stimulus GO:0071462 1 0.012
intracellular protein transmembrane transport GO:0065002 24 0.012
purine nucleotide catabolic process GO:0006195 405 0.012
dephosphorylation GO:0016311 209 0.012
glycosyl compound catabolic process GO:1901658 413 0.012
response to water GO:0009415 2 0.011
ion transmembrane transport GO:0034220 338 0.011
inorganic ion transmembrane transport GO:0098660 231 0.011
guanosine containing compound metabolic process GO:1901068 244 0.011
protein deubiquitination GO:0016579 79 0.011
actin filament based process GO:0030029 224 0.011
response to biotic stimulus GO:0009607 276 0.011
cellular response to reactive oxygen species GO:0034614 50 0.011
jak stat cascade GO:0007259 46 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.011
negative regulation of phosphate metabolic process GO:0045936 267 0.011
regulation of alcohol biosynthetic process GO:1902930 22 0.011
glial cell migration GO:0008347 4 0.011
negative regulation of interferon gamma mediated signaling pathway GO:0060336 2 0.011
positive regulation of jak stat cascade GO:0046427 35 0.011
positive regulation of synaptic transmission GO:0050806 4 0.011
long term memory GO:0007616 2 0.011
protein localization to mitochondrion GO:0070585 25 0.011
response to molecule of bacterial origin GO:0002237 82 0.011
peptide metabolic process GO:0006518 51 0.011
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.011
regulation of ras gtpase activity GO:0032318 128 0.011
neuron projection morphogenesis GO:0048812 50 0.011
regulation of cytoplasmic transport GO:1903649 149 0.011
cell part morphogenesis GO:0032990 137 0.011
cell type specific apoptotic process GO:0097285 125 0.011
regulation of feeding behavior GO:0060259 3 0.011
tissue morphogenesis GO:0048729 96 0.011
negative regulation of wnt signaling pathway GO:0030178 69 0.010
multicellular organismal response to stress GO:0033555 1 0.010
positive regulation of cell differentiation GO:0045597 211 0.010
negative regulation of growth GO:0045926 97 0.010
establishment of protein localization to mitochondrion GO:0072655 22 0.010
microtubule cytoskeleton organization GO:0000226 176 0.010
regulation of transmembrane transport GO:0034762 139 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.010
response to ketone GO:1901654 19 0.010
response to muramyl dipeptide GO:0032495 4 0.010
response to oxidative stress GO:0006979 121 0.010
regulation of cytokine mediated signaling pathway GO:0001959 41 0.010
stem cell differentiation GO:0048863 93 0.010
purine ribonucleotide catabolic process GO:0009154 404 0.010
positive regulation of cell cycle phase transition GO:1901989 22 0.010
interleukin 8 production GO:0032637 51 0.010
cell adhesion GO:0007155 325 0.010

COMMD1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.068
disease of cellular proliferation DOID:14566 174 0.068
organ system cancer DOID:0050686 164 0.068
kidney cancer DOID:263 11 0.034
urinary system cancer DOID:3996 15 0.034
renal carcinoma DOID:4451 8 0.034
bone disease DOID:0080001 88 0.012
musculoskeletal system disease DOID:17 223 0.012
connective tissue disease DOID:65 109 0.012
central nervous system disease DOID:331 186 0.012
nervous system disease DOID:863 431 0.012