Homo sapiens

0 known processes

WFDC2

WAP four-disulfide core domain 2

(Aliases: HE4,dJ461P17.6,MGC57529,WAP5,EDDM4)

WFDC2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
system process GO:0003008 349 0.242
organ morphogenesis GO:0009887 147 0.124
epithelium development GO:0060429 227 0.118
epithelial cell differentiation GO:0030855 141 0.080
transmembrane transport GO:0055085 399 0.079
positive regulation of plasminogen activation GO:0010756 3 0.075
regulation of systemic arterial blood pressure by atrial natriuretic peptide GO:0003050 1 0.070
multi organism cellular process GO:0044764 156 0.068
ion transmembrane transport GO:0034220 338 0.063
skin development GO:0043588 76 0.057
tissue morphogenesis GO:0048729 96 0.057
cation transport GO:0006812 331 0.056
chemical homeostasis GO:0048878 306 0.053
negative regulation of multicellular organismal process GO:0051241 317 0.051
cation homeostasis GO:0055080 189 0.051
immune response GO:0006955 307 0.050
inorganic ion transmembrane transport GO:0098660 231 0.049
epithelial cell proliferation GO:0050673 128 0.047
hormone metabolic process GO:0042445 61 0.046
post embryonic development GO:0009791 2 0.046
cellular homeostasis GO:0019725 196 0.045
cellular amine metabolic process GO:0044106 41 0.045
viral process GO:0016032 146 0.044
regulation of cellular amino acid metabolic process GO:0006521 6 0.044
regulation of hormone levels GO:0010817 125 0.041
cellular amino acid metabolic process GO:0006520 116 0.039
regulation of cellular amine metabolic process GO:0033238 11 0.039
epidermis morphogenesis GO:0048730 3 0.038
viral life cycle GO:0019058 132 0.038
determination of adult lifespan GO:0008340 2 0.037
basement membrane organization GO:0071711 3 0.037
positive regulation of cellular amine metabolic process GO:0033240 7 0.037
multicellular organismal homeostasis GO:0048871 67 0.036
monovalent inorganic cation homeostasis GO:0055067 37 0.036
positive regulation of cellular component organization GO:0051130 376 0.035
negative regulation of developmental process GO:0051093 247 0.035
metal ion transport GO:0030001 272 0.035
regulation of multi organism process GO:0043900 157 0.035
actin filament based process GO:0030029 224 0.034
startle response GO:0001964 3 0.034
secretion GO:0046903 254 0.034
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.034
negative regulation of catalytic activity GO:0043086 335 0.034
cellular component morphogenesis GO:0032989 314 0.033
positive regulation of programmed cell death GO:0043068 249 0.033
anion transport GO:0006820 161 0.033
cellular sodium ion homeostasis GO:0006883 8 0.033
cell morphogenesis GO:0000902 296 0.033
tissue homeostasis GO:0001894 63 0.033
positive regulation of cell death GO:0010942 263 0.032
multicellular organismal aging GO:0010259 3 0.032
morphogenesis of an epithelium GO:0002009 60 0.031
interspecies interaction between organisms GO:0044419 156 0.031
regulation of protein maturation GO:1903317 150 0.031
innate immune response GO:0045087 178 0.030
neuromuscular junction development GO:0007528 3 0.030
regulation of protein kinase activity GO:0045859 289 0.030
urogenital system development GO:0001655 65 0.030
positive regulation of cell proliferation GO:0008284 301 0.030
response to oxygen containing compound GO:1901700 369 0.030
ion homeostasis GO:0050801 230 0.029
protein maturation GO:0051604 233 0.029
wnt signaling pathway GO:0016055 156 0.029
regulation of kinase activity GO:0043549 314 0.029
regulation of cell growth GO:0001558 135 0.029
dephosphorylation GO:0016311 209 0.028
cellular response to endogenous stimulus GO:0071495 336 0.028
positive regulation of apoptotic process GO:0043065 246 0.027
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.027
negative regulation of cell death GO:0060548 345 0.026
defense response GO:0006952 315 0.026
cellular response to nitrogen compound GO:1901699 144 0.026
amine metabolic process GO:0009308 44 0.026
regulation of viral process GO:0050792 103 0.025
retina homeostasis GO:0001895 42 0.025
positive regulation of protein phosphorylation GO:0001934 313 0.025
renal system development GO:0072001 63 0.025
actin mediated cell contraction GO:0070252 12 0.025
regulation of systemic arterial blood pressure by hormone GO:0001990 12 0.025
secretion by cell GO:0032940 226 0.024
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.024
positive regulation of phosphorylation GO:0042327 394 0.024
morphogenesis of embryonic epithelium GO:0016331 4 0.024
protein processing GO:0016485 226 0.024
cellular lipid metabolic process GO:0044255 303 0.024
water homeostasis GO:0030104 14 0.024
regulation of endopeptidase activity GO:0052548 170 0.023
neurological system process GO:0050877 163 0.023
response to abiotic stimulus GO:0009628 336 0.023
cation transmembrane transport GO:0098655 238 0.023
anatomical structure homeostasis GO:0060249 100 0.022
inorganic cation transmembrane transport GO:0098662 194 0.022
hair follicle morphogenesis GO:0031069 2 0.022
embryonic epithelial tube formation GO:0001838 4 0.022
regulation of branching involved in ureteric bud morphogenesis GO:0090189 3 0.021
regulation of growth GO:0040008 165 0.021
mating GO:0007618 1 0.021
negative regulation of cellular protein metabolic process GO:0032269 353 0.021
negative regulation of phosphate metabolic process GO:0045936 267 0.021
growth GO:0040007 202 0.021
metal ion homeostasis GO:0055065 169 0.021
regulation of protein processing GO:0070613 150 0.021
tube development GO:0035295 125 0.021
purine ribonucleoside catabolic process GO:0046130 398 0.021
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 12 0.021
reproductive process GO:0022414 106 0.021
negative regulation of cell proliferation GO:0008285 228 0.021
female gamete generation GO:0007292 2 0.021
cellular ketone metabolic process GO:0042180 80 0.020
vesicle mediated transport GO:0016192 371 0.020
positive regulation of viral entry into host cell GO:0046598 3 0.020
actin filament based movement GO:0030048 17 0.020
cell adhesion GO:0007155 325 0.020
blood circulation GO:0008015 113 0.020
regulation of proteolysis GO:0030162 293 0.020
epithelial cell migration GO:0010631 119 0.020
cell projection organization GO:0030030 252 0.020
protein autoprocessing GO:0016540 4 0.019
cell growth GO:0016049 160 0.019
single organism reproductive process GO:0044702 98 0.019
negative regulation of hydrolase activity GO:0051346 182 0.019
negative regulation of programmed cell death GO:0043069 321 0.019
cellular component disassembly GO:0022411 92 0.019
cardiac muscle cell contraction GO:0086003 4 0.019
response to external biotic stimulus GO:0043207 261 0.019
positive regulation of hydrolase activity GO:0051345 331 0.019
cellular ion homeostasis GO:0006873 168 0.019
rho protein signal transduction GO:0007266 26 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
canonical wnt signaling pathway GO:0060070 116 0.019
regulation of cytoskeleton organization GO:0051493 177 0.019
regulation of body fluid levels GO:0050878 99 0.018
circulatory system development GO:0072359 262 0.018
regeneration GO:0031099 4 0.018
cellular macromolecular complex assembly GO:0034622 324 0.018
protein localization to organelle GO:0033365 280 0.018
embryonic placenta development GO:0001892 1 0.018
regulation of actin filament based process GO:0032970 141 0.018
nitrogen compound transport GO:0071705 191 0.018
nucleoside triphosphate metabolic process GO:0009141 422 0.018
regulation of cellular ketone metabolic process GO:0010565 50 0.018
regulation of vesicle mediated transport GO:0060627 130 0.018
cellular protein complex assembly GO:0043623 188 0.017
divalent metal ion transport GO:0070838 152 0.017
purine nucleotide catabolic process GO:0006195 405 0.017
circulatory system process GO:0003013 113 0.017
cellular chemical homeostasis GO:0055082 180 0.017
cell cell junction organization GO:0045216 69 0.017
positive regulation of acrosome reaction GO:2000344 4 0.017
enzyme linked receptor protein signaling pathway GO:0007167 303 0.017
lung alveolus development GO:0048286 4 0.017
response to other organism GO:0051707 261 0.016
oogenesis GO:0048477 2 0.016
segmentation GO:0035282 4 0.016
positive regulation of transferase activity GO:0051347 227 0.016
nucleoside triphosphate catabolic process GO:0009143 394 0.016
small gtpase mediated signal transduction GO:0007264 78 0.016
kidney development GO:0001822 53 0.016
extracellular structure organization GO:0043062 41 0.016
purine nucleoside triphosphate metabolic process GO:0009144 412 0.016
regulation of secretion GO:0051046 194 0.016
negative regulation of cellular component organization GO:0051129 235 0.016
lipid metabolic process GO:0006629 381 0.016
ras protein signal transduction GO:0007265 73 0.016
negative regulation of phosphorus metabolic process GO:0010563 267 0.016
meiotic chromosome segregation GO:0045132 4 0.016
regulation of locomotion GO:0040012 329 0.016
regulation of mapk cascade GO:0043408 262 0.016
glycosyl compound catabolic process GO:1901658 413 0.016
ossification GO:0001503 121 0.015
regulation of transferase activity GO:0051338 355 0.015
regulation of cell cycle process GO:0010564 266 0.015
nucleoside catabolic process GO:0009164 408 0.015
purine ribonucleoside metabolic process GO:0046128 437 0.015
plasminogen activation GO:0031639 11 0.015
melanin metabolic process GO:0006582 1 0.015
cellular metal ion homeostasis GO:0006875 146 0.015
multi organism metabolic process GO:0044033 41 0.015
endocrine process GO:0050886 25 0.015
negative regulation of growth GO:0045926 97 0.015
positive regulation of transport GO:0051050 336 0.015
regulation of cell migration GO:0030334 289 0.015
regulation of epithelial cell proliferation GO:0050678 113 0.015
inner ear morphogenesis GO:0042472 4 0.015
sensory perception GO:0007600 103 0.015
negative regulation of cell morphogenesis involved in differentiation GO:0010771 24 0.015
negative regulation of intracellular signal transduction GO:1902532 183 0.015
anterior posterior axis specification GO:0009948 2 0.015
signal transduction by phosphorylation GO:0023014 297 0.015
tissue migration GO:0090130 119 0.015
negative regulation of epithelial cell proliferation GO:0050680 48 0.014
response to bacterium GO:0009617 144 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014
embryonic morphogenesis GO:0048598 85 0.014
calcium ion transport GO:0006816 147 0.014
entry into other organism involved in symbiotic interaction GO:0051828 25 0.014
activation of protein kinase activity GO:0032147 90 0.014
embryo development GO:0009790 123 0.014
mitotic cell cycle GO:0000278 326 0.014
extracellular matrix organization GO:0030198 41 0.014
chloride transmembrane transport GO:1902476 38 0.014
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.014
negative regulation of protein metabolic process GO:0051248 391 0.014
epithelial to mesenchymal transition GO:0001837 48 0.014
ribonucleoside triphosphate metabolic process GO:0009199 412 0.014
negative regulation of protein maturation GO:1903318 142 0.014
mapk cascade GO:0000165 288 0.014
sodium ion homeostasis GO:0055078 14 0.014
posttranscriptional regulation of gene expression GO:0010608 213 0.014
regulation of organ morphogenesis GO:2000027 24 0.014
positive regulation of multi organism process GO:0043902 56 0.014
divalent inorganic cation transport GO:0072511 158 0.014
cell type specific apoptotic process GO:0097285 125 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
regulation of dephosphorylation GO:0035303 96 0.014
negative regulation of transport GO:0051051 176 0.014
keratinization GO:0031424 2 0.014
sensory perception of mechanical stimulus GO:0050954 37 0.014
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
regulation of protein localization GO:0032880 296 0.013
regulation of stem cell differentiation GO:2000736 56 0.013
positive regulation of protein kinase activity GO:0045860 190 0.013
regulation of cellular response to stress GO:0080135 244 0.013
epidermis development GO:0008544 59 0.013
positive regulation of kinase activity GO:0033674 204 0.013
negative regulation of cell migration GO:0030336 102 0.013
regulation of epithelial to mesenchymal transition GO:0010717 37 0.013
regulation of purine nucleotide metabolic process GO:1900542 264 0.013
mitotic cell cycle process GO:1903047 286 0.013
cellular cation homeostasis GO:0030003 163 0.013
regulation of peptidase activity GO:0052547 180 0.013
tube morphogenesis GO:0035239 95 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
cellular response to organic cyclic compound GO:0071407 127 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.013
regulation of dna metabolic process GO:0051052 153 0.013
regulation of cell morphogenesis GO:0022604 153 0.013
response to biotic stimulus GO:0009607 276 0.013
negative regulation of kidney development GO:0090185 2 0.013
glycoprotein metabolic process GO:0009100 110 0.013
muscle system process GO:0003012 81 0.013
chromatin organization GO:0006325 351 0.013
organelle assembly GO:0070925 176 0.013
locomotory behavior GO:0007626 1 0.013
regulation of cell cycle GO:0051726 393 0.013
cardiovascular system development GO:0072358 262 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
cellular component assembly involved in morphogenesis GO:0010927 73 0.012
cellular macromolecule catabolic process GO:0044265 380 0.012
neural tube formation GO:0001841 3 0.012
single organism cellular localization GO:1902580 332 0.012
negative regulation of proteolysis GO:0045861 132 0.012
regulation of protein transport GO:0051223 213 0.012
mesenchymal cell differentiation GO:0048762 52 0.012
cellular amide metabolic process GO:0043603 69 0.012
regulation of establishment of protein localization GO:0070201 242 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.012
nucleotide catabolic process GO:0009166 408 0.012
positive regulation of immune system process GO:0002684 283 0.012
sex determination GO:0007530 3 0.012
spermatid development GO:0007286 4 0.012
vasculature development GO:0001944 181 0.012
positive regulation of intracellular protein transport GO:0090316 76 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
ribonucleoside triphosphate catabolic process GO:0009203 391 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
regulation of cell cycle phase transition GO:1901987 126 0.012
cellular response to oxygen containing compound GO:1901701 276 0.012
nucleoside phosphate catabolic process GO:1901292 412 0.012
response to organonitrogen compound GO:0010243 156 0.012
blastocyst development GO:0001824 3 0.012
ribonucleoside catabolic process GO:0042454 406 0.012
negative regulation of protein modification process GO:0031400 200 0.012
viral entry into host cell GO:0046718 24 0.012
apoptotic signaling pathway GO:0097190 268 0.012
nucleocytoplasmic transport GO:0006913 176 0.012
carbohydrate derivative biosynthetic process GO:1901137 207 0.012
cilium morphogenesis GO:0060271 75 0.012
negative regulation of epithelial to mesenchymal transition GO:0010719 14 0.011
spermatid differentiation GO:0048515 4 0.011
regulation of meiotic cell cycle GO:0051445 4 0.011
cytoplasmic transport GO:0016482 379 0.011
carbohydrate metabolic process GO:0005975 207 0.011
negative regulation of transferase activity GO:0051348 124 0.011
fucosylation GO:0036065 4 0.011
ameboidal type cell migration GO:0001667 135 0.011
actin cytoskeleton organization GO:0030036 207 0.011
sensory perception of sound GO:0007605 37 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
protein modification by small protein conjugation GO:0032446 342 0.011
regulation of intracellular protein transport GO:0033157 123 0.011
multicellular organismal water homeostasis GO:0050891 14 0.011
ribonucleotide catabolic process GO:0009261 405 0.011
oocyte development GO:0048599 1 0.011
biological adhesion GO:0022610 331 0.011
cell projection assembly GO:0030031 126 0.011
positive regulation of epithelial cell proliferation GO:0050679 65 0.011
establishment of protein localization to organelle GO:0072594 172 0.011
stem cell development GO:0048864 69 0.011
positive regulation of cellular component biogenesis GO:0044089 158 0.011
protein targeting GO:0006605 187 0.011
intracellular protein transport GO:0006886 270 0.011
prostate gland development GO:0030850 3 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.011
regulation of nucleotide metabolic process GO:0006140 269 0.011
negative regulation of protein processing GO:0010955 142 0.011
blastoderm segmentation GO:0007350 2 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
heart development GO:0007507 95 0.011
salivary gland morphogenesis GO:0007435 4 0.011
cellular response to abiotic stimulus GO:0071214 117 0.011
mammary gland morphogenesis GO:0060443 2 0.011
photoreceptor cell differentiation GO:0046530 2 0.011
response to decreased oxygen levels GO:0036293 96 0.011
entry into cell of other organism involved in symbiotic interaction GO:0051806 25 0.011
single organism carbohydrate metabolic process GO:0044723 193 0.011
cell part morphogenesis GO:0032990 137 0.011
multicellular organismal signaling GO:0035637 34 0.011
cell cycle phase transition GO:0044770 173 0.011
g protein coupled receptor signaling pathway GO:0007186 207 0.011
compound eye development GO:0048749 1 0.011
peptidyl lysine acetylation GO:0018394 101 0.011
inorganic anion transport GO:0015698 60 0.011
cell morphogenesis involved in differentiation GO:0000904 144 0.011
cytokine production GO:0001816 247 0.011
microtubule based process GO:0007017 210 0.011
regulation of phosphatase activity GO:0010921 81 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.011
establishment of planar polarity GO:0001736 3 0.010
regulation of actin cytoskeleton organization GO:0032956 116 0.010
regulation of immune response GO:0050776 201 0.010
organic anion transport GO:0015711 103 0.010
blood vessel development GO:0001568 172 0.010
negative regulation of kinase activity GO:0033673 106 0.010
inflammatory response GO:0006954 79 0.010
striated muscle contraction GO:0006941 52 0.010
kidney epithelium development GO:0072073 25 0.010
positive regulation of mapk cascade GO:0043410 190 0.010
glycoprotein biosynthetic process GO:0009101 91 0.010
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.010
regulation of viral entry into host cell GO:0046596 17 0.010
cell cell signaling GO:0007267 155 0.010
entry into host cell GO:0030260 25 0.010
lipid biosynthetic process GO:0008610 177 0.010
blood vessel morphogenesis GO:0048514 162 0.010
activation of immune response GO:0002253 114 0.010
regulation of cellular component biogenesis GO:0044087 281 0.010
nuclear transport GO:0051169 179 0.010
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.010
cardiac muscle contraction GO:0060048 34 0.010

WFDC2 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.058
nervous system disease DOID:863 431 0.058
primary ciliary dyskinesia DOID:9562 27 0.031
eye and adnexa disease DOID:1492 150 0.030
musculoskeletal system disease DOID:17 223 0.024
auditory system disease DOID:2742 53 0.024
eye disease DOID:5614 149 0.017
bone disease DOID:0080001 88 0.016
connective tissue disease DOID:65 109 0.016
disease of cellular proliferation DOID:14566 174 0.013
cancer DOID:162 167 0.012
organ system cancer DOID:0050686 164 0.012
renal tubular transport disease DOID:447 11 0.011
kidney disease DOID:557 36 0.011
urinary system disease DOID:18 40 0.011
cardiovascular system disease DOID:1287 106 0.011
nonsyndromic deafness DOID:0050563 50 0.010