Homo sapiens

34 known processes

DHFR

dihydrofolate reductase

(Aliases: DHFRP1,DYR)

DHFR biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna repair GO:0006281 198 0.230
dna recombination GO:0006310 77 0.120
protein maturation GO:0051604 233 0.093
post embryonic development GO:0009791 2 0.087
cellular response to dna damage stimulus GO:0006974 379 0.083
protein processing GO:0016485 226 0.069
mitotic cell cycle GO:0000278 326 0.061
regulation of dna metabolic process GO:0051052 153 0.059
ribonucleotide catabolic process GO:0009261 405 0.059
double strand break repair GO:0006302 101 0.054
nucleotide biosynthetic process GO:0009165 109 0.049
regulation of proteolysis GO:0030162 293 0.047
positive regulation of hydrolase activity GO:0051345 331 0.045
nucleoside phosphate biosynthetic process GO:1901293 109 0.043
oxidation reduction process GO:0055114 396 0.040
meiotic chromosome segregation GO:0045132 4 0.039
cellular macromolecular complex assembly GO:0034622 324 0.039
regulation of cell cycle process GO:0010564 266 0.039
immune system development GO:0002520 195 0.033
chromatin organization GO:0006325 351 0.031
response to abiotic stimulus GO:0009628 336 0.031
cellular amino acid metabolic process GO:0006520 116 0.030
response to external biotic stimulus GO:0043207 261 0.030
regeneration GO:0031099 4 0.030
negative regulation of organelle organization GO:0010639 126 0.029
female gamete generation GO:0007292 2 0.029
biological adhesion GO:0022610 331 0.029
dna packaging GO:0006323 77 0.028
single organism reproductive process GO:0044702 98 0.028
response to oxygen containing compound GO:1901700 369 0.027
cellular macromolecule catabolic process GO:0044265 380 0.027
mitotic cell cycle process GO:1903047 286 0.026
dna replication GO:0006260 116 0.025
response to lipid GO:0033993 206 0.025
purine nucleoside triphosphate metabolic process GO:0009144 412 0.024
regulation of protein processing GO:0070613 150 0.024
regulation of cellular amino acid metabolic process GO:0006521 6 0.023
nuclear division GO:0000280 128 0.023
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.023
regulation of cell division GO:0051302 116 0.023
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.023
cellular ketone metabolic process GO:0042180 80 0.023
protein oligomerization GO:0051259 173 0.022
regulation of endopeptidase activity GO:0052548 170 0.022
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.022
ribonucleoside monophosphate catabolic process GO:0009158 158 0.021
deoxyribonucleotide metabolic process GO:0009262 6 0.021
negative regulation of catalytic activity GO:0043086 335 0.021
nucleoside triphosphate catabolic process GO:0009143 394 0.021
negative regulation of protein modification process GO:0031400 200 0.021
response to biotic stimulus GO:0009607 276 0.021
mitotic cell cycle phase transition GO:0044772 162 0.020
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.020
cell cycle phase transition GO:0044770 173 0.020
cell adhesion GO:0007155 325 0.020
nucleoside phosphate catabolic process GO:1901292 412 0.020
regulation of meiotic cell cycle GO:0051445 4 0.020
negative regulation of cellular component organization GO:0051129 235 0.020
nucleoside catabolic process GO:0009164 408 0.019
sex differentiation GO:0007548 45 0.019
regulation of cell cycle GO:0051726 393 0.019
cellular protein complex assembly GO:0043623 188 0.019
nucleoside triphosphate metabolic process GO:0009141 422 0.019
immune response GO:0006955 307 0.019
secretion GO:0046903 254 0.019
organelle fission GO:0048285 149 0.019
response to other organism GO:0051707 261 0.019
negative regulation of cell death GO:0060548 345 0.019
response to radiation GO:0009314 151 0.018
organophosphate biosynthetic process GO:0090407 163 0.018
regulation of cellular ketone metabolic process GO:0010565 50 0.018
positive regulation of programmed cell death GO:0043068 249 0.018
organonitrogen compound biosynthetic process GO:1901566 200 0.018
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.018
positive regulation of proteolysis GO:0045862 142 0.018
purine nucleoside monophosphate metabolic process GO:0009126 186 0.018
regulation of cysteine type endopeptidase activity GO:2000116 127 0.017
regulation of protein ubiquitination GO:0031396 95 0.017
zymogen activation GO:0031638 70 0.017
regulation of mitotic cell cycle GO:0007346 189 0.017
regulation of nuclear division GO:0051783 65 0.017
embryo development GO:0009790 123 0.017
dna catabolic process GO:0006308 49 0.017
positive regulation of immune system process GO:0002684 283 0.017
regulation of peptidase activity GO:0052547 180 0.017
purine nucleoside triphosphate catabolic process GO:0009146 392 0.017
purine ribonucleoside metabolic process GO:0046128 437 0.017
determination of adult lifespan GO:0008340 2 0.016
negative regulation of programmed cell death GO:0043069 321 0.016
cellular response to oxygen containing compound GO:1901701 276 0.016
positive regulation of apoptotic process GO:0043065 246 0.016
negative regulation of cell cycle GO:0045786 193 0.016
reproductive process GO:0022414 106 0.016
positive regulation of cell death GO:0010942 263 0.016
protein modification by small protein conjugation GO:0032446 342 0.016
covalent chromatin modification GO:0016569 254 0.016
glycosyl compound catabolic process GO:1901658 413 0.016
cell division GO:0051301 168 0.016
hindbrain development GO:0030902 3 0.016
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.015
dna conformation change GO:0071103 113 0.015
regulation of cellular response to stress GO:0080135 244 0.015
positive regulation of peptidase activity GO:0010952 88 0.015
reproductive structure development GO:0048608 55 0.015
nucleoside monophosphate metabolic process GO:0009123 191 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.015
regulation of meiosis GO:0040020 3 0.014
posttranscriptional regulation of gene expression GO:0010608 213 0.014
response to activity GO:0014823 0 0.014
positive regulation of cell cycle process GO:0090068 106 0.014
purine containing compound catabolic process GO:0072523 411 0.014
cell cycle checkpoint GO:0000075 117 0.014
response to drug GO:0042493 81 0.014
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.013
regulation of nucleotide metabolic process GO:0006140 269 0.013
negative regulation of apoptotic process GO:0043066 316 0.013
regulation of response to dna damage stimulus GO:2001020 94 0.013
multicellular organismal aging GO:0010259 3 0.013
ribonucleoside triphosphate catabolic process GO:0009203 391 0.013
negative regulation of cellular protein metabolic process GO:0032269 353 0.012
purine nucleoside catabolic process GO:0006152 398 0.012
dna catabolic process endonucleolytic GO:0000737 37 0.012
mitotic nuclear division GO:0007067 119 0.012
neuron fate commitment GO:0048663 2 0.012
nervous system development GO:0007399 293 0.012
purine ribonucleoside catabolic process GO:0046130 398 0.012
proteasomal protein catabolic process GO:0010498 176 0.012
regulation of mitotic cell cycle phase transition GO:1901990 118 0.012
negative regulation of mitotic cell cycle GO:0045930 102 0.012
cellular amine metabolic process GO:0044106 41 0.012
regulation of immune response GO:0050776 201 0.012
carbohydrate derivative biosynthetic process GO:1901137 207 0.012
protein ubiquitination GO:0016567 314 0.011
oocyte differentiation GO:0009994 2 0.011
regulation of immune effector process GO:0002697 91 0.011
positive regulation of immune response GO:0050778 159 0.011
positive regulation of endopeptidase activity GO:0010950 84 0.011
response to inorganic substance GO:0010035 127 0.011
histone modification GO:0016570 251 0.011
membrane organization GO:0061024 292 0.011
positive regulation of transport GO:0051050 336 0.011
amine metabolic process GO:0009308 44 0.011
negative regulation of dna metabolic process GO:0051053 57 0.011
response to oxidative stress GO:0006979 121 0.011
dna biosynthetic process GO:0071897 40 0.011
regulation of transferase activity GO:0051338 355 0.011
nucleus localization GO:0051647 1 0.010
chromatin modification GO:0016568 298 0.010
regulation of protein catabolic process GO:0042176 155 0.010
establishment of nucleus localization GO:0040023 1 0.010
protein dna complex assembly GO:0065004 64 0.010
regulation of dna repair GO:0006282 47 0.010
production of molecular mediator of immune response GO:0002440 37 0.010
ribonucleoside triphosphate metabolic process GO:0009199 412 0.010
regulation of lymphocyte activation GO:0051249 103 0.010
negative regulation of catabolic process GO:0009895 104 0.010
nucleotide catabolic process GO:0009166 408 0.010
single organism cellular localization GO:1902580 332 0.010
purine nucleotide catabolic process GO:0006195 405 0.010

DHFR disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.028
disease of cellular proliferation DOID:14566 174 0.028
organ system cancer DOID:0050686 164 0.028
immune system disease DOID:2914 155 0.024
disease of metabolism DOID:0014667 295 0.022
inherited metabolic disorder DOID:655 242 0.022
hematopoietic system disease DOID:74 100 0.006
anemia DOID:2355 55 0.004
macrocytic anemia DOID:2361 3 0.001
megaloblastic anemia DOID:13382 3 0.001