Homo sapiens

144 known processes

PLCG1

phospholipase C, gamma 1

(Aliases: PLC1,PLC-II,PLCgamma1,NCKAP3,PLC148)

PLCG1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 1.000
enzyme linked receptor protein signaling pathway GO:0007167 303 1.000
positive regulation of endothelial cell migration GO:0010595 39 1.000
positive regulation of map kinase activity GO:0043406 80 1.000
tyrosine phosphorylation of stat3 protein GO:0042503 20 0.999
cellular component morphogenesis GO:0032989 314 0.999
positive regulation of mesenchymal cell proliferation GO:0002053 2 0.997
regulation of transferase activity GO:0051338 355 0.997
bud outgrowth involved in lung branching GO:0060447 1 0.997
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.997
regulation of blood coagulation GO:0030193 42 0.996
purine nucleoside triphosphate catabolic process GO:0009146 392 0.996
Human
regulation of lipid kinase activity GO:0043550 19 0.995
cellular response to endogenous stimulus GO:0071495 336 0.995
taxis GO:0042330 157 0.994
regulation of cell migration GO:0030334 289 0.994
regulation of protein kinase activity GO:0045859 289 0.993
peptidyl tyrosine phosphorylation GO:0018108 170 0.992
circulatory system development GO:0072359 262 0.992
positive regulation of cell motility GO:2000147 177 0.991
regulation of axon guidance GO:1902667 3 0.991
regulation of kinase activity GO:0043549 314 0.991
cell activation GO:0001775 213 0.991
activation of mapk activity GO:0000187 45 0.990
regulation of cellular amine metabolic process GO:0033238 11 0.989
response to growth factor GO:0070848 205 0.989
nucleoside catabolic process GO:0009164 408 0.989
Human
regulation of map kinase activity GO:0043405 108 0.989
glycerophospholipid metabolic process GO:0006650 84 0.988
Human
ribonucleoside triphosphate metabolic process GO:0009199 412 0.987
Human
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.987
actin filament based process GO:0030029 224 0.986
cellular response to nitrogen compound GO:1901699 144 0.985
amine metabolic process GO:0009308 44 0.984
regulation of cellular ketone metabolic process GO:0010565 50 0.982
actin cytoskeleton organization GO:0030036 207 0.982
regulation of metanephric mesenchymal cell migration GO:2000589 2 0.981
branching involved in salivary gland morphogenesis GO:0060445 1 0.980
chemotaxis GO:0006935 157 0.980
cellular amino acid metabolic process GO:0006520 116 0.980
response to nitrogen compound GO:1901698 184 0.978
Rat Fly
glycerolipid biosynthetic process GO:0045017 51 0.978
Human
regulation of erk1 and erk2 cascade GO:0070372 99 0.978
vegf activated platelet derived growth factor receptor signaling pathway GO:0038086 3 0.977
regulation of hemostasis GO:1900046 42 0.977
coagulation GO:0050817 78 0.976
regulation of nucleoside metabolic process GO:0009118 209 0.974
Human
leukocyte activation GO:0045321 164 0.974
positive regulation of cardiac muscle cell proliferation GO:0060045 2 0.972
regulation of locomotion GO:0040012 329 0.972
rho protein signal transduction GO:0007266 26 0.970
tor signaling GO:0031929 39 0.970
motor neuron axon guidance GO:0008045 2 0.969
regulation of mapk cascade GO:0043408 262 0.966
Human
fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 1 0.964
ribonucleoside triphosphate catabolic process GO:0009203 391 0.963
Human
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:1900238 2 0.961
cell morphogenesis GO:0000902 296 0.961
positive regulation of nucleoside metabolic process GO:0045979 186 0.961
Human
positive regulation of lipid kinase activity GO:0090218 13 0.960
small gtpase mediated signal transduction GO:0007264 78 0.960
anatomical structure formation involved in morphogenesis GO:0048646 284 0.958
regulation of chemotaxis GO:0050920 74 0.957
peptidyl tyrosine modification GO:0018212 170 0.956
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 9 0.956
response to organonitrogen compound GO:0010243 156 0.955
Rat Fly
cellular response to organonitrogen compound GO:0071417 124 0.955
phosphatidylinositol mediated signaling GO:0048015 55 0.954
Human
positive regulation of cell proliferation by vegf activated platelet derived growth factor receptor signaling pathway GO:0038091 3 0.954
organophosphate catabolic process GO:0046434 430 0.951
Human
glycosyl compound catabolic process GO:1901658 413 0.950
Human
regulation of cell activation GO:0050865 125 0.947
behavior GO:0007610 112 0.947
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:0035793 2 0.943
positive regulation of protein kinase b signaling GO:0051897 42 0.940
positive regulation of lipid metabolic process GO:0045834 50 0.940
positive regulation of metanephros development GO:0072216 3 0.938
positive regulation of positive chemotaxis GO:0050927 13 0.937
associative learning GO:0008306 1 0.936
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.931
Human
platelet derived growth factor receptor alpha signaling pathway GO:0035790 1 0.930
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.924
Human
cellular response to growth factor stimulus GO:0071363 197 0.922
regulation of nucleotide catabolic process GO:0030811 205 0.920
Human
cell migration involved in kidney development GO:0035787 2 0.918
positive regulation of metanephric mesenchymal cell migration GO:2000591 2 0.917
purine nucleotide catabolic process GO:0006195 405 0.916
Human
positive regulation of locomotion GO:0040017 186 0.916
positive regulation of lipase activity GO:0060193 28 0.913
cell development GO:0048468 328 0.913
Fly
actin filament organization GO:0007015 128 0.912
positive regulation of phosphorylation GO:0042327 394 0.906
Human
epithelium migration GO:0090132 119 0.904
lymphocyte activation GO:0046649 133 0.904
cell chemotaxis GO:0060326 112 0.902
stem cell division GO:0017145 2 0.901
regulation of nucleotide metabolic process GO:0006140 269 0.899
Human
metanephric nephron development GO:0072210 9 0.897
cellular response to oxygen containing compound GO:1901701 276 0.893
vesicle mediated transport GO:0016192 371 0.893
Worm
regulation of gtpase activity GO:0043087 180 0.889
Human
negative regulation of protein phosphorylation GO:0001933 140 0.889
protein autophosphorylation GO:0046777 123 0.886
nucleoside triphosphate catabolic process GO:0009143 394 0.884
Human
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 12 0.881
positive regulation of protein kinase activity GO:0045860 190 0.880
nerve development GO:0021675 4 0.878
regulation of phospholipase activity GO:0010517 26 0.877
negative regulation of cellular protein metabolic process GO:0032269 353 0.875
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.874
ras protein signal transduction GO:0007265 73 0.871
cell projection organization GO:0030030 252 0.870
response to macrophage colony stimulating factor GO:0036005 4 0.867
granulocyte migration GO:0097530 40 0.866
response to oxygen containing compound GO:1901700 369 0.865
Rat Fly
positive regulation of small gtpase mediated signal transduction GO:0051057 12 0.864
regulation of cell morphogenesis GO:0022604 153 0.862
glomerulus development GO:0032835 15 0.862
regulation of phospholipase c activity GO:1900274 14 0.861
outer ear morphogenesis GO:0042473 2 0.858
negative regulation of phosphate metabolic process GO:0045936 267 0.857
regulation of axon extension involved in axon guidance GO:0048841 2 0.856
positive regulation of hydrolase activity GO:0051345 331 0.855
Human
nucleoside phosphate catabolic process GO:1901292 412 0.855
Human
regulation of cell development GO:0060284 161 0.853
activation of protein kinase activity GO:0032147 90 0.853
phosphatidylinositol metabolic process GO:0046488 53 0.849
Human
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.844
positive regulation of immune system process GO:0002684 283 0.842
Mouse
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.842
regulation of anatomical structure morphogenesis GO:0022603 286 0.840
lung alveolus development GO:0048286 4 0.840
regulation of cellular amino acid metabolic process GO:0006521 6 0.839
cell junction assembly GO:0034329 67 0.837
ribonucleotide catabolic process GO:0009261 405 0.836
Human
regulation of endothelial cell migration GO:0010594 67 0.835
lung growth GO:0060437 2 0.833
regulation of small gtpase mediated signal transduction GO:0051056 156 0.833
metanephros development GO:0001656 16 0.829
positive regulation of cell fate specification GO:0042660 2 0.829
positive regulation of kinase activity GO:0033674 204 0.822
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.821
nucleotide catabolic process GO:0009166 408 0.820
Human
cellular response to macrophage colony stimulating factor stimulus GO:0036006 4 0.819
glycerolipid metabolic process GO:0046486 107 0.819
Human
mononuclear cell proliferation GO:0032943 71 0.816
regulation of lipid metabolic process GO:0019216 96 0.814
negative regulation of phosphorylation GO:0042326 174 0.810
dna replication GO:0006260 116 0.810
regulation of urothelial cell proliferation GO:0050675 1 0.807
antigen receptor mediated signaling pathway GO:0050851 38 0.805
Mouse
cell migration involved in metanephros development GO:0035788 2 0.804
regulation of cell differentiation GO:0045595 393 0.795
Fly
mast cell degranulation GO:0043303 4 0.793
negative regulation of axon extension GO:0030517 2 0.789
regulation of cellular component movement GO:0051270 334 0.788
regulation of purine nucleotide metabolic process GO:1900542 264 0.786
Human
platelet derived growth factor receptor beta signaling pathway GO:0035791 4 0.782
kidney development GO:0001822 53 0.781
gtp metabolic process GO:0046039 239 0.779
Human
regulation of protein serine threonine kinase activity GO:0071900 179 0.773
biological adhesion GO:0022610 331 0.771
substrate dependent cerebral cortex tangential migration GO:0021825 2 0.771
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.764
Human
metanephric mesenchymal cell migration GO:0035789 2 0.761
purine ribonucleoside catabolic process GO:0046130 398 0.759
Human
positive regulation of cell proliferation GO:0008284 301 0.756
regulation of angiogenesis GO:0045765 92 0.756
glomerular mesangial cell proliferation GO:0072110 3 0.754
asymmetric stem cell division GO:0098722 1 0.752
generation of neurons GO:0048699 152 0.751
salivary gland morphogenesis GO:0007435 4 0.749
negative regulation of calcium mediated signaling GO:0050849 4 0.741
tyrosine phosphorylation of stat protein GO:0007260 33 0.739
positive regulation of phospholipase activity GO:0010518 22 0.738
renal system development GO:0072001 63 0.734
organ formation GO:0048645 3 0.732
positive regulation of transferase activity GO:0051347 227 0.731
blood vessel development GO:0001568 172 0.731
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 20 0.730
cellular ion homeostasis GO:0006873 168 0.726
positive regulation of urothelial cell proliferation GO:0050677 1 0.726
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.725
Human
purine containing compound catabolic process GO:0072523 411 0.716
Human
regulation of purine nucleotide catabolic process GO:0033121 205 0.714
Human
gtp catabolic process GO:0006184 237 0.713
Human
regulation of gtp catabolic process GO:0033124 180 0.711
Human
regulation of cell shape GO:0008360 48 0.705
neuron projection guidance GO:0097485 12 0.703
positive regulation of histone deacetylase activity GO:1901727 3 0.702
positive regulation of ras gtpase activity GO:0032320 117 0.701
blood vessel morphogenesis GO:0048514 162 0.700
fibroblast growth factor receptor signaling pathway GO:0008543 26 0.700
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 16 0.696
neuronal stem cell division GO:0036445 1 0.696
negative regulation of protein metabolic process GO:0051248 391 0.689
regulation of body fluid levels GO:0050878 99 0.689
axonogenesis GO:0007409 31 0.689
phospholipid metabolic process GO:0006644 99 0.688
Human
cell proliferation involved in kidney development GO:0072111 3 0.687
negative regulation of programmed cell death GO:0043069 321 0.687
development of primary male sexual characteristics GO:0046546 23 0.679
cellular response to hormone stimulus GO:0032870 125 0.678
axon guidance GO:0007411 12 0.674
angiogenesis GO:0001525 147 0.672
calcium mediated signaling using intracellular calcium source GO:0035584 7 0.672
angiogenesis involved in wound healing GO:0060055 4 0.672
regulation of glomerular mesangial cell proliferation GO:0072124 3 0.672
neuron projection development GO:0031175 106 0.668
jak stat cascade GO:0007259 46 0.668
metanephric glomerulus development GO:0072224 2 0.664
cellular amine metabolic process GO:0044106 41 0.662
positive chemotaxis GO:0050918 33 0.661
positive regulation of nervous system development GO:0051962 54 0.661
cellular ketone metabolic process GO:0042180 80 0.658
positive regulation of rac gtpase activity GO:0032855 31 0.658
positive regulation of myoblast differentiation GO:0045663 6 0.656
postnatal olfactory bulb interneuron migration GO:0021827 2 0.655
vascular endothelial growth factor receptor 1 signaling pathway GO:0036323 1 0.653
cell migration involved in sprouting angiogenesis GO:0002042 19 0.650
urothelial cell proliferation GO:0050674 1 0.645
positive regulation of gtpase activity GO:0043547 166 0.642
Human
negative regulation of tyrosine phosphorylation of stat3 protein GO:0042518 2 0.636
positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 3 0.636
negative regulation of cellular amine metabolic process GO:0033239 3 0.633
neuroblast division GO:0055057 1 0.629
fc receptor signaling pathway GO:0038093 2 0.622
regulation of interleukin 6 mediated signaling pathway GO:0070103 3 0.618
leukocyte proliferation GO:0070661 74 0.615
cytokine mediated signaling pathway GO:0019221 109 0.612
Human
negative regulation of apoptotic process GO:0043066 316 0.610
memory GO:0007613 3 0.609
negative regulation of hemostasis GO:1900047 22 0.608
female gamete generation GO:0007292 2 0.606
Worm Fly
cellular divalent inorganic cation homeostasis GO:0072503 128 0.606
cell junction organization GO:0034330 79 0.603
tyrosine phosphorylation of stat5 protein GO:0042506 13 0.600
cellular lipid metabolic process GO:0044255 303 0.600
Human
regulation of behavior GO:0050795 82 0.590
regulation of hair follicle cell proliferation GO:0071336 1 0.589
regulation of leukocyte activation GO:0002694 115 0.583
regulation of branching involved in salivary gland morphogenesis by mesenchymal epithelial signaling GO:0060665 1 0.577
secretion by lung epithelial cell involved in lung growth GO:0061033 2 0.577
regulation of lymphocyte activation GO:0051249 103 0.573
regulation of cardiac muscle cell proliferation GO:0060043 4 0.571
cellular response to stem cell factor stimulus GO:0036216 1 0.568
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.568
positive regulation of gtp catabolic process GO:0033126 166 0.568
Human
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.565
vascular wound healing GO:0061042 4 0.561
blood coagulation GO:0007596 76 0.559
regulation of epithelial cell migration GO:0010632 93 0.558
regulation of endodermal cell fate specification GO:0042663 1 0.555
positive regulation of ras protein signal transduction GO:0046579 12 0.553
positive regulation of neurogenesis GO:0050769 49 0.548
cranial nerve development GO:0021545 4 0.546
granulocyte chemotaxis GO:0071621 37 0.545
positive regulation of leukocyte proliferation GO:0070665 48 0.544
epithelium development GO:0060429 227 0.539
Fly
cell part morphogenesis GO:0032990 137 0.536
monocyte chemotaxis GO:0002548 20 0.535
regulation of cell motility GO:2000145 299 0.531
axon development GO:0061564 34 0.526
regulation of cellular component size GO:0032535 82 0.525
leukocyte differentiation GO:0002521 98 0.524
Zebrafish
system process GO:0003008 349 0.522
Human Zebrafish
positive regulation of protein phosphorylation GO:0001934 313 0.520
regulation of leukocyte differentiation GO:1902105 61 0.518
purine ribonucleoside metabolic process GO:0046128 437 0.517
Human
neuroblast proliferation GO:0007405 4 0.514
negative regulation of blood pressure GO:0045776 3 0.512
secretion GO:0046903 254 0.510
Rat
branch elongation involved in ureteric bud branching GO:0060681 2 0.508
regulation of rho protein signal transduction GO:0035023 79 0.507
positive regulation of interferon gamma mediated signaling pathway GO:0060335 2 0.505
positive regulation of adherens junction organization GO:1903393 12 0.502
positive regulation of protein kinase c signaling GO:0090037 5 0.500
regulation of coagulation GO:0050818 44 0.499
regulation of immune response GO:0050776 201 0.498
Mouse
negative regulation of cell death GO:0060548 345 0.497
endodermal cell fate specification GO:0001714 4 0.496
hemostasis GO:0007599 76 0.495
insulin receptor signaling pathway GO:0008286 23 0.492
cell junction maintenance GO:0034331 4 0.490
regulation of lymphocyte proliferation GO:0050670 64 0.488
cranial nerve morphogenesis GO:0021602 1 0.475
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.475
organophosphate biosynthetic process GO:0090407 163 0.475
Human Rat
positive regulation of peptidyl tyrosine autophosphorylation GO:1900086 1 0.469
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 11 0.468
Fly
purine ribonucleotide catabolic process GO:0009154 404 0.467
Human
positive regulation of cellular component organization GO:0051130 376 0.465
mesodermal cell fate specification GO:0007501 2 0.465
cell morphogenesis involved in differentiation GO:0000904 144 0.464
regulation of neuron differentiation GO:0045664 70 0.461
regulation of cellular component biogenesis GO:0044087 281 0.461
nucleoside triphosphate metabolic process GO:0009141 422 0.460
Human
cell division GO:0051301 168 0.458
hematopoietic or lymphoid organ development GO:0048534 186 0.457
Zebrafish
negative regulation of catalytic activity GO:0043086 335 0.456
positive regulation of keratinocyte proliferation GO:0010838 4 0.455
organ induction GO:0001759 4 0.452
vasculature development GO:0001944 181 0.450
regulation of organ formation GO:0003156 4 0.447
innate immune response GO:0045087 178 0.445
epithelial cell differentiation GO:0030855 141 0.444
Fly
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.442
regulation of ras protein signal transduction GO:0046578 155 0.442
positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 6 0.436
positive regulation of epithelial cell proliferation GO:0050679 65 0.428
metal ion homeostasis GO:0055065 169 0.427
positive regulation of glomerular mesangial cell proliferation GO:0072126 1 0.427
cellular response to dna damage stimulus GO:0006974 379 0.426
positive regulation of organelle organization GO:0010638 195 0.425
regulation of lipase activity GO:0060191 37 0.425
kit signaling pathway GO:0038109 1 0.423
positive regulation of cell differentiation GO:0045597 211 0.421
sprouting angiogenesis GO:0002040 29 0.420
regulation of actin cytoskeleton organization GO:0032956 116 0.419
secretion by cell GO:0032940 226 0.414
Rat
purine nucleoside catabolic process GO:0006152 398 0.411
Human
defense response GO:0006952 315 0.405
response to radiation GO:0009314 151 0.399
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 11 0.398
response to drug GO:0042493 81 0.396
regulation of platelet activation GO:0010543 9 0.395
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 28 0.394
ribonucleoside catabolic process GO:0042454 406 0.393
Human
mapk cascade GO:0000165 288 0.386
Human
t cell receptor signaling pathway GO:0050852 21 0.384
Mouse
lymphocyte differentiation GO:0030098 35 0.383
phospholipid biosynthetic process GO:0008654 44 0.376
Human
positive regulation of glomerulus development GO:0090193 1 0.375
positive regulation of smooth muscle cell proliferation GO:0048661 14 0.374
growth GO:0040007 202 0.373
Zebrafish Fly
positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway GO:0038033 4 0.364
cell projection morphogenesis GO:0048858 129 0.364
cellular response to peptide GO:1901653 59 0.360
positive regulation of cell adhesion GO:0045785 84 0.359
regulation of leukocyte proliferation GO:0070663 67 0.358
rap protein signal transduction GO:0032486 7 0.358
positive regulation of stress activated mapk cascade GO:0032874 60 0.355
Human
regulation of apoptotic signaling pathway GO:2001233 175 0.355
tangential migration from the subventricular zone to the olfactory bulb GO:0022028 3 0.354
exocytosis GO:0006887 71 0.354
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 3 0.353
regulation of secretion by cell GO:1903530 177 0.352
forebrain generation of neurons GO:0021872 3 0.352
morphogenesis of a branching structure GO:0001763 21 0.352
male genitalia development GO:0030539 1 0.348
ameboidal type cell migration GO:0001667 135 0.347
negative regulation of phosphorus metabolic process GO:0010563 267 0.342
regulation of mast cell chemotaxis GO:0060753 4 0.342
regulation of glomerulus development GO:0090192 3 0.342
regulation of t cell proliferation GO:0042129 42 0.339
tube morphogenesis GO:0035239 95 0.338
positive regulation of cellular component movement GO:0051272 181 0.338
positive regulation of rap gtpase activity GO:0032854 8 0.335
mast cell cytokine production GO:0032762 1 0.335
positive regulation of nucleotide metabolic process GO:0045981 230 0.334
Human
muscle structure development GO:0061061 98 0.334
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.333
regulation of t cell differentiation GO:0045580 19 0.333
regulation of mesoderm development GO:2000380 4 0.332
vascular endothelial growth factor receptor signaling pathway GO:0048010 19 0.332
positive regulation of blood vessel endothelial cell migration GO:0043536 16 0.331
nephron morphogenesis GO:0072028 15 0.329
positive regulation of neural precursor cell proliferation GO:2000179 2 0.325
regulation of actin filament based process GO:0032970 141 0.324
ephrin receptor signaling pathway GO:0048013 15 0.323
positive regulation of developmental process GO:0051094 314 0.322
positive regulation of actin cytoskeleton reorganization GO:2000251 9 0.321
positive regulation of dna replication GO:0045740 35 0.318
mitotic cell cycle process GO:1903047 286 0.317
response to abiotic stimulus GO:0009628 336 0.317
Rat
asymmetric neuroblast division GO:0055059 1 0.316
ureteric bud development GO:0001657 13 0.314
erk1 and erk2 cascade GO:0070371 104 0.312
protein processing GO:0016485 226 0.309
epithelial cell migration GO:0010631 119 0.306
nephron development GO:0072006 30 0.305
immune response regulating signaling pathway GO:0002764 97 0.303
Mouse
metal ion transport GO:0030001 272 0.303
positive regulation of jnk cascade GO:0046330 52 0.298
Human
regulation of neurogenesis GO:0050767 82 0.298
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.298
positive regulation of leukocyte activation GO:0002696 80 0.297
neuron differentiation GO:0030182 138 0.297
immune system development GO:0002520 195 0.296
Zebrafish
divalent metal ion transport GO:0070838 152 0.294
cytosolic calcium ion homeostasis GO:0051480 89 0.294
mesonephric tubule development GO:0072164 14 0.293
cellular metal ion homeostasis GO:0006875 146 0.293
negative regulation of kinase activity GO:0033673 106 0.292
regulation of actin cytoskeleton reorganization GO:2000249 12 0.292
regulation of cytoskeleton organization GO:0051493 177 0.290
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 3 0.290
ureteric bud elongation GO:0060677 2 0.287
regeneration GO:0031099 4 0.285
Zebrafish
cation transport GO:0006812 331 0.283
cellular response to insulin stimulus GO:0032869 41 0.281
focal adhesion assembly GO:0048041 30 0.280
positive regulation of p38mapk cascade GO:1900745 8 0.279
cell cell signaling GO:0007267 155 0.276
protein maturation GO:0051604 233 0.275
positive regulation of dna metabolic process GO:0051054 73 0.275
inactivation of mapk activity GO:0000188 5 0.273
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.273
endothelial cell migration GO:0043542 86 0.271
wound healing GO:0042060 115 0.271
Zebrafish
regulation of heart growth GO:0060420 4 0.268
positive regulation of nucleotide catabolic process GO:0030813 185 0.266
Human
glial cell migration GO:0008347 4 0.265
response to fibroblast growth factor GO:0071774 39 0.265
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 11 0.265
divalent inorganic cation transport GO:0072511 158 0.263
long term memory GO:0007616 2 0.259
positive regulation of cell division GO:0051781 59 0.258
positive regulation of cellular response to insulin stimulus GO:1900078 6 0.258
positive regulation of phospholipase c activity GO:0010863 13 0.255
immune response activating signal transduction GO:0002757 90 0.255
Mouse
regulation of receptor mediated endocytosis GO:0048259 32 0.254
positive regulation of neuron projection development GO:0010976 34 0.253
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.251
regulation of saliva secretion GO:0046877 2 0.250
positive regulation of chemotaxis GO:0050921 57 0.250
negative regulation of coagulation GO:0050819 24 0.249
positive regulation of epithelial cell migration GO:0010634 55 0.249
lipid metabolic process GO:0006629 381 0.246
Human
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.244
cellular response to peptide hormone stimulus GO:0071375 56 0.241
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.240
leukocyte migration GO:0050900 107 0.238
negative regulation of blood coagulation GO:0030195 22 0.238
endodermal cell fate commitment GO:0001711 4 0.235
kidney epithelium development GO:0072073 25 0.234
negative regulation of phosphatidylinositol biosynthetic process GO:0010512 2 0.232
positive regulation of mast cell chemotaxis GO:0060754 4 0.231
positive regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061419 2 0.230
inositol lipid mediated signaling GO:0048017 55 0.228
Human
nerve growth factor signaling pathway GO:0038180 4 0.226
extrinsic apoptotic signaling pathway GO:0097191 119 0.226
cell substrate adherens junction assembly GO:0007045 30 0.222
response to peptide GO:1901652 65 0.221
Fly
regulated secretory pathway GO:0045055 20 0.221
renal system vasculature morphogenesis GO:0061438 1 0.219
positive regulation of immune response GO:0050778 159 0.218
Mouse
regulation of blood vessel endothelial cell migration GO:0043535 30 0.217
positive regulation of vascular wound healing GO:0035470 1 0.217
muscle cell proliferation GO:0033002 35 0.217
positive regulation of protein tyrosine kinase activity GO:0061098 24 0.215
regulation of protein kinase b signaling GO:0051896 61 0.215
cardiac myofibril assembly GO:0055003 3 0.215
hemopoiesis GO:0030097 180 0.213
Zebrafish
negative regulation of fibroblast migration GO:0010764 3 0.212
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 18 0.210
positive regulation of mononuclear cell proliferation GO:0032946 47 0.209
response to cytokine GO:0034097 232 0.209
Human
morphogenesis of embryonic epithelium GO:0016331 4 0.209
rab protein signal transduction GO:0032482 4 0.209
negative regulation of protein modification process GO:0031400 200 0.208
neuron projection morphogenesis GO:0048812 50 0.208
striated muscle cell differentiation GO:0051146 43 0.207
guanosine containing compound metabolic process GO:1901068 244 0.207
Human
positive regulation of cellular component biogenesis GO:0044089 158 0.206
regulation of cardiac muscle tissue growth GO:0055021 4 0.204
tissue migration GO:0090130 119 0.204
t cell activation GO:0042110 99 0.203
regulation of response to wounding GO:1903034 101 0.201
positive regulation of angiogenesis GO:0045766 51 0.201
response to nerve growth factor GO:1990089 6 0.200
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.199
Mouse
regulation of wound healing GO:0061041 56 0.198
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 15 0.196
establishment or maintenance of neuroblast polarity GO:0045196 1 0.195
brain derived neurotrophic factor receptor signaling pathway GO:0031547 1 0.195
learning GO:0007612 11 0.193
regulation of reactive oxygen species metabolic process GO:2000377 41 0.193
regulation of cell migration involved in sprouting angiogenesis GO:0090049 9 0.192
positive regulation of keratinocyte migration GO:0051549 4 0.192
b cell differentiation GO:0030183 6 0.191
mesonephros development GO:0001823 17 0.188
aminoglycan metabolic process GO:0006022 39 0.188
mammary gland formation GO:0060592 1 0.188
t cell differentiation GO:0030217 29 0.188
heart development GO:0007507 95 0.187

PLCG1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.869
cancer DOID:162 167 0.562
kidney disease DOID:557 36 0.242
urinary system disease DOID:18 40 0.242
organ system cancer DOID:0050686 164 0.231
disease of metabolism DOID:0014667 295 0.226
carbohydrate metabolism disease DOID:0050013 32 0.226
acquired metabolic disease DOID:0060158 58 0.226