Homo sapiens

80 known processes

HIST2H4A

histone cluster 2, H4a

(Aliases: HIST1H4C,HIST1H4B,HIST1H4A,HIST1H4H,HIST1H4F,HIST1H4E,HIST1H4D,HIST1H4K,HIST1H4J,HIST1H4I,H4/n,H4FN,H4,HIST1H4L,H4F2,HIST4H4,HIST2H4,FO108,HIST2H4B)

HIST2H4A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna replication dependent nucleosome assembly GO:0006335 32 0.795
nucleosome assembly GO:0006334 50 0.786
negative regulation of megakaryocyte differentiation GO:0045653 16 0.631
chromatin assembly or disassembly GO:0006333 78 0.600
dna replication dependent nucleosome organization GO:0034723 32 0.508
chromatin assembly GO:0031497 61 0.499
dna replication independent nucleosome organization GO:0034724 27 0.485
dna replication independent nucleosome assembly GO:0006336 27 0.474
chromatin organization GO:0006325 351 0.287
dna conformation change GO:0071103 113 0.268
protein dna complex assembly GO:0065004 64 0.265
negative regulation of myeloid cell differentiation GO:0045638 42 0.199
cellular macromolecular complex assembly GO:0034622 324 0.165
dna packaging GO:0006323 77 0.164
megakaryocyte differentiation GO:0030219 25 0.156
myeloid cell differentiation GO:0030099 117 0.150
regulation of myeloid cell differentiation GO:0045637 81 0.150
nucleosome organization GO:0034728 66 0.136
protein dna complex subunit organization GO:0071824 80 0.132
chromatin modification GO:0016568 298 0.131
histone modification GO:0016570 251 0.129
regulation of hematopoietic progenitor cell differentiation GO:1901532 24 0.118
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.109
negative regulation of multicellular organismal process GO:0051241 317 0.101
negative regulation of immune system process GO:0002683 136 0.091
covalent chromatin modification GO:0016569 254 0.086
negative regulation of developmental process GO:0051093 247 0.082
cellular response to dna damage stimulus GO:0006974 379 0.075
negative regulation of hematopoietic progenitor cell differentiation GO:1901533 18 0.074
immune system development GO:0002520 195 0.072
post embryonic development GO:0009791 2 0.072
hemopoiesis GO:0030097 180 0.063
regulation of cellular amine metabolic process GO:0033238 11 0.062
dna repair GO:0006281 198 0.062
regulation of cell differentiation GO:0045595 393 0.062
cellular component disassembly GO:0022411 92 0.061
regulation of cellular ketone metabolic process GO:0010565 50 0.059
hematopoietic or lymphoid organ development GO:0048534 186 0.057
female gamete generation GO:0007292 2 0.057
negative regulation of cell differentiation GO:0045596 171 0.057
cellular amino acid metabolic process GO:0006520 116 0.055
protein complex disassembly GO:0043241 52 0.053
amine metabolic process GO:0009308 44 0.053
cellular macromolecule catabolic process GO:0044265 380 0.052
response to abiotic stimulus GO:0009628 336 0.052
positive regulation of cellular component organization GO:0051130 376 0.050
protein alkylation GO:0008213 74 0.048
cellular amine metabolic process GO:0044106 41 0.048
cellular ketone metabolic process GO:0042180 80 0.047
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.047
regulation of cellular amino acid metabolic process GO:0006521 6 0.047
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.046
oogenesis GO:0048477 2 0.046
negative regulation of cellular protein metabolic process GO:0032269 353 0.044
cell cycle checkpoint GO:0000075 117 0.044
negative regulation of protein metabolic process GO:0051248 391 0.044
methylation GO:0032259 106 0.042
determination of adult lifespan GO:0008340 2 0.041
modification dependent protein catabolic process GO:0019941 209 0.040
purine ribonucleoside metabolic process GO:0046128 437 0.038
purine nucleoside triphosphate metabolic process GO:0009144 412 0.037
multicellular organismal aging GO:0010259 3 0.037
protein ubiquitination GO:0016567 314 0.037
positive regulation of cellular amine metabolic process GO:0033240 7 0.036
macromolecule methylation GO:0043414 97 0.036
regulation of gene silencing GO:0060968 24 0.036
purine nucleotide catabolic process GO:0006195 405 0.036
macromolecular complex disassembly GO:0032984 60 0.036
nucleoside triphosphate metabolic process GO:0009141 422 0.035
cellular response to uv GO:0034644 32 0.035
hematopoietic progenitor cell differentiation GO:0002244 38 0.034
regulation of cellular component biogenesis GO:0044087 281 0.033
gene silencing GO:0016458 49 0.033
ribonucleoside triphosphate metabolic process GO:0009199 412 0.033
regulation of gene expression epigenetic GO:0040029 73 0.033
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.032
immune response GO:0006955 307 0.032
segmentation GO:0035282 4 0.032
glycosyl compound catabolic process GO:1901658 413 0.032
anatomical structure formation involved in morphogenesis GO:0048646 284 0.031
rna processing GO:0006396 255 0.031
ubiquitin dependent protein catabolic process GO:0006511 206 0.031
cellular protein catabolic process GO:0044257 261 0.030
ribonucleoside triphosphate catabolic process GO:0009203 391 0.030
regulation of megakaryocyte differentiation GO:0045652 22 0.030
protein catabolic process GO:0030163 325 0.030
mrna metabolic process GO:0016071 175 0.030
protein processing GO:0016485 226 0.029
ribonucleoside catabolic process GO:0042454 406 0.029
modification dependent macromolecule catabolic process GO:0043632 212 0.029
nucleotide catabolic process GO:0009166 408 0.028
proteasomal protein catabolic process GO:0010498 176 0.028
purine nucleoside catabolic process GO:0006152 398 0.028
neuromuscular junction development GO:0007528 3 0.028
regulation of mitotic cell cycle GO:0007346 189 0.028
growth GO:0040007 202 0.028
positive regulation of organelle organization GO:0010638 195 0.027
nucleoside phosphate catabolic process GO:1901292 412 0.027
regulation of cell cycle GO:0051726 393 0.027
protein modification by small protein conjugation GO:0032446 342 0.027
cellular response to abiotic stimulus GO:0071214 117 0.027
regulation of proteolysis GO:0030162 293 0.026
regeneration GO:0031099 4 0.026
purine ribonucleoside catabolic process GO:0046130 398 0.026
ribonucleotide catabolic process GO:0009261 405 0.026
nucleoside triphosphate catabolic process GO:0009143 394 0.026
nucleoside catabolic process GO:0009164 408 0.026
organophosphate catabolic process GO:0046434 430 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.025
protein localization to organelle GO:0033365 280 0.024
ras protein signal transduction GO:0007265 73 0.024
cell development GO:0048468 328 0.024
protein methylation GO:0006479 74 0.024
positive regulation of hydrolase activity GO:0051345 331 0.024
innate immune response GO:0045087 178 0.024
mitotic cell cycle process GO:1903047 286 0.023
locomotory behavior GO:0007626 1 0.023
small gtpase mediated signal transduction GO:0007264 78 0.023
protein maturation GO:0051604 233 0.023
response to radiation GO:0009314 151 0.023
cell projection organization GO:0030030 252 0.023
cellular response to radiation GO:0071478 65 0.023
purine containing compound catabolic process GO:0072523 411 0.023
posttranscriptional regulation of gene expression GO:0010608 213 0.023
response to uv GO:0009411 73 0.023
negative regulation of programmed cell death GO:0043069 321 0.022
cytoplasmic transport GO:0016482 379 0.022
defense response GO:0006952 315 0.021
mrna processing GO:0006397 133 0.021
purine nucleoside triphosphate catabolic process GO:0009146 392 0.021
negative regulation of proteolysis GO:0045861 132 0.021
adult locomotory behavior GO:0008344 1 0.021
positive regulation of catabolic process GO:0009896 310 0.021
cell morphogenesis GO:0000902 296 0.021
enzyme linked receptor protein signaling pathway GO:0007167 303 0.020
oocyte differentiation GO:0009994 2 0.020
negative regulation of cell death GO:0060548 345 0.020
cell growth GO:0016049 160 0.020
regulation of nucleotide metabolic process GO:0006140 269 0.020
oxidation reduction process GO:0055114 396 0.020
cellular protein complex assembly GO:0043623 188 0.020
positive regulation of cell proliferation GO:0008284 301 0.020
negative regulation of catalytic activity GO:0043086 335 0.020
cellular component morphogenesis GO:0032989 314 0.019
response to light stimulus GO:0009416 87 0.019
negative regulation of cell cycle GO:0045786 193 0.019
maintenance of location GO:0051235 112 0.019
regulation of cell cycle process GO:0010564 266 0.019
regulation of chromosome organization GO:0033044 103 0.019
response to oxygen containing compound GO:1901700 369 0.019
cellular lipid metabolic process GO:0044255 303 0.019
regulation of cellular response to stress GO:0080135 244 0.019
organelle fission GO:0048285 149 0.019
cell cycle phase transition GO:0044770 173 0.018
purine ribonucleotide catabolic process GO:0009154 404 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.018
actin filament based process GO:0030029 224 0.018
negative regulation of phosphate metabolic process GO:0045936 267 0.018
negative regulation of cell proliferation GO:0008285 228 0.018
histone methylation GO:0016571 60 0.018
chromosome segregation GO:0007059 114 0.018
oocyte development GO:0048599 1 0.018
ribonucleoside monophosphate metabolic process GO:0009161 187 0.018
spermatid differentiation GO:0048515 4 0.017
negative regulation of protein maturation GO:1903318 142 0.017
lipid metabolic process GO:0006629 381 0.017
response to cytokine GO:0034097 232 0.017
positive regulation of phosphorylation GO:0042327 394 0.017
rho protein signal transduction GO:0007266 26 0.017
regulation of protein processing GO:0070613 150 0.016
neurogenesis GO:0022008 169 0.016
carbohydrate derivative biosynthetic process GO:1901137 207 0.016
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.016
carbohydrate metabolic process GO:0005975 207 0.016
chemical homeostasis GO:0048878 306 0.016
response to growth factor GO:0070848 205 0.016
dna damage checkpoint GO:0000077 68 0.016
apoptotic signaling pathway GO:0097190 268 0.016
nervous system development GO:0007399 293 0.016
chromatin silencing GO:0006342 12 0.016
dephosphorylation GO:0016311 209 0.016
single organism cellular localization GO:1902580 332 0.016
negative regulation of cellular component organization GO:0051129 235 0.016
regulation of purine nucleotide metabolic process GO:1900542 264 0.016
regulation of chromatin organization GO:1902275 56 0.016
negative regulation of hydrolase activity GO:0051346 182 0.016
gtp catabolic process GO:0006184 237 0.016
regulation of endopeptidase activity GO:0052548 170 0.015
positive regulation of transport GO:0051050 336 0.015
positive regulation of cellular catabolic process GO:0031331 284 0.015
response to external biotic stimulus GO:0043207 261 0.015
cell projection morphogenesis GO:0048858 129 0.015
regulation of dna metabolic process GO:0051052 153 0.015
mitotic cell cycle phase transition GO:0044772 162 0.015
generation of neurons GO:0048699 152 0.015
nitrogen compound transport GO:0071705 191 0.015
signal transduction by phosphorylation GO:0023014 297 0.015
regulation of growth GO:0040008 165 0.015
response to hormone GO:0009725 175 0.015
positive regulation of cell death GO:0010942 263 0.015
cell division GO:0051301 168 0.015
vesicle mediated transport GO:0016192 371 0.015
single organism reproductive process GO:0044702 98 0.015
negative regulation of apoptotic process GO:0043066 316 0.015
regulation of establishment of protein localization GO:0070201 242 0.015
cellular homeostasis GO:0019725 196 0.015
single organism carbohydrate metabolic process GO:0044723 193 0.015
wnt signaling pathway GO:0016055 156 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
organonitrogen compound biosynthetic process GO:1901566 200 0.014
peptidyl tyrosine phosphorylation GO:0018108 170 0.014
negative regulation of organelle organization GO:0010639 126 0.014
cellular chemical homeostasis GO:0055082 180 0.014
negative regulation of protein modification process GO:0031400 200 0.014
dna integrity checkpoint GO:0031570 71 0.014
single organism membrane organization GO:0044802 268 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
cellular response to cytokine stimulus GO:0071345 181 0.014
negative regulation of phosphorus metabolic process GO:0010563 267 0.014
regulation of protein maturation GO:1903317 150 0.014
positive regulation of developmental process GO:0051094 314 0.014
ion homeostasis GO:0050801 230 0.014
protein acylation GO:0043543 138 0.014
positive regulation of apoptotic process GO:0043065 246 0.014
organ morphogenesis GO:0009887 147 0.014
regulation of cell motility GO:2000145 299 0.014
regulation of cellular component movement GO:0051270 334 0.014
purine nucleoside monophosphate metabolic process GO:0009126 186 0.014
metal ion transport GO:0030001 272 0.014
nucleoside monophosphate metabolic process GO:0009123 191 0.014
regulation of protein localization GO:0032880 296 0.014
regulation of protein kinase activity GO:0045859 289 0.014
biological adhesion GO:0022610 331 0.014
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
ion transmembrane transport GO:0034220 338 0.013
neuron differentiation GO:0030182 138 0.013
cellular response to endogenous stimulus GO:0071495 336 0.013
blastoderm segmentation GO:0007350 2 0.013
regulation of peptidase activity GO:0052547 180 0.013
hindbrain development GO:0030902 3 0.013
mitotic cell cycle GO:0000278 326 0.013
regulation of protein transport GO:0051223 213 0.013
positive regulation of protein phosphorylation GO:0001934 313 0.013
regulation of kinase activity GO:0043549 314 0.013
anterior posterior axis specification GO:0009948 2 0.013
regulation of transferase activity GO:0051338 355 0.013
regulation of cellular protein catabolic process GO:1903362 96 0.013
regulation of cell division GO:0051302 116 0.013
protein acetylation GO:0006473 116 0.013
guanosine containing compound metabolic process GO:1901068 244 0.013
peptidyl lysine acetylation GO:0018394 101 0.013
regulation of response to external stimulus GO:0032101 222 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.013
peptidyl lysine modification GO:0018205 144 0.013
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.013
positive regulation of programmed cell death GO:0043068 249 0.013
regulation of nucleotide catabolic process GO:0030811 205 0.013
cellular response to oxygen containing compound GO:1901701 276 0.013
regulation of defense response GO:0031347 154 0.013
regulation of vesicle mediated transport GO:0060627 130 0.013
compound eye development GO:0048749 1 0.013
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.013
cation transport GO:0006812 331 0.013
response to biotic stimulus GO:0009607 276 0.013
cation homeostasis GO:0055080 189 0.013
gtp metabolic process GO:0046039 239 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
regulation of protein catabolic process GO:0042176 155 0.012
purine nucleoside monophosphate catabolic process GO:0009128 158 0.012
multi organism cellular process GO:0044764 156 0.012
circulatory system development GO:0072359 262 0.012
response to nitrogen compound GO:1901698 184 0.012
positive regulation of nucleoside metabolic process GO:0045979 186 0.012
negative regulation of cell cycle process GO:0010948 121 0.012
morphogenesis of embryonic epithelium GO:0016331 4 0.012
viral process GO:0016032 146 0.012
neuron development GO:0048666 113 0.012
spermatid development GO:0007286 4 0.012
regulation of ras protein signal transduction GO:0046578 155 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.012
positive regulation of nucleotide catabolic process GO:0030813 185 0.012
system process GO:0003008 349 0.012
regulation of locomotion GO:0040012 329 0.012
organelle assembly GO:0070925 176 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
transmembrane transport GO:0055085 399 0.012
regulation of multi organism process GO:0043900 157 0.012
protein targeting GO:0006605 187 0.012
protein oligomerization GO:0051259 173 0.012
atp metabolic process GO:0046034 176 0.012
secretion by cell GO:0032940 226 0.012
positive regulation of chromosome organization GO:2001252 41 0.012
positive regulation of cellular component biogenesis GO:0044089 158 0.012
nuclear transport GO:0051169 179 0.012
cell adhesion GO:0007155 325 0.012
interspecies interaction between organisms GO:0044419 156 0.012
mitotic nuclear division GO:0007067 119 0.012
tripartite regional subdivision GO:0007351 2 0.012
negative regulation of multi organism process GO:0043901 92 0.012
peripheral nervous system development GO:0007422 2 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
response to organic cyclic compound GO:0014070 204 0.011
cell part morphogenesis GO:0032990 137 0.011
negative regulation of gene expression epigenetic GO:0045814 19 0.011
sensory perception GO:0007600 103 0.011
regulation of cell migration GO:0030334 289 0.011
ameboidal type cell migration GO:0001667 135 0.011
nerve development GO:0021675 4 0.011
viral life cycle GO:0019058 132 0.011
atp catabolic process GO:0006200 157 0.011
tissue regeneration GO:0042246 3 0.011
regulation of nucleoside metabolic process GO:0009118 209 0.011
microtubule based process GO:0007017 210 0.011
cell morphogenesis involved in differentiation GO:0000904 144 0.011
actin cytoskeleton organization GO:0030036 207 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
nucleoside monophosphate catabolic process GO:0009125 159 0.011
lipid biosynthetic process GO:0008610 177 0.011
ribonucleoside monophosphate catabolic process GO:0009158 158 0.011
negative regulation of protein processing GO:0010955 142 0.011
response to inorganic substance GO:0010035 127 0.011
regulation of cytoplasmic transport GO:1903649 149 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
histone lysine methylation GO:0034968 50 0.011
blood vessel development GO:0001568 172 0.011
inorganic ion transmembrane transport GO:0098660 231 0.011
ossification GO:0001503 121 0.011
divalent inorganic cation transport GO:0072511 158 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.011
thymus development GO:0048538 3 0.011
cardiovascular system development GO:0072358 262 0.011
intracellular protein transport GO:0006886 270 0.011
positive regulation of cell cycle GO:0045787 140 0.011
embryo development GO:0009790 123 0.011
regulation of chromatin modification GO:1903308 51 0.011
cellular ion homeostasis GO:0006873 168 0.011
taxis GO:0042330 157 0.010
negative regulation of transferase activity GO:0051348 124 0.010
negative regulation of intracellular signal transduction GO:1902532 183 0.010
regulation of gtpase activity GO:0043087 180 0.010
membrane organization GO:0061024 292 0.010
chemotaxis GO:0006935 157 0.010
memory GO:0007613 3 0.010
cellular response to light stimulus GO:0071482 34 0.010
regulation of mitotic cell cycle phase transition GO:1901990 118 0.010
response to wounding GO:0009611 168 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.010
response to lipid GO:0033993 206 0.010
organ formation GO:0048645 3 0.010
positive regulation of kinase activity GO:0033674 204 0.010
regulation of protein complex assembly GO:0043254 147 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.010
cell activation GO:0001775 213 0.010
positive regulation of immune system process GO:0002684 283 0.010
meiotic chromosome segregation GO:0045132 4 0.010
nuclear division GO:0000280 128 0.010
regulation of cysteine type endopeptidase activity GO:2000116 127 0.010

HIST2H4A disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.022
sensory system disease DOID:0050155 203 0.018
nervous system disease DOID:863 431 0.018
eye and adnexa disease DOID:1492 150 0.017
central nervous system disease DOID:331 186 0.016
cancer DOID:162 167 0.015
disease of cellular proliferation DOID:14566 174 0.015
organ system cancer DOID:0050686 164 0.015
inherited metabolic disorder DOID:655 242 0.014
eye disease DOID:5614 149 0.011
neurodegenerative disease DOID:1289 102 0.010