Homo sapiens

347 known processes

TPR

translocated promoter region (to activated MET oncogene)

TPR biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cell differentiation GO:0045596 171 0.467
negative regulation of developmental process GO:0051093 247 0.446
chromatin organization GO:0006325 351 0.422
positive regulation of cellular component organization GO:0051130 376 0.412
post embryonic development GO:0009791 2 0.412
Worm
organelle fission GO:0048285 149 0.377
chromatin remodeling GO:0006338 55 0.362
locomotory behavior GO:0007626 1 0.199
microtubule cytoskeleton organization GO:0000226 176 0.178
regulation of cell development GO:0060284 161 0.166
neurogenesis GO:0022008 169 0.154
vesicle mediated transport GO:0016192 371 0.138
positive regulation of organelle organization GO:0010638 195 0.131
segmentation GO:0035282 4 0.125
chromatin assembly GO:0031497 61 0.122
organelle assembly GO:0070925 176 0.119
nervous system development GO:0007399 293 0.116
protein modification by small protein removal GO:0070646 92 0.104
regulation of cell cycle GO:0051726 393 0.096
oogenesis GO:0048477 2 0.094
cellular macromolecular complex assembly GO:0034622 324 0.093
stem cell differentiation GO:0048863 93 0.091
protein localization to organelle GO:0033365 280 0.090
negative regulation of protein metabolic process GO:0051248 391 0.089
cell development GO:0048468 328 0.088
microtubule based process GO:0007017 210 0.087
actin filament based process GO:0030029 224 0.082
chromatin assembly or disassembly GO:0006333 78 0.081
chromatin modification GO:0016568 298 0.078
cellular component morphogenesis GO:0032989 314 0.078
cellular response to dna damage stimulus GO:0006974 379 0.074
centrosome organization GO:0051297 58 0.073
nucleoside catabolic process GO:0009164 408 0.071
protein catabolic process GO:0030163 325 0.070
mitotic cell cycle GO:0000278 326 0.069
negative regulation of cell development GO:0010721 48 0.067
apoptotic signaling pathway GO:0097190 268 0.066
positive regulation of cell cycle GO:0045787 140 0.065
oocyte development GO:0048599 1 0.064
immune response GO:0006955 307 0.064
regulation of chromatin modification GO:1903308 51 0.064
regulation of chromosome organization GO:0033044 103 0.064
sister chromatid segregation GO:0000819 54 0.062
enzyme linked receptor protein signaling pathway GO:0007167 303 0.059
regulation of cell differentiation GO:0045595 393 0.059
multicellular organismal aging GO:0010259 3 0.059
purine nucleoside triphosphate catabolic process GO:0009146 392 0.058
cell division GO:0051301 168 0.055
ribonucleoside triphosphate catabolic process GO:0009203 391 0.055
purine ribonucleoside metabolic process GO:0046128 437 0.052
negative regulation of organelle organization GO:0010639 126 0.052
positive regulation of apoptotic process GO:0043065 246 0.052
negative regulation of cellular protein metabolic process GO:0032269 353 0.051
intrinsic apoptotic signaling pathway GO:0097193 127 0.051
intracellular protein transport GO:0006886 270 0.051
nuclear export GO:0051168 69 0.051
positive regulation of cell division GO:0051781 59 0.050
Fly
positive regulation of mitosis GO:0045840 25 0.049
Fly
regulation of proteolysis GO:0030162 293 0.046
generation of neurons GO:0048699 152 0.046
cellular response to oxygen containing compound GO:1901701 276 0.043
mitotic cell cycle process GO:1903047 286 0.041
cytokinesis GO:0000910 96 0.041
stem cell maintenance GO:0019827 19 0.041
cellular protein complex assembly GO:0043623 188 0.041
mitotic nuclear division GO:0007067 119 0.040
anatomical structure homeostasis GO:0060249 100 0.040
positive regulation of programmed cell death GO:0043068 249 0.039
stem cell development GO:0048864 69 0.039
embryo development GO:0009790 123 0.039
Worm
nucleoside triphosphate metabolic process GO:0009141 422 0.039
positive regulation of cell death GO:0010942 263 0.038
single organism cellular localization GO:1902580 332 0.038
posttranscriptional regulation of gene expression GO:0010608 213 0.038
purine ribonucleoside catabolic process GO:0046130 398 0.038
regulation of cellular amino acid metabolic process GO:0006521 6 0.038
protein deubiquitination GO:0016579 79 0.038
ribonucleoside catabolic process GO:0042454 406 0.037
regulation of anatomical structure morphogenesis GO:0022603 286 0.037
purine nucleotide catabolic process GO:0006195 405 0.037
spermatid differentiation GO:0048515 4 0.035
organophosphate catabolic process GO:0046434 430 0.035
female gamete generation GO:0007292 2 0.035
neuromuscular junction development GO:0007528 3 0.034
tube morphogenesis GO:0035239 95 0.034
negative regulation of apoptotic process GO:0043066 316 0.033
positive regulation of cellular component biogenesis GO:0044089 158 0.033
regulation of cellular component biogenesis GO:0044087 281 0.033
blood vessel maturation GO:0001955 1 0.032
meiosis i GO:0007127 4 0.032
dna packaging GO:0006323 77 0.032
regulation of cellular response to stress GO:0080135 244 0.032
purine nucleoside monophosphate metabolic process GO:0009126 186 0.032
signal transduction by phosphorylation GO:0023014 297 0.031
negative regulation of neurogenesis GO:0050768 26 0.031
positive regulation of cell cycle process GO:0090068 106 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.031
negative regulation of cell cycle GO:0045786 193 0.030
reciprocal meiotic recombination GO:0007131 4 0.030
actin cytoskeleton organization GO:0030036 207 0.030
response to abiotic stimulus GO:0009628 336 0.029
cellular amine metabolic process GO:0044106 41 0.029
cell projection organization GO:0030030 252 0.029
cellular ketone metabolic process GO:0042180 80 0.029
regulation of cellular amine metabolic process GO:0033238 11 0.029
negative regulation of phosphate metabolic process GO:0045936 267 0.029
negative regulation of chromosome organization GO:2001251 48 0.028
determination of adult lifespan GO:0008340 2 0.028
negative regulation of catalytic activity GO:0043086 335 0.027
regulation of immune response GO:0050776 201 0.027
ribonucleoside monophosphate metabolic process GO:0009161 187 0.027
regulation of neurogenesis GO:0050767 82 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.026
nucleotide catabolic process GO:0009166 408 0.026
cell morphogenesis GO:0000902 296 0.026
heterochromatin organization GO:0070828 6 0.026
cellular response to nitrogen compound GO:1901699 144 0.026
dna conformation change GO:0071103 113 0.026
chromosome segregation GO:0007059 114 0.025
cell projection morphogenesis GO:0048858 129 0.025
ribonucleotide catabolic process GO:0009261 405 0.025
negative regulation of cellular component organization GO:0051129 235 0.025
positive regulation of chromatin modification GO:1903310 30 0.024
mitotic cell cycle phase transition GO:0044772 162 0.024
atp metabolic process GO:0046034 176 0.024
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.024
centrosome cycle GO:0007098 32 0.024
cellular protein catabolic process GO:0044257 261 0.023
regulation of protein maturation GO:1903317 150 0.023
nuclear transport GO:0051169 179 0.023
nucleosome organization GO:0034728 66 0.023
neuron differentiation GO:0030182 138 0.023
cell morphogenesis involved in differentiation GO:0000904 144 0.023
nucleic acid transport GO:0050657 39 0.023
negative regulation of multicellular organismal process GO:0051241 317 0.023
membrane organization GO:0061024 292 0.023
cellular macromolecule catabolic process GO:0044265 380 0.022
cilium morphogenesis GO:0060271 75 0.022
sister chromatid cohesion GO:0007062 24 0.022
response to organic cyclic compound GO:0014070 204 0.022
rna interference GO:0016246 4 0.021
purine containing compound catabolic process GO:0072523 411 0.021
sex differentiation GO:0007548 45 0.021
regulation of cell morphogenesis GO:0022604 153 0.021
regulation of response to external stimulus GO:0032101 222 0.021
response to nitrogen compound GO:1901698 184 0.021
mating GO:0007618 1 0.020
fat cell differentiation GO:0045444 32 0.020
amine metabolic process GO:0009308 44 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.020
morphogenesis of a polarized epithelium GO:0001738 3 0.020
reproduction GO:0000003 63 0.019
meiotic chromosome segregation GO:0045132 4 0.019
regulation of protein processing GO:0070613 150 0.019
modification dependent macromolecule catabolic process GO:0043632 212 0.019
regulation of intracellular protein transport GO:0033157 123 0.019
regulation of gene expression epigenetic GO:0040029 73 0.019
ribonucleoprotein complex subunit organization GO:0071826 81 0.019
positive regulation of intracellular protein transport GO:0090316 76 0.019
jak stat cascade GO:0007259 46 0.019
organelle localization GO:0051640 84 0.018
Fly
response to oxygen containing compound GO:1901700 369 0.018
positive regulation of immune system process GO:0002684 283 0.018
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.018
nucleoside monophosphate catabolic process GO:0009125 159 0.018
activation of protein kinase activity GO:0032147 90 0.017
brain development GO:0007420 97 0.017
protein dna complex subunit organization GO:0071824 80 0.017
purine nucleoside triphosphate metabolic process GO:0009144 412 0.017
tube development GO:0035295 125 0.017
reproductive system development GO:0061458 56 0.017
male sex differentiation GO:0046661 25 0.017
negative regulation of phosphorus metabolic process GO:0010563 267 0.017
glycosyl compound catabolic process GO:1901658 413 0.017
system process GO:0003008 349 0.017
nucleoside phosphate catabolic process GO:1901292 412 0.017
nucleus organization GO:0006997 28 0.017
regulation of establishment of protein localization GO:0070201 242 0.017
chemotaxis GO:0006935 157 0.017
regulation of cell cycle process GO:0010564 266 0.017
nucleocytoplasmic transport GO:0006913 176 0.017
epithelial cell migration GO:0010631 119 0.016
negative regulation of hydrolase activity GO:0051346 182 0.016
single organism reproductive process GO:0044702 98 0.016
developmental process involved in reproduction GO:0003006 66 0.016
regulation of transcription by chromatin organization GO:0034401 1 0.016
Fly
ubiquitin dependent protein catabolic process GO:0006511 206 0.016
chromosome separation GO:0051304 23 0.016
neuroblast proliferation GO:0007405 4 0.016
regulation of meiosis GO:0040020 3 0.016
endocytosis GO:0006897 159 0.016
regulation of dna metabolic process GO:0051052 153 0.016
cellular component assembly involved in morphogenesis GO:0010927 73 0.016
negative regulation of cell death GO:0060548 345 0.016
anterior posterior axis specification embryo GO:0008595 2 0.016
behavior GO:0007610 112 0.016
regulation of chromatin organization GO:1902275 56 0.016
regulation of dephosphorylation GO:0035303 96 0.016
positive regulation of proteolysis GO:0045862 142 0.016
cilium assembly GO:0042384 63 0.016
nucleobase containing compound transport GO:0015931 51 0.016
embryonic epithelial tube formation GO:0001838 4 0.016
response to other organism GO:0051707 261 0.016
positive regulation of cellular amine metabolic process GO:0033240 7 0.016
regulation of cellular protein catabolic process GO:1903362 96 0.015
rna transport GO:0050658 39 0.015
histone deacetylation GO:0016575 32 0.015
muscle system process GO:0003012 81 0.015
maintenance of location GO:0051235 112 0.015
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.015
cell junction organization GO:0034330 79 0.015
central nervous system development GO:0007417 123 0.015
establishment of protein localization to organelle GO:0072594 172 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.015
rna splicing GO:0008380 131 0.015
regulation of nervous system development GO:0051960 88 0.015
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.014
methylation GO:0032259 106 0.014
positive regulation of nervous system development GO:0051962 54 0.014
protein maturation GO:0051604 233 0.014
nuclear division GO:0000280 128 0.014
rna processing GO:0006396 255 0.014
reproductive process GO:0022414 106 0.014
reciprocal dna recombination GO:0035825 4 0.014
blastoderm segmentation GO:0007350 2 0.014
smad protein import into nucleus GO:0007184 13 0.014
regulation of organ morphogenesis GO:2000027 24 0.014
branching morphogenesis of an epithelial tube GO:0048754 19 0.014
nucleosome assembly GO:0006334 50 0.013
protein export from nucleus GO:0006611 29 0.013
negative regulation of protein processing GO:0010955 142 0.013
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.013
cell cycle phase transition GO:0044770 173 0.013
digestive tract morphogenesis GO:0048546 56 0.013
protein processing GO:0016485 226 0.013
ribonucleoside triphosphate metabolic process GO:0009199 412 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.013
axis elongation GO:0003401 4 0.013
positive regulation of protein phosphorylation GO:0001934 313 0.013
negative regulation of programmed cell death GO:0043069 321 0.013
regulation of apoptotic signaling pathway GO:2001233 175 0.013
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.013
mrna export from nucleus GO:0006406 29 0.013
nucleus localization GO:0051647 1 0.013
regulation of transferase activity GO:0051338 355 0.013
cell projection assembly GO:0030031 126 0.012
response to wounding GO:0009611 168 0.012
anterior posterior axis specification GO:0009948 2 0.012
positive regulation of cellular catabolic process GO:0031331 284 0.012
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.012
dna recombination GO:0006310 77 0.012
positive regulation of developmental process GO:0051094 314 0.012
forelimb morphogenesis GO:0035136 4 0.012
response to hormone GO:0009725 175 0.012
protein targeting GO:0006605 187 0.012
innate immune response GO:0045087 178 0.012
negative regulation of chromatin modification GO:1903309 21 0.012
protein oligomerization GO:0051259 173 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
neuron development GO:0048666 113 0.012
dna replication GO:0006260 116 0.012
heterochromatin assembly GO:0031507 6 0.012
reproductive structure development GO:0048608 55 0.012
regulation of phosphatase activity GO:0010921 81 0.012
negative regulation of immune system process GO:0002683 136 0.012
regulation of neuron differentiation GO:0045664 70 0.012
establishment of rna localization GO:0051236 39 0.012
modification dependent protein catabolic process GO:0019941 209 0.012
cell part morphogenesis GO:0032990 137 0.012
positive regulation of hydrolase activity GO:0051345 331 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.011
defense response to fungus GO:0050832 4 0.011
cellular response to inorganic substance GO:0071241 45 0.011
microtubule organizing center organization GO:0031023 62 0.011
biological adhesion GO:0022610 331 0.011
regulation of cell cycle phase transition GO:1901987 126 0.011
rhythmic behavior GO:0007622 2 0.011
growth GO:0040007 202 0.011
engulfment of apoptotic cell GO:0043652 2 0.011
double strand break repair GO:0006302 101 0.011
response to uv GO:0009411 73 0.011
establishment of protein localization to membrane GO:0090150 121 0.011
positive regulation of phosphorylation GO:0042327 394 0.011
macromolecule deacylation GO:0098732 41 0.011
telomere organization GO:0032200 33 0.011
purine nucleoside catabolic process GO:0006152 398 0.011
regulation of meiotic cell cycle GO:0051445 4 0.011
regulation of response to dna damage stimulus GO:2001020 94 0.011
positive regulation of transport GO:0051050 336 0.011
immune effector process GO:0002252 159 0.011
positive regulation of apoptotic signaling pathway GO:2001235 70 0.011
nuclear pore complex assembly GO:0051292 7 0.011
cellular response to abiotic stimulus GO:0071214 117 0.010
tube closure GO:0060606 3 0.010
response to salt stress GO:0009651 3 0.010
cytoplasmic transport GO:0016482 379 0.010
regulation of nuclear division GO:0051783 65 0.010
tripartite regional subdivision GO:0007351 2 0.010
positive regulation of mitotic cell cycle GO:0045931 60 0.010
dna dependent dna replication GO:0006261 44 0.010
negative regulation of phosphatase activity GO:0010923 61 0.010

TPR disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.034
cancer DOID:162 167 0.030
organ system cancer DOID:0050686 164 0.030
sensory system disease DOID:0050155 203 0.028
eye and adnexa disease DOID:1492 150 0.028
nervous system disease DOID:863 431 0.028
central nervous system disease DOID:331 186 0.025
neurodegenerative disease DOID:1289 102 0.025
eye disease DOID:5614 149 0.016