Homo sapiens

41 known processes

EXO1

exonuclease 1

(Aliases: HEX1,hExoI)

EXO1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna repair GO:0006281 198 0.978
cellular response to dna damage stimulus GO:0006974 379 0.889
double strand break repair via homologous recombination GO:0000724 50 0.826
nuclear division GO:0000280 128 0.705
dna recombination GO:0006310 77 0.690
atp catabolic process GO:0006200 157 0.683
recombinational repair GO:0000725 50 0.651
nucleotide excision repair GO:0006289 31 0.569
double strand break repair GO:0006302 101 0.539
Yeast
cellular macromolecule catabolic process GO:0044265 380 0.494
organelle fission GO:0048285 149 0.469
mismatch repair GO:0006298 15 0.402
nucleoside monophosphate metabolic process GO:0009123 191 0.376
nucleoside triphosphate metabolic process GO:0009141 422 0.315
post embryonic development GO:0009791 2 0.260
meiosis i GO:0007127 4 0.256
ribonucleoside triphosphate metabolic process GO:0009199 412 0.246
mitotic cell cycle phase transition GO:0044772 162 0.231
regulation of dna metabolic process GO:0051052 153 0.220
purine nucleotide catabolic process GO:0006195 405 0.219
purine nucleoside monophosphate metabolic process GO:0009126 186 0.210
nucleoside phosphate catabolic process GO:1901292 412 0.205
dna integrity checkpoint GO:0031570 71 0.192
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.188
g2 dna damage checkpoint GO:0031572 26 0.184
ribonucleotide catabolic process GO:0009261 405 0.182
purine nucleoside catabolic process GO:0006152 398 0.175
anatomical structure homeostasis GO:0060249 100 0.157
Yeast
chromosome segregation GO:0007059 114 0.155
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.154
ribonucleoside monophosphate metabolic process GO:0009161 187 0.148
female gamete generation GO:0007292 2 0.147
dna biosynthetic process GO:0071897 40 0.147
dna geometric change GO:0032392 32 0.140
mitotic cell cycle checkpoint GO:0007093 68 0.135
dna catabolic process GO:0006308 49 0.135
atp metabolic process GO:0046034 176 0.126
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.119
organophosphate catabolic process GO:0046434 430 0.118
ribonucleoside triphosphate catabolic process GO:0009203 391 0.116
negative regulation of dna recombination GO:0045910 6 0.113
purine ribonucleoside metabolic process GO:0046128 437 0.110
negative regulation of cell death GO:0060548 345 0.110
regulation of cell cycle GO:0051726 393 0.108
dna dependent dna replication GO:0006261 44 0.108
positive regulation of hydrolase activity GO:0051345 331 0.107
dna replication GO:0006260 116 0.106
nucleoside monophosphate catabolic process GO:0009125 159 0.104
embryo development GO:0009790 123 0.103
isotype switching GO:0045190 3 0.101
Mouse
cell cycle phase transition GO:0044770 173 0.099
microtubule based process GO:0007017 210 0.098
cell division GO:0051301 168 0.097
purine containing compound catabolic process GO:0072523 411 0.096
ribonucleoside monophosphate catabolic process GO:0009158 158 0.096
purine nucleoside triphosphate catabolic process GO:0009146 392 0.093
dna conformation change GO:0071103 113 0.090
immune response GO:0006955 307 0.089
Mouse
sex determination GO:0007530 3 0.088
Yeast
double strand break repair via single strand annealing GO:0045002 4 0.086
meiotic nuclear division GO:0007126 10 0.086
purine ribonucleoside catabolic process GO:0046130 398 0.085
nucleoside triphosphate catabolic process GO:0009143 394 0.085
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.084
lymphocyte activation GO:0046649 133 0.083
Mouse
response to uv GO:0009411 73 0.081
response to abiotic stimulus GO:0009628 336 0.078
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.077
negative regulation of apoptotic process GO:0043066 316 0.072
glycosyl compound catabolic process GO:1901658 413 0.071
response to radiation GO:0009314 151 0.069
maintenance of dna repeat elements GO:0043570 4 0.069
immune system development GO:0002520 195 0.068
Mouse
mitotic dna integrity checkpoint GO:0044774 30 0.067
cell development GO:0048468 328 0.067
regulation of cell cycle phase transition GO:1901987 126 0.067
vesicle mediated transport GO:0016192 371 0.067
somatic diversification of immune receptors via somatic mutation GO:0002566 1 0.065
Mouse
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.062
mitotic cell cycle GO:0000278 326 0.062
intrinsic apoptotic signaling pathway GO:0097193 127 0.059
meiotic cell cycle GO:0051321 13 0.059
Yeast
mitotic dna damage checkpoint GO:0044773 28 0.058
dna damage checkpoint GO:0000077 68 0.056
protein catabolic process GO:0030163 325 0.056
regulation of dna recombination GO:0000018 23 0.054
leukocyte activation GO:0045321 164 0.052
Mouse
negative regulation of cell cycle process GO:0010948 121 0.052
regulation of double strand break repair GO:2000779 22 0.051
negative regulation of mitotic cell cycle GO:0045930 102 0.050
cellular protein catabolic process GO:0044257 261 0.048
non recombinational repair GO:0000726 14 0.048
negative regulation of programmed cell death GO:0043069 321 0.048
dna duplex unwinding GO:0032508 30 0.047
response to light stimulus GO:0009416 87 0.047
dna double strand break processing GO:0000729 10 0.046
Yeast
chromosome separation GO:0051304 23 0.045
determination of adult lifespan GO:0008340 2 0.045
oogenesis GO:0048477 2 0.043
nucleotide catabolic process GO:0009166 408 0.042
meiotic chromosome segregation GO:0045132 4 0.042
gene conversion GO:0035822 1 0.042
Yeast
cell activation involved in immune response GO:0002263 30 0.041
Mouse
negative regulation of cell cycle phase transition GO:1901988 89 0.040
purine ribonucleotide catabolic process GO:0009154 404 0.040
cellular response to endogenous stimulus GO:0071495 336 0.040
apoptotic signaling pathway GO:0097190 268 0.038
regulation of cellular ketone metabolic process GO:0010565 50 0.038
sister chromatid segregation GO:0000819 54 0.037
translesion synthesis GO:0019985 8 0.036
mitochondrion organization GO:0007005 156 0.035
purine nucleoside triphosphate metabolic process GO:0009144 412 0.035
negative regulation of cellular protein metabolic process GO:0032269 353 0.035
response to oxygen containing compound GO:1901700 369 0.034
positive regulation of programmed cell death GO:0043068 249 0.033
regulation of protein catabolic process GO:0042176 155 0.033
organophosphate biosynthetic process GO:0090407 163 0.033
regulation of mitotic cell cycle GO:0007346 189 0.033
nucleotide biosynthetic process GO:0009165 109 0.033
nucleoside catabolic process GO:0009164 408 0.032
dephosphorylation GO:0016311 209 0.032
cell activation GO:0001775 213 0.032
Mouse
regulation of cell cycle process GO:0010564 266 0.032
multicellular organismal aging GO:0010259 3 0.032
developmental process involved in reproduction GO:0003006 66 0.030
Yeast
base excision repair GO:0006284 21 0.029
negative regulation of phosphate metabolic process GO:0045936 267 0.029
negative regulation of catalytic activity GO:0043086 335 0.029
postreplication repair GO:0006301 12 0.028
dna catabolic process exonucleolytic GO:0000738 17 0.028
positive regulation of catabolic process GO:0009896 310 0.028
mitotic recombination GO:0006312 8 0.027
Yeast
negative regulation of protein maturation GO:1903318 142 0.027
mitotic cell cycle process GO:1903047 286 0.027
reproductive process GO:0022414 106 0.027
Yeast
single organism reproductive process GO:0044702 98 0.026
Yeast
regulation of dna repair GO:0006282 47 0.026
protein homooligomerization GO:0051260 100 0.026
male meiosis GO:0007140 1 0.025
single organism cellular localization GO:1902580 332 0.025
telomere maintenance GO:0000723 32 0.025
Yeast
positive regulation of cell death GO:0010942 263 0.025
protein ubiquitination GO:0016567 314 0.025
negative regulation of cell cycle GO:0045786 193 0.025
single organism membrane organization GO:0044802 268 0.025
cell cycle checkpoint GO:0000075 117 0.025
regulation of protein maturation GO:1903317 150 0.024
meiotic chromosome separation GO:0051307 3 0.024
asymmetric stem cell division GO:0098722 1 0.024
regulation of anatomical structure morphogenesis GO:0022603 286 0.024
cell cycle arrest GO:0007050 71 0.024
cellular protein complex assembly GO:0043623 188 0.024
ubiquitin dependent protein catabolic process GO:0006511 206 0.024
positive regulation of phosphorylation GO:0042327 394 0.023
regulation of proteolysis GO:0030162 293 0.023
regulation of double strand break repair via homologous recombination GO:0010569 11 0.022
cell type specific apoptotic process GO:0097285 125 0.022
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.022
cellular ketone metabolic process GO:0042180 80 0.022
response to nitrogen compound GO:1901698 184 0.022
cilium morphogenesis GO:0060271 75 0.021
nervous system development GO:0007399 293 0.021
embryo development ending in birth or egg hatching GO:0009792 34 0.021
cellular component morphogenesis GO:0032989 314 0.021
reproduction GO:0000003 63 0.021
Yeast
meiotic cell cycle process GO:1903046 8 0.021
Yeast
reciprocal meiotic recombination GO:0007131 4 0.021
regulation of cellular amino acid metabolic process GO:0006521 6 0.021
protein heterotetramerization GO:0051290 3 0.020
centrosome organization GO:0051297 58 0.020
secretion GO:0046903 254 0.020
covalent chromatin modification GO:0016569 254 0.020
cell cycle g2 m phase transition GO:0044839 43 0.019
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
regulation of kinase activity GO:0043549 314 0.019
regulation of dna replication GO:0006275 68 0.018
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.018
Mouse
response to organic cyclic compound GO:0014070 204 0.018
modification dependent macromolecule catabolic process GO:0043632 212 0.018
growth GO:0040007 202 0.017
immune effector process GO:0002252 159 0.017
Mouse
positive regulation of cell proliferation GO:0008284 301 0.017
lymphocyte differentiation GO:0030098 35 0.017
modification dependent protein catabolic process GO:0019941 209 0.017
receptor mediated endocytosis GO:0006898 84 0.017
neuroblast division GO:0055057 1 0.017
regulation of mitotic sister chromatid segregation GO:0033047 27 0.017
positive regulation of meiotic cell cycle GO:0051446 2 0.017
negative regulation of transferase activity GO:0051348 124 0.016
endocytosis GO:0006897 159 0.016
regulation of cellular amine metabolic process GO:0033238 11 0.016
protein autophosphorylation GO:0046777 123 0.016
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.016
Mouse
negative regulation of hydrolase activity GO:0051346 182 0.016
ribonucleoside catabolic process GO:0042454 406 0.016
positive regulation of immune system process GO:0002684 283 0.016
microtubule organizing center organization GO:0031023 62 0.016
positive regulation of cell cycle GO:0045787 140 0.016
regulation of endopeptidase activity GO:0052548 170 0.016
regulation of protein localization GO:0032880 296 0.016
blastocyst development GO:0001824 3 0.016
cellular amino acid metabolic process GO:0006520 116 0.015
anatomical structure formation involved in morphogenesis GO:0048646 284 0.015
cellular response to organonitrogen compound GO:0071417 124 0.015
leukocyte differentiation GO:0002521 98 0.015
carbohydrate derivative biosynthetic process GO:1901137 207 0.015
negative regulation of protein metabolic process GO:0051248 391 0.015
nucleoside phosphate biosynthetic process GO:1901293 109 0.015
multicellular organism reproduction GO:0032504 42 0.015
regulation of t cell activation GO:0050863 77 0.015
cell projection organization GO:0030030 252 0.015
positive regulation of apoptotic process GO:0043065 246 0.015
cytoplasmic transport GO:0016482 379 0.015
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.015
response to inorganic substance GO:0010035 127 0.015
chemical homeostasis GO:0048878 306 0.015
regeneration GO:0031099 4 0.014
cell fate determination GO:0001709 3 0.014
multi organism reproductive process GO:0044703 54 0.014
regulation of mitotic cell cycle phase transition GO:1901990 118 0.014
proteasomal protein catabolic process GO:0010498 176 0.014
interstrand cross link repair GO:0036297 3 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
g2 m transition of mitotic cell cycle GO:0000086 41 0.013
membrane organization GO:0061024 292 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
amine metabolic process GO:0009308 44 0.013
positive regulation of kinase activity GO:0033674 204 0.013
purine nucleoside monophosphate catabolic process GO:0009128 158 0.013
neurogenesis GO:0022008 169 0.013
protein processing GO:0016485 226 0.013
protein acylation GO:0043543 138 0.013
response to biotic stimulus GO:0009607 276 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.013
regulation of protein kinase activity GO:0045859 289 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.013
cell projection assembly GO:0030031 126 0.012
cellular response to radiation GO:0071478 65 0.012
positive regulation of developmental process GO:0051094 314 0.012
positive regulation of cell cycle process GO:0090068 106 0.012
defense response GO:0006952 315 0.012
system process GO:0003008 349 0.012
response to purine containing compound GO:0014074 40 0.012
negative regulation of cell size GO:0045792 3 0.012
mitotic sister chromatid cohesion GO:0007064 12 0.012
signal transduction by phosphorylation GO:0023014 297 0.012
regulation of binding GO:0051098 111 0.012
cell cycle g1 s phase transition GO:0044843 80 0.012
organonitrogen compound biosynthetic process GO:1901566 200 0.012
maintenance of location in cell GO:0051651 62 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
negative regulation of catabolic process GO:0009895 104 0.012
cellular response to abiotic stimulus GO:0071214 117 0.012
reciprocal dna recombination GO:0035825 4 0.012
histone acetylation GO:0016573 93 0.012
regulation of transferase activity GO:0051338 355 0.011
circulatory system development GO:0072359 262 0.011
actin filament based process GO:0030029 224 0.011
maintenance of location GO:0051235 112 0.011
peptidyl lysine modification GO:0018205 144 0.011
mitotic nuclear division GO:0007067 119 0.011
negative regulation of dna metabolic process GO:0051053 57 0.011
cellular response to oxygen containing compound GO:1901701 276 0.011
regulation of protein processing GO:0070613 150 0.011
cellular amine metabolic process GO:0044106 41 0.011
regulation of neural precursor cell proliferation GO:2000177 4 0.011
cofactor metabolic process GO:0051186 87 0.011
dna synthesis involved in dna repair GO:0000731 6 0.011
somatic hypermutation of immunoglobulin genes GO:0016446 1 0.011
Mouse
regulation of lymphocyte activation GO:0051249 103 0.011
protein oligomerization GO:0051259 173 0.011
cell cell signaling GO:0007267 155 0.011
cellular response to organic cyclic compound GO:0071407 127 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
positive regulation of organelle organization GO:0010638 195 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
internal protein amino acid acetylation GO:0006475 101 0.011
multicellular organismal reproductive process GO:0048609 40 0.011
rna processing GO:0006396 255 0.010
oocyte development GO:0048599 1 0.010
protein localization to organelle GO:0033365 280 0.010
production of molecular mediator of immune response GO:0002440 37 0.010
Mouse

EXO1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.294
disease of cellular proliferation DOID:14566 174 0.294
organ system cancer DOID:0050686 164 0.294
breast cancer DOID:1612 21 0.062
thoracic cancer DOID:5093 21 0.062
immune system disease DOID:2914 155 0.043
hematopoietic system disease DOID:74 100 0.043
bone marrow disease DOID:4961 31 0.027
aplastic anemia DOID:12449 30 0.012
anemia DOID:2355 55 0.012