Homo sapiens

41 known processes

VKORC1

vitamin K epoxide reductase complex, subunit 1

(Aliases: MST576,EDTP308,MST134,FLJ00289,IMAGE3455200,MGC2694,VKOR,VKCFD2)

VKORC1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carbohydrate metabolic process GO:0005975 207 0.097
cellular ketone metabolic process GO:0042180 80 0.089
positive regulation of transport GO:0051050 336 0.088
lipid metabolic process GO:0006629 381 0.087
regulation of kinase activity GO:0043549 314 0.083
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.079
regulation of establishment of protein localization GO:0070201 242 0.074
positive regulation of kinase activity GO:0033674 204 0.071
positive regulation of protein phosphorylation GO:0001934 313 0.068
glycoside metabolic process GO:0016137 13 0.068
negative regulation of cell proliferation GO:0008285 228 0.067
positive regulation of developmental process GO:0051094 314 0.065
positive regulation of ossification GO:0045778 32 0.064
cellular amine metabolic process GO:0044106 41 0.061
cellular amino acid metabolic process GO:0006520 116 0.059
regulation of protein kinase activity GO:0045859 289 0.058
lipid biosynthetic process GO:0008610 177 0.058
positive regulation of protein kinase activity GO:0045860 190 0.056
negative regulation of catalytic activity GO:0043086 335 0.056
carboxylic acid biosynthetic process GO:0046394 97 0.055
positive regulation of transferase activity GO:0051347 227 0.054
regulation of protein serine threonine kinase activity GO:0071900 179 0.052
mitochondrial calcium ion homeostasis GO:0051560 11 0.052
cell adhesion GO:0007155 325 0.052
biological adhesion GO:0022610 331 0.051
regulation of protein transport GO:0051223 213 0.051
regulation of ossification GO:0030278 58 0.051
vesicle mediated transport GO:0016192 371 0.049
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.049
positive regulation of mapk cascade GO:0043410 190 0.048
phosphatidylinositol biosynthetic process GO:0006661 25 0.047
negative regulation of cellular protein metabolic process GO:0032269 353 0.044
response to virus GO:0009615 126 0.043
protein homooligomerization GO:0051260 100 0.042
osteoblast differentiation GO:0001649 92 0.042
cellular lipid metabolic process GO:0044255 303 0.041
regulation of mapk cascade GO:0043408 262 0.041
regulation of protein localization GO:0032880 296 0.040
post embryonic development GO:0009791 2 0.039
positive regulation of cellular amine metabolic process GO:0033240 7 0.039
regulation of cellular amino acid metabolic process GO:0006521 6 0.038
regulation of growth GO:0040008 165 0.038
negative regulation of cellular catabolic process GO:0031330 83 0.038
regulation of apoptotic signaling pathway GO:2001233 175 0.037
thiamine transport GO:0015888 3 0.037
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.037
protein maturation GO:0051604 233 0.035
blastocyst development GO:0001824 3 0.035
signal transduction by phosphorylation GO:0023014 297 0.035
posttranscriptional regulation of gene expression GO:0010608 213 0.035
mitochondrion organization GO:0007005 156 0.035
regulation of cellular amine metabolic process GO:0033238 11 0.034
mapk cascade GO:0000165 288 0.034
ossification GO:0001503 121 0.034
regulation of multi organism process GO:0043900 157 0.033
regulation of endopeptidase activity GO:0052548 170 0.033
amine metabolic process GO:0009308 44 0.032
regulation of calcium ion transport GO:0051924 79 0.032
cellular homeostasis GO:0019725 196 0.032
metal ion transport GO:0030001 272 0.032
positive regulation of phosphorylation GO:0042327 394 0.031
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.030
secretion by cell GO:0032940 226 0.030
regulation of protein secretion GO:0050708 86 0.029
positive regulation of osteoblast differentiation GO:0045669 23 0.029
negative regulation of phosphate metabolic process GO:0045936 267 0.029
negative regulation of programmed cell death GO:0043069 321 0.029
negative regulation of catabolic process GO:0009895 104 0.029
glycerolipid biosynthetic process GO:0045017 51 0.029
thiamine transmembrane transport GO:0071934 2 0.029
regulation of cellular component movement GO:0051270 334 0.028
regulation of secretion by cell GO:1903530 177 0.028
single organism carbohydrate metabolic process GO:0044723 193 0.027
protein oligomerization GO:0051259 173 0.027
regulation of map kinase activity GO:0043405 108 0.027
regulation of cellular ketone metabolic process GO:0010565 50 0.026
regulation of cell motility GO:2000145 299 0.026
regulation of osteoblast differentiation GO:0045667 38 0.026
locomotory behavior GO:0007626 1 0.026
regulation of secretion GO:0051046 194 0.026
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.025
carbohydrate derivative biosynthetic process GO:1901137 207 0.025
regulation of protein stability GO:0031647 87 0.025
myosin filament organization GO:0031033 2 0.025
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.025
leukocyte chemotaxis GO:0030595 76 0.025
cell aging GO:0007569 52 0.024
negative regulation of hydrolase activity GO:0051346 182 0.024
peptidyl tyrosine modification GO:0018212 170 0.024
actin mediated cell contraction GO:0070252 12 0.024
immune effector process GO:0002252 159 0.024
regulation of ion transport GO:0043269 189 0.024
positive regulation of map kinase activity GO:0043406 80 0.024
regulation of proteolysis GO:0030162 293 0.024
regulation of gtpase activity GO:0043087 180 0.023
regulation of transferase activity GO:0051338 355 0.023
innate immune response GO:0045087 178 0.022
plasma membrane fusion GO:0045026 2 0.022
positive regulation of protein transport GO:0051222 135 0.021
organic hydroxy compound metabolic process GO:1901615 147 0.021
determination of adult lifespan GO:0008340 2 0.021
epithelium development GO:0060429 227 0.021
negative regulation of striated muscle cell apoptotic process GO:0010664 2 0.021
cell growth GO:0016049 160 0.021
positive regulation of locomotion GO:0040017 186 0.020
positive regulation of hydrolase activity GO:0051345 331 0.020
regulation of peptidase activity GO:0052547 180 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.020
regulation of membrane potential GO:0042391 95 0.020
positive regulation of cell activation GO:0050867 81 0.020
glycerophospholipid metabolic process GO:0006650 84 0.020
regulation of stress activated mapk cascade GO:0032872 84 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
regulation of cell cycle GO:0051726 393 0.019
multicellular organismal aging GO:0010259 3 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
positive regulation of immune system process GO:0002684 283 0.019
negative regulation of protein processing GO:0010955 142 0.019
positive regulation of cell motility GO:2000147 177 0.019
positive chemotaxis GO:0050918 33 0.019
negative regulation of purine nucleotide metabolic process GO:1900543 28 0.019
response to other organism GO:0051707 261 0.019
erk1 and erk2 cascade GO:0070371 104 0.019
regulation of system process GO:0044057 101 0.018
positive regulation of nucleotide biosynthetic process GO:0030810 38 0.018
blood circulation GO:0008015 113 0.018
monocarboxylic acid metabolic process GO:0032787 185 0.018
negative regulation of protein maturation GO:1903318 142 0.018
glycerolipid metabolic process GO:0046486 107 0.018
regulation of mitochondrion organization GO:0010821 54 0.018
response to wounding GO:0009611 168 0.018
small molecule biosynthetic process GO:0044283 157 0.017
response to biotic stimulus GO:0009607 276 0.017
ribonucleoside catabolic process GO:0042454 406 0.017
protein catabolic process GO:0030163 325 0.017
regulation of cell growth GO:0001558 135 0.017
positive regulation of organelle organization GO:0010638 195 0.016
regulation of epithelial cell proliferation GO:0050678 113 0.016
response to external biotic stimulus GO:0043207 261 0.016
intracellular protein transport GO:0006886 270 0.016
cellular metal ion homeostasis GO:0006875 146 0.016
hemopoiesis GO:0030097 180 0.016
positive regulation of programmed cell death GO:0043068 249 0.016
growth GO:0040007 202 0.016
secretion GO:0046903 254 0.016
regulation of nucleotide metabolic process GO:0006140 269 0.016
carbohydrate catabolic process GO:0016052 36 0.016
protein processing GO:0016485 226 0.016
second messenger mediated signaling GO:0019932 78 0.015
cell activation GO:0001775 213 0.015
positive regulation of cell differentiation GO:0045597 211 0.015
establishment of viral latency GO:0019043 1 0.015
positive regulation of leukocyte activation GO:0002696 80 0.015
regulation of camp metabolic process GO:0030814 52 0.015
single organism membrane fusion GO:0044801 37 0.015
leukocyte migration GO:0050900 107 0.015
negative regulation of protein metabolic process GO:0051248 391 0.015
positive regulation of protein secretion GO:0050714 60 0.015
hindbrain development GO:0030902 3 0.015
regulation of protein catabolic process GO:0042176 155 0.015
divalent inorganic cation homeostasis GO:0072507 136 0.015
cellular response to oxygen containing compound GO:1901701 276 0.014
organophosphate biosynthetic process GO:0090407 163 0.014
single organism membrane organization GO:0044802 268 0.014
taxis GO:0042330 157 0.014
regulation of wnt protein secretion GO:0061356 1 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.014
immune response GO:0006955 307 0.014
phosphatidylinositol metabolic process GO:0046488 53 0.014
regulation of purine nucleotide metabolic process GO:1900542 264 0.014
negative regulation of cell motility GO:2000146 104 0.014
transmembrane transport GO:0055085 399 0.014
regulation of intracellular protein transport GO:0033157 123 0.014
cellular modified amino acid metabolic process GO:0006575 64 0.014
regulation of ion transmembrane transport GO:0034765 132 0.014
wound healing GO:0042060 115 0.014
regeneration GO:0031099 4 0.014
vitamin metabolic process GO:0006766 26 0.014
regulation of locomotion GO:0040012 329 0.013
positive regulation of calcium ion transport GO:0051928 51 0.013
protein localization to organelle GO:0033365 280 0.013
gtp catabolic process GO:0006184 237 0.013
cellular ion homeostasis GO:0006873 168 0.013
protein secretion GO:0009306 98 0.013
cytosolic calcium ion homeostasis GO:0051480 89 0.013
circulatory system process GO:0003013 113 0.013
extracellular structure organization GO:0043062 41 0.013
response to radiation GO:0009314 151 0.013
negative regulation of nucleoside metabolic process GO:0045978 18 0.013
cation transport GO:0006812 331 0.013
negative regulation of cell death GO:0060548 345 0.013
positive regulation of cellular component movement GO:0051272 181 0.013
positive regulation of cytokine production GO:0001819 167 0.013
actin filament based movement GO:0030048 17 0.012
myosin filament assembly GO:0031034 2 0.012
regulation of gtp catabolic process GO:0033124 180 0.012
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.012
monocarboxylic acid biosynthetic process GO:0072330 67 0.012
purine nucleoside catabolic process GO:0006152 398 0.012
calcium mediated signaling GO:0019722 44 0.012
positive regulation of axon extension GO:0045773 4 0.012
wnt protein secretion GO:0061355 1 0.012
regulation of anatomical structure morphogenesis GO:0022603 286 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
organonitrogen compound biosynthetic process GO:1901566 200 0.012
glycerophospholipid biosynthetic process GO:0046474 40 0.012
cytokine secretion GO:0050663 64 0.012
negative regulation of cell cycle GO:0045786 193 0.012
positive regulation of cellular component organization GO:0051130 376 0.012
protein targeting GO:0006605 187 0.012
regulation of vasculature development GO:1901342 97 0.012
positive regulation of secretion GO:0051047 116 0.012
regulation of metal ion transport GO:0010959 120 0.012
phospholipid metabolic process GO:0006644 99 0.012
phospholipid biosynthetic process GO:0008654 44 0.012
glycosyl compound catabolic process GO:1901658 413 0.012
cellular protein complex assembly GO:0043623 188 0.012
unsaturated fatty acid biosynthetic process GO:0006636 21 0.012
blood vessel morphogenesis GO:0048514 162 0.012
cellular response to dna damage stimulus GO:0006974 379 0.012
membrane organization GO:0061024 292 0.012
cell chemotaxis GO:0060326 112 0.012
regulation of cellular response to stress GO:0080135 244 0.011
nitrogen compound transport GO:0071705 191 0.011
negative regulation of rho gtpase activity GO:0034259 4 0.011
peptidyl serine modification GO:0018209 106 0.011
regulation of transmembrane transport GO:0034762 139 0.011
negative regulation of cell migration GO:0030336 102 0.011
chemical homeostasis GO:0048878 306 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
single organism cell adhesion GO:0098602 179 0.011
signal transduction by p53 class mediator GO:0072331 72 0.011
peripheral nervous system development GO:0007422 2 0.011
positive regulation of catabolic process GO:0009896 310 0.011
liposaccharide metabolic process GO:1903509 27 0.011
striated muscle contraction GO:0006941 52 0.011
vitamin transmembrane transport GO:0035461 4 0.011
regulation of intracellular transport GO:0032386 195 0.011
cellular macromolecule catabolic process GO:0044265 380 0.011
ion homeostasis GO:0050801 230 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.011
maintenance of location in cell GO:0051651 62 0.011
cell part morphogenesis GO:0032990 137 0.011
striated muscle myosin thick filament assembly GO:0071688 2 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
blood vessel development GO:0001568 172 0.011
cellular macromolecular complex assembly GO:0034622 324 0.011
response to abiotic stimulus GO:0009628 336 0.011
macrophage chemotaxis GO:0048246 10 0.011
cardiac muscle cell contraction GO:0086003 4 0.011
cell cycle arrest GO:0007050 71 0.011
organic acid biosynthetic process GO:0016053 97 0.011
regulation of cytokine secretion GO:0050707 57 0.011
chemotaxis GO:0006935 157 0.011
regulation of protein processing GO:0070613 150 0.010
regulation of smooth muscle cell proliferation GO:0048660 28 0.010
stress activated protein kinase signaling cascade GO:0031098 94 0.010
reactive oxygen species metabolic process GO:0072593 75 0.010
negative regulation of cell cycle process GO:0010948 121 0.010
epithelial cell proliferation GO:0050673 128 0.010
skeletal system development GO:0001501 79 0.010
Mouse
positive regulation of mitochondrion organization GO:0010822 30 0.010
skin development GO:0043588 76 0.010
oogenesis GO:0048477 2 0.010
negative regulation of proteolysis GO:0045861 132 0.010
system process GO:0003008 349 0.010
regulation of protein kinase b signaling GO:0051896 61 0.010

VKORC1 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.124
connective tissue disease DOID:65 109 0.124
immune system disease DOID:2914 155 0.108
osteochondrodysplasia DOID:2256 35 0.050
osteogenesis imperfecta DOID:12347 13 0.050
bone development disease DOID:0080006 55 0.050
bone disease DOID:0080001 88 0.050
hematopoietic system disease DOID:74 100 0.032
disease of metabolism DOID:0014667 295 0.019
carbohydrate metabolic disorder DOID:2978 55 0.019
inherited metabolic disorder DOID:655 242 0.019
central nervous system disease DOID:331 186 0.014
nervous system disease DOID:863 431 0.014