|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.997
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.993
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.992
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.991
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.991
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.987
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.985
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.984
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.982
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.980
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.977
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.973
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.967
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.965
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.965
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.955
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.953
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.950
|
|
|
|
i kappab phosphorylation
|
GO:0007252 |
7 |
0.940
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.933
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.928
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.926
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.925
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.917
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.914
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.912
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.909
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.907
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.902
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.901
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.899
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.898
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.897
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.888
|
Fly |
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.888
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.887
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.885
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.884
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.883
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.878
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.878
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.877
|
Fly |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.873
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.873
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.871
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.867
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.863
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.855
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.851
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.846
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.845
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.838
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.838
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.828
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.826
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.819
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.819
|
Fly |
|
|
protein processing
|
GO:0016485 |
226 |
0.817
|
|
|
|
cerebral cortex radially oriented cell migration
|
GO:0021799 |
1 |
0.811
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.806
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.805
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.805
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.797
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.796
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.789
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.783
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.779
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.779
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.778
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.776
|
|
|
|
desensitization of g protein coupled receptor protein signaling pathway by arrestin
|
GO:0002032 |
2 |
0.772
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.770
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.766
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.764
|
Fly |
|
|
negative regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014067 |
4 |
0.763
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.760
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.753
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.748
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.746
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.745
|
|
|
|
positive regulation of neuron migration
|
GO:2001224 |
1 |
0.740
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.739
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.739
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.738
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.733
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.730
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.726
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.722
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.716
|
|
|
|
positive regulation of rho protein signal transduction
|
GO:0035025 |
4 |
0.716
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.710
|
Fly |
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.704
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.698
|
|
|
|
internal protein amino acid acetylation
|
GO:0006475 |
101 |
0.698
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.693
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.689
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.686
|
|
|
|
cerebral cortex cell migration
|
GO:0021795 |
3 |
0.677
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.675
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.673
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.672
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.660
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.657
|
|
|
|
negative regulation of cyclin catabolic process
|
GO:2000599 |
3 |
0.656
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.656
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.648
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.647
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.647
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.645
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.642
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.641
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.632
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.632
|
|
|
|
pallium development
|
GO:0021543 |
10 |
0.631
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.629
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.627
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.626
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.622
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.618
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.614
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
49 |
0.614
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.611
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.607
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.603
|
|
|
|
positive regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903052 |
35 |
0.598
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.598
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.596
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.595
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.593
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.589
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.582
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.582
|
Fly |
|
|
negative regulation of cellular response to growth factor stimulus
|
GO:0090288 |
41 |
0.570
|
|
|
|
response to epidermal growth factor
|
GO:0070849 |
14 |
0.569
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.566
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.564
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.556
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.556
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.552
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.550
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.550
|
|
|
|
positive regulation of cell cycle process
|
GO:0090068 |
106 |
0.548
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.548
|
|
|
|
arf protein signal transduction
|
GO:0032011 |
0 |
0.546
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.540
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.538
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.536
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.533
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.532
|
|
|
|
negative regulation of canonical wnt signaling pathway
|
GO:0090090 |
55 |
0.531
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.531
|
|
|
|
growth
|
GO:0040007 |
202 |
0.529
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.529
|
|
|
|
cerebral cortex development
|
GO:0021987 |
10 |
0.527
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.523
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.520
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.518
|
|
|
|
regulation of epithelial to mesenchymal transition
|
GO:0010717 |
37 |
0.518
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.513
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.510
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.510
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.507
|
|
|
|
regulation of endothelial cell migration
|
GO:0010594 |
67 |
0.503
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.502
|
|
|
|
activation of mapkkk activity
|
GO:0000185 |
7 |
0.499
|
|
|
|
camp biosynthetic process
|
GO:0006171 |
47 |
0.499
|
|
|
|
negative adaptation of signaling pathway
|
GO:0022401 |
7 |
0.498
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.497
|
|
|
|
g protein coupled receptor internalization
|
GO:0002031 |
6 |
0.494
|
|
|
|
system process
|
GO:0003008 |
349 |
0.489
|
|
|
|
peptidyl lysine modification
|
GO:0018205 |
144 |
0.487
|
|
|
|
cellular response to interleukin 1
|
GO:0071347 |
35 |
0.486
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.480
|
|
|
|
chemotaxis
|
GO:0006935 |
157 |
0.477
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.475
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.474
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.466
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.466
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.463
|
|
|
|
positive regulation of proteasomal protein catabolic process
|
GO:1901800 |
35 |
0.459
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.458
|
|
|
|
negative regulation of vasculature development
|
GO:1901343 |
43 |
0.458
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.458
|
|
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
37 |
0.456
|
|
|
|
cellular response to vascular endothelial growth factor stimulus
|
GO:0035924 |
26 |
0.453
|
|
|
|
forebrain development
|
GO:0030900 |
26 |
0.451
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.451
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.449
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.445
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
23 |
0.445
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.444
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.442
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.441
|
|
|
|
regulation of neuron migration
|
GO:2001222 |
3 |
0.434
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.433
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.429
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.428
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.425
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.418
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.418
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.416
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.412
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.410
|
Fly |
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.405
|
|
|
|
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
|
GO:0070059 |
12 |
0.405
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.404
|
|
|
|
cerebral cortex radial glia guided migration
|
GO:0021801 |
1 |
0.399
|
|
|
|
regulation of arf protein signal transduction
|
GO:0032012 |
1 |
0.394
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.394
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.387
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.387
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.386
|
|
|
|
histone acetylation
|
GO:0016573 |
93 |
0.385
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.380
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.378
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.376
|
|
|
|
mesenchymal cell development
|
GO:0014031 |
50 |
0.370
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.370
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.367
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.365
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.364
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.363
|
|
|
|
negative regulation of cellular response to vascular endothelial growth factor stimulus
|
GO:1902548 |
3 |
0.359
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.358
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.354
|
|
|
|
regulation of vascular endothelial growth factor signaling pathway
|
GO:1900746 |
6 |
0.354
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.353
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.349
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.346
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.345
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.344
|
|
|
|
histone h4 acetylation
|
GO:0043967 |
47 |
0.340
|
|
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.340
|
|
|
|
desensitization of g protein coupled receptor protein signaling pathway
|
GO:0002029 |
7 |
0.331
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.328
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.322
|
|
|
|
activation of innate immune response
|
GO:0002218 |
55 |
0.318
|
|
|
|
regulation of cellular response to vascular endothelial growth factor stimulus
|
GO:1902547 |
7 |
0.317
|
|
|
|
cellular response to radiation
|
GO:0071478 |
65 |
0.316
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.315
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.315
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.313
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.311
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.311
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.310
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.310
|
|
|
|
negative regulation of purine nucleotide metabolic process
|
GO:1900543 |
28 |
0.298
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.296
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.295
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.287
|
|
|
|
p38mapk cascade
|
GO:0038066 |
9 |
0.287
|
|
|
|
regulation of behavior
|
GO:0050795 |
82 |
0.287
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.286
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.284
|
|
|
|
negative regulation of blood vessel morphogenesis
|
GO:2000181 |
41 |
0.284
|
|
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.283
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.281
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.278
|
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.277
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.276
|
|
|
|
internal peptidyl lysine acetylation
|
GO:0018393 |
97 |
0.275
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.275
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.274
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.274
|
|
|
|
stabilization of membrane potential
|
GO:0030322 |
1 |
0.272
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.270
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.270
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.269
|
|
|
|
protein acylation
|
GO:0043543 |
138 |
0.267
|
|
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.267
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.267
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.264
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.257
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.257
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.254
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.253
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.253
|
|
|
|
peptide hormone secretion
|
GO:0030072 |
50 |
0.252
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.252
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.250
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.249
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.247
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.245
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.242
|
|
|
|
negative regulation of catenin import into nucleus
|
GO:0035414 |
7 |
0.240
|
|
|
|
negative regulation of g0 to g1 transition
|
GO:0070317 |
2 |
0.239
|
|
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.239
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.236
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.234
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.233
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.232
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.231
|
|
|
|
regulation of activation of jak2 kinase activity
|
GO:0010534 |
5 |
0.231
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.230
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.228
|
|
|
|
actin filament based movement
|
GO:0030048 |
17 |
0.227
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.226
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.225
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.223
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.222
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.222
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.219
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.218
|
|
|
|
negative regulation of lipid metabolic process
|
GO:0045833 |
38 |
0.217
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.216
|
|
|
|
negative regulation of cytoplasmic transport
|
GO:1903650 |
46 |
0.212
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.211
|
|
|
|
fibroblast proliferation
|
GO:0048144 |
33 |
0.210
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.210
|
|
|
|
negative regulation of epithelial cell migration
|
GO:0010633 |
38 |
0.210
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
48 |
0.209
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.209
|
|
|
|
activation of janus kinase activity
|
GO:0042976 |
7 |
0.207
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.205
|
|
|
|
negative regulation of cell growth
|
GO:0030308 |
83 |
0.203
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.202
|
|
|
|
hormone secretion
|
GO:0046879 |
65 |
0.202
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.201
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.199
|
|
|
|
epithelial to mesenchymal transition
|
GO:0001837 |
48 |
0.197
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.197
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.197
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
92 |
0.196
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.196
|
|
|
|
regulation of vasculature development
|
GO:1901342 |
97 |
0.196
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.195
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.194
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.192
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.190
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.190
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.190
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.189
|
|
|
|
mesenchyme development
|
GO:0060485 |
59 |
0.189
|
|
|
|
head development
|
GO:0060322 |
108 |
0.187
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.186
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.185
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.184
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.183
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.182
|
|
|
|
negative regulation of endothelial cell migration
|
GO:0010596 |
29 |
0.182
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.181
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.178
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.178
|
|
|
|
sensory perception
|
GO:0007600 |
103 |
0.177
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.177
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.176
|
|
|
|
forebrain generation of neurons
|
GO:0021872 |
3 |
0.176
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.176
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.173
|
|
|
|
protein acetylation
|
GO:0006473 |
116 |
0.173
|
|
|
|
regulation of g protein coupled receptor protein signaling pathway
|
GO:0008277 |
35 |
0.173
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.172
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.168
|
|
|
|
peptidyl lysine acetylation
|
GO:0018394 |
101 |
0.166
|
|
|
|
response to axon injury
|
GO:0048678 |
1 |
0.163
|
|
|
|
mrna metabolic process
|
GO:0016071 |
175 |
0.163
|
|
|
|
phototransduction
|
GO:0007602 |
3 |
0.163
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.160
|
|
|
|
activation of mapkk activity
|
GO:0000186 |
18 |
0.160
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.159
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.159
|
|
|
|
negative regulation of stem cell differentiation
|
GO:2000737 |
22 |
0.159
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.155
|
|
|
|
telencephalon cell migration
|
GO:0022029 |
4 |
0.154
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.153
|
|
|
|
negative regulation of angiogenesis
|
GO:0016525 |
39 |
0.153
|
|
|
|
negative regulation of cell motility
|
GO:2000146 |
104 |
0.152
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.151
|
|
|
|
mesenchymal cell differentiation
|
GO:0048762 |
52 |
0.151
|
|
|
|
hormone transport
|
GO:0009914 |
68 |
0.150
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.147
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.147
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.147
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.146
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.146
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.146
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.145
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.145
|
|
|
|
dendrite development
|
GO:0016358 |
24 |
0.144
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.144
|
|
|
|
long term memory
|
GO:0007616 |
2 |
0.142
|
|
|
|
vascular endothelial growth factor signaling pathway
|
GO:0038084 |
15 |
0.142
|
|
|
|
activation of jak2 kinase activity
|
GO:0042977 |
5 |
0.142
|
|
|
|
response to interferon gamma
|
GO:0034341 |
39 |
0.142
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.141
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
44 |
0.141
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.141
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.141
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.139
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.138
|
|
|
|
negative regulation of cellular component movement
|
GO:0051271 |
106 |
0.136
|
|
|
|
spliceosomal snrnp assembly
|
GO:0000387 |
28 |
0.136
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.135
|
|
|
|
vascular endothelial growth factor receptor signaling pathway
|
GO:0048010 |
19 |
0.134
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.133
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
102 |
0.133
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.133
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.131
|
|
|
|
positive regulation of hormone secretion
|
GO:0046887 |
25 |
0.129
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.129
|
|
|
|
regulation of fibroblast proliferation
|
GO:0048145 |
32 |
0.128
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.125
|
|
|
|
cyclin catabolic process
|
GO:0008054 |
6 |
0.125
|
|
|
|
negative regulation of wnt signaling pathway
|
GO:0030178 |
69 |
0.124
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
61 |
0.124
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.124
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.124
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.123
|
|
|
|
cell chemotaxis
|
GO:0060326 |
112 |
0.122
|
|
|
|
negative regulation of nucleotide catabolic process
|
GO:0030812 |
16 |
0.122
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.121
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.120
|
|
|
|
sensory perception of pain
|
GO:0019233 |
4 |
0.119
|
|
|
|
regulation of lipid biosynthetic process
|
GO:0046890 |
47 |
0.119
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.118
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.118
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.118
|
|
|
|
cell migration involved in gastrulation
|
GO:0042074 |
1 |
0.116
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.116
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.116
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.116
|
|
|
|
detection of stimulus
|
GO:0051606 |
85 |
0.116
|
|
|
|
regulation of activation of janus kinase activity
|
GO:0010533 |
6 |
0.115
|
|
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.115
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.114
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.114
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.112
|
|
|
|
negative regulation of binding
|
GO:0051100 |
57 |
0.112
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.112
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.111
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.111
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.111
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.110
|
|
|
|
epidermis development
|
GO:0008544 |
59 |
0.110
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.109
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.109
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.109
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.108
|
|
|
|
hemostasis
|
GO:0007599 |
76 |
0.108
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.108
|
|
|
|
blood circulation
|
GO:0008015 |
113 |
0.107
|
|
|
|
negative regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042518 |
2 |
0.107
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.107
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.106
|
|
|
|
circulatory system process
|
GO:0003013 |
113 |
0.105
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.105
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.105
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.105
|
|
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.104
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.103
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.103
|
|
|
|
cellular response to hydrogen peroxide
|
GO:0070301 |
37 |
0.103
|
|
|
|
coagulation
|
GO:0050817 |
78 |
0.101
|
|
|
|
negative regulation of nucleoside metabolic process
|
GO:0045978 |
18 |
0.100
|
|
|
|
negative regulation of nucleotide metabolic process
|
GO:0045980 |
29 |
0.100
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.098
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.098
|
|
|
|
negative regulation of intracellular protein transport
|
GO:0090317 |
42 |
0.098
|
|
|
|
activation of jun kinase activity
|
GO:0007257 |
7 |
0.098
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
56 |
0.098
|
|
|
|
negative regulation of fibroblast proliferation
|
GO:0048147 |
12 |
0.098
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.098
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.097
|
Mouse |
|
|
glucose homeostasis
|
GO:0042593 |
31 |
0.097
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
57 |
0.096
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.095
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.094
|
|
|
|
hair follicle morphogenesis
|
GO:0031069 |
2 |
0.094
|
|
|
|
regulation of toll like receptor signaling pathway
|
GO:0034121 |
17 |
0.093
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.092
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
25 |
0.092
|
|
|
|
cellular senescence
|
GO:0090398 |
34 |
0.091
|
|
|
|
regulation of feeding behavior
|
GO:0060259 |
3 |
0.089
|
|
|
|
memory
|
GO:0007613 |
3 |
0.089
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.089
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.087
|
|
|
|
regulation of receptor mediated endocytosis
|
GO:0048259 |
32 |
0.087
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.086
|
|
|
|
negative regulation of epidermal growth factor receptor signaling pathway
|
GO:0042059 |
11 |
0.086
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.085
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.084
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.084
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.083
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.083
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.083
|
|
|
|
regulation of catenin import into nucleus
|
GO:0035412 |
18 |
0.082
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.082
|
|
|
|
negative regulation of gtpase activity
|
GO:0034260 |
11 |
0.082
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.082
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.081
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.081
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.080
|
|
|
|
cellular response to decreased oxygen levels
|
GO:0036294 |
51 |
0.080
|
|
|
|
intrinsic apoptotic signaling pathway in response to oxidative stress
|
GO:0008631 |
21 |
0.080
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.080
|
|
|
|
regulation of g0 to g1 transition
|
GO:0070316 |
2 |
0.080
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.079
|
|
|
|
negative regulation of vascular endothelial growth factor receptor signaling pathway
|
GO:0030948 |
3 |
0.079
|
|
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.079
|
|
|
|
regulation of tyrosine phosphorylation of stat protein
|
GO:0042509 |
30 |
0.079
|
|
