Homo sapiens

0 known processes

CASZ1

castor zinc finger 1

(Aliases: SRG,FLJ12223,dJ734G22.1,CST,FLJ20321,ZNF693)

CASZ1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.068
Fly
regulation of anatomical structure morphogenesis GO:0022603 286 0.062
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.059
epithelium development GO:0060429 227 0.052
purine nucleoside triphosphate metabolic process GO:0009144 412 0.052
organ morphogenesis GO:0009887 147 0.051
cellular ketone metabolic process GO:0042180 80 0.050
regulation of cellular ketone metabolic process GO:0010565 50 0.047
cellular amino acid metabolic process GO:0006520 116 0.045
purine nucleotide catabolic process GO:0006195 405 0.044
negative regulation of cell proliferation GO:0008285 228 0.044
nucleoside catabolic process GO:0009164 408 0.043
glycosyl compound catabolic process GO:1901658 413 0.043
regulation of cellular amine metabolic process GO:0033238 11 0.042
purine nucleoside catabolic process GO:0006152 398 0.042
nucleoside phosphate catabolic process GO:1901292 412 0.042
small gtpase mediated signal transduction GO:0007264 78 0.041
cellular component morphogenesis GO:0032989 314 0.040
purine ribonucleoside metabolic process GO:0046128 437 0.040
mating GO:0007618 1 0.039
actin filament based process GO:0030029 224 0.039
regulation of transferase activity GO:0051338 355 0.039
positive regulation of cellular component organization GO:0051130 376 0.039
purine nucleoside triphosphate catabolic process GO:0009146 392 0.038
multicellular organismal aging GO:0010259 3 0.038
ribonucleoside triphosphate catabolic process GO:0009203 391 0.037
regulation of cellular amino acid metabolic process GO:0006521 6 0.036
female gamete generation GO:0007292 2 0.036
cell morphogenesis GO:0000902 296 0.035
morphogenesis of embryonic epithelium GO:0016331 4 0.035
ras protein signal transduction GO:0007265 73 0.034
cell development GO:0048468 328 0.034
Fly
nervous system development GO:0007399 293 0.034
Fly
ribonucleoside catabolic process GO:0042454 406 0.033
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.033
cellular amine metabolic process GO:0044106 41 0.033
purine ribonucleoside catabolic process GO:0046130 398 0.033
locomotory behavior GO:0007626 1 0.033
anatomical structure formation involved in morphogenesis GO:0048646 284 0.032
ribonucleotide catabolic process GO:0009261 405 0.032
segmentation GO:0035282 4 0.032
purine containing compound catabolic process GO:0072523 411 0.032
guanosine containing compound metabolic process GO:1901068 244 0.031
regulation of cell differentiation GO:0045595 393 0.031
metal ion transport GO:0030001 272 0.031
neuromuscular junction development GO:0007528 3 0.031
response to abiotic stimulus GO:0009628 336 0.031
nucleotide catabolic process GO:0009166 408 0.030
determination of adult lifespan GO:0008340 2 0.030
ribonucleoside triphosphate metabolic process GO:0009199 412 0.030
negative regulation of multicellular organismal process GO:0051241 317 0.030
circulatory system development GO:0072359 262 0.030
purine ribonucleotide catabolic process GO:0009154 404 0.030
regulation of cellular component movement GO:0051270 334 0.030
epidermis morphogenesis GO:0048730 3 0.030
amine metabolic process GO:0009308 44 0.030
nucleoside triphosphate metabolic process GO:0009141 422 0.029
nucleoside triphosphate catabolic process GO:0009143 394 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.029
cellular response to dna damage stimulus GO:0006974 379 0.029
organophosphate catabolic process GO:0046434 430 0.028
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.027
regulation of kinase activity GO:0043549 314 0.027
cell projection organization GO:0030030 252 0.027
chromatin organization GO:0006325 351 0.027
positive regulation of catabolic process GO:0009896 310 0.027
memory GO:0007613 3 0.027
positive regulation of cellular catabolic process GO:0031331 284 0.026
regulation of purine nucleotide metabolic process GO:1900542 264 0.026
cardiovascular system development GO:0072358 262 0.026
embryonic epithelial tube formation GO:0001838 4 0.026
cellular macromolecular complex assembly GO:0034622 324 0.026
guanosine containing compound catabolic process GO:1901069 239 0.026
negative regulation of phosphorus metabolic process GO:0010563 267 0.025
regulation of cell cycle GO:0051726 393 0.025
protein catabolic process GO:0030163 325 0.025
actin cytoskeleton organization GO:0030036 207 0.025
negative regulation of catalytic activity GO:0043086 335 0.025
dephosphorylation GO:0016311 209 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
regulation of nucleotide metabolic process GO:0006140 269 0.025
gtp catabolic process GO:0006184 237 0.024
regulation of protein kinase activity GO:0045859 289 0.024
negative regulation of cellular protein metabolic process GO:0032269 353 0.024
enzyme linked receptor protein signaling pathway GO:0007167 303 0.024
negative regulation of cellular component organization GO:0051129 235 0.024
histone modification GO:0016570 251 0.024
positive regulation of immune system process GO:0002684 283 0.024
system process GO:0003008 349 0.024
positive regulation of hydrolase activity GO:0051345 331 0.023
negative regulation of cell death GO:0060548 345 0.023
membrane organization GO:0061024 292 0.023
single organism cellular localization GO:1902580 332 0.023
positive regulation of cellular amine metabolic process GO:0033240 7 0.023
cellular lipid metabolic process GO:0044255 303 0.023
cell adhesion GO:0007155 325 0.023
covalent chromatin modification GO:0016569 254 0.023
regulation of locomotion GO:0040012 329 0.023
signal transduction by phosphorylation GO:0023014 297 0.023
rho protein signal transduction GO:0007266 26 0.023
ion homeostasis GO:0050801 230 0.022
response to oxygen containing compound GO:1901700 369 0.022
positive regulation of nucleoside metabolic process GO:0045979 186 0.022
gtp metabolic process GO:0046039 239 0.022
oocyte development GO:0048599 1 0.022
tissue morphogenesis GO:0048729 96 0.022
peripheral nervous system development GO:0007422 2 0.022
cell fate determination GO:0001709 3 0.022
positive regulation of nucleotide metabolic process GO:0045981 230 0.022
positive regulation of phosphorylation GO:0042327 394 0.022
regulation of cell development GO:0060284 161 0.022
organelle assembly GO:0070925 176 0.022
inorganic ion transmembrane transport GO:0098660 231 0.021
chemical homeostasis GO:0048878 306 0.021
negative regulation of phosphate metabolic process GO:0045936 267 0.021
positive regulation of developmental process GO:0051094 314 0.021
negative regulation of protein metabolic process GO:0051248 391 0.021
lipid metabolic process GO:0006629 381 0.021
cation transport GO:0006812 331 0.021
regeneration GO:0031099 4 0.021
mitotic cell cycle GO:0000278 326 0.021
cellular response to endogenous stimulus GO:0071495 336 0.021
regulation of gtpase activity GO:0043087 180 0.021
mapk cascade GO:0000165 288 0.021
regulation of purine nucleotide catabolic process GO:0033121 205 0.021
regulation of cell motility GO:2000145 299 0.020
regulation of cellular component biogenesis GO:0044087 281 0.020
regulation of nucleotide catabolic process GO:0030811 205 0.020
positive regulation of nucleotide catabolic process GO:0030813 185 0.020
regulation of nucleoside metabolic process GO:0009118 209 0.020
chromatin modification GO:0016568 298 0.020
negative regulation of developmental process GO:0051093 247 0.020
cell division GO:0051301 168 0.020
cell morphogenesis involved in differentiation GO:0000904 144 0.020
regulation of response to external stimulus GO:0032101 222 0.020
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.020
negative regulation of apoptotic process GO:0043066 316 0.020
blastoderm segmentation GO:0007350 2 0.020
mitotic cell cycle process GO:1903047 286 0.020
regulation of cellular response to stress GO:0080135 244 0.020
cation transmembrane transport GO:0098655 238 0.020
organ formation GO:0048645 3 0.020
negative regulation of programmed cell death GO:0043069 321 0.020
apoptotic signaling pathway GO:0097190 268 0.020
growth GO:0040007 202 0.019
cranial nerve development GO:0021545 4 0.019
biological adhesion GO:0022610 331 0.019
positive regulation of ras gtpase activity GO:0032320 117 0.019
oogenesis GO:0048477 2 0.019
immune system development GO:0002520 195 0.019
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
negative regulation of phosphorylation GO:0042326 174 0.019
organic hydroxy compound metabolic process GO:1901615 147 0.019
positive regulation of gtpase activity GO:0043547 166 0.019
cellular macromolecule catabolic process GO:0044265 380 0.018
single organism membrane organization GO:0044802 268 0.018
hindbrain development GO:0030902 3 0.018
stem cell division GO:0017145 2 0.018
regulation of cytoskeleton organization GO:0051493 177 0.018
positive regulation of protein kinase activity GO:0045860 190 0.018
regulation of neural precursor cell proliferation GO:2000177 4 0.018
anterior posterior axis specification GO:0009948 2 0.018
monovalent inorganic cation transport GO:0015672 128 0.018
rhythmic behavior GO:0007622 2 0.018
protein ubiquitination GO:0016567 314 0.018
epithelial cell differentiation GO:0030855 141 0.018
regulation of mitotic cell cycle GO:0007346 189 0.018
neuroblast proliferation GO:0007405 4 0.018
cellular protein complex assembly GO:0043623 188 0.018
cellular protein catabolic process GO:0044257 261 0.018
regulation of gtp catabolic process GO:0033124 180 0.018
cytoplasmic transport GO:0016482 379 0.018
vesicle mediated transport GO:0016192 371 0.018
regulation of small gtpase mediated signal transduction GO:0051056 156 0.017
epidermis development GO:0008544 59 0.017
cellular response to oxygen containing compound GO:1901701 276 0.017
microtubule based process GO:0007017 210 0.017
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.017
regulation of cell cycle process GO:0010564 266 0.017
positive regulation of transferase activity GO:0051347 227 0.017
immune response GO:0006955 307 0.017
vasculature development GO:0001944 181 0.017
positive regulation of gtp catabolic process GO:0033126 166 0.017
modification dependent protein catabolic process GO:0019941 209 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.017
cellular homeostasis GO:0019725 196 0.017
epithelial cell proliferation GO:0050673 128 0.017
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.017
negative regulation of protein modification process GO:0031400 200 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
positive regulation of cell death GO:0010942 263 0.017
regulation of cell migration GO:0030334 289 0.017
ubiquitin dependent protein catabolic process GO:0006511 206 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.017
response to organic cyclic compound GO:0014070 204 0.016
positive regulation of cell proliferation GO:0008284 301 0.016
compound eye development GO:0048749 1 0.016
circadian behavior GO:0048512 2 0.016
modification dependent macromolecule catabolic process GO:0043632 212 0.016
oocyte differentiation GO:0009994 2 0.016
neuron fate commitment GO:0048663 2 0.016
carbohydrate metabolic process GO:0005975 207 0.016
establishment of protein localization to membrane GO:0090150 121 0.016
cell part morphogenesis GO:0032990 137 0.016
regulation of cell morphogenesis GO:0022604 153 0.016
regulation of ras protein signal transduction GO:0046578 155 0.016
positive regulation of cell differentiation GO:0045597 211 0.016
positive regulation of kinase activity GO:0033674 204 0.016
regulation of ras gtpase activity GO:0032318 128 0.016
cardiac muscle cell contraction GO:0086003 4 0.016
wnt signaling pathway GO:0016055 156 0.016
posttranscriptional regulation of gene expression GO:0010608 213 0.015
nerve development GO:0021675 4 0.015
cell projection morphogenesis GO:0048858 129 0.015
neuron differentiation GO:0030182 138 0.015
tube development GO:0035295 125 0.015
positive regulation of programmed cell death GO:0043068 249 0.015
behavior GO:0007610 112 0.015
protein maturation GO:0051604 233 0.015
microtubule cytoskeleton organization GO:0000226 176 0.015
stem cell differentiation GO:0048863 93 0.015
Fly
dna repair GO:0006281 198 0.015
negative regulation of cell differentiation GO:0045596 171 0.015
central nervous system development GO:0007417 123 0.015
Fly
ameboidal type cell migration GO:0001667 135 0.015
associative learning GO:0008306 1 0.015
endomembrane system organization GO:0010256 196 0.015
regulation of mapk cascade GO:0043408 262 0.015
positive regulation of organelle organization GO:0010638 195 0.015
maintenance of location GO:0051235 112 0.015
positive regulation of transport GO:0051050 336 0.015
defense response GO:0006952 315 0.015
regulation of growth GO:0040008 165 0.015
anterior posterior axis specification embryo GO:0008595 2 0.015
intracellular protein transport GO:0006886 270 0.015
positive regulation of protein phosphorylation GO:0001934 313 0.014
inner ear morphogenesis GO:0042472 4 0.014
generation of neurons GO:0048699 152 0.014
Fly
metal ion homeostasis GO:0055065 169 0.014
protein modification by small protein conjugation GO:0032446 342 0.014
regulation of body fluid levels GO:0050878 99 0.014
blood vessel morphogenesis GO:0048514 162 0.014
regulation of hormone levels GO:0010817 125 0.014
motor neuron axon guidance GO:0008045 2 0.014
protein processing GO:0016485 226 0.014
inorganic cation transmembrane transport GO:0098662 194 0.014
organonitrogen compound biosynthetic process GO:1901566 200 0.014
negative regulation of cell cycle GO:0045786 193 0.014
regulation of protein serine threonine kinase activity GO:0071900 179 0.014
regulation of neurogenesis GO:0050767 82 0.014
hemopoiesis GO:0030097 180 0.014
neural crest cell development GO:0014032 3 0.014
spermatid differentiation GO:0048515 4 0.014
response to lipid GO:0033993 206 0.014
tripartite regional subdivision GO:0007351 2 0.014
transmembrane transport GO:0055085 399 0.014
response to inorganic substance GO:0010035 127 0.014
oxidation reduction process GO:0055114 396 0.013
actin filament based movement GO:0030048 17 0.013
embryo development GO:0009790 123 0.013
negative regulation of cell migration GO:0030336 102 0.013
stem cell development GO:0048864 69 0.013
Fly
regulation of stem cell differentiation GO:2000736 56 0.013
single organism carbohydrate metabolic process GO:0044723 193 0.013
blood vessel development GO:0001568 172 0.013
organophosphate biosynthetic process GO:0090407 163 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
cytokine production GO:0001816 247 0.013
hematopoietic or lymphoid organ development GO:0048534 186 0.013
cell substrate adhesion GO:0031589 132 0.013
secretion by cell GO:0032940 226 0.013
response to biotic stimulus GO:0009607 276 0.013
regulation of protein localization GO:0032880 296 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.013
response to external biotic stimulus GO:0043207 261 0.013
head development GO:0060322 108 0.013
Fly
tissue migration GO:0090130 119 0.013
negative regulation of cell motility GO:2000146 104 0.013
regulation of protein transport GO:0051223 213 0.013
regulation of cell projection organization GO:0031344 107 0.013
response to oxidative stress GO:0006979 121 0.013
cell projection assembly GO:0030031 126 0.013
rna processing GO:0006396 255 0.013
cellular cation homeostasis GO:0030003 163 0.013
protein localization to organelle GO:0033365 280 0.013
negative regulation of organelle organization GO:0010639 126 0.013
reactive nitrogen species metabolic process GO:2001057 3 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.013
morphogenesis of a polarized epithelium GO:0001738 3 0.013
sex determination GO:0007530 3 0.013
protein targeting GO:0006605 187 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.013
regulation of secretion by cell GO:1903530 177 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
blastocyst development GO:0001824 3 0.013
reproductive process GO:0022414 106 0.012
protein localization to membrane GO:0072657 160 0.012
angiogenesis GO:0001525 147 0.012
spermatid development GO:0007286 4 0.012
cell cycle phase transition GO:0044770 173 0.012
myeloid cell differentiation GO:0030099 117 0.012
embryonic morphogenesis GO:0048598 85 0.012
skin development GO:0043588 76 0.012
cation homeostasis GO:0055080 189 0.012
photoreceptor cell differentiation GO:0046530 2 0.012
small molecule biosynthetic process GO:0044283 157 0.012
nitrogen compound transport GO:0071705 191 0.012
neural tube formation GO:0001841 3 0.012
ion transmembrane transport GO:0034220 338 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
pattern specification process GO:0007389 43 0.012
cell activation GO:0001775 213 0.012
positive regulation of locomotion GO:0040017 186 0.012
regulation of actin cytoskeleton organization GO:0032956 116 0.012
myosin filament assembly GO:0031034 2 0.012
asymmetric stem cell division GO:0098722 1 0.012
salivary gland morphogenesis GO:0007435 4 0.012
regulation of meiotic cell cycle GO:0051445 4 0.012
response to wounding GO:0009611 168 0.012
endocytosis GO:0006897 159 0.012
regulation of protein catabolic process GO:0042176 155 0.012
syncytium formation by plasma membrane fusion GO:0000768 2 0.012
negative regulation of locomotion GO:0040013 118 0.012
cellular metal ion homeostasis GO:0006875 146 0.012
epithelium migration GO:0090132 119 0.012
regulation of cell division GO:0051302 116 0.012
lipid biosynthetic process GO:0008610 177 0.012
single organism cell adhesion GO:0098602 179 0.012
stress activated protein kinase signaling cascade GO:0031098 94 0.012
cell growth GO:0016049 160 0.012
response to oxygen levels GO:0070482 100 0.012
regulation of secretion GO:0051046 194 0.012
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.012
cellular chemical homeostasis GO:0055082 180 0.012
cell differentiation in spinal cord GO:0021515 1 0.011
negative regulation of protein kinase activity GO:0006469 98 0.011
carbohydrate derivative biosynthetic process GO:1901137 207 0.011
canonical wnt signaling pathway GO:0060070 116 0.011
visual behavior GO:0007632 2 0.011
positive regulation of cell cycle GO:0045787 140 0.011
response to growth factor GO:0070848 205 0.011
somatic stem cell division GO:0048103 1 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.011
regulation of dephosphorylation GO:0035303 96 0.011
regulation of proteolysis GO:0030162 293 0.011
innate immune response GO:0045087 178 0.011
tissue regeneration GO:0042246 3 0.011
regulation of cytokine production GO:0001817 232 0.011
peptidyl lysine modification GO:0018205 144 0.011
somitogenesis GO:0001756 2 0.011
regulation of cell adhesion GO:0030155 166 0.011
cellular component assembly involved in morphogenesis GO:0010927 73 0.011
neuron projection development GO:0031175 106 0.011
response to nitrogen compound GO:1901698 184 0.011
myoblast fusion GO:0007520 1 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.011
limbic system development GO:0021761 3 0.011
secretion GO:0046903 254 0.011
somatic stem cell maintenance GO:0035019 4 0.011
positive regulation of cell development GO:0010720 92 0.011
single organism reproductive process GO:0044702 98 0.011
morphogenesis of an epithelium GO:0002009 60 0.011
positive regulation of cellular component movement GO:0051272 181 0.011
actin mediated cell contraction GO:0070252 12 0.011
response to metal ion GO:0010038 84 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
neurogenesis GO:0022008 169 0.011
Fly
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.011
t cell differentiation in thymus GO:0033077 4 0.011
negative regulation of cellular component movement GO:0051271 106 0.011
cuticle development GO:0042335 1 0.011
regulation of vasculature development GO:1901342 97 0.011
tube morphogenesis GO:0035239 95 0.011
plasma membrane organization GO:0007009 115 0.011
regulation of actin filament based process GO:0032970 141 0.011
ribonucleoside monophosphate metabolic process GO:0009161 187 0.011
negative regulation of transport GO:0051051 176 0.011
neurological system process GO:0050877 163 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
adult locomotory behavior GO:0008344 1 0.011
response to axon injury GO:0048678 1 0.011
thymus development GO:0048538 3 0.011
primary neural tube formation GO:0014020 3 0.011
regulation of chromosome organization GO:0033044 103 0.011
brain development GO:0007420 97 0.011
Fly
cell cell signaling GO:0007267 155 0.011
regulation of protein maturation GO:1903317 150 0.011
hair follicle morphogenesis GO:0031069 2 0.011
embryonic placenta development GO:0001892 1 0.011
circulatory system process GO:0003013 113 0.011
regulation of nervous system development GO:0051960 88 0.011
positive regulation of mapk cascade GO:0043410 190 0.011
immune effector process GO:0002252 159 0.011
gland development GO:0048732 48 0.011
regulation of cell cycle phase transition GO:1901987 126 0.011
leukocyte activation GO:0045321 164 0.011
regulation of anatomical structure size GO:0090066 101 0.010
myosin filament organization GO:0031033 2 0.010
positive regulation of cell cycle process GO:0090068 106 0.010
regulation of protein processing GO:0070613 150 0.010
wound healing GO:0042060 115 0.010
cellular response to cytokine stimulus GO:0071345 181 0.010
positive regulation of secretion GO:0051047 116 0.010
negative regulation of proteolysis GO:0045861 132 0.010
regulation of apoptotic signaling pathway GO:2001233 175 0.010
protein localization to plasma membrane GO:0072659 93 0.010
regulation of epithelial cell proliferation GO:0050678 113 0.010
prostate gland development GO:0030850 3 0.010
spinal cord development GO:0021510 4 0.010
fatty acid metabolic process GO:0006631 115 0.010
response to other organism GO:0051707 261 0.010
response to radiation GO:0009314 151 0.010
regulation of protein complex assembly GO:0043254 147 0.010
mammary gland morphogenesis GO:0060443 2 0.010
embryonic camera type eye development GO:0031076 2 0.010
cytokinesis GO:0000910 96 0.010
cellular calcium ion homeostasis GO:0006874 117 0.010
regulation of axon guidance GO:1902667 3 0.010
response to fungus GO:0009620 4 0.010
long term memory GO:0007616 2 0.010
micturition GO:0060073 3 0.010
macromolecule methylation GO:0043414 97 0.010
peptidyl tyrosine modification GO:0018212 170 0.010
regulation of wnt signaling pathway GO:0030111 123 0.010
protein acylation GO:0043543 138 0.010
jnk cascade GO:0007254 80 0.010
developmental programmed cell death GO:0010623 3 0.010
response to hormone GO:0009725 175 0.010
regulation of cell growth GO:0001558 135 0.010

CASZ1 disease predictions

Disease DO term ID Size Probability Func Analog Org
sensory system disease DOID:0050155 203 0.021
nervous system disease DOID:863 431 0.021
musculoskeletal system disease DOID:17 223 0.018
disease of cellular proliferation DOID:14566 174 0.017
cancer DOID:162 167 0.017
organ system cancer DOID:0050686 164 0.017
disease of metabolism DOID:0014667 295 0.015
immune system disease DOID:2914 155 0.012
auditory system disease DOID:2742 53 0.012
central nervous system disease DOID:331 186 0.012
neurodegenerative disease DOID:1289 102 0.011