Homo sapiens

11 known processes

IDH2

isocitrate dehydrogenase 2 (NADP+), mitochondrial

(Aliases: D2HGA2,IDH,IDPM,mNADP-IDH,ICD-M,IDP,IDHM)

IDH2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxidation reduction process GO:0055114 396 0.456
carboxylic acid catabolic process GO:0046395 71 0.177
Yeast
lipid catabolic process GO:0016042 84 0.168
Yeast
cofactor metabolic process GO:0051186 87 0.132
small molecule catabolic process GO:0044282 92 0.123
Yeast
organic acid catabolic process GO:0016054 71 0.117
Yeast
fatty acid metabolic process GO:0006631 115 0.115
Yeast
cellular ketone metabolic process GO:0042180 80 0.115
single organism carbohydrate metabolic process GO:0044723 193 0.099
determination of adult lifespan GO:0008340 2 0.094
generation of precursor metabolites and energy GO:0006091 68 0.091
organic hydroxy compound metabolic process GO:1901615 147 0.085
carbohydrate metabolic process GO:0005975 207 0.074
regulation of hormone levels GO:0010817 125 0.071
energy derivation by oxidation of organic compounds GO:0015980 43 0.070
post embryonic development GO:0009791 2 0.069
cellular amino acid metabolic process GO:0006520 116 0.064
multicellular organismal aging GO:0010259 3 0.058
tricarboxylic acid cycle GO:0006099 4 0.057
cellular lipid catabolic process GO:0044242 65 0.056
Yeast
purine ribonucleoside metabolic process GO:0046128 437 0.053
monocarboxylic acid metabolic process GO:0032787 185 0.052
Yeast
lipid metabolic process GO:0006629 381 0.049
Yeast
isocitrate metabolic process GO:0006102 1 0.047
Human Yeast
nucleoside triphosphate metabolic process GO:0009141 422 0.042
negative regulation of transport GO:0051051 176 0.041
oogenesis GO:0048477 2 0.041
cellular lipid metabolic process GO:0044255 303 0.039
Yeast
regulation of secretion by cell GO:1903530 177 0.039
response to oxygen containing compound GO:1901700 369 0.037
nitrogen compound transport GO:0071705 191 0.036
ribonucleoside monophosphate metabolic process GO:0009161 187 0.036
regulation of secretion GO:0051046 194 0.036
purine nucleoside triphosphate metabolic process GO:0009144 412 0.034
ion transmembrane transport GO:0034220 338 0.034
amine metabolic process GO:0009308 44 0.034
cellular amine metabolic process GO:0044106 41 0.034
secretion by cell GO:0032940 226 0.034
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.033
negative regulation of programmed cell death GO:0043069 321 0.033
nervous system development GO:0007399 293 0.033
cellular carbohydrate metabolic process GO:0044262 84 0.032
regulation of hormone secretion GO:0046883 57 0.031
protein tetramerization GO:0051262 47 0.031
response to hormone GO:0009725 175 0.030
regulation of cellular amino acid metabolic process GO:0006521 6 0.030
secretion GO:0046903 254 0.030
citrate metabolic process GO:0006101 2 0.030
regulation of cellular amine metabolic process GO:0033238 11 0.029
negative regulation of catalytic activity GO:0043086 335 0.029
ribonucleoside triphosphate metabolic process GO:0009199 412 0.028
dephosphorylation GO:0016311 209 0.028
coenzyme metabolic process GO:0006732 65 0.028
cell development GO:0048468 328 0.028
organophosphate biosynthetic process GO:0090407 163 0.027
neuroblast proliferation GO:0007405 4 0.027
chemical homeostasis GO:0048878 306 0.027
organophosphate catabolic process GO:0046434 430 0.027
female gamete generation GO:0007292 2 0.027
carbohydrate derivative biosynthetic process GO:1901137 207 0.027
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
amide transport GO:0042886 76 0.026
steroid metabolic process GO:0008202 94 0.026
insulin secretion GO:0030073 39 0.026
signal release GO:0023061 70 0.025
protein oligomerization GO:0051259 173 0.025
regulation of cellular ketone metabolic process GO:0010565 50 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
positive regulation of cell death GO:0010942 263 0.024
doxorubicin metabolic process GO:0044598 8 0.024
negative regulation of protein metabolic process GO:0051248 391 0.024
biological adhesion GO:0022610 331 0.024
atp metabolic process GO:0046034 176 0.024
organic acid biosynthetic process GO:0016053 97 0.023
organelle assembly GO:0070925 176 0.023
response to activity GO:0014823 0 0.023
organonitrogen compound biosynthetic process GO:1901566 200 0.023
apoptotic signaling pathway GO:0097190 268 0.023
generation of neurons GO:0048699 152 0.023
epithelium development GO:0060429 227 0.023
cellular protein complex assembly GO:0043623 188 0.022
positive regulation of apoptotic process GO:0043065 246 0.022
regulation of neural precursor cell proliferation GO:2000177 4 0.022
cellular component morphogenesis GO:0032989 314 0.022
peptide transport GO:0015833 74 0.022
nucleotide biosynthetic process GO:0009165 109 0.022
segmentation GO:0035282 4 0.022
transmembrane transport GO:0055085 399 0.022
protein processing GO:0016485 226 0.022
microtubule based process GO:0007017 210 0.022
system process GO:0003008 349 0.021
ribonucleoside triphosphate catabolic process GO:0009203 391 0.021
oxidoreduction coenzyme metabolic process GO:0006733 19 0.021
negative regulation of cell death GO:0060548 345 0.021
negative regulation of phosphate metabolic process GO:0045936 267 0.021
actin filament based process GO:0030029 224 0.021
positive regulation of cellular amine metabolic process GO:0033240 7 0.021
reactive oxygen species metabolic process GO:0072593 75 0.021
fatty acid oxidation GO:0019395 31 0.021
Yeast
ras protein signal transduction GO:0007265 73 0.021
nucleoside phosphate biosynthetic process GO:1901293 109 0.021
cation transport GO:0006812 331 0.020
organic anion transport GO:0015711 103 0.020
regulation of cell cycle process GO:0010564 266 0.020
protein homooligomerization GO:0051260 100 0.020
neuromuscular junction development GO:0007528 3 0.020
cellular macromolecular complex assembly GO:0034622 324 0.020
regulation of transferase activity GO:0051338 355 0.020
negative regulation of developmental process GO:0051093 247 0.019
regulation of proteolysis GO:0030162 293 0.019
glycoside metabolic process GO:0016137 13 0.019
cell cell signaling GO:0007267 155 0.019
alcohol metabolic process GO:0006066 114 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
negative regulation of protein modification process GO:0031400 200 0.019
regulation of peptidase activity GO:0052547 180 0.019
response to organonitrogen compound GO:0010243 156 0.019
anion transport GO:0006820 161 0.019
negative regulation of multicellular organismal process GO:0051241 317 0.019
regulation of insulin secretion GO:0050796 33 0.019
locomotory behavior GO:0007626 1 0.019
response to abiotic stimulus GO:0009628 336 0.019
nucleoside phosphate catabolic process GO:1901292 412 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.019
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.018
ribonucleotide catabolic process GO:0009261 405 0.018
endomembrane system organization GO:0010256 196 0.018
negative regulation of secretion by cell GO:1903531 52 0.018
cellular respiration GO:0045333 21 0.018
mitotic cell cycle process GO:1903047 286 0.018
anatomical structure formation involved in morphogenesis GO:0048646 284 0.018
cell morphogenesis GO:0000902 296 0.017
polyketide metabolic process GO:0030638 8 0.017
positive regulation of hydrolase activity GO:0051345 331 0.017
aerobic respiration GO:0009060 7 0.017
nucleoside monophosphate metabolic process GO:0009123 191 0.017
protein maturation GO:0051604 233 0.017
regulation of kinase activity GO:0043549 314 0.017
regulation of endopeptidase activity GO:0052548 170 0.017
regulation of cell cycle GO:0051726 393 0.017
pyruvate metabolic process GO:0006090 26 0.017
regulation of peptide secretion GO:0002791 42 0.017
neuron differentiation GO:0030182 138 0.017
peptide secretion GO:0002790 51 0.017
regulation of peptide transport GO:0090087 62 0.017
regulation of cell differentiation GO:0045595 393 0.017
carbohydrate catabolic process GO:0016052 36 0.017
response to axon injury GO:0048678 1 0.017
multicellular organismal homeostasis GO:0048871 67 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.017
regeneration GO:0031099 4 0.017
carboxylic acid biosynthetic process GO:0046394 97 0.017
myosin filament organization GO:0031033 2 0.016
cellular response to dna damage stimulus GO:0006974 379 0.016
response to drug GO:0042493 81 0.016
alpha amino acid metabolic process GO:1901605 72 0.016
positive regulation of cellular component organization GO:0051130 376 0.016
purine containing compound catabolic process GO:0072523 411 0.016
striated muscle myosin thick filament assembly GO:0071688 2 0.016
nucleotide catabolic process GO:0009166 408 0.016
positive regulation of transport GO:0051050 336 0.016
cell adhesion GO:0007155 325 0.016
tricarboxylic acid metabolic process GO:0072350 4 0.016
Human Yeast
reactive nitrogen species metabolic process GO:2001057 3 0.016
pyridine nucleotide metabolic process GO:0019362 14 0.016
regulation of peptide hormone secretion GO:0090276 41 0.016
cell activation GO:0001775 213 0.016
defense response GO:0006952 315 0.015
cell projection organization GO:0030030 252 0.015
regulation of protein kinase activity GO:0045859 289 0.015
regulation of nucleoside metabolic process GO:0009118 209 0.015
negative regulation of hydrolase activity GO:0051346 182 0.015
positive regulation of phosphorylation GO:0042327 394 0.015
regulation of protein serine threonine kinase activity GO:0071900 179 0.015
positive regulation of programmed cell death GO:0043068 249 0.015
actin cytoskeleton organization GO:0030036 207 0.015
small molecule biosynthetic process GO:0044283 157 0.015
purine nucleoside monophosphate metabolic process GO:0009126 186 0.014
regulation of anatomical structure morphogenesis GO:0022603 286 0.014
neurogenesis GO:0022008 169 0.014
cellular macromolecule catabolic process GO:0044265 380 0.014
thymus development GO:0048538 3 0.014
negative regulation of secretion GO:0051048 58 0.014
mapk cascade GO:0000165 288 0.014
epithelial cell differentiation GO:0030855 141 0.014
response to external biotic stimulus GO:0043207 261 0.014
cellular amino acid catabolic process GO:0009063 31 0.014
membrane organization GO:0061024 292 0.014
single organism carbohydrate catabolic process GO:0044724 33 0.014
sulfur compound metabolic process GO:0006790 101 0.014
cell division GO:0051301 168 0.014
response to biotic stimulus GO:0009607 276 0.014
monosaccharide metabolic process GO:0005996 74 0.014
positive regulation of protein phosphorylation GO:0001934 313 0.014
rna interference GO:0016246 4 0.014
lipid biosynthetic process GO:0008610 177 0.014
single organism cellular localization GO:1902580 332 0.013
regulation of cell development GO:0060284 161 0.013
inorganic ion transmembrane transport GO:0098660 231 0.013
response to nitrogen compound GO:1901698 184 0.013
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.013
cellular chemical homeostasis GO:0055082 180 0.013
regulation of cell adhesion GO:0030155 166 0.013
hemopoiesis GO:0030097 180 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
microtubule cytoskeleton organization GO:0000226 176 0.013
adult locomotory behavior GO:0008344 1 0.013
cellular response to nutrient levels GO:0031669 69 0.013
immune response GO:0006955 307 0.013
mitochondrial transport GO:0006839 60 0.013
negative regulation of transferase activity GO:0051348 124 0.013
2 oxoglutarate metabolic process GO:0006103 4 0.013
Human
pyridine containing compound metabolic process GO:0072524 18 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
sensory perception of pain GO:0019233 4 0.013
regulation of synaptic plasticity GO:0048167 3 0.013
mitotic cell cycle GO:0000278 326 0.013
regulation of cysteine type endopeptidase activity GO:2000116 127 0.012
response to inorganic substance GO:0010035 127 0.012
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
protein catabolic process GO:0030163 325 0.012
reproductive process GO:0022414 106 0.012
response to wounding GO:0009611 168 0.012
positive regulation of mapk cascade GO:0043410 190 0.012
regulation of cell motility GO:2000145 299 0.012
quinone metabolic process GO:1901661 18 0.012
cell projection morphogenesis GO:0048858 129 0.012
glycosyl compound catabolic process GO:1901658 413 0.012
positive regulation of immune system process GO:0002684 283 0.012
embryo development GO:0009790 123 0.012
inorganic cation transmembrane transport GO:0098662 194 0.012
positive regulation of kinase activity GO:0033674 204 0.012
signal transduction by phosphorylation GO:0023014 297 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
single organism membrane organization GO:0044802 268 0.012
purine containing compound biosynthetic process GO:0072522 88 0.012
positive regulation of developmental process GO:0051094 314 0.012
growth GO:0040007 202 0.012
peripheral nervous system development GO:0007422 2 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
response to metal ion GO:0010038 84 0.011
hormone secretion GO:0046879 65 0.011
neurological system process GO:0050877 163 0.011
negative regulation of growth GO:0045926 97 0.011
regulation of neuroblast proliferation GO:1902692 3 0.011
negative regulation of cell proliferation GO:0008285 228 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
cytoplasmic transport GO:0016482 379 0.011
regulation of purine nucleotide catabolic process GO:0033121 205 0.011
cell part morphogenesis GO:0032990 137 0.011
cellular response to endogenous stimulus GO:0071495 336 0.011
cellular homeostasis GO:0019725 196 0.011
guanosine containing compound catabolic process GO:1901069 239 0.011
negative regulation of cell differentiation GO:0045596 171 0.011
spinal cord development GO:0021510 4 0.011
purine nucleotide catabolic process GO:0006195 405 0.011
regulation of cell morphogenesis GO:0022604 153 0.011
regulation of cellular component biogenesis GO:0044087 281 0.011
positive regulation of synaptic transmission GO:0050806 4 0.011
regulation of cellular response to stress GO:0080135 244 0.011
hexose metabolic process GO:0019318 55 0.011
glycerolipid metabolic process GO:0046486 107 0.011
aminoglycoside antibiotic metabolic process GO:0030647 8 0.011
cell growth GO:0016049 160 0.011
ion homeostasis GO:0050801 230 0.011
negative regulation of cellular component organization GO:0051129 235 0.011
hemostasis GO:0007599 76 0.011
metencephalon development GO:0022037 2 0.010
protein homotetramerization GO:0051289 28 0.010
regulation of protein maturation GO:1903317 150 0.010
positive regulation of transferase activity GO:0051347 227 0.010
metal ion transport GO:0030001 272 0.010
regulation of mapk cascade GO:0043408 262 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.010
spermatid development GO:0007286 4 0.010
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.010
reactive oxygen species biosynthetic process GO:1903409 4 0.010

IDH2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.665
inherited metabolic disorder DOID:655 242 0.665
amino acid metabolic disorder DOID:9252 50 0.190
carbohydrate metabolic disorder DOID:2978 55 0.083
disease of cellular proliferation DOID:14566 174 0.027
Human
cancer DOID:162 167 0.027
Human
musculoskeletal system disease DOID:17 223 0.026
organ system cancer DOID:0050686 164 0.025
urinary system disease DOID:18 40 0.021
sensory system disease DOID:0050155 203 0.020
eye and adnexa disease DOID:1492 150 0.020
nervous system disease DOID:863 431 0.020
eye disease DOID:5614 149 0.020
myopathy DOID:423 104 0.017
muscular disease DOID:0080000 114 0.017
muscle tissue disease DOID:66 113 0.017
hyperinsulinemic hypoglycemia DOID:13317 7 0.016
cardiovascular system disease DOID:1287 106 0.015
central nervous system disease DOID:331 186 0.015
immune system disease DOID:2914 155 0.014
retinal disease DOID:5679 118 0.010
2 hydroxyglutaric aciduria DOID:0050573 3 0.001