Homo sapiens

61 known processes

BRE

brain and reproductive organ-expressed (TNFRSF1A modulator)

(Aliases: BRCC45,BRCC4)

BRE biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of dna repair GO:0045739 25 0.888
positive regulation of response to dna damage stimulus GO:2001022 43 0.800
protein deubiquitination GO:0016579 79 0.749
protein k63 linked deubiquitination GO:0070536 21 0.728
double strand break repair GO:0006302 101 0.602
g2 dna damage checkpoint GO:0031572 26 0.572
cellular response to dna damage stimulus GO:0006974 379 0.563
dna repair GO:0006281 198 0.538
positive regulation of dna metabolic process GO:0051054 73 0.450
response to ionizing radiation GO:0010212 65 0.438
dna damage checkpoint GO:0000077 68 0.432
cell cycle checkpoint GO:0000075 117 0.411
response to abiotic stimulus GO:0009628 336 0.391
regulation of cellular response to stress GO:0080135 244 0.390
regulation of dna repair GO:0006282 47 0.390
protein modification by small protein removal GO:0070646 92 0.389
response to radiation GO:0009314 151 0.339
dna integrity checkpoint GO:0031570 71 0.326
nadph oxidation GO:0070995 3 0.275
regulation of response to dna damage stimulus GO:2001020 94 0.260
histone deubiquitination GO:0016578 16 0.245
covalent chromatin modification GO:0016569 254 0.114
chromatin modification GO:0016568 298 0.096
chromatin organization GO:0006325 351 0.096
regulation of dna metabolic process GO:0051052 153 0.096
coenzyme metabolic process GO:0006732 65 0.093
purine nucleoside triphosphate metabolic process GO:0009144 412 0.093
oxidation reduction process GO:0055114 396 0.089
purine ribonucleoside catabolic process GO:0046130 398 0.078
cellular amino acid metabolic process GO:0006520 116 0.073
purine ribonucleoside metabolic process GO:0046128 437 0.066
amine metabolic process GO:0009308 44 0.062
regulation of cellular amino acid metabolic process GO:0006521 6 0.061
ribonucleoside monophosphate metabolic process GO:0009161 187 0.060
negative regulation of protein metabolic process GO:0051248 391 0.057
regulation of cellular amine metabolic process GO:0033238 11 0.055
mitochondrion organization GO:0007005 156 0.055
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.053
negative regulation of protein processing GO:0010955 142 0.051
nucleoside monophosphate metabolic process GO:0009123 191 0.049
organophosphate catabolic process GO:0046434 430 0.049
nucleoside phosphate catabolic process GO:1901292 412 0.048
cellular ketone metabolic process GO:0042180 80 0.048
ribonucleoside triphosphate metabolic process GO:0009199 412 0.048
histone modification GO:0016570 251 0.047
ribonucleoside catabolic process GO:0042454 406 0.047
protein catabolic process GO:0030163 325 0.047
modification dependent macromolecule catabolic process GO:0043632 212 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.042
protein processing GO:0016485 226 0.041
positive regulation of cellular amine metabolic process GO:0033240 7 0.040
purine nucleotide catabolic process GO:0006195 405 0.040
ribonucleoside triphosphate catabolic process GO:0009203 391 0.040
female gamete generation GO:0007292 2 0.039
protein maturation GO:0051604 233 0.039
multicellular organismal aging GO:0010259 3 0.039
cellular macromolecule catabolic process GO:0044265 380 0.038
small gtpase mediated signal transduction GO:0007264 78 0.037
cytoplasmic transport GO:0016482 379 0.037
nucleoside catabolic process GO:0009164 408 0.036
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.036
nucleoside triphosphate metabolic process GO:0009141 422 0.036
ion homeostasis GO:0050801 230 0.035
locomotory behavior GO:0007626 1 0.034
regulation of proteasomal protein catabolic process GO:0061136 87 0.034
purine nucleoside triphosphate catabolic process GO:0009146 392 0.034
regulation of protein processing GO:0070613 150 0.034
actin filament based process GO:0030029 224 0.033
cellular protein catabolic process GO:0044257 261 0.033
cellular amine metabolic process GO:0044106 41 0.032
regulation of purine nucleotide metabolic process GO:1900542 264 0.032
response to wounding GO:0009611 168 0.032
carbohydrate derivative biosynthetic process GO:1901137 207 0.032
atp metabolic process GO:0046034 176 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.031
cell division GO:0051301 168 0.031
negative regulation of transport GO:0051051 176 0.031
transmembrane transport GO:0055085 399 0.030
negative regulation of catalytic activity GO:0043086 335 0.030
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.030
glycosyl compound catabolic process GO:1901658 413 0.029
regulation of cellular ketone metabolic process GO:0010565 50 0.029
regeneration GO:0031099 4 0.029
oogenesis GO:0048477 2 0.029
carboxylic acid catabolic process GO:0046395 71 0.029
wound healing GO:0042060 115 0.029
organonitrogen compound biosynthetic process GO:1901566 200 0.028
nucleotide catabolic process GO:0009166 408 0.028
post embryonic development GO:0009791 2 0.028
purine ribonucleotide catabolic process GO:0009154 404 0.028
endosomal transport GO:0016197 129 0.028
positive regulation of transport GO:0051050 336 0.028
regulation of protein maturation GO:1903317 150 0.028
ribonucleotide catabolic process GO:0009261 405 0.028
regulation of nucleotide metabolic process GO:0006140 269 0.028
reactive nitrogen species metabolic process GO:2001057 3 0.027
positive regulation of catabolic process GO:0009896 310 0.026
metal ion homeostasis GO:0055065 169 0.026
negative regulation of cellular protein metabolic process GO:0032269 353 0.026
protein oligomerization GO:0051259 173 0.026
positive regulation of phosphorylation GO:0042327 394 0.026
carbohydrate metabolic process GO:0005975 207 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.025
dicarboxylic acid metabolic process GO:0043648 29 0.025
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.025
negative regulation of catabolic process GO:0009895 104 0.025
single organism carbohydrate metabolic process GO:0044723 193 0.025
regulation of nucleoside metabolic process GO:0009118 209 0.025
negative regulation of protein modification process GO:0031400 200 0.025
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.024
regulation of nucleotide catabolic process GO:0030811 205 0.024
negative regulation of programmed cell death GO:0043069 321 0.024
tissue regeneration GO:0042246 3 0.024
regulation of proteolysis GO:0030162 293 0.024
innate immune response GO:0045087 178 0.024
lipid metabolic process GO:0006629 381 0.023
cellular ion homeostasis GO:0006873 168 0.023
proteasomal protein catabolic process GO:0010498 176 0.023
regulation of defense response GO:0031347 154 0.023
purine containing compound biosynthetic process GO:0072522 88 0.023
purine nucleoside monophosphate metabolic process GO:0009126 186 0.023
small molecule catabolic process GO:0044282 92 0.023
oocyte differentiation GO:0009994 2 0.023
response to oxidative stress GO:0006979 121 0.022
regulation of protein localization GO:0032880 296 0.022
cellular modified amino acid metabolic process GO:0006575 64 0.022
cytokinesis GO:0000910 96 0.022
defense response GO:0006952 315 0.022
interspecies interaction between organisms GO:0044419 156 0.021
determination of adult lifespan GO:0008340 2 0.021
purine containing compound catabolic process GO:0072523 411 0.021
regulation of cell cycle process GO:0010564 266 0.021
regulation of small gtpase mediated signal transduction GO:0051056 156 0.020
tricarboxylic acid metabolic process GO:0072350 4 0.020
regulation of immune response GO:0050776 201 0.020
regulation of establishment of protein localization GO:0070201 242 0.020
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.020
regulation of intracellular transport GO:0032386 195 0.019
cation transport GO:0006812 331 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
generation of precursor metabolites and energy GO:0006091 68 0.019
regulation of ras protein signal transduction GO:0046578 155 0.019
cellular lipid metabolic process GO:0044255 303 0.019
negative regulation of multicellular organismal process GO:0051241 317 0.019
protein modification by small protein conjugation GO:0032446 342 0.019
macromolecule glycosylation GO:0043413 63 0.019
alpha amino acid metabolic process GO:1901605 72 0.018
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.018
viral process GO:0016032 146 0.018
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.018
neuromuscular junction development GO:0007528 3 0.018
negative regulation of apoptotic process GO:0043066 316 0.018
organic acid catabolic process GO:0016054 71 0.018
citrate metabolic process GO:0006101 2 0.018
negative regulation of cellular catabolic process GO:0031330 83 0.018
positive regulation of nucleotide metabolic process GO:0045981 230 0.018
nitrogen compound transport GO:0071705 191 0.018
cofactor metabolic process GO:0051186 87 0.018
metal ion transport GO:0030001 272 0.017
negative regulation of protein catabolic process GO:0042177 59 0.017
negative regulation of cellular component organization GO:0051129 235 0.017
associative learning GO:0008306 1 0.017
positive regulation of nucleoside metabolic process GO:0045979 186 0.017
nucleoside triphosphate catabolic process GO:0009143 394 0.017
regulation of protein complex assembly GO:0043254 147 0.017
positive regulation of hydrolase activity GO:0051345 331 0.017
guanosine containing compound metabolic process GO:1901068 244 0.017
ion transmembrane transport GO:0034220 338 0.017
oocyte development GO:0048599 1 0.017
small molecule biosynthetic process GO:0044283 157 0.017
positive regulation of nucleotide catabolic process GO:0030813 185 0.016
negative regulation of cell proliferation GO:0008285 228 0.016
regulation of cytoplasmic transport GO:1903649 149 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.016
positive regulation of gtpase activity GO:0043547 166 0.016
response to inorganic substance GO:0010035 127 0.016
calcium ion transport GO:0006816 147 0.016
cation transmembrane transport GO:0098655 238 0.016
positive regulation of protein phosphorylation GO:0001934 313 0.016
regulation of peptidase activity GO:0052547 180 0.016
guanosine containing compound catabolic process GO:1901069 239 0.016
viral life cycle GO:0019058 132 0.016
regulation of gtp catabolic process GO:0033124 180 0.016
adult locomotory behavior GO:0008344 1 0.016
modification dependent protein catabolic process GO:0019941 209 0.016
response to cytokine GO:0034097 232 0.016
negative regulation of peptidase activity GO:0010466 91 0.016
immune effector process GO:0002252 159 0.016
ketone catabolic process GO:0042182 3 0.016
protein localization to organelle GO:0033365 280 0.015
regulation of protein kinase activity GO:0045859 289 0.015
positive regulation of secretion by cell GO:1903532 108 0.015
vitamin metabolic process GO:0006766 26 0.015
positive regulation of cellular component organization GO:0051130 376 0.015
reactive oxygen species biosynthetic process GO:1903409 4 0.015
regulation of cellular component movement GO:0051270 334 0.015
protein glycosylation GO:0006486 62 0.015
positive regulation of apoptotic process GO:0043065 246 0.015
gtp catabolic process GO:0006184 237 0.015
negative regulation of proteolysis GO:0045861 132 0.015
spermatid differentiation GO:0048515 4 0.015
biological adhesion GO:0022610 331 0.015
regulation of cell cycle GO:0051726 393 0.015
glycoprotein metabolic process GO:0009100 110 0.015
segmentation GO:0035282 4 0.015
regulation of locomotion GO:0040012 329 0.015
ras protein signal transduction GO:0007265 73 0.015
memory GO:0007613 3 0.015
regulation of cysteine type endopeptidase activity GO:2000116 127 0.015
cellular amino acid catabolic process GO:0009063 31 0.015
regulation of protein transport GO:0051223 213 0.015
regulation of transmembrane transporter activity GO:0022898 74 0.015
regulation of secretion GO:0051046 194 0.015
mitochondrial transport GO:0006839 60 0.015
actin mediated cell contraction GO:0070252 12 0.014
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.014
divalent inorganic cation transport GO:0072511 158 0.014
visual behavior GO:0007632 2 0.014
purine nucleotide biosynthetic process GO:0006164 84 0.014
cardiac muscle cell contraction GO:0086003 4 0.014
cytokine production GO:0001816 247 0.014
positive regulation of cytokine production GO:0001819 167 0.014
regulation of secretion by cell GO:1903530 177 0.014
cell cell signaling GO:0007267 155 0.014
positive regulation of gtp catabolic process GO:0033126 166 0.014
organic hydroxy compound metabolic process GO:1901615 147 0.014
growth GO:0040007 202 0.014
spermatid development GO:0007286 4 0.014
negative regulation of growth GO:0045926 97 0.014
nervous system development GO:0007399 293 0.014
gtp metabolic process GO:0046039 239 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.014
negative regulation of endopeptidase activity GO:0010951 84 0.013
regulation of synaptic plasticity GO:0048167 3 0.013
protein acylation GO:0043543 138 0.013
positive regulation of cellular component biogenesis GO:0044089 158 0.013
negative regulation of cellular protein catabolic process GO:1903363 38 0.013
atp catabolic process GO:0006200 157 0.013
rho protein signal transduction GO:0007266 26 0.013
regulation of kinase activity GO:0043549 314 0.013
positive regulation of immune system process GO:0002684 283 0.013
cellular response to cytokine stimulus GO:0071345 181 0.013
regulation of mitotic cell cycle GO:0007346 189 0.013
response to oxygen containing compound GO:1901700 369 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
positive regulation of programmed cell death GO:0043068 249 0.013
monocarboxylic acid biosynthetic process GO:0072330 67 0.013
endoplasmic reticulum organization GO:0007029 20 0.013
cellular protein complex assembly GO:0043623 188 0.013
negative regulation of cell cycle process GO:0010948 121 0.013
chemical homeostasis GO:0048878 306 0.013
multi organism cellular process GO:0044764 156 0.013
ribonucleotide biosynthetic process GO:0009260 81 0.013
nerve development GO:0021675 4 0.013
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.013
cellular response to oxidative stress GO:0034599 85 0.013
regulation of ion transport GO:0043269 189 0.013
dephosphorylation GO:0016311 209 0.012
positive regulation of cell death GO:0010942 263 0.012
immune response GO:0006955 307 0.012
actin filament based movement GO:0030048 17 0.012
regulation of cell differentiation GO:0045595 393 0.012
one carbon metabolic process GO:0006730 1 0.012
regulation of innate immune response GO:0045088 97 0.012
regulation of chromosome organization GO:0033044 103 0.012
regulation of mitotic cell cycle phase transition GO:1901990 118 0.012
motor neuron axon guidance GO:0008045 2 0.012
regulation of oxidoreductase activity GO:0051341 43 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
secretion by cell GO:0032940 226 0.012
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.012
negative regulation of protein phosphorylation GO:0001933 140 0.012
apoptotic signaling pathway GO:0097190 268 0.012
regulation of intracellular protein transport GO:0033157 123 0.012
protein tetramerization GO:0051262 47 0.012
blastoderm segmentation GO:0007350 2 0.012
system process GO:0003008 349 0.012
divalent metal ion transport GO:0070838 152 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.012
peripheral nervous system development GO:0007422 2 0.012
negative regulation of transferase activity GO:0051348 124 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.012
negative regulation of kinase activity GO:0033673 106 0.012
energy derivation by oxidation of organic compounds GO:0015980 43 0.012
alcohol metabolic process GO:0006066 114 0.012
neurotransmitter secretion GO:0007269 4 0.012
secretion GO:0046903 254 0.012
negative regulation of protein transport GO:0051224 75 0.011
regulation of cell division GO:0051302 116 0.011
calcium ion transmembrane transport GO:0070588 76 0.011
cellular component morphogenesis GO:0032989 314 0.011
positive regulation of cell differentiation GO:0045597 211 0.011
maintenance of location GO:0051235 112 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
response to external biotic stimulus GO:0043207 261 0.011
organophosphate biosynthetic process GO:0090407 163 0.011
glycosylation GO:0070085 71 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
regulation of cytokine production GO:0001817 232 0.011
negative regulation of intracellular transport GO:0032387 60 0.011
regulation of atp metabolic process GO:1903578 29 0.011
regulation of ras gtpase activity GO:0032318 128 0.011
negative regulation of transcription from rna polymerase iii promoter GO:0016480 3 0.011
negative regulation of protein maturation GO:1903318 142 0.011
mitotic cell cycle GO:0000278 326 0.011
response to lipid GO:0033993 206 0.011
sulfur compound metabolic process GO:0006790 101 0.011
regulation of transferase activity GO:0051338 355 0.011
protein ubiquitination GO:0016567 314 0.011
cofactor biosynthetic process GO:0051188 31 0.011
autophagy GO:0006914 88 0.011
nucleotide biosynthetic process GO:0009165 109 0.011
compound eye development GO:0048749 1 0.011
rhythmic behavior GO:0007622 2 0.011
positive regulation of transferase activity GO:0051347 227 0.011
regulation of transporter activity GO:0032409 82 0.011
ribose phosphate biosynthetic process GO:0046390 82 0.011
photoreceptor cell differentiation GO:0046530 2 0.011
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.010
inorganic ion transmembrane transport GO:0098660 231 0.010
actin cytoskeleton organization GO:0030036 207 0.010
mitotic cell cycle phase transition GO:0044772 162 0.010
membrane hyperpolarization GO:0060081 1 0.010
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.010
positive regulation of synaptic transmission GO:0050806 4 0.010
myeloid cell differentiation GO:0030099 117 0.010
metencephalon development GO:0022037 2 0.010
regulation of growth GO:0040008 165 0.010
peptidyl threonine modification GO:0018210 45 0.010
dna dealkylation GO:0035510 13 0.010
synaptic vesicle recycling GO:0036465 3 0.010
sensory perception of pain GO:0019233 4 0.010
monocarboxylic acid metabolic process GO:0032787 185 0.010
regulation of cell migration GO:0030334 289 0.010
ubiquitin dependent protein catabolic process GO:0006511 206 0.010
single organism cell adhesion GO:0098602 179 0.010
response to other organism GO:0051707 261 0.010
negative regulation of protein kinase activity GO:0006469 98 0.010
ribonucleoprotein complex assembly GO:0022618 78 0.010
cellular macromolecular complex assembly GO:0034622 324 0.010
cellular divalent inorganic cation homeostasis GO:0072503 128 0.010
nuclear export GO:0051168 69 0.010
hindbrain development GO:0030902 3 0.010

BRE disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.141
inherited metabolic disorder DOID:655 242 0.141
central nervous system disease DOID:331 186 0.043
nervous system disease DOID:863 431 0.043
immune system disease DOID:2914 155 0.030
disease of cellular proliferation DOID:14566 174 0.026
cancer DOID:162 167 0.024
retinal disease DOID:5679 118 0.023
sensory system disease DOID:0050155 203 0.023
eye and adnexa disease DOID:1492 150 0.023
eye disease DOID:5614 149 0.023
neurodegenerative disease DOID:1289 102 0.022
amino acid metabolic disorder DOID:9252 50 0.018
retinal degeneration DOID:8466 89 0.017
organ system cancer DOID:0050686 164 0.016
musculoskeletal system disease DOID:17 223 0.013
carbohydrate metabolic disorder DOID:2978 55 0.012
muscular disease DOID:0080000 114 0.010
muscle tissue disease DOID:66 113 0.010