Homo sapiens

60 known processes

APTX

aprataxin

(Aliases: FHA-HIT,EAOH,AXA1,AOA,MGC1072,AOA1,FLJ20157,EOAHA)

APTX biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna repair GO:0006281 198 0.911
dna damage response detection of dna damage GO:0042769 3 0.808
cellular macromolecule catabolic process GO:0044265 380 0.791
cellular response to dna damage stimulus GO:0006974 379 0.707
dna ligation involved in dna repair GO:0051103 4 0.690
double strand break repair GO:0006302 101 0.689
base excision repair GO:0006284 21 0.516
pro b cell differentiation GO:0002328 1 0.458
protein ubiquitination GO:0016567 314 0.339
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.298
vesicle mediated transport GO:0016192 371 0.274
immunoglobulin v d j recombination GO:0033152 1 0.269
response to abiotic stimulus GO:0009628 336 0.229
protein modification by small protein conjugation GO:0032446 342 0.221
response to oxidative stress GO:0006979 121 0.176
protein autoubiquitination GO:0051865 37 0.154
meiotic chromosome segregation GO:0045132 4 0.153
response to radiation GO:0009314 151 0.153
limbic system development GO:0021761 3 0.150
dna ligation GO:0006266 10 0.130
Mouse
response to ionizing radiation GO:0010212 65 0.121
cytoplasmic transport GO:0016482 379 0.111
cellular response to ionizing radiation GO:0071479 32 0.097
hippocampus development GO:0021766 1 0.087
cell type specific apoptotic process GO:0097285 125 0.083
viral life cycle GO:0019058 132 0.074
establishment of protein localization to organelle GO:0072594 172 0.073
non recombinational repair GO:0000726 14 0.072
negative regulation of apoptotic process GO:0043066 316 0.071
regulation of growth GO:0040008 165 0.071
response to gamma radiation GO:0010332 14 0.070
cytokinesis GO:0000910 96 0.070
t cell activation GO:0042110 99 0.064
positive regulation of developmental process GO:0051094 314 0.062
macromolecule glycosylation GO:0043413 63 0.060
cellular response to abiotic stimulus GO:0071214 117 0.060
regulation of cellular response to stress GO:0080135 244 0.059
glycoprotein biosynthetic process GO:0009101 91 0.058
post embryonic development GO:0009791 2 0.058
negative regulation of dna metabolic process GO:0051053 57 0.057
response to drug GO:0042493 81 0.056
apoptotic signaling pathway GO:0097190 268 0.054
microtubule cytoskeleton organization GO:0000226 176 0.053
regulation of protein kinase activity GO:0045859 289 0.053
positive regulation of dna metabolic process GO:0051054 73 0.053
negative regulation of organelle assembly GO:1902116 7 0.052
regulation of protein ubiquitination GO:0031396 95 0.051
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.048
protein targeting GO:0006605 187 0.047
regulation of viral process GO:0050792 103 0.046
signal transduction involved in regulation of gene expression GO:0023019 1 0.046
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.046
lymphocyte activation GO:0046649 133 0.046
negative regulation of protein modification process GO:0031400 200 0.044
negative regulation of organelle organization GO:0010639 126 0.044
membrane organization GO:0061024 292 0.043
cell aging GO:0007569 52 0.043
regulation of kinase activity GO:0043549 314 0.042
cellular protein catabolic process GO:0044257 261 0.042
dna recombination GO:0006310 77 0.042
centrosome cycle GO:0007098 32 0.042
single strand break repair GO:0000012 6 0.041
regulation of cell cycle process GO:0010564 266 0.041
negative regulation of protein metabolic process GO:0051248 391 0.041
protein autoprocessing GO:0016540 4 0.041
protein localization to organelle GO:0033365 280 0.040
nucleoside triphosphate metabolic process GO:0009141 422 0.040
chromosome segregation GO:0007059 114 0.040
mitochondrion organization GO:0007005 156 0.040
organelle assembly GO:0070925 176 0.039
multi organism cellular process GO:0044764 156 0.039
central nervous system development GO:0007417 123 0.039
negative regulation of catalytic activity GO:0043086 335 0.038
viral process GO:0016032 146 0.038
response to decreased oxygen levels GO:0036293 96 0.038
hemopoiesis GO:0030097 180 0.038
double strand break repair via nonhomologous end joining GO:0006303 10 0.038
negative regulation of cell cycle GO:0045786 193 0.035
negative regulation of cellular component organization GO:0051129 235 0.035
protein maturation GO:0051604 233 0.035
positive regulation of transport GO:0051050 336 0.035
replicative cell aging GO:0001302 3 0.035
system process GO:0003008 349 0.035
lipid biosynthetic process GO:0008610 177 0.034
nucleoside monophosphate metabolic process GO:0009123 191 0.033
v d j recombination GO:0033151 3 0.033
immune system development GO:0002520 195 0.032
nucleoside catabolic process GO:0009164 408 0.032
b cell activation GO:0042113 33 0.032
intracellular protein transport GO:0006886 270 0.032
lymphoid progenitor cell differentiation GO:0002320 3 0.031
regulation of transferase activity GO:0051338 355 0.031
positive regulation of cellular catabolic process GO:0031331 284 0.031
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.031
leukocyte activation GO:0045321 164 0.031
negative regulation of protein phosphorylation GO:0001933 140 0.030
cytoskeleton dependent cytokinesis GO:0061640 22 0.030
centriole replication GO:0007099 13 0.029
single organism membrane organization GO:0044802 268 0.029
receptor mediated endocytosis GO:0006898 84 0.029
interspecies interaction between organisms GO:0044419 156 0.029
regulation of cell growth GO:0001558 135 0.028
cellular response to radiation GO:0071478 65 0.028
purine ribonucleoside metabolic process GO:0046128 437 0.028
microtubule organizing center organization GO:0031023 62 0.028
glycosyl compound catabolic process GO:1901658 413 0.028
glycosylation GO:0070085 71 0.028
regulation of protein transport GO:0051223 213 0.027
cellular amino acid metabolic process GO:0006520 116 0.027
positive regulation of cell development GO:0010720 92 0.027
ribonucleotide catabolic process GO:0009261 405 0.027
regulation of cell cycle GO:0051726 393 0.026
negative regulation of cell death GO:0060548 345 0.026
amine metabolic process GO:0009308 44 0.026
regulation of ligase activity GO:0051340 29 0.026
telencephalon development GO:0021537 17 0.026
purine nucleoside catabolic process GO:0006152 398 0.026
covalent chromatin modification GO:0016569 254 0.025
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.025
cell division GO:0051301 168 0.025
single organism cellular localization GO:1902580 332 0.025
determination of adult lifespan GO:0008340 2 0.024
negative regulation of viral process GO:0048525 66 0.024
organophosphate catabolic process GO:0046434 430 0.024
glycoprotein metabolic process GO:0009100 110 0.023
guanosine containing compound catabolic process GO:1901069 239 0.023
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.023
negative regulation of cell proliferation GO:0008285 228 0.023
single organism carbohydrate metabolic process GO:0044723 193 0.023
negative regulation of cellular protein metabolic process GO:0032269 353 0.022
nucleotide excision repair GO:0006289 31 0.022
negative regulation of cell cycle process GO:0010948 121 0.022
ubiquitin dependent protein catabolic process GO:0006511 206 0.021
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.021
endocytosis GO:0006897 159 0.021
modification dependent protein catabolic process GO:0019941 209 0.021
positive regulation of cell growth GO:0030307 48 0.020
centrosome organization GO:0051297 58 0.020
purine ribonucleotide catabolic process GO:0009154 404 0.020
macromolecule methylation GO:0043414 97 0.020
brain development GO:0007420 97 0.020
nuclear transport GO:0051169 179 0.020
regulation of multi organism process GO:0043900 157 0.020
t cell differentiation in thymus GO:0033077 4 0.020
protein glycosylation GO:0006486 62 0.019
regulation of anatomical structure morphogenesis GO:0022603 286 0.019
regulation of dna metabolic process GO:0051052 153 0.019
ribonucleoside triphosphate metabolic process GO:0009199 412 0.019
cell growth GO:0016049 160 0.019
nucleoside triphosphate catabolic process GO:0009143 394 0.019
response to hypoxia GO:0001666 96 0.019
gtp metabolic process GO:0046039 239 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.019
protein localization to nucleus GO:0034504 136 0.018
regulation of response to dna damage stimulus GO:2001020 94 0.018
interaction with host GO:0051701 42 0.018
regulation of protein import into nucleus GO:0042306 78 0.018
anatomical structure homeostasis GO:0060249 100 0.018
carbohydrate derivative biosynthetic process GO:1901137 207 0.018
negative regulation of protein ubiquitination GO:0031397 35 0.018
regulation of cell differentiation GO:0045595 393 0.018
immune response GO:0006955 307 0.018
protein adp ribosylation GO:0006471 9 0.018
hematopoietic or lymphoid organ development GO:0048534 186 0.017
nervous system development GO:0007399 293 0.017
cell projection morphogenesis GO:0048858 129 0.017
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.017
mitotic cell cycle GO:0000278 326 0.017
cellular response to uv GO:0034644 32 0.017
generation of neurons GO:0048699 152 0.017
negative regulation of phosphorylation GO:0042326 174 0.016
cell activation GO:0001775 213 0.016
neuromuscular junction development GO:0007528 3 0.016
posttranscriptional regulation of gene expression GO:0010608 213 0.016
regulation of cellular amine metabolic process GO:0033238 11 0.016
nucleotide catabolic process GO:0009166 408 0.016
protein catabolic process GO:0030163 325 0.016
purine nucleotide catabolic process GO:0006195 405 0.016
negative regulation of transferase activity GO:0051348 124 0.016
positive regulation of catabolic process GO:0009896 310 0.016
proteasomal protein catabolic process GO:0010498 176 0.016
positive regulation of cell proliferation GO:0008284 301 0.015
protein import GO:0017038 130 0.015
cellular component disassembly GO:0022411 92 0.015
secretion by cell GO:0032940 226 0.015
leukocyte differentiation GO:0002521 98 0.015
meiosis i GO:0007127 4 0.014
regulation of protein catabolic process GO:0042176 155 0.014
modification by host of symbiont morphology or physiology GO:0051851 26 0.014
regulation of protein targeting GO:1903533 91 0.014
histone modification GO:0016570 251 0.014
lymphocyte differentiation GO:0030098 35 0.014
neurological system process GO:0050877 163 0.014
regulation of growth rate GO:0040009 1 0.014
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.014
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.014
regulation of establishment of protein localization GO:0070201 242 0.013
microtubule based process GO:0007017 210 0.013
negative regulation of phosphorus metabolic process GO:0010563 267 0.013
nucleoside monophosphate catabolic process GO:0009125 159 0.013
dna modification GO:0006304 27 0.013
regulation of intracellular transport GO:0032386 195 0.013
transmembrane transport GO:0055085 399 0.013
mitochondrial transport GO:0006839 60 0.013
regulation of ion transport GO:0043269 189 0.012
dna catabolic process GO:0006308 49 0.012
intrinsic apoptotic signaling pathway GO:0097193 127 0.012
positive regulation of immune response GO:0050778 159 0.012
centrosome separation GO:0051299 3 0.012
negative regulation of growth GO:0045926 97 0.012
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.012
negative regulation of protein kinase activity GO:0006469 98 0.012
forebrain development GO:0030900 26 0.012
divalent metal ion transport GO:0070838 152 0.012
carbohydrate metabolic process GO:0005975 207 0.012
rna interference GO:0016246 4 0.012
negative regulation of phosphate metabolic process GO:0045936 267 0.012
detection of stimulus GO:0051606 85 0.012
protein processing GO:0016485 226 0.012
positive regulation by host of viral transcription GO:0043923 11 0.012
response to light stimulus GO:0009416 87 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
embryonic eye morphogenesis GO:0048048 2 0.011
cell part morphogenesis GO:0032990 137 0.011
response to reactive oxygen species GO:0000302 61 0.011
cellular response to oxidative stress GO:0034599 85 0.011
negative regulation of centrosome cycle GO:0046606 4 0.011
growth GO:0040007 202 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
multicellular organismal aging GO:0010259 3 0.011
positive regulation of t cell apoptotic process GO:0070234 4 0.011
regulation of microtubule based process GO:0032886 74 0.011
regulation of cytoskeleton organization GO:0051493 177 0.011
response to toxic substance GO:0009636 37 0.011
positive regulation of hydrolase activity GO:0051345 331 0.011
nitrogen compound transport GO:0071705 191 0.011
negative regulation of protein processing GO:0010955 142 0.011
defense response GO:0006952 315 0.011
modulation by host of symbiont transcription GO:0052472 20 0.011
regulation of cellular component movement GO:0051270 334 0.011
hindbrain development GO:0030902 3 0.011
cell projection assembly GO:0030031 126 0.011
telomere maintenance GO:0000723 32 0.011
response to caffeine GO:0031000 3 0.011
secretion GO:0046903 254 0.011
cell projection organization GO:0030030 252 0.011
multicellular organismal signaling GO:0035637 34 0.010
regulation of immune response GO:0050776 201 0.010
regulation of nucleocytoplasmic transport GO:0046822 98 0.010
nuclear import GO:0051170 106 0.010
signal transduction by p53 class mediator GO:0072331 72 0.010
head development GO:0060322 108 0.010
ribonucleoside catabolic process GO:0042454 406 0.010
mitotic cell cycle process GO:1903047 286 0.010
response to wounding GO:0009611 168 0.010
negative regulation of intracellular signal transduction GO:1902532 183 0.010
positive regulation of locomotion GO:0040017 186 0.010
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.010
cell morphogenesis GO:0000902 296 0.010
response to uv GO:0009411 73 0.010

APTX disease predictions

Disease DO term ID Size Probability Func Analog Org
epilepsy syndrome DOID:1826 41 0.451
central nervous system disease DOID:331 186 0.451
brain disease DOID:936 73 0.451
electroclinical syndrome DOID:0050701 32 0.451
neonatal period electroclinical syndrome DOID:0050702 19 0.451
nervous system disease DOID:863 431 0.451
immune system disease DOID:2914 155 0.209
disease of cellular proliferation DOID:14566 174 0.098
cancer DOID:162 167 0.026
organ system cancer DOID:0050686 164 0.026
ohtahara syndrome DOID:0050709 17 0.019
idiopathic generalized epilepsy DOID:1827 21 0.017
hematopoietic system disease DOID:74 100 0.011