Homo sapiens

35 known processes

POLE4

polymerase (DNA-directed), epsilon 4 (p12 subunit)

(Aliases: YHHQ1,p12)

POLE4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.287
covalent chromatin modification GO:0016569 254 0.191
internal peptidyl lysine acetylation GO:0018393 97 0.138
protein acetylation GO:0006473 116 0.114
cellular response to dna damage stimulus GO:0006974 379 0.110
Yeast Fly
peptidyl lysine modification GO:0018205 144 0.110
nuclear migration GO:0007097 1 0.109
histone modification GO:0016570 251 0.105
chromatin modification GO:0016568 298 0.101
histone acetylation GO:0016573 93 0.091
chromatin organization GO:0006325 351 0.088
histone h3 acetylation GO:0043966 45 0.079
dna repair GO:0006281 198 0.074
Yeast
protein acylation GO:0043543 138 0.072
establishment of nucleus localization GO:0040023 1 0.069
dna dependent dna replication GO:0006261 44 0.064
Yeast
regulation of mitotic cell cycle GO:0007346 189 0.061
response to oxygen containing compound GO:1901700 369 0.060
nucleus localization GO:0051647 1 0.060
protein dna complex assembly GO:0065004 64 0.055
cellular macromolecule catabolic process GO:0044265 380 0.054
cellular protein catabolic process GO:0044257 261 0.051
response to abiotic stimulus GO:0009628 336 0.050
centromere complex assembly GO:0034508 10 0.048
dna replication independent nucleosome assembly GO:0006336 27 0.047
histone exchange GO:0043486 3 0.047
apoptotic signaling pathway GO:0097190 268 0.044
amine metabolic process GO:0009308 44 0.043
reproductive process GO:0022414 106 0.043
cellular macromolecular complex assembly GO:0034622 324 0.041
vesicle mediated transport GO:0016192 371 0.041
nucleosome organization GO:0034728 66 0.039
response to radiation GO:0009314 151 0.037
negative regulation of programmed cell death GO:0043069 321 0.036
negative regulation of apoptotic process GO:0043066 316 0.036
protein ubiquitination GO:0016567 314 0.036
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.035
regulation of cellular amine metabolic process GO:0033238 11 0.033
regulation of proteolysis GO:0030162 293 0.033
single organism membrane organization GO:0044802 268 0.032
protein maturation GO:0051604 233 0.032
mitotic cell cycle process GO:1903047 286 0.032
positive regulation of cellular catabolic process GO:0031331 284 0.031
mitochondrion organization GO:0007005 156 0.031
endocytosis GO:0006897 159 0.030
negative regulation of cell death GO:0060548 345 0.030
negative regulation of cellular component organization GO:0051129 235 0.030
atp dependent chromatin remodeling GO:0043044 25 0.030
regulation of peptidase activity GO:0052547 180 0.029
purine ribonucleoside metabolic process GO:0046128 437 0.028
single fertilization GO:0007338 11 0.028
regulation of cell cycle phase transition GO:1901987 126 0.027
cellular component morphogenesis GO:0032989 314 0.027
cellular amine metabolic process GO:0044106 41 0.027
dephosphorylation GO:0016311 209 0.026
lipid metabolic process GO:0006629 381 0.026
membrane organization GO:0061024 292 0.026
regulation of nucleotide metabolic process GO:0006140 269 0.025
cellular response to abiotic stimulus GO:0071214 117 0.025
positive regulation of cell death GO:0010942 263 0.025
positive regulation of catabolic process GO:0009896 310 0.025
small molecule biosynthetic process GO:0044283 157 0.024
protein localization to organelle GO:0033365 280 0.024
regulation of transcription by chromatin organization GO:0034401 1 0.024
cellular ketone metabolic process GO:0042180 80 0.024
chromatin assembly or disassembly GO:0006333 78 0.024
apoptotic mitochondrial changes GO:0008637 57 0.024
protein catabolic process GO:0030163 325 0.024
positive regulation of programmed cell death GO:0043068 249 0.023
dna biosynthetic process GO:0071897 40 0.023
Yeast
intrinsic apoptotic signaling pathway GO:0097193 127 0.023
single organism reproductive process GO:0044702 98 0.023
protein modification by small protein conjugation GO:0032446 342 0.023
locomotory behavior GO:0007626 1 0.022
positive regulation of nucleotide metabolic process GO:0045981 230 0.022
hindbrain development GO:0030902 3 0.022
protein targeting GO:0006605 187 0.022
negative regulation of cellular protein metabolic process GO:0032269 353 0.021
chromosome segregation GO:0007059 114 0.021
protein dna complex subunit organization GO:0071824 80 0.021
ubiquitin dependent protein catabolic process GO:0006511 206 0.021
dna replication GO:0006260 116 0.021
Yeast
dna replication independent nucleosome organization GO:0034724 27 0.021
cellular lipid metabolic process GO:0044255 303 0.021
regulation of gene expression epigenetic GO:0040029 73 0.020
Yeast
posttranscriptional regulation of gene expression GO:0010608 213 0.020
response to oxidative stress GO:0006979 121 0.020
regulation of nucleoside metabolic process GO:0009118 209 0.020
cellular response to oxygen containing compound GO:1901701 276 0.020
regulation of purine nucleotide metabolic process GO:1900542 264 0.020
adult locomotory behavior GO:0008344 1 0.020
positive regulation of transport GO:0051050 336 0.020
regulation of cellular response to stress GO:0080135 244 0.020
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.020
cellular response to radiation GO:0071478 65 0.020
aging GO:0007568 66 0.019
Yeast
cellular response to endogenous stimulus GO:0071495 336 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.019
modification dependent protein catabolic process GO:0019941 209 0.019
positive regulation of apoptotic process GO:0043065 246 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
regulation of cellular amino acid metabolic process GO:0006521 6 0.018
chemical homeostasis GO:0048878 306 0.018
heterochromatin organization GO:0070828 6 0.018
Yeast
negative regulation of catalytic activity GO:0043086 335 0.018
cell cycle phase transition GO:0044770 173 0.018
peptidyl lysine acetylation GO:0018394 101 0.018
cation homeostasis GO:0055080 189 0.018
negative regulation of hydrolase activity GO:0051346 182 0.018
regulation of cellular component biogenesis GO:0044087 281 0.018
regulation of protein processing GO:0070613 150 0.018
release of cytochrome c from mitochondria GO:0001836 35 0.018
positive regulation of nucleoside metabolic process GO:0045979 186 0.018
cytoplasmic transport GO:0016482 379 0.018
gtp metabolic process GO:0046039 239 0.017
embryo development GO:0009790 123 0.017
reactive oxygen species metabolic process GO:0072593 75 0.017
regulation of cell cycle process GO:0010564 266 0.017
regulation of cellular ketone metabolic process GO:0010565 50 0.017
defense response GO:0006952 315 0.016
epithelium development GO:0060429 227 0.016
positive regulation of cellular amine metabolic process GO:0033240 7 0.016
actin filament based process GO:0030029 224 0.016
regulation of apoptotic signaling pathway GO:2001233 175 0.016
cellular response to ionizing radiation GO:0071479 32 0.016
protein processing GO:0016485 226 0.016
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.016
organ formation GO:0048645 3 0.016
immune response GO:0006955 307 0.016
response to organic cyclic compound GO:0014070 204 0.016
chromatin remodeling at centromere GO:0031055 2 0.016
response to lipid GO:0033993 206 0.016
dna templated transcription initiation GO:0006352 35 0.015
organelle localization GO:0051640 84 0.015
negative regulation of protein metabolic process GO:0051248 391 0.015
small gtpase mediated signal transduction GO:0007264 78 0.015
regulation of wnt signaling pathway GO:0030111 123 0.015
transmembrane transport GO:0055085 399 0.015
peripheral nervous system development GO:0007422 2 0.015
neurogenesis GO:0022008 169 0.015
regulation of cysteine type endopeptidase activity GO:2000116 127 0.015
ras protein signal transduction GO:0007265 73 0.015
muscle contraction GO:0006936 73 0.015
ion homeostasis GO:0050801 230 0.015
response to ionizing radiation GO:0010212 65 0.015
microtubule cytoskeleton organization GO:0000226 176 0.015
positive regulation of hydrolase activity GO:0051345 331 0.014
female gamete generation GO:0007292 2 0.014
negative regulation of catabolic process GO:0009895 104 0.014
guanosine containing compound catabolic process GO:1901069 239 0.014
multicellular organismal aging GO:0010259 3 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
regulation of endopeptidase activity GO:0052548 170 0.014
wnt signaling pathway GO:0016055 156 0.014
cell morphogenesis GO:0000902 296 0.014
innate immune response GO:0045087 178 0.014
positive regulation of ion transport GO:0043270 87 0.014
regulation of cell cycle GO:0051726 393 0.014
regulation of protein catabolic process GO:0042176 155 0.014
regulation of protein maturation GO:1903317 150 0.014
positive regulation of cell proliferation GO:0008284 301 0.014
regulation of transferase activity GO:0051338 355 0.013
cell type specific apoptotic process GO:0097285 125 0.013
regulation of protein localization GO:0032880 296 0.013
single organism cell adhesion GO:0098602 179 0.013
regulation of mitotic cell cycle phase transition GO:1901990 118 0.013
fertilization GO:0009566 12 0.013
metal ion homeostasis GO:0055065 169 0.013
negative regulation of cellular catabolic process GO:0031330 83 0.013
ribonucleoside monophosphate metabolic process GO:0009161 187 0.013
engulfment of apoptotic cell GO:0043652 2 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.013
mapk cascade GO:0000165 288 0.013
oxidation reduction process GO:0055114 396 0.013
reactive oxygen species biosynthetic process GO:1903409 4 0.013
cell adhesion GO:0007155 325 0.013
negative regulation of organelle organization GO:0010639 126 0.013
protein import GO:0017038 130 0.012
postreplication repair GO:0006301 12 0.012
Yeast
regeneration GO:0031099 4 0.012
alcohol biosynthetic process GO:0046165 52 0.012
establishment of protein localization to organelle GO:0072594 172 0.012
rho protein signal transduction GO:0007266 26 0.012
positive regulation of cytokine production GO:0001819 167 0.012
gtp catabolic process GO:0006184 237 0.012
mitotic cell cycle GO:0000278 326 0.012
cellular response to lipid GO:0071396 127 0.012
dna recombination GO:0006310 77 0.012
negative regulation of cell cycle GO:0045786 193 0.012
organic hydroxy compound metabolic process GO:1901615 147 0.012
positive regulation of cellular component organization GO:0051130 376 0.012
internal protein amino acid acetylation GO:0006475 101 0.012
response to external biotic stimulus GO:0043207 261 0.012
ribonucleoside catabolic process GO:0042454 406 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.012
guanosine containing compound metabolic process GO:1901068 244 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.012
protein dephosphorylation GO:0006470 81 0.012
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.012
autophagy GO:0006914 88 0.012
modification dependent macromolecule catabolic process GO:0043632 212 0.012
response to extracellular stimulus GO:0009991 85 0.012
lipid biosynthetic process GO:0008610 177 0.012
cytokine production GO:0001816 247 0.012
cellular response to organic cyclic compound GO:0071407 127 0.011
regulation of membrane potential GO:0042391 95 0.011
phospholipid metabolic process GO:0006644 99 0.011
regulation of response to external stimulus GO:0032101 222 0.011
positive regulation of protein transport GO:0051222 135 0.011
organophosphate catabolic process GO:0046434 430 0.011
positive regulation of endopeptidase activity GO:0010950 84 0.011
cellular response to oxidative stress GO:0034599 85 0.011
regulation of reactive oxygen species metabolic process GO:2000377 41 0.011
biological adhesion GO:0022610 331 0.011
regulation of mitochondrion organization GO:0010821 54 0.011
translesion synthesis GO:0019985 8 0.011
Yeast
nucleotide catabolic process GO:0009166 408 0.011
negative regulation of protein processing GO:0010955 142 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.011
determination of adult lifespan GO:0008340 2 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
response to reactive oxygen species GO:0000302 61 0.011
microtubule based process GO:0007017 210 0.011
signal transduction by phosphorylation GO:0023014 297 0.011
negative regulation of immune system process GO:0002683 136 0.011
response to biotic stimulus GO:0009607 276 0.011
glycerophospholipid metabolic process GO:0006650 84 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
regulation of gtpase activity GO:0043087 180 0.011
regulation of cytokine production GO:0001817 232 0.011
canonical wnt signaling pathway GO:0060070 116 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.011
methylation GO:0032259 106 0.011
negative regulation of protein maturation GO:1903318 142 0.010
positive regulation of gtpase activity GO:0043547 166 0.010
replicative senescence GO:0090399 8 0.010
Yeast
neuromuscular junction development GO:0007528 3 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.010
single organism cellular localization GO:1902580 332 0.010
cellular response to extracellular stimulus GO:0031668 72 0.010
metal ion transport GO:0030001 272 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.010
negative regulation of intracellular signal transduction GO:1902532 183 0.010
negative regulation of phosphorus metabolic process GO:0010563 267 0.010
morphogenesis of embryonic epithelium GO:0016331 4 0.010
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.010
regulation of binding GO:0051098 111 0.010
dna packaging GO:0006323 77 0.010

POLE4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.033
cancer DOID:162 167 0.020
organ system cancer DOID:0050686 164 0.020
disease of metabolism DOID:0014667 295 0.012
sensory system disease DOID:0050155 203 0.012
nervous system disease DOID:863 431 0.012
eye and adnexa disease DOID:1492 150 0.010