Homo sapiens

0 known processes

POLE2

polymerase (DNA directed), epsilon 2 (p59 subunit)

(Aliases: DPE2)

POLE2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna dependent dna replication GO:0006261 44 0.981
Yeast
dna repair GO:0006281 198 0.965
Yeast
dna replication GO:0006260 116 0.901
Yeast
regulation of transcription by chromatin organization GO:0034401 1 0.872
cellular response to dna damage stimulus GO:0006974 379 0.810
Yeast
double strand break repair GO:0006302 101 0.756
heterochromatin organization GO:0070828 6 0.688
dna biosynthetic process GO:0071897 40 0.592
Yeast
dna recombination GO:0006310 77 0.582
dna strand elongation involved in dna replication GO:0006271 3 0.552
nuclear division GO:0000280 128 0.328
post embryonic development GO:0009791 2 0.324
Worm
chromosome segregation GO:0007059 114 0.316
chromatin organization GO:0006325 351 0.236
double strand break repair via homologous recombination GO:0000724 50 0.225
regulation of cell cycle GO:0051726 393 0.192
mitotic cell cycle GO:0000278 326 0.173
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.166
purine containing compound catabolic process GO:0072523 411 0.164
establishment of nucleus localization GO:0040023 1 0.164
purine ribonucleoside metabolic process GO:0046128 437 0.162
nucleoside monophosphate metabolic process GO:0009123 191 0.155
dna strand elongation GO:0022616 5 0.140
ribonucleoside monophosphate metabolic process GO:0009161 187 0.130
mitotic cell cycle phase transition GO:0044772 162 0.124
sister chromatid segregation GO:0000819 54 0.124
leading strand elongation GO:0006272 1 0.121
histone acetylation GO:0016573 93 0.114
protein acetylation GO:0006473 116 0.112
recombinational repair GO:0000725 50 0.109
cellular macromolecular complex assembly GO:0034622 324 0.106
translesion synthesis GO:0019985 8 0.100
Yeast
nucleoside triphosphate metabolic process GO:0009141 422 0.098
nuclear migration GO:0007097 1 0.091
nucleoside monophosphate catabolic process GO:0009125 159 0.089
postreplication repair GO:0006301 12 0.089
Yeast
dna conformation change GO:0071103 113 0.087
non recombinational repair GO:0000726 14 0.086
organelle fission GO:0048285 149 0.086
mitotic cell cycle process GO:1903047 286 0.083
nucleus localization GO:0051647 1 0.082
embryo development GO:0009790 123 0.082
Worm
regulation of mitotic cell cycle GO:0007346 189 0.081
regulation of gene expression epigenetic GO:0040029 73 0.080
sister chromatid cohesion GO:0007062 24 0.079
nucleoside phosphate biosynthetic process GO:1901293 109 0.078
mitotic nuclear division GO:0007067 119 0.074
peptidyl lysine modification GO:0018205 144 0.073
cell aging GO:0007569 52 0.070
response to abiotic stimulus GO:0009628 336 0.069
purine nucleoside monophosphate metabolic process GO:0009126 186 0.068
meiotic chromosome segregation GO:0045132 4 0.067
internal peptidyl lysine acetylation GO:0018393 97 0.066
microtubule based process GO:0007017 210 0.065
ribonucleoside triphosphate metabolic process GO:0009199 412 0.065
chromatin assembly GO:0031497 61 0.063
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.060
carbohydrate derivative biosynthetic process GO:1901137 207 0.057
purine nucleoside monophosphate catabolic process GO:0009128 158 0.057
gene conversion GO:0035822 1 0.057
reproductive structure development GO:0048608 55 0.053
Worm
internal protein amino acid acetylation GO:0006475 101 0.051
negative regulation of cell cycle GO:0045786 193 0.051
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.049
vesicle mediated transport GO:0016192 371 0.049
microtubule cytoskeleton organization GO:0000226 176 0.047
negative regulation of mitotic cell cycle GO:0045930 102 0.047
nucleoside triphosphate catabolic process GO:0009143 394 0.046
regulation of dna metabolic process GO:0051052 153 0.045
gene silencing GO:0016458 49 0.045
reproduction GO:0000003 63 0.045
Worm
organophosphate catabolic process GO:0046434 430 0.044
negative regulation of gene expression epigenetic GO:0045814 19 0.044
ribonucleotide catabolic process GO:0009261 405 0.042
base excision repair GO:0006284 21 0.041
mitotic cell cycle checkpoint GO:0007093 68 0.041
dna damage checkpoint GO:0000077 68 0.041
g2 m transition of mitotic cell cycle GO:0000086 41 0.041
response to ionizing radiation GO:0010212 65 0.039
nucleotide biosynthetic process GO:0009165 109 0.039
regulation of cellular amine metabolic process GO:0033238 11 0.039
ribonucleoside triphosphate catabolic process GO:0009203 391 0.038
protein acylation GO:0043543 138 0.036
ribonucleoside monophosphate catabolic process GO:0009158 158 0.036
cell cycle phase transition GO:0044770 173 0.036
regulation of mitotic cell cycle phase transition GO:1901990 118 0.035
mitotic sister chromatid segregation GO:0000070 53 0.034
negative regulation of cell cycle phase transition GO:1901988 89 0.034
chromatin assembly or disassembly GO:0006333 78 0.034
nucleoside phosphate catabolic process GO:1901292 412 0.033
negative regulation of cell cycle process GO:0010948 121 0.033
cell division GO:0051301 168 0.033
cell cycle checkpoint GO:0000075 117 0.032
aging GO:0007568 66 0.032
organophosphate biosynthetic process GO:0090407 163 0.031
regulation of cell cycle process GO:0010564 266 0.031
mitotic dna damage checkpoint GO:0044773 28 0.031
regulation of cell cycle phase transition GO:1901987 126 0.031
embryo development ending in birth or egg hatching GO:0009792 34 0.029
Worm
chromatin modification GO:0016568 298 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.029
protein dna complex subunit organization GO:0071824 80 0.027
dna geometric change GO:0032392 32 0.027
dna integrity checkpoint GO:0031570 71 0.027
nucleus organization GO:0006997 28 0.026
regulation of proteolysis GO:0030162 293 0.026
response to radiation GO:0009314 151 0.026
cellular response to ionizing radiation GO:0071479 32 0.026
peptidyl lysine acetylation GO:0018394 101 0.025
reproductive process GO:0022414 106 0.025
Worm
positive regulation of immune system process GO:0002684 283 0.025
histone h3 acetylation GO:0043966 45 0.025
atp catabolic process GO:0006200 157 0.025
chromatin silencing GO:0006342 12 0.024
cell activation GO:0001775 213 0.024
purine ribonucleoside catabolic process GO:0046130 398 0.023
cellular response to radiation GO:0071478 65 0.023
determination of adult lifespan GO:0008340 2 0.023
purine nucleoside catabolic process GO:0006152 398 0.023
cellular response to abiotic stimulus GO:0071214 117 0.022
regeneration GO:0031099 4 0.022
chromatin remodeling GO:0006338 55 0.021
cellular macromolecule catabolic process GO:0044265 380 0.021
organelle localization GO:0051640 84 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.020
cell cycle g2 m phase transition GO:0044839 43 0.020
dna packaging GO:0006323 77 0.020
single organism reproductive process GO:0044702 98 0.020
Worm
reproductive system development GO:0061458 56 0.020
Worm
purine nucleotide catabolic process GO:0006195 405 0.019
maintenance of location GO:0051235 112 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.019
purine ribonucleotide catabolic process GO:0009154 404 0.019
apoptotic signaling pathway GO:0097190 268 0.019
cellular ketone metabolic process GO:0042180 80 0.018
regulation of g2 m transition of mitotic cell cycle GO:0010389 20 0.018
negative regulation of cell death GO:0060548 345 0.018
purine nucleoside triphosphate metabolic process GO:0009144 412 0.018
reciprocal meiotic recombination GO:0007131 4 0.017
modification dependent macromolecule catabolic process GO:0043632 212 0.017
intra s dna damage checkpoint GO:0031573 4 0.017
nucleosome organization GO:0034728 66 0.017
cellular amino acid metabolic process GO:0006520 116 0.017
protein localization to organelle GO:0033365 280 0.017
nucleotide catabolic process GO:0009166 408 0.016
covalent chromatin modification GO:0016569 254 0.016
dna duplex unwinding GO:0032508 30 0.016
mitotic dna integrity checkpoint GO:0044774 30 0.015
negative regulation of cellular protein metabolic process GO:0032269 353 0.015
protein catabolic process GO:0030163 325 0.015
histone modification GO:0016570 251 0.015
meiosis i GO:0007127 4 0.015
organonitrogen compound biosynthetic process GO:1901566 200 0.015
protein processing GO:0016485 226 0.015
single organism cellular localization GO:1902580 332 0.014
blastocyst development GO:0001824 3 0.014
regulation of protein catabolic process GO:0042176 155 0.014
negative regulation of catalytic activity GO:0043086 335 0.014
positive regulation of cell proliferation GO:0008284 301 0.014
centromere complex assembly GO:0034508 10 0.014
g1 s transition of mitotic cell cycle GO:0000082 78 0.014
ubiquitin dependent protein catabolic process GO:0006511 206 0.014
cellular amine metabolic process GO:0044106 41 0.013
dephosphorylation GO:0016311 209 0.013
atp metabolic process GO:0046034 176 0.013
cardiovascular system development GO:0072358 262 0.013
oxidation reduction process GO:0055114 396 0.013
negative regulation of cellular component organization GO:0051129 235 0.013
nucleotide excision repair GO:0006289 31 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.013
development of primary sexual characteristics GO:0045137 35 0.013
Worm
regulation of response to dna damage stimulus GO:2001020 94 0.013
multicellular organismal aging GO:0010259 3 0.012
positive regulation of cellular catabolic process GO:0031331 284 0.012
protein dna complex assembly GO:0065004 64 0.012
histone exchange GO:0043486 3 0.012
regulation of cellular response to stress GO:0080135 244 0.012
regulation of dna replication GO:0006275 68 0.012
cell cycle g1 s phase transition GO:0044843 80 0.012
dna catabolic process GO:0006308 49 0.012
endomembrane system organization GO:0010256 196 0.011
protein maturation GO:0051604 233 0.011
maintenance of location in cell GO:0051651 62 0.011
regulation of cell activation GO:0050865 125 0.011
cell cell signaling GO:0007267 155 0.011
cell morphogenesis GO:0000902 296 0.011
regulation of protein localization GO:0032880 296 0.011
glycosyl compound catabolic process GO:1901658 413 0.011
modification dependent protein catabolic process GO:0019941 209 0.011
regulation of cellular component biogenesis GO:0044087 281 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
protein targeting GO:0006605 187 0.011
negative regulation of proteolysis GO:0045861 132 0.010
positive regulation of phosphorylation GO:0042327 394 0.010
negative regulation of apoptotic process GO:0043066 316 0.010
endocytosis GO:0006897 159 0.010
intracellular protein transport GO:0006886 270 0.010
negative regulation of programmed cell death GO:0043069 321 0.010
regulation of chromosome organization GO:0033044 103 0.010
positive regulation of catabolic process GO:0009896 310 0.010

POLE2 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.190
disease of cellular proliferation DOID:14566 174 0.190
organ system cancer DOID:0050686 164 0.190
disease of metabolism DOID:0014667 295 0.052
inherited metabolic disorder DOID:655 242 0.052
immune system disease DOID:2914 155 0.019
gastrointestinal system cancer DOID:3119 52 0.013
large intestine cancer DOID:5672 29 0.013
intestinal cancer DOID:10155 29 0.013
colorectal cancer DOID:9256 29 0.013