Homo sapiens

67 known processes

LEPROT

leptin receptor overlapping transcript

(Aliases: OBRGRP,FLJ37482,LEPR,OB-RGRP,FLJ90360,VPS55)

LEPROT biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
apoptotic signaling pathway GO:0097190 268 0.155
defense response GO:0006952 315 0.096
positive regulation of transport GO:0051050 336 0.090
intracellular protein transport GO:0006886 270 0.087
negative regulation of multicellular organismal process GO:0051241 317 0.084
single organism membrane organization GO:0044802 268 0.073
immune effector process GO:0002252 159 0.069
cytoplasmic transport GO:0016482 379 0.069
post golgi vesicle mediated transport GO:0006892 36 0.067
determination of adult lifespan GO:0008340 2 0.067
establishment of protein localization to organelle GO:0072594 172 0.066
purine nucleoside triphosphate metabolic process GO:0009144 412 0.066
endomembrane system organization GO:0010256 196 0.066
regulation of cellular component movement GO:0051270 334 0.066
protein localization to organelle GO:0033365 280 0.065
secretion by cell GO:0032940 226 0.062
single organism cellular localization GO:1902580 332 0.059
circulatory system development GO:0072359 262 0.059
immune response GO:0006955 307 0.055
positive regulation of phosphorylation GO:0042327 394 0.054
positive regulation of immune system process GO:0002684 283 0.054
nucleoside triphosphate catabolic process GO:0009143 394 0.053
negative regulation of developmental process GO:0051093 247 0.053
enzyme linked receptor protein signaling pathway GO:0007167 303 0.052
nucleoside phosphate catabolic process GO:1901292 412 0.052
metal ion transport GO:0030001 272 0.052
protein localization to plasma membrane GO:0072659 93 0.051
purine ribonucleotide catabolic process GO:0009154 404 0.051
regulation of protein localization GO:0032880 296 0.051
positive regulation of cellular component organization GO:0051130 376 0.049
blood vessel morphogenesis GO:0048514 162 0.048
purine ribonucleoside metabolic process GO:0046128 437 0.047
post embryonic development GO:0009791 2 0.046
transmembrane transport GO:0055085 399 0.045
regulation of apoptotic signaling pathway GO:2001233 175 0.045
cell adhesion GO:0007155 325 0.044
regulation of cell motility GO:2000145 299 0.044
endosomal transport GO:0016197 129 0.043
golgi to vacuole transport GO:0006896 3 0.043
negative regulation of glycoprotein metabolic process GO:1903019 8 0.043
protein localization to membrane GO:0072657 160 0.043
angiogenesis GO:0001525 147 0.042
purine nucleoside catabolic process GO:0006152 398 0.042
ion transmembrane transport GO:0034220 338 0.041
regulation of locomotion GO:0040012 329 0.041
regulation of secretion GO:0051046 194 0.041
plasma membrane organization GO:0007009 115 0.037
ribonucleotide catabolic process GO:0009261 405 0.036
vesicle mediated transport GO:0016192 371 0.036
establishment of protein localization to membrane GO:0090150 121 0.035
wnt signaling pathway GO:0016055 156 0.035
negative regulation of programmed cell death GO:0043069 321 0.034
membrane organization GO:0061024 292 0.034
regulation of secretion by cell GO:1903530 177 0.034
oogenesis GO:0048477 2 0.033
cellular response to endogenous stimulus GO:0071495 336 0.033
positive regulation of catabolic process GO:0009896 310 0.033
positive regulation of gtpase activity GO:0043547 166 0.033
biological adhesion GO:0022610 331 0.033
positive regulation of apoptotic process GO:0043065 246 0.033
regulation of multi organism process GO:0043900 157 0.033
negative regulation of transport GO:0051051 176 0.033
ras protein signal transduction GO:0007265 73 0.032
purine nucleotide catabolic process GO:0006195 405 0.032
regulation of cell migration GO:0030334 289 0.032
regulation of establishment of protein localization GO:0070201 242 0.032
inorganic ion transmembrane transport GO:0098660 231 0.032
positive regulation of cellular catabolic process GO:0031331 284 0.032
amine metabolic process GO:0009308 44 0.032
negative regulation of cellular component organization GO:0051129 235 0.031
positive regulation of natural killer cell activation GO:0032816 8 0.031
multicellular organismal aging GO:0010259 3 0.031
regulation of proteolysis GO:0030162 293 0.031
purine nucleoside triphosphate catabolic process GO:0009146 392 0.031
regulation of protein maturation GO:1903317 150 0.030
positive regulation of immune response GO:0050778 159 0.030
cardiovascular system development GO:0072358 262 0.030
cellular component morphogenesis GO:0032989 314 0.030
anion transport GO:0006820 161 0.030
negative regulation of protein metabolic process GO:0051248 391 0.030
positive regulation of exocytosis GO:0045921 35 0.029
regulation of immune response GO:0050776 201 0.029
rho protein signal transduction GO:0007266 26 0.029
regulation of peptidase activity GO:0052547 180 0.029
negative regulation of cell proliferation GO:0008285 228 0.029
innate immune response GO:0045087 178 0.029
segmentation GO:0035282 4 0.028
purine containing compound catabolic process GO:0072523 411 0.028
cell activation GO:0001775 213 0.028
positive regulation of hydrolase activity GO:0051345 331 0.027
negative regulation of cellular component movement GO:0051271 106 0.027
female gamete generation GO:0007292 2 0.027
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.027
sodium ion transport GO:0006814 61 0.026
extrinsic apoptotic signaling pathway GO:0097191 119 0.026
regulation of nucleoside metabolic process GO:0009118 209 0.026
epithelium development GO:0060429 227 0.026
negative regulation of protein maturation GO:1903318 142 0.026
cell morphogenesis GO:0000902 296 0.026
regulation of glycoprotein metabolic process GO:1903018 19 0.026
protein processing GO:0016485 226 0.025
regulation of intracellular transport GO:0032386 195 0.025
locomotory behavior GO:0007626 1 0.025
golgi vesicle transport GO:0048193 80 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.025
organophosphate catabolic process GO:0046434 430 0.025
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.025
negative regulation of apoptotic process GO:0043066 316 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.025
negative regulation of cell motility GO:2000146 104 0.025
membrane fusion GO:0061025 43 0.024
cellular response to glucocorticoid stimulus GO:0071385 4 0.024
regulation of cellular amino acid metabolic process GO:0006521 6 0.024
regulation of defense response GO:0031347 154 0.024
regulation of protein localization to plasma membrane GO:1903076 40 0.023
positive regulation of cell proliferation GO:0008284 301 0.023
positive regulation of secretion by cell GO:1903532 108 0.023
defense response to other organism GO:0098542 129 0.023
posttranscriptional regulation of gene expression GO:0010608 213 0.023
regulation of exocytosis GO:0017157 46 0.023
positive regulation of locomotion GO:0040017 186 0.023
vasculature development GO:0001944 181 0.023
blastoderm segmentation GO:0007350 2 0.023
guanosine containing compound metabolic process GO:1901068 244 0.023
positive regulation of programmed cell death GO:0043068 249 0.023
cellular homeostasis GO:0019725 196 0.023
regulation of vesicle mediated transport GO:0060627 130 0.022
response to biotic stimulus GO:0009607 276 0.022
positive regulation of cellular component movement GO:0051272 181 0.022
nucleoside catabolic process GO:0009164 408 0.022
cation transport GO:0006812 331 0.022
positive regulation of cell migration GO:0030335 172 0.022
guanosine containing compound catabolic process GO:1901069 239 0.022
regulation of transferase activity GO:0051338 355 0.022
regulation of cellular response to growth factor stimulus GO:0090287 76 0.022
organelle assembly GO:0070925 176 0.021
negative regulation of locomotion GO:0040013 118 0.021
inorganic cation transmembrane transport GO:0098662 194 0.021
negative regulation of cell differentiation GO:0045596 171 0.021
cellular ketone metabolic process GO:0042180 80 0.021
negative regulation of catalytic activity GO:0043086 335 0.021
organophosphate biosynthetic process GO:0090407 163 0.021
response to external biotic stimulus GO:0043207 261 0.021
response to oxidative stress GO:0006979 121 0.021
regulation of protein stability GO:0031647 87 0.021
cell development GO:0048468 328 0.021
mapk cascade GO:0000165 288 0.020
cation homeostasis GO:0055080 189 0.020
metal ion homeostasis GO:0055065 169 0.020
gtp metabolic process GO:0046039 239 0.020
cellular component disassembly GO:0022411 92 0.020
blood vessel development GO:0001568 172 0.020
regulation of lymphocyte mediated immunity GO:0002706 33 0.020
regulation of cell differentiation GO:0045595 393 0.020
cellular macromolecule catabolic process GO:0044265 380 0.020
regulation of anatomical structure morphogenesis GO:0022603 286 0.020
granzyme mediated apoptotic signaling pathway GO:0008626 4 0.020
protein catabolic process GO:0030163 325 0.020
response to wounding GO:0009611 168 0.020
cellular response to growth factor stimulus GO:0071363 197 0.020
intrinsic apoptotic signaling pathway GO:0097193 127 0.020
response to bacterium GO:0009617 144 0.020
cellular macromolecular complex assembly GO:0034622 324 0.019
nucleotide catabolic process GO:0009166 408 0.019
positive regulation of cell motility GO:2000147 177 0.019
positive regulation of protein phosphorylation GO:0001934 313 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
actin filament based process GO:0030029 224 0.019
lymphocyte mediated immunity GO:0002449 48 0.019
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.019
regulation of ras gtpase activity GO:0032318 128 0.019
small gtpase mediated signal transduction GO:0007264 78 0.019
negative regulation of cellular protein metabolic process GO:0032269 353 0.019
signal transduction by phosphorylation GO:0023014 297 0.019
negative regulation of protein processing GO:0010955 142 0.019
ribonucleoside catabolic process GO:0042454 406 0.019
regulation of protein processing GO:0070613 150 0.019
regulation of purine nucleotide metabolic process GO:1900542 264 0.019
epithelial cell proliferation GO:0050673 128 0.019
regulation of ion transport GO:0043269 189 0.019
negative regulation of hydrolase activity GO:0051346 182 0.019
regulation of protein transport GO:0051223 213 0.019
lipid metabolic process GO:0006629 381 0.018
regulation of leukocyte activation GO:0002694 115 0.018
lysosomal transport GO:0007041 33 0.018
regulation of cytokine production GO:0001817 232 0.018
protein ubiquitination GO:0016567 314 0.018
positive regulation of leukocyte mediated immunity GO:0002705 24 0.018
microtubule based process GO:0007017 210 0.018
response to oxygen containing compound GO:1901700 369 0.018
regulation of nucleotide metabolic process GO:0006140 269 0.018
regulation of protein catabolic process GO:0042176 155 0.018
response to other organism GO:0051707 261 0.018
secretion GO:0046903 254 0.018
sensory perception of smell GO:0007608 2 0.018
mitotic cell cycle GO:0000278 326 0.018
protein modification by small protein conjugation GO:0032446 342 0.018
positive regulation of cell adhesion GO:0045785 84 0.018
regulation of protein kinase activity GO:0045859 289 0.018
negative regulation of cell death GO:0060548 345 0.018
gtp catabolic process GO:0006184 237 0.018
cellular metal ion homeostasis GO:0006875 146 0.017
cellular amine metabolic process GO:0044106 41 0.017
ribonucleoside triphosphate metabolic process GO:0009199 412 0.017
cellular protein catabolic process GO:0044257 261 0.017
regulation of wnt signaling pathway GO:0030111 123 0.017
positive regulation of leukocyte degranulation GO:0043302 3 0.017
negative regulation of trophoblast cell migration GO:1901164 3 0.017
positive regulation of ras gtpase activity GO:0032320 117 0.017
purine ribonucleoside catabolic process GO:0046130 398 0.017
cell substrate adhesion GO:0031589 132 0.017
glycoprotein metabolic process GO:0009100 110 0.017
cellular amino acid metabolic process GO:0006520 116 0.017
viral life cycle GO:0019058 132 0.017
wound healing GO:0042060 115 0.017
response to hormone GO:0009725 175 0.017
response to growth factor GO:0070848 205 0.017
cation transmembrane transport GO:0098655 238 0.017
neuromuscular junction development GO:0007528 3 0.017
natural killer cell degranulation GO:0043320 2 0.017
positive regulation of nucleotide metabolic process GO:0045981 230 0.017
protein localization to synapse GO:0035418 2 0.016
protein maturation GO:0051604 233 0.016
divalent inorganic cation homeostasis GO:0072507 136 0.016
positive regulation of transferase activity GO:0051347 227 0.016
regulation of endothelial cell migration GO:0010594 67 0.016
regulation of endopeptidase activity GO:0052548 170 0.016
positive regulation of nucleoside metabolic process GO:0045979 186 0.016
sodium ion transmembrane transport GO:0035725 59 0.016
actin cytoskeleton organization GO:0030036 207 0.016
cellular ion homeostasis GO:0006873 168 0.016
urate transport GO:0015747 3 0.016
glycoprotein biosynthetic process GO:0009101 91 0.016
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 11 0.016
negative regulation of cell migration GO:0030336 102 0.016
positive regulation of cellular amine metabolic process GO:0033240 7 0.016
positive regulation of secretion GO:0051047 116 0.016
nuclear transport GO:0051169 179 0.016
cellular amide metabolic process GO:0043603 69 0.015
positive regulation of intracellular transport GO:0032388 104 0.015
memory GO:0007613 3 0.015
carbohydrate derivative biosynthetic process GO:1901137 207 0.015
ribonucleoside triphosphate catabolic process GO:0009203 391 0.015
regulation of kinase activity GO:0043549 314 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.015
cellular response to oxygen containing compound GO:1901701 276 0.015
chemical homeostasis GO:0048878 306 0.015
regulation of gtpase activity GO:0043087 180 0.015
maintenance of location GO:0051235 112 0.015
nervous system development GO:0007399 293 0.015
immune system development GO:0002520 195 0.015
cell chemotaxis GO:0060326 112 0.015
cell division GO:0051301 168 0.015
ameboidal type cell migration GO:0001667 135 0.015
organic anion transport GO:0015711 103 0.015
defense response to bacterium GO:0042742 63 0.015
protein stabilization GO:0050821 64 0.015
regulation of cellular ketone metabolic process GO:0010565 50 0.015
establishment of protein localization to plasma membrane GO:0090002 68 0.015
regulation of cellular response to stress GO:0080135 244 0.015
protein targeting to nucleus GO:0044744 104 0.014
regulation of immune effector process GO:0002697 91 0.014
single organism nuclear import GO:1902593 104 0.014
single organism cell adhesion GO:0098602 179 0.014
positive regulation of nucleotide catabolic process GO:0030813 185 0.014
endothelial cell migration GO:0043542 86 0.014
regulation of protein secretion GO:0050708 86 0.014
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.014
response to metal ion GO:0010038 84 0.014
negative regulation of cytokine production GO:0001818 82 0.014
endocytosis GO:0006897 159 0.014
regulation of leukocyte mediated immunity GO:0002703 38 0.014
protein import into nucleus GO:0006606 104 0.014
regulation of purine nucleotide catabolic process GO:0033121 205 0.014
embryo development GO:0009790 123 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.014
cell cycle phase transition GO:0044770 173 0.014
exocytosis GO:0006887 71 0.014
tissue migration GO:0090130 119 0.014
cellular hormone metabolic process GO:0034754 41 0.014
positive regulation of gtp catabolic process GO:0033126 166 0.014
divalent inorganic cation transport GO:0072511 158 0.013
neuron development GO:0048666 113 0.013
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.013
protein import GO:0017038 130 0.013
glycosyl compound catabolic process GO:1901658 413 0.013
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.013
positive regulation of ion transport GO:0043270 87 0.013
morphogenesis of a polarized epithelium GO:0001738 3 0.013
protein targeting GO:0006605 187 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.013
negative regulation of secretion by cell GO:1903531 52 0.013
regulation of lymphocyte activation GO:0051249 103 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
regeneration GO:0031099 4 0.013
cell killing GO:0001906 34 0.013
peptidyl tyrosine modification GO:0018212 170 0.013
organic hydroxy compound metabolic process GO:1901615 147 0.013
nucleocytoplasmic transport GO:0006913 176 0.013
vacuolar transport GO:0007034 34 0.013
regulation of amyloid precursor protein biosynthetic process GO:0042984 4 0.013
cell projection organization GO:0030030 252 0.013
regulation of epithelial cell migration GO:0010632 93 0.013
anterior posterior axis specification embryo GO:0008595 2 0.013
cellular response to oxidative stress GO:0034599 85 0.013
response to inorganic substance GO:0010035 127 0.013
mating GO:0007618 1 0.013
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.013
positive regulation of protein kinase activity GO:0045860 190 0.013
taxis GO:0042330 157 0.012
natural killer cell activation involved in immune response GO:0002323 2 0.012
microtubule based movement GO:0007018 32 0.012
receptor metabolic process GO:0043112 81 0.012
tripartite regional subdivision GO:0007351 2 0.012
compound eye development GO:0048749 1 0.012
membrane lipid metabolic process GO:0006643 53 0.012
negative regulation of peptidase activity GO:0010466 91 0.012
response to abiotic stimulus GO:0009628 336 0.012
peripheral nervous system development GO:0007422 2 0.012
regulation of nucleotide catabolic process GO:0030811 205 0.012
mitochondrion organization GO:0007005 156 0.012
neurogenesis GO:0022008 169 0.012
cellular cation homeostasis GO:0030003 163 0.012
leukocyte activation involved in immune response GO:0002366 30 0.012
regulation of cell killing GO:0031341 22 0.012
positive regulation of cell death GO:0010942 263 0.012
spermatid differentiation GO:0048515 4 0.012
adult locomotory behavior GO:0008344 1 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.012
actin filament organization GO:0007015 128 0.012
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 0.012
regulation of nervous system development GO:0051960 88 0.012
regulation of cellular amine metabolic process GO:0033238 11 0.012
leukocyte activation GO:0045321 164 0.011
regulation of cell cycle GO:0051726 393 0.011
hemopoiesis GO:0030097 180 0.011
reproductive process GO:0022414 106 0.011
reactive oxygen species metabolic process GO:0072593 75 0.011
negative regulation of multi organism process GO:0043901 92 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.011
ion homeostasis GO:0050801 230 0.011
cytokinesis GO:0000910 96 0.011
bmp signaling pathway GO:0030509 49 0.011
regulation of cytoplasmic transport GO:1903649 149 0.011
long term memory GO:0007616 2 0.011
leukocyte mediated immunity GO:0002443 59 0.011
cellular protein complex disassembly GO:0043624 36 0.011
cellular response to nutrient levels GO:0031669 69 0.011
single organism membrane fusion GO:0044801 37 0.011
nerve development GO:0021675 4 0.011
nitrogen compound transport GO:0071705 191 0.011
nuclear import GO:0051170 106 0.011
regulation of actin filament based process GO:0032970 141 0.011
negative regulation of secretion GO:0051048 58 0.011
convergent extension GO:0060026 1 0.011
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.011
positive regulation of organelle organization GO:0010638 195 0.011
cell migration involved in gastrulation GO:0042074 1 0.011
keratinocyte differentiation GO:0030216 36 0.011
macromolecular complex disassembly GO:0032984 60 0.011
regulation of gtp catabolic process GO:0033124 180 0.011
regulation of cysteine type endopeptidase activity GO:2000116 127 0.011
tissue regeneration GO:0042246 3 0.011
response to nutrient levels GO:0031667 81 0.011
regulation of ion transmembrane transport GO:0034765 132 0.011
chemotaxis GO:0006935 157 0.011
regulation of cell morphogenesis GO:0022604 153 0.011
regulation of mapk cascade GO:0043408 262 0.011
peptidyl tyrosine phosphorylation GO:0018108 170 0.011
protein localization to nucleus GO:0034504 136 0.010
positive regulation of aldosterone metabolic process GO:0032346 2 0.010
regulation of cell projection organization GO:0031344 107 0.010
cell part morphogenesis GO:0032990 137 0.010
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.010
protein oligomerization GO:0051259 173 0.010
cardiac muscle cell fate commitment GO:0060923 4 0.010
regulation of dna metabolic process GO:0051052 153 0.010
positive regulation of kinase activity GO:0033674 204 0.010
regulation of angiogenesis GO:0045765 92 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.010
proteasomal protein catabolic process GO:0010498 176 0.010
regulation of metal ion transport GO:0010959 120 0.010
negative regulation of protein transport GO:0051224 75 0.010
response to virus GO:0009615 126 0.010
alcohol metabolic process GO:0006066 114 0.010
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.010

LEPROT disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.311
inherited metabolic disorder DOID:655 242 0.311
lysosomal storage disease DOID:3211 47 0.091
cancer DOID:162 167 0.025
disease of cellular proliferation DOID:14566 174 0.025
sensory system disease DOID:0050155 203 0.022
nervous system disease DOID:863 431 0.022
acquired metabolic disease DOID:0060158 58 0.019
retinal disease DOID:5679 118 0.019
eye and adnexa disease DOID:1492 150 0.019
eye disease DOID:5614 149 0.019
organ system cancer DOID:0050686 164 0.015
cardiovascular system disease DOID:1287 106 0.013
retinal degeneration DOID:8466 89 0.013
musculoskeletal system disease DOID:17 223 0.011
epilepsy syndrome DOID:1826 41 0.010
central nervous system disease DOID:331 186 0.010
brain disease DOID:936 73 0.010
variable age at onset electroclinical syndrome DOID:0050706 8 0.010
electroclinical syndrome DOID:0050701 32 0.010